Clinical trials: Weaning From Mechanical Ventilation
Respiration, Artificial
Weaning From Mechanical Ventilation Comparison of Open-loop Decision Support System and Routine Care
The purpose of this study is to compare mechanical ventilation following advice from the Beacon Caresystem to that of routine care in patients from the state of requiring invasive mechanical ventilation until successful…
- Trial name
- BEACON (NCT02842944)
- Testing
- open loop weaning group (Beacon), Routine care
- Where
- France
- Volunteers
- 29 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Acute Respiratory Failure, Respiration, Artificial
Ultrasound to Evaluate Failure of Liberation From Mechanical Ventilation
This study will evaluate the heart, lungs and diaphragm of patients who fail a trial of spontaneous breathing to determine the physiological mechanism of weaning failure.
- Conditions
- Acute Respiratory Failure, Respiration, Artificial, Weaning
- Trial name
- USEFUL (NCT02723565)
- Where
- 3 sites in Canada
- Volunteers
- 7 people
- Sponsor
- University Health Network, Toronto
Respiratory Mechanics, Monitoring, Physiologic
Dynamic Non-invasive Monitoring of Inspiratory Effort
This prospective, observational cohort study aims to evaluate whether the dynamic monitoring of a patient's breathing effort can predict successful liberation from invasive mechanical ventilation.
- Conditions
- Respiratory Mechanics, Monitoring, Physiologic, Respiratory Insufficiency Requiring Mechanical Ventilation, Critical Illness
- Trial name
- NCT07839949
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Fundació d'investigació Sanitària de les Illes Balears
Weaning From Mechanical Ventilation
High Flow Nasal Cannula Versus High Velocity Nasal Insufflation for Weaning
In intensive care units (ICUs), approximately 10% to 15%of patients ready to be separated from a ventilator experience extubation failure leading to reintubation.
- Trial name
- NCT07133698
- Testing
- High Flow nasal Cannula, High velocity nasal insufflation, Noninvasive ventilation
- Where
- Egypt
- Volunteers
- 105 people
- Sponsor
- Assiut University
Critical Care, Weaning
Heart Rate Variability During Weaning From Mechanical Ventilation
The discontinuation of mechanical ventilation (MV) and the recovery of spontaneous breathing can lead to important cardiovascular alterations due to changes in the intrathoracic pressure.
- Trial name
- NCT00851825
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Mechanical Ventilator Weaning, Critically Ill
Neurally Adjusted Ventilatory Assist for Weaning From Invasive Mechanical Ventilation in Critically Ill Children
The goal of this clinical trial is to compare weaning from mechanical ventilation in critically ill children. The main questions it aims to answer are: Will weaning with neurally adjusted ventilatory assist (NAVA) mode…
- Conditions
- Mechanical Ventilator Weaning, Critically Ill, Mechanical Ventilation, Neurally Adjusted Ventilatory Assist
- Trial name
- NCT06157593
- Testing
- NAVA
- Where
- Thailand
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Mechanical Ventilation Weaning, Weaning Failure
Comprehensive Ultrasound Evaluation as a Predictor of Weaning
Several studies investigated the role of specific clinical predictors of weaning success, but it is determined by a combination of different aspects that can result in success or failure.
- Trial name
- NCT05539599
- Testing
- Comprehensive evaluation
- Where
- 2 sites in Italy
- Volunteers
- 89 people
- Sponsor
- Università degli Studi di Ferrara
Tracheostomized Patients, Mechanical Ventilation Weaning
High Flow Tracheal Oxygen for Weaning of Tracheostomized Patients
In this pilot randomized controlled trial (RCT), the investigators aim to explore the feasibility of conducting a powered RCT that examines the efficacy and safety of high flow tracheal oxygen (HFTO) in weaning critically ill…
- Conditions
- Tracheostomized Patients, Mechanical Ventilation Weaning, High Flow Oxygen Therapy
- Trial name
- HFTO-WEAN (NCT07559591)
- Testing
- High-flow tracheal oxygen (HFTO), Tracheal Mask (TM)
- Where
- Saudi Arabia
- Volunteers
- 88 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Diaphragm, Diaphragm Disease
Diaphragmatic Ultrasound and Weaning After Lung Transplant.
The prevalence and adverse effect of diaphragm dysfunction (DD) after bilateral-lung transplant (LT) are still unclear, despite a well-known negative impact on weaning and outcome in other cohorts of critically ill and surgical…
- Conditions
- Diaphragm, Diaphragm Disease, Diaphragm Issues, Weakness, Muscle
- Trial name
- NCT05670327
- Testing
- Diaphragmatic ultrasound assessment
- Where
- Italy
- Volunteers
- 43 people
- Sponsor
- University of Padova
Critical Illness, Respiratory Insufficiency
Combined Predictive Value of RSBI and CALLY Index in Predicting Weaning Success in ICU Patients
The primary objective of this prospective observational study is to evaluate the effectiveness of combining the Rapid Shallow Breathing Index (RSBI) and CRP-Albumin-Lymphocyte (CALLY) index to predict weaning success in adult…
- Conditions
- Critical Illness, Respiratory Insufficiency, Ventilator Weaning, Weaning Failure of Mechanical Ventilation
- Trial name
- NCT07571317
- Where
- Turkey (Türkiye)
- Volunteers
- 106 people
- Sponsor
- Istanbul University - Cerrahpasa
Ventilator Weaning, Weaning Failure
Voices of Patients' Relatives to Support Weaning From Mechanical Ventilation
Patients with severe brain injuries, such as ischemic stroke and intracranial hemorrhage, frequently require mechanical ventilation. Weaning of stroke patients is complicated by impaired consciousness and respiratory drive.
- Conditions
- Ventilator Weaning, Weaning Failure, Brain Injuries
- Trial name
- VOICE-WEANING (NCT03795623)
- Testing
- Voice-Weaning
- Where
- Germany
- Volunteers
- 45 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Adult Patients Ventilated More Than 48 h, Stable Respiratory and Hemodynamic Conditions for SBT
Pulmonary and Cardiac Ultrasound During Weaning From Mechanical Ventilation
Prospective observational clinical multicentric study in ICU with ventilated patients requiring chest ultrasound analysis.
- Conditions
- Adult Patients Ventilated More Than 48 h, Stable Respiratory and Hemodynamic Conditions for SBT, Consent of Patients, Arterial Line
- Trial name
- PULCO (NCT01098773)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Clermont-Ferrand
Assess the Prediction of Successful SBT and Extubation of Trachea by Bedside Lung Ultrasound in Mechanically Ventilated Patients
Prediction of Weaning Outcome From Mechanical Ventilation Using Ultrasound
Examine the predictive value of lung ultrasound in assessing the success of SBTs and tracheal extubation among patients receiving mechanical ventilation in the intensive care unit (ICU).
- Trial name
- NCT06685224
- Testing
- Ultrasound Assessment of the aeration of lung tissue and Parasternal Intercostal Muscle Thickness
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Tanta University
Mechanical Ventilation
Optimization of Serum Phosphorus Level and Weaning From Mechanical Ventilation
The goal of this clinical trial is to test the impact of serum phosphorus level optimization on weaning from mechanical ventilation in adult ICU patients in Alexandria University Hospitals.
- Trial name
- NCT05682846
- Testing
- Sodium glycerophosphate pentahydrate solution
- Where
- Egypt
- Volunteers
- 124 people
- Sponsor
- Alexandria University
Traumatic Brain Injury, Weaning Failure
Study of Variables Related to the Discontinuation of Mechanical Ventilation in Patients With Head Injury
The purpose of this study is to evaluate physiological variables to the decision about the appropriate time to discontinuation of mechanical ventilation in patients with traumatic brain injury.
- Conditions
- Traumatic Brain Injury, Weaning Failure, Mechanical Ventilation Complication
- Trial name
- INDEXTBI (NCT01713010)
- Testing
- Predictive indexes of weaning from mechanical ventilation
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of Uberlandia
Respiration, Artificial, Critical Care
Weaning Algorithm for Mechanical VEntilation
To compare the duration of mechanical ventilation and the weaning period between two groups of patients managed with either Standard Care or with mechanical ventilation adjusted according to the Beacon Caresystem, in patients…
- Conditions
- Respiration, Artificial, Critical Care, Respiratory Insufficiency, Intensive Care (ICU) Myopathy
- Trial name
- WAVE (NCT03697785)
- Testing
- Beacon Care System
- Where
- 2 sites in United Kingdom
- Volunteers
- 286 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Tracheostomy, Mechanical Ventilation
Trcheal High-flow for Weaning From Mechanical Ventilation
Multicentre randomized trial to determine whether tracheal high-flow nasal oxygen can improve weaning outcome vs. conventional oxygen therapy in critically ill tracheostomized patients who are hypoxemic.
- Conditions
- Tracheostomy, Mechanical Ventilation, Hypoxemic Respiratory Failure
- Trial name
- TRACFLOW (NCT07714564)
- Testing
- Oxygen therapy
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Ventilator Weaning, Mechanical Ventilation
Comparison of Diaphragm Ultrasound and RSBI for Predicting Weaning Success in Mechanically Ventilated ICU Patients
The goal of this observational study is to evaluate the predictive value of diaphragmatic ultrasound compared to the Rapid Shallow Breathing Index (RSBI) in determining weaning success among mechanically ventilated patients in…
- Conditions
- Ventilator Weaning, Mechanical Ventilation, Respiratory Insufficiency Requiring Mechanical Ventilation, Weaning From Mechanical Ventilation
- Trial name
- NCT07120438
- Volunteers
- 55 people
- Sponsor
- Gadjah Mada University
Mechanical Ventilation Weaning
Ultrasound Diagnostic for Diaphragmatic Dysfunction in Reanimation
Extubation is a crucial step when patients are being weaned from mechanical ventilator support. Indeed, the patient has to face an increasing burden imposed to the ventilation system.
- Trial name
- ECHODIAPH II (NCT02883465)
- Testing
- Diaphragmatic ultrasound
- Where
- 3 sites in France
- Volunteers
- 74 people
- Sponsor
- Centre Hospitalier Saint Joseph Saint Luc de Lyon
Neuromodulation, Phrenic Nerve Stimulation
Randomized Study of the pdSTIM™ System in Failure to Wean Mechanically Ventilated Patients
This prospective, multi-center, randomized, controlled clinical trial is being conducted to evaluate the safety and efficacy of the pdSTIM System to facilitate weaning from mechanical ventilation through phrenic nerve…
- Conditions
- Neuromodulation, Phrenic Nerve Stimulation, Ventilator Induced Diaphragm Dysfunction, Mechanical Ventilation Weaning
- Trial name
- ReInvigorate (NCT05998018)
- Testing
- pdSTIM System Therapy, Conventional Medical Management
- Where
- 16 sites in United States
- Volunteers
- 32 people
- Sponsor
- Stimdia Medical Inc.