Clinical trials: Weaning Mechanical Ventilation
Invasive Mechanical Ventilation, Critical Illness
Mechanical Ventilation Discontinuation Practices
Background: The requirement for ventilator support is a defining feature of critical illness. Weaning is the process during which the work of breathing is transferred from the ventilator back to the patient.
- Conditions
- Invasive Mechanical Ventilation, Critical Illness, Spontaneous Breathing Trial, Weaning Invasive Mechanical Ventilation
- Trial name
- IOS (NCT03955874)
- Where
- 14 sites in United States, Canada
- Volunteers
- 1,868 people
- Sponsor
- Unity Health Toronto
Weaning Failure
Weaning From Mechanical Ventilation: Spontaneous Breathing Trial and the Assessment of Work of Breathing
The main objective of the study is to examine the extent of agreement between patient and health care provider assessments of work of breathing and the association of agreement with demographic- and disease-related factors.
- Trial name
- NCT01928277
- Where
- 2 sites in Norway
- Volunteers
- 100 people
- Sponsor
- University of Tromso
Ventilator Weaning
Spontaneous Breathing Trial With T-piece or Inspiratory Pressure Augmentation
Weaning is an important process to gradually separate mechanically ventilated patients from ventilators. A good weaning strategy aims to early identify mechanically ventilated patients who are ready for extubation but not to…
- Trial name
- SBT-TIP (NCT04222205)
- Testing
- Spontaneous breathing trial (SBT) crossover sequence 1, Spontaneous breathing trial (SBT) crossover sequence 2
- Where
- 3 sites in Taiwan
- Volunteers
- 2,143 people
- Sponsor
- National Taiwan University Hospital
Extubation Failure
Validation of an Effort-Based Cough Peak Flow Algorithm to Predict Extubation Outcomes
This study aims to prospectively validate the diagnostic accuracy of an effort-stratified Cough Peak Flow (CPF) decision algorithm for predicting extubation failure, maintaining strict blinding of the clinical team.
- Trial name
- NCT07737483
- Testing
- Observational measurement of Cough Peak Flow and Tidal Volume
- Volunteers
- 150 people
- Sponsor
- Hospital H+ Queretaro
Muscle Weakness Condition, Mechanical Ventilation Complication
Hand Grip Strength and Medical Research Council Scale as Predictors of Weaning Failure
The handgrip strength (HGS) will be measured with a digital dynamometer. Three measurements will be taken, whose average of the three measurements will be collected.
- Conditions
- Muscle Weakness Condition, Mechanical Ventilation Complication, Weaning Failure
- Trial name
- NCT03991702
- Testing
- diagnostic test
- Where
- Brazil
- Volunteers
- 102 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Mechanical Ventilation Complication
Effect of Three Modalities of Spontaneous Breathing Tests on Respiratory Efforts in Tracheostomized Patients
Datas are lacking concerning weaning from mechanical ventilation for tracheostomized patients. In particular, the effect of different modalities of spontaneous breathing trials on respiratory effort has not been extensively…
- Trial name
- TWEEP (NCT03856424)
- Testing
- Modality 1, Modality 2, Modality 3
- Where
- Switzerland
- Volunteers
- 18 people
- Sponsor
- Piquilloud Imboden Lise
Mechanical Ventilation Complication
Change In Diaphragmatic Thickness Predicts Extubation Success
We will investigate whether measurement of the change in thickness of the diaphragm during the respiratory cycle by ultrasound can predict extubation success in a 48 hour window.
- Trial name
- NCT02656199
- Testing
- Diaphragm Ultrasound
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Albert Einstein Healthcare Network
Emergence From Anesthesia, Mechanical Ventilation
Controlled Ventilation During Anesthetic Emergence
Absolutely - for a ClinicalTrials.gov-style Brief Summary, I'd keep it simple and patient-friendly like your example: The goal of this clinical trial is to learn whether maintaining controlled mechanical ventilation during…
- Trial name
- NCT07853547
- Testing
- Controlled/Full-Support Mechanical Ventilation During Emergence
- Where
- Saudi Arabia
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz Medical City
Respiration, Artificial, Ventilator Weaning
Pressure Support Reduction Versus Spontaneous Breathing Trials in Weaning From Ventilation
This study is a comparison of two most commonly used modes of weaning and the outcomes in the two groups.
- Trial name
- NCT00911378
- Testing
- Pressure support ventilation, Spontaneous breathing trials
- Where
- India
- Volunteers
- 130 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Critical Illness Myopathy, Respiratory Paralysis
ICU Acquired Neuromyopathy and Diaphragm Function
Critical illness neuromyopathy is a common disease acquired during ICU stay leading to a deep weakness involving the respiratory muscle work which result in a delayed weaning of mechanical ventilation.
- Trial name
- NCT01968889
- Testing
- Non invasive phrenic nerve stimulation
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Montpellier
Acute Respiratory Distress Syndrome (ARDS), Pneumonia
Medical Device Clinical Trial Without CE Marking to Evidence Safety and Performance of the INBENTUS VERSATILE Ventilator in Patients Requiring Assisted/Controlled Mechanical Ventilation and Weaning.
Pre-market clinical trial on 81 aldults participants to evidence safety and performance of the non-CE-marked medical device INBENTUS VERSATILE ventilator.
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), Pneumonia, COPD (Chronic Obstructive Pulmonary Disease), Postoperative Respiratory Distress
- Trial name
- NCT07432191
- Testing
- INBENTUS VERSATILE
- Where
- Spain
- Volunteers
- 81 people
- Sponsor
- Iconic Solutions By Murcia SL
Weaning Failure, Mechanical Ventilation Complication
Development of a Multimodal Index to Improve the Predictive Value of Success in Weaning From Mechanical Ventilation
Weaning from mechanical ventilation (MV) is a complex process in which patients are liberated from the ventilator. Prolongued weaning and weaning failure, defined as the need for reintubation, have different adverse effects…
- Trial name
- NCT04554095
- Testing
- Clinical data collection
- Where
- Spain
- Volunteers
- 126 people
- Sponsor
- Corporacion Parc Tauli
Mechanical Ventilation Complication
Preoperative Inspiratory Muscle Training
In light of the corona virus pandemic (COVID-19), there is critical need to conserve scarce mechanical ventilation (MV) resources.
- Trial name
- NCT04423614
- Testing
- Inspiratory Muscle Training, Relaxation Breathing
- Sponsor
- University of Florida
Ventilated Patients, Weaning Invasive Mechanical Ventilation
Ultrasound Assessment During Weaning from Mechanical Ventilation
The ECO-WEANING study aims to improve the process of safely removing patients from mechanical ventilation in the Intensive Care Unit (ICU).
- Conditions
- Ventilated Patients, Weaning Invasive Mechanical Ventilation, ICU, Ultrasound
- Trial name
- ECO-WEANING (NCT06609798)
- Where
- Argentina
- Volunteers
- 429 people
- Sponsor
- Hospital Italiano de Buenos Aires
Weaning Mechanical Ventilation
Airway Occlusion Pressure Derived Parameters During Spotaneous Breathing Trial for Predicting Extubation Failure
Weaning from invasive mechanical ventilation (IMV) is a critical stage of the intensive care unit (ICU) stay. Premature IMV discontinuation may expose patients to substantial cardiopulmonary stress, whereas prolonged weaning…
- Trial name
- Weaning-POP (NCT07786519)
- Where
- 4 sites in France
- Volunteers
- 225 people
- Sponsor
- Rennes University Hospital
Respiratory Insufficiency
Effectiveness Inspirational Muscle Training
The long stay in mechanical ventilation can induce several complications, among them respiratory muscle weakness, this has been related to the duration of mechanical ventilation, delay and failure to wean, resulting in longer…
- Trial name
- IMTversusMV (NCT03758573)
- Testing
- Inspiratory Muscle Training (IMT), Intensive Physiotherapy (IPT)
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Universidade Federal do vale do São Francisco
Respiratory Failure
Study to Improve Treatments and Follow-up of Children Who Need Respiratory Support
Mechanical ventilation is a vital therapeutic support, widely used in pediatric intensive care. Invasive ventilation (IV) is associated with risk of major complications ( nosocomial pneumonia, secondary pulmonary barotrauma…
- Trial name
- Edi-PTP (NCT02154542)
- Testing
- Neurovent Monitor XIII
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- St. Justine's Hospital
Obesity, Obesity With Complications
Prevalence, Determinants and Consequences of Dyspnea During Weaning in Critically Ill Obese Patients
ICU patients encounter numerous discomforts, with dyspnea (the sensation of breathlessness) being among the most distressing and impactful.
- Conditions
- Obesity, Obesity With Complications, Weaning From Mechanical Ventilation in Care Unit, Dyspnea
- Trial name
- WEAN OBESE (NCT06867354)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diaphragmatic Ultrasound in Weaning
Diaphragmatic Ultrasound as a Guide Tool During Weaning From Mechanical Ventilation
To assess value of adding ultrasound derived variables to the usual parameters on success rate of weaning from mechanical ventilation in critically ill patients and to validate sensitivity and specificity of ultrasound derived…
- Trial name
- NCT03608332
- Testing
- diaphragmatic ultrasound
- Where
- Egypt
- Volunteers
- 160 people
- Sponsor
- Cairo University
Aging, Respiration, Artificial
ABC Trial: Awakening and Breathing Controlled
The purpose of this study is to determine the impact of a new RN/RRT (Registered Nurse/Registered Respiratory Therapist) directed 2-step protocol to wean patients off of a ventilator.
- Trial name
- NCT00097630
- Testing
- SAT: Spontaneous Awakening Trial, SBT: Spontaneous Breathing Trial
- Where
- 4 sites in United States
- Volunteers
- 334 people
- Sponsor
- National Institute on Aging (NIA)