Clinical trials: Weaning of Mechanical Ventilation
Ventilator Lung
Assessment of Process and Outcome of Protocol-based Weaning From Mechanical Ventilation in the Medical Patients
This is a prospective, single-center, observational study to describe characteristics of weaning process and factors associated with duration of weaning and its outcomes in all consecutive adult (aged 19 years and older) patients…
- Trial name
- NCT05134467
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Samsung Medical Center
Restlessness
Loxapine in the Management of Restlessness During Mechanical Ventilation Weaning
This study aims to assess the efficacy of a drug (loxapine, a neuroleptic) in calming patients down in a situation of restlessness during mechanical ventilation weaning.
- Trial name
- Sevralox (NCT01193816)
- Testing
- loxapine
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Prolonged Mechanical Ventilation
Diaphragm Dysfunction During Prolonged Mechanical Ventilation
The transition to unassisted breathing after invasive ventilation often proves challenging. Persistent ventilator dependence predisposes patients to nosocomial complications and death and increases the economic burden of critical…
- Trial name
- DD-SRPR (NCT03676998)
- Testing
- Measurement of diaphragm function
- Where
- France
- Volunteers
- 52 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
ARDS
Effect of Nava on Weaning Outcome in Patients With Mechanical Ventilation
This study intends to compare the effects of NAVA and PSV on weaning success rate and mechanical ventilation time in patients with tracheotomy patients through a randomized controlled study.
- Trial name
- NCT05219643
- Testing
- NAVA, PSV
- Where
- 2 sites in China
- Volunteers
- 130 people
- Sponsor
- Southeast University, China
Respiratory Failure
Noninvasive Positive Pressure Ventilation for Difficult Weaning in Tracheotomy Patients
The investigators adopt Noninvasive Positive Pressure Ventilation for weaning in tracheotomy patients innovatively. The investigators randomly allocate the subjects into two groups. One group is weaned by traditional strategy.
- Trial name
- NCT01900990
- Testing
- Noninvasive ventilation weaning
- Where
- 2 sites in China
- Volunteers
- 32 people
- Sponsor
- Chongqing Medical University
Weaning Failure
The Effect of High Flow Oxygen Therapy Via Tracheostomy on Diaphragm Function
While the high flow oxygen therapy (HFOT) respiratory support system, delivered through nasal cannulas, has demonstrated clinical benefits on respiratory function, limited data exist on whether such effects are also present in…
- Trial name
- NCT04758910
- Testing
- High Flow Oxygen Therapy, T-piece
- Volunteers
- 30 people
- Sponsor
- Evangelismos Hospital
Mechanical Ventilation
Work of Breathing Assessment During Weaning From Mechanical Ventilation
Introduction In patients assisted by mechanical ventilation, the Work Of Breathing (WOB) is shared between the patient and the ventilator.
- Trial name
- WOAW (NCT02762292)
- Testing
- Measurement of work of breathing using indirect calorimeter
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- St. Justine's Hospital
Weaning From Mechanical Ventilation
Effect of Adding PNF to IMT on Weaning Off MV
the goal of this clinical trial is to find out the effect of adding proprioceptive neuromuscular facilitation to inspiratory muscle training on weaning off mechanical ventilation.
- Trial name
- PNF/IMT/MV (NCT07536347)
- Testing
- threshold inspiratory muscle training + conventional chest physiotherapy, proprioceptive neuromuscular facilitation + threshold inspiratory muscle training + conventional chest physiotherapy, Conventional Chest Physiotherapy
- Volunteers
- 93 people
- Sponsor
- Beni-Suef University
Respiratory Failure, Weaning Failure
Estimation of the Diaphragm Electrical Activity and Intercostal Thickening Fraction During Different Pattern of Mechanical Ventilation: PSV Versus NAVA
the introduction of new MV modalities has shown promising results in reducing the incidence of weaning failure, mainly due to a more physiologic approach which allows respiratory muscle preservation.
- Trial name
- InterThick (NCT05990348)
- Testing
- difficult weaning patients
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Cardiometry, Thorathic Fluid Content
The Validity of Thorathic Fluid Content as Non Invasive Predictor on Weaning of Mechanical Ventilation in Critically Ill Patients
Introduction Weaning from mechanical ventilation (MV) could be described as the process of removing ventilator support. Weaning from MV often implies two separate but closely linked views of care, elimination of MV of any…
- Conditions
- Cardiometry, Thorathic Fluid Content, Weaning From Mechanical Ventilation
- Trial name
- NCT06685406
- Testing
- Thorathic fluid content measurement by cardiometry
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Zagazig University
Weaning, Chronic Respiratory Failure
Non Invasive Ventilation and Weaning : VENISE Trial
The clinical efficacy of noninvasive ventilation (NIV) has now been demonstrated in the management of acute-on-chronic respiratory failure (ACRF) of various etiologies.
- Trial name
- VENISE (NCT00213499)
- Testing
- non invasive ventilation
- Where
- France
- Volunteers
- 205 people
- Sponsor
- University Hospital, Rouen
Mechanical Ventilator Weaning, Mechanical Ventilation
Use of a Physiotherapy Assessment to Predict Extubation Failure in Mechanically Ventilated Patients: the EPIC Assessment
"Weaning from mechanical ventilation is a crucial step in the intensive care unit. Several factors complicate weaning and increase the risk of failure.
- Trial name
- PREDEXTUB (NCT06450678)
- Where
- France
- Volunteers
- 330 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Prolonged Mechanical Ventilation
Effects of Continuous Mobility Training in Prolonged Mechanical Ventilation
Background: The exercise intervention can help participants with prolonged mechanical ventilation improve ventilator weaning; however, the content of exercise intervention is diverse and inconsistent.
- Trial name
- NCT05688267
- Testing
- Continuous Mobility Training, Usual Care
- Where
- Taiwan
- Volunteers
- 56 people
- Sponsor
- Taichung Tzu Chi Hospital
Acute Exacerbation of COPD
Randomized Controlled Study of Programmed Weaning From NIV for AECOPD
Purpose of research:to explore a reasonable programmed withdrawal process of noninvasive ventilation and thereby reduce the duration of noninvasive mechanical ventilation in patients with acute exacerbations of chronic…
- Trial name
- NCT06014034
- Testing
- Programmed Weaning From Noninvasive Mechanical Ventilation
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Peking University Third Hospital
Acute Lung Injury, Adult Respiratory Distress Syndrome
Variable Pressure Support Trial
In 2008 a new ventilation strategy termed variable Pressure Support ventilation (PSV) was introduced, which is able to increase the variability of the respiratory pattern independent from the inspiratory effort.
- Conditions
- Acute Lung Injury, Adult Respiratory Distress Syndrome, at Least 24 h of Controlled Mechanical Ventilation
- Trial name
- ViPS (NCT01769053)
- Testing
- Variable Ventilation
- Where
- Germany
- Volunteers
- 130 people
- Sponsor
- Technische Universität Dresden
Weaning Failure, COPD Exacerbation
Comparison of Two Ventilator Mode During the Night: New Strategy of Mechanical Ventilation Weaning
The purpose of the study is to compare pressure controlled continuous mandatory ventilation versus pressure support ventilation during the night for weaning to mechanical ventilation in chronic obstructive pulmonary disease…
- Trial name
- REVENTIL (NCT01573481)
- Testing
- pressure support ventilation, Pressure controlled ventilation
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Acute Respiratory Failure, Mechanical Ventilation Complication
Evaluation of Regional Ventilation Distribution Using Electrical Impedance Tomography During Weaning From Mechanical Ventilation
The goal of this physiological cross-over clinical trial is to evaluate the effect of different clinically used weaning trials on regional mechanical ventilation in a population of patients undergoing weaning from mechanical…
- Conditions
- Acute Respiratory Failure, Mechanical Ventilation Complication, Ventilator-Induced Lung Injury, Weaning Failure
- Trial name
- WEAN-EIT (NCT05726513)
- Testing
- Weaning trial - Low support, high Positive end-expiratory pressure, Weaning trial - Low support, zero positive end-expiratory pressure, Weaning trial - Zero support, zero positive end-expiratory pressure
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Università degli Studi di Ferrara
Mechanical Ventilation, Weaning
Computer Driven Management of Weaning Following Prolonged Mechanical Ventilation
After an episode of acute respiratory failure requiring mechanical ventilation, weaning the patient from the ventilator may be difficult.
- Conditions
- Mechanical Ventilation, Weaning, Prolonged Ventilation
- Trial name
- NCT00502489
- Testing
- Closed-loop sytem for5 weaning from mechanical ventilation
- Volunteers
- 50 people
- Sponsor
- Rabin Medical Center
Systemic Inflammatory Response Syndrome, Ventilator Weaning
The Predictive Effect of the Inflammatory Response on the Evacuation of Mechanical Ventilation and the Mechanism
Infection and trauma take a important role in the acute respiratory failure.There are different causes and degrees of inflammatory reaction in the critically ill patient.
- Trial name
- NCT02820090
- Volunteers
- 300 people
- Sponsor
- Beijing Chao Yang Hospital
Mechanically Ventilated ICU Patients
Grip Test in Ventilated ICU Patients
ICU patients do experience extubation failure. Guidelines rarely include muscle strength criteria. Prior work indicates that grip strength is a reliable surrogate for muscle strength.
- Trial name
- griptest92 (NCT01305421)
- Testing
- grip test
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire Brugmann