Clinical trials: Weaning of Mechanical Ventilation
Acute Brain Injury, Mechanical Ventilation
Regional Ventilation Evaluation During Neuro-injury Weaning Study
This study evaluates changes in regional lung ventilation using thoracic electrical impedance tomography (EIT) during the weaning process from mechanical ventilation in ICU patients with acute brain injury.
- Conditions
- Acute Brain Injury, Mechanical Ventilation, Prolonged Weaning, Traumatic Brain Injury
- Trial name
- ReVENtS (NCT07067671)
- Testing
- Internal Thoracic Impedance
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COPD (Chronic Obstructive Pulmonary Disease), Cardiometry
Cardio-circulatory and Respiratory Monitoring for Prediction of Outcome in Mechanically Ventilated Chronic Obstructive Pulmonary Disease Patients
Chronic Obstructive Pulmonary Disease (COPD) remains a leading cause of morbidity and mortality worldwide, often necessitating invasive mechanical ventilation (MV) during acute exacerbations.
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), Cardiometry, Weaning Invasive Mechanical Ventilation
- Trial name
- NCT07109206
- Where
- Egypt
- Volunteers
- 104 people
- Sponsor
- Assiut University
Diaphragm Issues, Ventilator-Induced Lung Injury
Randomized Study to Investigate the Safety and Performance of Diaphragm Stimulation Coupled With Mechanical Ventilation
This study is a randomized prospective, single-center feasibility study of the use and benefits of NeuRx DPS in patients undergoing tracheostomy for failure to wean.
- Conditions
- Diaphragm Issues, Ventilator-Induced Lung Injury, Tracheostomy
- Trial name
- NCT04457427
- Testing
- NeuRx Diaphragm Pacing System (DPS)
- Where
- Turkey (Türkiye)
- Sponsor
- Synapse Biomedical
Intensive Care Unit, Invasive Mechanical Ventilation
Determination of the Optimal Spontaneous Breathing Trial During Weaning of Mechanical Ventilation
Assessment and comparison of three spontaneous breathing trials in five specific profiles of intensive care unit and perioperative patients. A physiological cross over study
- Conditions
- Intensive Care Unit, Invasive Mechanical Ventilation, Ready to Wean From Ventilation
- Trial name
- GLOBAL WEAN (NCT04222569)
- Testing
- T-piece, PSV 7 and PEEP 0, PSV 0 and PEEP 0
- Where
- France
- Volunteers
- 117 people
- Sponsor
- University Hospital, Montpellier
Respiratory Insufficiency
Music Therapy for Patients Being Weaned From Mechanical Ventilation
The purpose of the study is to determine whether Music Therapy interventions can be used as supportive therapy for patients undergoing weaning from mechanical ventilation.
- Trial name
- NCT00178139
- Testing
- Music Therapy
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- University of Rochester
Respiration, Artificial, Weaning
Optimal Timing for Spontaneous Breathing Trials
This study aims to explore how the timing of Spontaneous Breathing Trials (SBTs) affects recovery in adult patients who are on mechanical ventilation in the ICU.
- Trial name
- NCT06561295
- Testing
- Later Morning Timing of Spontaneous Breathing Trials
- Where
- United States
- Volunteers
- 348 people
- Sponsor
- Rush University Medical Center
Chronic Obstructive Pulmonary Disease (COPD), Mechanical Ventilator Weaning
D-RSBI Versus RSBI for Predicting Weaning Success in COPD Patients
This prospective observational cohort study aims to compare the predictive accuracy of diaphragmatic rapid shallow breathing index (D-RSBI) versus traditional rapid shallow breathing index (RSBI) for predicting weaning success…
- Trial name
- NCT07590362
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Ventilator Weaning, Mechanical Ventilation
Comparison of Diaphragm Ultrasound and RSBI for Predicting Weaning Success in Mechanically Ventilated ICU Patients
The goal of this observational study is to evaluate the predictive value of diaphragmatic ultrasound compared to the Rapid Shallow Breathing Index (RSBI) in determining weaning success among mechanically ventilated patients in…
- Conditions
- Ventilator Weaning, Mechanical Ventilation, Respiratory Insufficiency Requiring Mechanical Ventilation, Weaning From Mechanical Ventilation
- Trial name
- NCT07120438
- Volunteers
- 55 people
- Sponsor
- Gadjah Mada University
Ventilator Weaning
Echocardiographic Detection of Extravascular Lung Water Increase During Weaning From Mechanical Ventilation
Switching from positive airway pressure ventilation to spontaneous ventilation during weaning from mechanical ventilation, pulmonary edema may occur and in this case, doppler echocardiographic (U/S) indices of cardiac dysfunction…
- Trial name
- ECHOBAG (NCT02412202)
- Testing
- Monitoring of pulmonary oedema induced by weaning from mechanical ventilation
- Where
- Greece
- Volunteers
- 30 people
- Sponsor
- University of Thessaly
Weaning Failure, Muscle Weakness
TESTO-TRIAL: Use of Testosterone in Critically Ill Patients
The objective of this study is to evaluate whether the use of the anabolic agent testosterone cypionate in critically ill patients, compared to placebo, increases the number of ventilator-free days
- Conditions
- Weaning Failure, Muscle Weakness, Mechanical Ventilation Complication, ICU Acquired Weakness
- Trial name
- TT (NCT06592144)
- Testing
- Testosterone cypionate (200mg/3ml), Sesame oil (3ml)
- Where
- Brazil
- Volunteers
- 94 people
- Sponsor
- Leticia Maria Defendi Barboza Marson
Weaning, Respiratory Muscle Function
Role of Diaphragm Fatigue in Weaning From Mechanical Ventilation
The purpose of this study is to determine whether the diaphragm develops contractile fatigue during a weaning trial and if this is associated with weaning failure.
- Trial name
- NCT01135121
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- University Medical Center Nijmegen
Left Ventricular Diastolic Dysfunction, Weaning Failure
Left Ventricular Diastolic Dysfunction as a Predictor of Weaning Failure From Mechanical Ventilation
Both premature and delayed extubation prolong the duration of mechanical ventilation and the intensive care unit (ICU) length of stay and increase morbidity and mortality.
- Conditions
- Left Ventricular Diastolic Dysfunction, Weaning Failure, Mechanical Ventilation Complication, Diaphragmatic Disorder
- Trial name
- NCT04703387
- Testing
- transthoracic echocardiography
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Tanta University
DIAPHRAGM -Ultrasound -Weaning -Mechanical Ventilation
Diaphragm Training Ultrasound
Common neurological indications of intubation and initiation of mechanical ventilation (MV) include ischemic and hemorrhagic stroke, neurotrauma, and intracranial hemorrhage.
- Trial name
- DiaphUS (NCT04186325)
- Testing
- DIAPHRAGMATIC exercising
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Mansoura University
Acute Respiratory Failure, Respiration, Artificial
Ultrasound to Evaluate Failure of Liberation From Mechanical Ventilation
This study will evaluate the heart, lungs and diaphragm of patients who fail a trial of spontaneous breathing to determine the physiological mechanism of weaning failure.
- Conditions
- Acute Respiratory Failure, Respiration, Artificial, Weaning
- Trial name
- USEFUL (NCT02723565)
- Where
- 3 sites in Canada
- Volunteers
- 7 people
- Sponsor
- University Health Network, Toronto
Weaning
Effect of NAVA on Weaning Duration in Difficult to Wean Patients
It has been showed that over assist and patient ventilator asynchrony often occur in mechanical ventilated patients, especially in patients who failed weaning, which are associated with a prolonged duration of mechanical…
- Trial name
- NCT01280773
- Testing
- NAVA
- Where
- China
- Volunteers
- 99 people
- Sponsor
- Ling Liu
Delayed Extubation, Postoperative Intensive Care
Factors Associated With Late Extubation in Postoperative Patients in the Surgical Intensive Care Unit
Timely removal of a breathing tube after surgery is an important part of recovery for patients admitted to the intensive care unit (ICU).
- Conditions
- Delayed Extubation, Postoperative Intensive Care, Mechanical Ventilation Weaning
- Trial name
- NCT07658456
- Testing
- No Intervention - Retrospective Observational Study
- Where
- Taiwan
- Volunteers
- 204 people
- Sponsor
- Kaohsiung Armed Forces General Hospital
Acute Lung Injury, Adult Respiratory Distress Syndrome
Variable Pressure Support Trial
In 2008 a new ventilation strategy termed variable Pressure Support ventilation (PSV) was introduced, which is able to increase the variability of the respiratory pattern independent from the inspiratory effort.
- Conditions
- Acute Lung Injury, Adult Respiratory Distress Syndrome, at Least 24 h of Controlled Mechanical Ventilation
- Trial name
- ViPS (NCT01769053)
- Testing
- Variable Ventilation
- Where
- Germany
- Volunteers
- 130 people
- Sponsor
- Technische Universität Dresden
Respiratory Insufficiency
Impact of the Assisted Ventilation Mode on Diaphragm Efficiency in Critically Ill Patients
This study evaluates the impact of the assisted mode of mechanical ventilation on diaphragm efficiency in mechanically ventilated critically ill patients.
- Trial name
- NAVA_PSV (NCT02473172)
- Testing
- Pressure Support ventilation, Neurally Adjusted Ventilatory Assist
- Where
- Italy
- Volunteers
- 38 people
- Sponsor
- University of Bari
Weaning Failure of Mechanical Ventilation
Evaluation of Right Ventricular Function to Predict Weaning Success in the Intensive Care Unit
The goal of this prospective observational study is to evaluate whether right ventricular (RV) function parameters assessed via transthoracic echocardiography (TTE) can predict weaning success in adult intensive care unit (ICU)…
- Trial name
- NCT07073976
- Testing
- Transthoracic Echocardiography (TTE)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Ventilator Weaning, Intensive Care Unit
Use of Transient Elastogaphy to Assess Diaphragm Function in Mechanically Ventilated Patients
Mechanical ventilation is a life-saving treatment that can be associated with diaphragm dysfunction, a potentially deleterious acquired disability.
- Trial name
- Elasto-ICU (NCT03832231)
- Testing
- Shear Wave Elastography
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris