Clinical trials: Weaning Mechanical Ventilation
DIAPHRAGM -Ultrasound -Weaning -Mechanical Ventilation
Diaphragm Training Ultrasound
Common neurological indications of intubation and initiation of mechanical ventilation (MV) include ischemic and hemorrhagic stroke, neurotrauma, and intracranial hemorrhage.
- Trial name
- DiaphUS (NCT04186325)
- Testing
- DIAPHRAGMATIC exercising
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Mansoura University
Laryngeal Edema
Ultrafast Ultrasonographic Oro-laryngeal Measurement in Critically Ill Patients During Weaning From Mechanical Ventilation
In ICU, ventilatory weaning failure is common, accounting for up to 25% of extubations. These failures are largely due to swallowing disorders and laryngeal edema. Edema prevalence in ICU varies between 4 and 37%.
- Trial name
- REVEAL (NCT05611437)
- Testing
- Ultrafast ultrasonography
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Groupe Hospitalier du Havre
Weaning From Mechanical Ventilation
Assessment of Inspiratory Muscles Strength and Endurance Evolution on Difficult to Wean Patients in Intensive Care Unit
Ventilator-induced diaphragmatic dysfunction appears to contribute to slow weaning from mechanical ventilation. Several trials of inspiratory muscle training to facilitate weaning in intensive care have been performed, with…
- Trial name
- EFES (NCT03140267)
- Testing
- Difficult to wean patients
- Where
- 2 sites in France
- Volunteers
- 22 people
- Sponsor
- University Hospital, Bordeaux
Critically Ill
Parasternal Intercostal Muscle Thickening as an Additive Weaning Criterion
Increased days of MV are not without hazards, including barotraumas and ventilator-associated pneumonia. Similarly, premature separation of MV is associated with increased mortality secondary to adverse cardiorespiratory events.
- Trial name
- NCT07143695
- Testing
- Parasternal intercostal thickening fraction
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Cairo University
Chronic Respiratory Failure
Is Optimal Minute Ventilation a Predictor of Weaning in Patients With Prolong Mechanical Ventilation?
1. purpose of study: optimal minute could be the prediction of successful weaning and become the new weaning parameter. 2. study design: inclusion criteria: investigators will perform this study at our respiratory care center.
- Trial name
- NCT03348085
- Testing
- No intervention
- Volunteers
- 120 people
- Sponsor
- Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Weaning From Mechanical Ventilation
Physiological Effects of Non-invasive Mechanical Ventilation Versus High-flow Nasal Cannula in Critically Ill Patients at High Risk of Extubation Failure
Weaning is one of the most complex challenges in mechanically ventilated patients. Increased work of breathing after extubation would play a central role in weaning failure.
- Trial name
- NCT05012696
- Testing
- Non-invasive ventilation (NIV), High-flow nasal cannula
- Where
- Chile
- Volunteers
- 22 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Ventilator Weaning
Automatic Control of Pressure Support Ventilation in Surgical Intensive Care Units
This bicentric, randomized, controlled trial examines the effectiveness of an automatic control of pressure support ventilation (SmartCare/PS) in critically ill patients.
- Trial name
- ASOPI (NCT00445289)
- Testing
- SmartCare/PS
- Where
- 2 sites in Germany
- Volunteers
- 300 people
- Sponsor
- University Hospital Schleswig-Holstein
Dysphagia, NeuroMuscular Electrical Stimulation
Effectiveness of Transcutaneous NMES as an Adjunct for Swallowing Disorders in Tracheotomized Patients
Dysphagia can reach a prevalence of up to 80% in intensive care patients. The implementation or prolonged presence of medical devices such as the intubation tube, tracheostomy, or nasogastric tube alters the physiology of…
- Trial name
- SWALEC (NCT07529210)
- Testing
- Neuromuscular Electrical Stimulation (NMES)
- Volunteers
- 238 people
- Sponsor
- Hopital Forcilles
Mechanical Ventilation, Following Heart or Abdominal Surgery
Cardiac, Pulmonary and Diaphragm Sonography for the Early Diagnosis of the Different Etiologies Underlying Failure of Weaning From Mechanical Ventilation
Weaning patients off ventilation in an ICU is sometimes difficult, because of three major inter-related etiologies: impaired lung, heart and diaphragm function.
- Trial name
- WEAN US (NCT03261440)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Critical Illness, Intensive Care Unit
Oxygen Consumption (VO2), Effort, and Weaning in the Mechanically Ventilated Patient in the Intensive Care Unit (ICU)
In patients who are mechanically ventilated for more than 72 hours weaning failure is a common issue. The Spontaneous breathing trial (SBT) is often done to assess if the patient can be extubated with a high chance of success.
- Conditions
- Critical Illness, Intensive Care Unit, Oxygen Consumption, Weaning Failure
- Trial name
- EXTUBATE (NCT06391424)
- Testing
- Spontaneous Breathing Trial
- Where
- 2 sites in Netherlands
- Volunteers
- 60 people
- Sponsor
- Leiden University Medical Center
Weaning Invasive Mechanical Ventilation
Multidimensional Correlation Analysis of Heart Rate Variability and Weaning Assessment Parameters in Critically Mechanically Ventilated Patients
Background： Conventional weaning assessments are widely used but often affected by factors such as poor patient cooperation, neuromuscular issues, or unstable consciousness, leading to uncertainty in extubation timing.
- Trial name
- NCT07455214
- Testing
- BEATINFO ECG Sensor
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Fu Jen Catholic University Hospital
Weaning From Mechanical Ventilation
Post Extubation Chest Physiotherapy in ICU
The purpose of this study is to examine the efficacy of chest physiotheray treatment in preventing pulmonary complications and weaning faliure, in extubated critically ill patients.
- Trial name
- NCT01967108
- Testing
- chest physiotherapy
- Where
- Israel
- Volunteers
- 65 people
- Sponsor
- Rambam Health Care Campus
Traumatic Brain Injury, Weaning Failure
Study of Variables Related to the Discontinuation of Mechanical Ventilation in Patients With Head Injury
The purpose of this study is to evaluate physiological variables to the decision about the appropriate time to discontinuation of mechanical ventilation in patients with traumatic brain injury.
- Conditions
- Traumatic Brain Injury, Weaning Failure, Mechanical Ventilation Complication
- Trial name
- INDEXTBI (NCT01713010)
- Testing
- Predictive indexes of weaning from mechanical ventilation
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of Uberlandia
Ventilator Weaning
A Protocol to Wean From Noninvasive Mechanical Ventilation
The investigators use a protocol to wean from noninvasive mechanical ventilation.
- Trial name
- NCT01535755
- Testing
- protocol, physician's orders
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Duan jun
Noctural Ventilatory Mode and Weaning Duration
Impact of a Nocturnal Pressure Controlled Ventilation on Mechanical Ventilation Weaning Duration in Patients With Chronic Obstructive Respiratory Diseases
The weaning of mechanical ventilation is difficult period. This period is particularly difficult for patient with obstructive chronic respiratory disease and a long mechanical ventilation is associated with an increased risk of…
- Trial name
- REVENTIL 2 (NCT03428737)
- Testing
- Nocturnal controlled pressure control ventilation, Pressure support ventilation
- Where
- France
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Ventilator Weaning, Hand Strength
Handgrip Strength Value in Predicting Mechanical Ventilation Weaning
The purpose of this study is to test the association between ICU acquired weakness as evaluated by dominant handheld dynamometry (handgrip) and the mechanical ventilation weaning outcome
- Conditions
- Ventilator Weaning, Hand Strength, Respiration
- Trial name
- GRIPWEAN (NCT02946502)
- Testing
- Handheld dynamometry (handgrip strength)
- Where
- France
- Volunteers
- 261 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
High Velocity Nasal Insufflation, Simple Oxygen
A Randomized Clinical Trial for Predictors of Successful Extubation of Pediatric Patients With or Without High Velocity Nasal Insufflation
A randomized clinical trial about predictors of successful extubation of pediatric patients from mechanical ventilation either on High Velocity Nasal Insufflation or simple nasal oxygen and comparing the outcome
- Conditions
- High Velocity Nasal Insufflation, Simple Oxygen, Weaning Criteria
- Trial name
- NCT07383051
- Testing
- Comparing the outcome of pediatric patients after successful weaning on either High Velocity Nasal Insufflation or simple oxygen, comparing High Velocity Nasal Insufflation to simple oxygen after successful weaning of pediatric patients
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Deglutition Disorders, Tracheostomy Complication
Deflating the Tracheostomy Tube Cuff and Time for Decannulation
Introduction: Inpatients in an intensive care unit can need tracheostomy. To start the tracheostomy decannulation process, one of the procedures is to deflate the cuff.
- Trial name
- NCT05395728
- Testing
- Deflate the tracheostomy cuff early, Deflate the tracheostomy cuff after complete weaning mechanical ventilation
- Where
- Brazil
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Hospital Moinhos de Vento
Chronic Obstructive Pulmonary Disease (COPD), Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Nutritional Risk and Diaphragmatic Thickness in Mechanically Ventilated COPD Patients
Malnutrition and muscle wasting are frequent complications in patients with chronic obstructive pulmonary disease (COPD) experiencing acute exacerbations.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Malnutrition, Respiratory Failure
- Trial name
- NCT07788170
- Volunteers
- 120 people
- Sponsor
- Assiut University
Critical Care, Weaning of Mechanical Ventilation
A Cardiac Ultrasound Evaluation of Two Types of Weaning Trials of Mechanical Ventilation for a First Weaning Trial
Comparing the hemodynamic and cardiac effects of two types of weaning trials of mechanical ventilation in ICU patients of two French ICU.
- Conditions
- Critical Care, Weaning of Mechanical Ventilation, Trans-thoracic Echocardiography, Mitral Doppler
- Trial name
- CARWEAN (NCT02138903)
- Testing
- trans thoracic echocardiography
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Clermont-Ferrand