Clinical trials: Weaning Mechanical Ventilation
Mechanical Ventilation
Transcutaneous Electrical Diaphragmatic Stimulation in PMV Patients
Muscle atrophy and diaphragm dysfunction are common with prolonged mechanical ventilation (PMV). Electrical stimulation has been shown to be beneficial in severe chronic heart failure and chronic obstructive pulmonary disease.
- Trial name
- NCT04281810
- Testing
- transcutaneous electric diaphragm stimulation
- Where
- Taiwan
- Volunteers
- 59 people
- Sponsor
- Chang Gung Memorial Hospital
Parasternal Intercostal Muscle Thickness, Weaning From Mechanical Ventilation
Role of Ultrasound Assessment of Parasternal Intercostal Muscle Thickness During Weaning From Mechanical Ventilation
Assessment of the the parasternal intercostal muscles thickness by the ultrasonography as a weaning predictor of the mechanically ventilated patients
- Trial name
- NCT04779463
- Testing
- Parasternal intercostal muscles thickness ultrasound indicies
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Wesameldin Abelrahman Soltan
Critical Illness
Specialized Treatment, Rehabilitation and Outcome in Patients With Prolonged Critical Illness
This prospective observational study aims to describe the outcome for patients with persistent or chronic critical illness treated at Remeo, a clinic specialized for patients in need of prolonged intensive care and intensive care…
- Trial name
- CritillPro (NCT04247607)
- Where
- Sweden
- Volunteers
- 250 people
- Sponsor
- Remeo AB
Respiratory Insufficiency, Ventilator Weaning
Totally Transdermal Sedation in the Weaning From Remifentanil Infusion
The choice of the sedation protocol has a massive impact on the duration of mechanical ventilation and the timing of extubation. Many sedation protocols are described in the literature.
- Conditions
- Respiratory Insufficiency, Ventilator Weaning, Analgesics, Opioid
- Trial name
- TOES (NCT04204967)
- Testing
- Fentanyl Transdermal System, Remifentanil
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Weaning Failure
Role of Regional Lung Compliance and Dynamic Transpulmonary Driving Pressure in the Liberation Difficulty in Tracheostomized Patients Receiving Prolonged Mechanical Ventilation
This project focuses on the analysis of the correlation between transpulmonary driving pressure and uneven lung ventilation and regional lung compliance in patients using prolonged mechanical ventilation (PMV), in order to…
- Trial name
- NCT07003672
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Taiwan University Hospital
Neurosurgery, Mechanical Ventilation
Lung and Heart USG for Predicting Weaning in Neurosurgical Patients
Ultrasonography is a commonly used diagnostic and procedural adjunctive modality in intensive care. Weaning of neurosurgical patients off ventilatory support is a critical procedure, fraught with risks of hypoxia and hypercapnia.
- Conditions
- Neurosurgery, Mechanical Ventilation, Extubation
- Trial name
- NCT03580993
- Testing
- Lung Ultrasound
- Where
- India
- Volunteers
- 27 people
- Sponsor
- National Institute of Mental Health and Neuro Sciences, India
Prolonged Mechanical Ventilation
Serial Diaphragm Ultrasound Evaluation During Inspiratory Muscle Training in Prolonged Mechanical Ventilation
Diaphragm dysfunction contributes to prolonged mechanical ventilation (PMV) and difficult weaning. Inspiratory muscle training (IMT) may improve respiratory muscle performance, while serial diaphragm ultrasound offers a bedside…
- Trial name
- NCT07709793
- Testing
- High intensity IMT, Low intensity IMT
- Where
- Taiwan
- Volunteers
- 36 people
- Sponsor
- Chang Gung Memorial Hospital
Weaning Invasive Mechanical Ventilation
Multidimensional Correlation Analysis of Heart Rate Variability and Weaning Assessment Parameters in Critically Mechanically Ventilated Patients
Background： Conventional weaning assessments are widely used but often affected by factors such as poor patient cooperation, neuromuscular issues, or unstable consciousness, leading to uncertainty in extubation timing.
- Trial name
- NCT07455214
- Testing
- BEATINFO ECG Sensor
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Fu Jen Catholic University Hospital
Adults With Cardiopulmonary Disease at Risk of Prolonged Weaning From Mechanical Ventilation
Neurally Adjusted Ventilatory Assist in Adults at Risk of Delayed Weaning From Mechanical Ventilation
Many patients admitted to intensive care have heart or lung problems. Patients with these conditions often require longer durations of support from breathing machines.
- Trial name
- RESTUS (NCT01826890)
- Testing
- NAVA Technology
- Where
- United Kingdom
- Volunteers
- 78 people
- Sponsor
- King's College Hospital NHS Trust
Weaning From Mechanical Ventilation
Ultrasound Assessment of the Thickening Fraction of the Respiratory Muscles for Predicting Weaning Outcomes
The accuracy of ultrasound assessment of the thickening fraction of the diaphragm, parasternal intercostal, and abdominal expiratory muscles for predicting weaning outcomes in mechanically ventilated patients.
- Trial name
- NCT06724302
- Volunteers
- 80 people
- Sponsor
- Tanta University
Dyspnea
Dyspnea and Cerebral Cortex Activation Measured by fNIRS During Spontaneous Breathing Trial
Background: In Intensive Care Unit (ICU) patients, dyspnea is frequent, severe and exerts unfavorable effects on the short, medium and long term. Detection and quantification rely on the patient's self-reporting abilities.
- Trial name
- WEANIRS (NCT06211738)
- Testing
- no intervention
- Where
- France
- Volunteers
- 22 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Respiratory Failure, Midazolam Overdose
Sedation and Ease of Weaning From Mechanical Ventilation
Daily interruption of sedation is one of the modalities which is known to enhance early weaning and separation from mechanical ventilation .
- Conditions
- Respiratory Failure, Midazolam Overdose, Chronic Obstructive Pulmonary Disease, Weaning Failure
- Trial name
- NCT03406936
- Testing
- Daily interruption of midazolam
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Ventilator Induced Diaphragm Dysfunction
A Protocol Comparing Temporary Transvenous Diaphragm Pacing to Standard of Care for Weaning From Mechanical Ventilation
This clinical investigation is an open-label, multi-center RCT to demonstrate the safety and effective performance of the Lungpacer DPTS (plus standard of care) as compared to Control (standard of care only) in patients aged 18…
- Trial name
- RESCUE 3 (NCT03783884)
- Testing
- Lungpacer Diaphragm Pacing Therapy
- Where
- 33 sites in United States, France and 1 more
- Volunteers
- 223 people
- Sponsor
- Lungpacer Medical Inc.
Mechanical Ventilation
Ultrasonography Guided Weaning Protocol Development to Predict Successful Weaning
The investigators aimed to develop integrated ultrasound guided mechanical weaning protocol in critically ill patients. The analysis will be taken (1) just before the spontaneous breathing trial in enrolled patients with…
- Trial name
- NCT03574233
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Yonsei University
Airway Extubation, Ventilator Weaning
Mechanical Ventilation Reconnection for One Hour After Spontaneous Breathing Trial
The aim of this study is to evaluate the feasibility to perform a future larger clinical trial to analyze whether the mechanical ventilation reconnection for 1 hour after a successful spontaneous breathing trial reduces the risk…
- Trial name
- NCT05999526
- Testing
- Reconnection to mechanical ventilation for 1 hour, Direct extubation
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Centro Hospitalar Unimed de Joinville
Prolonged Mechanical Ventilation, Ventilator Weaning
Effects of Mobilization Using a Powered Lower-limb Exoskeleton With Prolonged Mechanical Ventilation
This study aims to evaluate the effects of powered lower-limb exoskeleton-assisted training on lower limb strength, respiratory parameters, 28-day ventilator-free days, and length of hospital stay in patients with prolonged…
- Conditions
- Prolonged Mechanical Ventilation, Ventilator Weaning, Ventilator Dependent, Exoskeleton Device
- Trial name
- NCT07445035
- Testing
- lower-limb exoskeleton, Standard medical treatment
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Fu Jen Catholic University
Airway Extubation
Maximum Expiratory Pressure in Induced Cough as a Predictor of Extubation Failure
Clinical trial for the evaluation of diagnostic tests. The sample was composed of adults under mechanical ventilation who passed the spontaneous breathing trial and was ready to be extubated.
- Trial name
- NCT04356625
- Testing
- MEPic
- Where
- Argentina
- Volunteers
- 80 people
- Sponsor
- Hospital Nacional Profesor Alejandro Posadas
Weaning From Mechanical Ventilation
Physiological Effects of Non-invasive Mechanical Ventilation Versus High-flow Nasal Cannula in Critically Ill Patients at High Risk of Extubation Failure
Weaning is one of the most complex challenges in mechanically ventilated patients. Increased work of breathing after extubation would play a central role in weaning failure.
- Trial name
- NCT05012696
- Testing
- Non-invasive ventilation (NIV), High-flow nasal cannula
- Where
- Chile
- Volunteers
- 22 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Respiration, Artificial, Ventilators, Mechanical
Pivotal Evaluation of Abdominal Neuromuscular Electrical Stimulation (VentFree) for Weaning From Mechanical Ventilation
The objective of this study is to evaluate the efficacy of the VentFree Respiratory Muscle Stimulator (VentFree) in critically ill adult patients who require invasive mechanical ventilation, when compared to sham.
- Trial name
- PREVENT (NCT05759013)
- Testing
- Breath synchronized abdominal FES
- Where
- 27 sites in United States, Australia and 2 more
- Volunteers
- 250 people
- Sponsor
- Liberate Medical
Anxiety, Cognitive Behavioral Therapy
Cognitive Behavioral Therapy for Mechanical Ventilation Wean
The purpose of this study is to use CBT strategies in assisting patients hospitalized in intensive care units in ventilation wean through a case series of 2 patients.
- Conditions
- Anxiety, Cognitive Behavioral Therapy, Mechanical Ventilation Complication
- Trial name
- NCT04763590
- Testing
- Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Pennsylvania