Clinical trials: Weaning of Mechanical Ventilation
Acute Respiratory Failure (ARF), Intensive Care Unit (ICU) Patients
Evaluation of the Clinical and Prognostic Value of Non-invasive Analysis of Mandibular Movements (MM) as a Marker of Inspiratory Effort in the Spontaneously Breathing Intensive Care Patient
Evaluate the performance for measuring inspiratory effort of non-invasive mandibular movement analysis compared to the reference technique oesophageal pressure (PES) variation, in ventilated and spontaneously breathing Intensive…
- Conditions
- Acute Respiratory Failure (ARF), Intensive Care Unit (ICU) Patients, Invasive Mechanical Ventilation
- Trial name
- MM-ICU (NCT07441590)
- Testing
- 2 recording phases
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Grenoble
Ventilator Weaning, Weaning Failure
Voices of Patients' Relatives to Support Weaning From Mechanical Ventilation
Patients with severe brain injuries, such as ischemic stroke and intracranial hemorrhage, frequently require mechanical ventilation. Weaning of stroke patients is complicated by impaired consciousness and respiratory drive.
- Conditions
- Ventilator Weaning, Weaning Failure, Brain Injuries
- Trial name
- VOICE-WEANING (NCT03795623)
- Testing
- Voice-Weaning
- Where
- Germany
- Volunteers
- 45 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Systemic Inflammatory Response Syndrome, Ventilator Weaning
The Predictive Effect of the Inflammatory Response on the Evacuation of Mechanical Ventilation and the Mechanism
Infection and trauma take a important role in the acute respiratory failure.There are different causes and degrees of inflammatory reaction in the critically ill patient.
- Trial name
- NCT02820090
- Volunteers
- 300 people
- Sponsor
- Beijing Chao Yang Hospital
Mechanical Ventilation, Weaning
Effect of Early Non-invasive Phrenic Nerve Stimulation on Weaning in Mechanically Ventilated Patients
the early application of non-invasive PNS in MV patients can increase the number of days without mechanical ventilation, delay disuse phrenic atrophy, and improve the strength of inspiratory muscle.
- Trial name
- NCT05629819
- Testing
- Non-invasive phrenic nerve stimulation
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Bing Sun
Respiratory Insufficiency
Music Therapy for Patients Being Weaned From Mechanical Ventilation
The purpose of the study is to determine whether Music Therapy interventions can be used as supportive therapy for patients undergoing weaning from mechanical ventilation.
- Trial name
- NCT00178139
- Testing
- Music Therapy
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- University of Rochester
Weaning Mechanical Ventilation, Mechanical Power
Evaluation of Mechanical Power and Ventilator Parameters to Predict Weaning Success in the Intensive Care Unit
The goal of this prospective observational study is to evaluate whether ventilator-based respiratory parameters can predict weaning success in adult intensive care unit (ICU) patients who are mechanically ventilated.
- Conditions
- Weaning Mechanical Ventilation, Mechanical Power, Negative Inspiratory Force, Airway Occlusion Pressure
- Trial name
- NCT07268989
- Testing
- Mechanical power
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Anıl Berkay Balıtatlı
Mechanical Ventilation Weaning From Mechanical Ventilation Extubation Failure Critical Illness
Delta Pocc During Spontaneous Breathing Trial to Predict Extubation Failure in Mechanically Ventilated Adults (DELTA-EXT)
This prospective observational single-center study will evaluate whether dynamic respiratory stress estimated by delta airway occlusion pressure deflection (Delta Pocc) during a standardized spontaneous breathing trial can…
- Trial name
- DELTA-EXT (NCT07634783)
- Testing
- Delta Pocc Measurement During Spontaneous Breathing Trial
- Where
- Argentina
- Volunteers
- 120 people
- Sponsor
- Sanatorio Parque, Argentina
Liberation From Mechanical Ventilation
The Accuracy of Combined Parasternal Intercostal Muscle Thickening Fraction and Diaphragmatic Excursion in Predicting Failure of Libration From Mechanical Ventilation
Approximately 20% of patients in the intensive care unit (ICU) requiring mechanical ventilation (MV) experience difficulty and prolonged weaning.
- Trial name
- NCT07702422
- Volunteers
- 70 people
- Sponsor
- Cairo University
Respiratory Failure
Respiratory Physiotherapy in Mechanical Ventilation
This study aimed to evaluate the effect of respiratory physiotherapy that is breathing exercise during weaning on ventilated patients in ICU.
- Trial name
- NCT04670939
- Testing
- breath exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people
- Sponsor
- Muğla Sıtkı Koçman University
Weaning Failure, Muscle Weakness
TESTO-TRIAL: Use of Testosterone in Critically Ill Patients
The objective of this study is to evaluate whether the use of the anabolic agent testosterone cypionate in critically ill patients, compared to placebo, increases the number of ventilator-free days
- Conditions
- Weaning Failure, Muscle Weakness, Mechanical Ventilation Complication, ICU Acquired Weakness
- Trial name
- TT (NCT06592144)
- Testing
- Testosterone cypionate (200mg/3ml), Sesame oil (3ml)
- Where
- Brazil
- Volunteers
- 94 people
- Sponsor
- Leticia Maria Defendi Barboza Marson
Abdominal Sepsis
Diaphragm Ultrasound in Weaning From Mechanical Ventilation
This study aims to evaluate the efficacy of ultrasound derived variables in prediction of success of weaning from mechanical ventilation in critically ill patients with abdominal sepsis
- Trial name
- NCT03094299
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Weaning Failure
Weaning From Mechanical Ventilation: Spontaneous Breathing Trial and the Assessment of Work of Breathing
The main objective of the study is to examine the extent of agreement between patient and health care provider assessments of work of breathing and the association of agreement with demographic- and disease-related factors.
- Trial name
- NCT01928277
- Where
- 2 sites in Norway
- Volunteers
- 100 people
- Sponsor
- University of Tromso
Patient Comfort, Anxiety
Family Support Weaning from Mechanical Ventilation in Cardiovascular Surgery
Mechanical ventilation support is used to ensure airway clarity in patients after surgery.If patients are not informed about mechanical ventilation treatment in the pre -operation period, panic, anxiety and comfort may be…
- Conditions
- Patient Comfort, Anxiety, Patient Satisfaction
- Trial name
- NCT05820789
- Testing
- Family support
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Kastamonu University
Respiratory Failure, Mechanical Ventilation
External Validation of AI-Aided Weaning Software Using Multicenter Retrospective Data
This multicenter retrospective study aims to externally validate an artificial intelligence-aided weaning software developed using intensive care unit data from Taichung Veterans General Hospital between 2015 and 2019.
- Conditions
- Respiratory Failure, Mechanical Ventilation, Critical Illness
- Trial name
- NCT07658131
- Where
- Taiwan
- Volunteers
- 1,500 people
- Sponsor
- Taichung Veterans General Hospital
Muscle Weakness Condition, Mechanical Ventilation Complication
Hand Grip Strength and Medical Research Council Scale as Predictors of Weaning Failure
The handgrip strength (HGS) will be measured with a digital dynamometer. Three measurements will be taken, whose average of the three measurements will be collected.
- Conditions
- Muscle Weakness Condition, Mechanical Ventilation Complication, Weaning Failure
- Trial name
- NCT03991702
- Testing
- diagnostic test
- Where
- Brazil
- Volunteers
- 102 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
COPD
Spirometry in Mechanically Ventilated Chronic Obstructive Pulmonary Disease (COPD) Patients
Patients with COPD who deteriorate to Respiratory Failure pose a challenge to the intensivist both in ventilating an obstructed patient and in weaning from mechanical ventilation.
- Trial name
- NCT00965029
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Assaf-Harofeh Medical Center
Intensive Care Medicine, Mechanical Ventilation
The Classification of Difficult Weaning and the Predictive Value of Relative Factors for Difficult Weaning
To evaluate the distribution of different types of difficult weaning and the predictive value of weaning relative factors.
- Conditions
- Intensive Care Medicine, Mechanical Ventilation, Weaning
- Trial name
- NCT02487927
- Testing
- weaning
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Jianfeng Xie
Intra-Abdominal Hypertension, Respiratory Mechanics
Intra-Abdominal Pressure, Respiratory Mechanics, and Ventilator Liberation After Emergency Major Laparotomy
This prospective observational cohort study aims to investigate the relationship between intra-abdominal pressure (IAP), respiratory system mechanics, and successful liberation from invasive mechanical ventilation in adult…
- Conditions
- Intra-Abdominal Hypertension, Respiratory Mechanics, Mechanical Ventilation
- Trial name
- IAP-VENT (NCT07889609)
- Testing
- Serial Intra-Abdominal Pressure and Respiratory Mechanics Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Chronic Obstructive Pulmonary Disease
Neurally Adjusted Ventilatory Assist and Synchrony in Patients With Chronic Obstructive Pulmonary Disease (COPD)
NAVA used the electrical activity of the diaphragm (EAdi) to initiate and deliver in proportion of an inspiratory assistance. During inspiration, EAdi signal occurred earlier than airflow or pressure variations in the airway.
- Trial name
- NAVASYNC (NCT01042080)
- Testing
- NAVA, Expiratory trigger (ET)
- Where
- 2 sites in France
- Volunteers
- 16 people
- Sponsor
- Hôpital Européen Marseille
Mechanical Ventilation Complication
The Effects of Early Mobilization and Endurance Training for Patients With Prolonged Mechanical Ventilator
The primary hypothesis is that prolonged mechanically ventilated adults who participate in an early mobilization and endurance exercise training protocol, have an improved pulmonary outcome and functional capacity and more…
- Trial name
- NCT05154786
- Testing
- Early Mobilization and endurance training, Usual Care
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Taichung Tzu Chi Hospital