Clinical trials: Weaning From Mechanical Ventilation
Respiratory Insufficiency, Ventilator Weaning
Totally Transdermal Sedation in the Weaning From Remifentanil Infusion
The choice of the sedation protocol has a massive impact on the duration of mechanical ventilation and the timing of extubation. Many sedation protocols are described in the literature.
- Conditions
- Respiratory Insufficiency, Ventilator Weaning, Analgesics, Opioid
- Trial name
- TOES (NCT04204967)
- Testing
- Fentanyl Transdermal System, Remifentanil
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Ventilator Weaning, Sarcopenia
Comparison of Sarcopenia Index, Diaphragm Ultrasonography, and Traditional Weaning Parameters in Predicting Successful Weaning From Mechanical Ventilation
This study investigates whether the Sarcopenia Index (SI = serum creatinine/cystatin C × 100), a simple biomarker derived from routine blood tests, can predict weaning success in critically ill patients undergoing invasive…
- Conditions
- Ventilator Weaning, Sarcopenia, Diaphragm Ultrasonography
- Trial name
- NCT07844421
- Testing
- sarcopenia index, diaphragma ultrasound, parameters of mechanical ventilation (MV)
- Volunteers
- 80 people
- Sponsor
- Kocaeli City Hospital
Emergence From Anesthesia, Mechanical Ventilation
Controlled Ventilation During Anesthetic Emergence
Absolutely - for a ClinicalTrials.gov-style Brief Summary, I'd keep it simple and patient-friendly like your example: The goal of this clinical trial is to learn whether maintaining controlled mechanical ventilation during…
- Trial name
- NCT07853547
- Testing
- Controlled/Full-Support Mechanical Ventilation During Emergence
- Where
- Saudi Arabia
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz Medical City
Ventilator Lung, Acute Brain Injury
Weaning From Mechanical Ventilation in Patients With Acute Brain Injury
Acute brain injury (ABI) patients frequently necessate intubation and invasive mechanical ventilation (IMV). While some ABI patients are capable of breathing spontaneously, which is one of the main criteria of extubation and…
- Trial name
- NCT06542107
- Where
- China
- Volunteers
- 605 people
- Sponsor
- Southeast University, China
Weaning Failure, Pulmonary Edema - Acute
Quantification of Systemic Congestion by Ultrasound As a Predictor of Weaning Failure From Mechanical Ventilation
Mechanical ventilation is an essential, life-saving therapy in the ICU, allowing critically ill patients to rest and recover. Transitioning patients back to spontaneous breathing-known as weaning-is clinically challenging.
- Conditions
- Weaning Failure, Pulmonary Edema - Acute, Mechanical Ventilation, POCUS
- Trial name
- SCOUT (NCT07343882)
- Testing
- point of care ultrasound
- Volunteers
- 350 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Myocardial Ischaemia During Surgery
Monitoring of Heart to Guide Myocardial Injury Patients to Wean From Ventilation
The goal of this prospective randomized controlled clinical trail is to explore the value of integrating continuous cardiac index variability indicators with existing weaning standards to guide perioperative myocardial injury…
- Trial name
- NCT06240104
- Testing
- cardiac output index monitor
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University People's Hospital
Respiration, Artificial, COVID-19
Characteristics of Weaning From Mechanical Ventilation in COVID-19
This report is a multicenter, observational, analytical and prospective study. The objective was to describe the weaning of mechanical ventilation in patients with SARS-CoV-2 and the clinical results according to the different…
- Trial name
- CovWean (NCT05049200)
- Where
- 2 sites in Argentina
- Volunteers
- 326 people
- Sponsor
- Sanatorio Anchorena San Martin
Ventilator Weaning, Alkalosis, Metabolic
Acetazolamide Facilitates Ventilator Weaning
Metabolic alkalosis(MA) is common metabolic disorder in ICU setting. MA could be cause of weaning failure or delay by depression of respiratory center.
- Trial name
- NCT01131377
- Testing
- acetazolamide, Saline
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Asan Medical Center
Weaning Mechanical Ventilation
Airway Occlusion Pressure Derived Parameters During Spotaneous Breathing Trial for Predicting Extubation Failure
Weaning from invasive mechanical ventilation (IMV) is a critical stage of the intensive care unit (ICU) stay. Premature IMV discontinuation may expose patients to substantial cardiopulmonary stress, whereas prolonged weaning…
- Trial name
- Weaning-POP (NCT07786519)
- Where
- 4 sites in France
- Volunteers
- 225 people
- Sponsor
- Rennes University Hospital
Dexmedetomidine
The Effect of Dexmedetomidine on Agitation During Weaning From Mechanical Ventilation
This study aims to evaluate the effect of dexmedetomidine on the level of agitation during the weaning process from mechanical ventilation in critically ill patients.
- Trial name
- NCT07066605
- Testing
- Group A (Dexmedetomidine Group), Group B (Control Group)
- Where
- Egypt
- Volunteers
- 62 people
- Sponsor
- Sohag University
Weaning Failure
The Effect of High Flow Oxygen Therapy Via Tracheostomy on Diaphragm Function
While the high flow oxygen therapy (HFOT) respiratory support system, delivered through nasal cannulas, has demonstrated clinical benefits on respiratory function, limited data exist on whether such effects are also present in…
- Trial name
- NCT04758910
- Testing
- High Flow Oxygen Therapy, T-piece
- Volunteers
- 30 people
- Sponsor
- Evangelismos Hospital
Patients With Acute Hypercapnic Respiratory Failure
Weaning Form Mechanical Ventilation Using Extracorporeal CO2 Removal
Weaning from invasive mechanical ventilation is one of the major clinical problem especially ion those patients with a pre-existing chronic respiratory disease and chronic hypercpania.
- Trial name
- WeanPRO (NCT02259335)
- Testing
- Extracorporeal CO2 removal device
- Where
- 2 sites in Italy
- Volunteers
- 15 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Weaning Failure
Peripheral Perfusion Index in Weaning From Mechanical Ventilation
Peripheral perfusion index (PPI) is variable measured by Radical-7 (Masimo) device and reflects the ratio between pulsatile and non-pulsatile portions of peripheral circulation.
- Trial name
- NCT03974568
- Where
- Egypt
- Volunteers
- 43 people
- Sponsor
- Cairo University
Weaning Failure, Pulmonary Collapse
Lung Volume Preservation During Extubation
Introduction: At present, the best spontaneous breathing trial (SBT) during weaning from mechanical ventilation is a 30-min test with pressure support (PSV) 8 cmH2O without positive end-expiratory pressure (PEEP).
- Trial name
- NCT05526053
- Testing
- Lung volume preservation
- Where
- Spain
- Volunteers
- 1,753 people
- Sponsor
- Althaia Xarxa Assistencial Universitària de Manresa
Respiratory Insufficiency
Effect of Sleep Disruption on the Outcome of Weaning From Mechanical Ventilation
Mechanically ventilated patients in the Intensive Care Unit (ICU) are highly susceptible to sleep disruption. Several studies in the last 15 years have demonstrated an extremely poor sleep quality and abnormal sleep pattern…
- Trial name
- SLEEWE (NCT02464735)
- Testing
- Polysomnography
- Where
- 3 sites in Canada
- Volunteers
- 44 people
- Sponsor
- Unity Health Toronto
Mechanical Ventilation, Autonomic Nervous System Diseases
Variability Analysis as a Predictor of Liberation From Mechanical Ventilation
The purpose of this study is to evaluate if the variability of biological signals, such as heart rate and temperature, can predict weaning from mechanical ventilation in patients with failure to wean.
- Trial name
- NCT01140750
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The Cleveland Clinic
Acute Hypoxemic Respiratory Failure
ATC vs PSV for Weaning in Patients With Respiratory Failure
Comparative study between automatic tube compensation and pressure support ventilation as a mode of weaning from mechanical ventilation in patients with respiratory failure
- Trial name
- NCT07238140
- Testing
- Automatic tube compensation, Pressure Support Ventilation
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Tracheotomy
Tracheostomy and Weaning From Mechanical Ventilation : Evaluation of the Lung Ultrasound Score
Prospective, interventional multicentric study in ICU during weaning from mechanical ventilation in tracheotomized patients
- Trial name
- TRAWELUS (NCT01793363)
- Testing
- Tracheotomy
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Clermont-Ferrand
Respiratory Failure, Midazolam Overdose
Sedation and Ease of Weaning From Mechanical Ventilation
Daily interruption of sedation is one of the modalities which is known to enhance early weaning and separation from mechanical ventilation .
- Conditions
- Respiratory Failure, Midazolam Overdose, Chronic Obstructive Pulmonary Disease, Weaning Failure
- Trial name
- NCT03406936
- Testing
- Daily interruption of midazolam
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Weaning Failure
Diaphragmatic Rapid Shallow Breathing Index for Predicting Weaning Outcome From Mechanical Ventilation
Predicting successful discontinuation from mechanical ventilation has been a focus of interest to all critical care physicians . Various weaning indices have been investigated to optimize the weaning process.
- Trial name
- NCT03561792
- Testing
- Diaphragm ultrasound
- Where
- Egypt
- Volunteers
- 106 people
- Sponsor
- Zagazig University