Clinical trials: Weaning of Mechanical Ventilation
Weaning, Mechanical Ventilation
Effect of High Flow Oxygen Therapy in Spontaneous Breathing Trial on Weaning in Mechanical Ventilated Patients
This clinical trial is aimed to show a spontaneous breathing trial using high flow oxygen therapy may lower weaning failure rate and reintubation rate than using T-piece.
- Conditions
- Weaning, Mechanical Ventilation, Extubation
- Trial name
- HOST (NCT03929328)
- Testing
- High flow oxygen therapy in spontaneous breathing trial
- Where
- South Korea
- Volunteers
- 98 people
- Sponsor
- Sang-Min Lee
Respiratory Failure
Effect of Different Proprioceptive Neuromuscular Facilitation Techniques Versus Flow Trigger Sensitivity on Weaning Off Mechanical Ventilation
Weaning is a critical stage in respiratory care, requiring strategies to optimize breathing muscle function and reduce patient dependence on ventilatory support.
- Trial name
- PNF techniques (NCT06831201)
- Testing
- Flow trigger sensitivity group, Active proprioceptive facilitation technique ( active PNF) technique, Passive proprioceptive facilitation technique ( passive PNF) technique
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Beni-Suef University
Dexmedetomidine
The Effect of Dexmedetomidine on Agitation During Weaning From Mechanical Ventilation
This study aims to evaluate the effect of dexmedetomidine on the level of agitation during the weaning process from mechanical ventilation in critically ill patients.
- Trial name
- NCT07066605
- Testing
- Group A (Dexmedetomidine Group), Group B (Control Group)
- Where
- Egypt
- Volunteers
- 62 people
- Sponsor
- Sohag University
High Flow Oxygen Therapy
Physiologic and Clinical Effect of High-flow Oxygen Therapy in Tracheostomized Patients With Prolonged Mechanical Ventilation Undergoing Weaning Trials
This study is aimed at patients who have been admitted to the respiratory care center of this hospital who meet the PMV conditions (defined as continuous use of the ventilator for at least ten days) who are about to receive the…
- Trial name
- NCT06357390
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- National Taiwan University Hospital
Tracheostomized Patients, Mechanical Ventilation Weaning
High Flow Tracheal Oxygen for Weaning of Tracheostomized Patients
In this pilot randomized controlled trial (RCT), the investigators aim to explore the feasibility of conducting a powered RCT that examines the efficacy and safety of high flow tracheal oxygen (HFTO) in weaning critically ill…
- Conditions
- Tracheostomized Patients, Mechanical Ventilation Weaning, High Flow Oxygen Therapy
- Trial name
- HFTO-WEAN (NCT07559591)
- Testing
- High-flow tracheal oxygen (HFTO), Tracheal Mask (TM)
- Where
- Saudi Arabia
- Volunteers
- 88 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Mechanical Ventilation Weaning, Weaning Failure
Comprehensive Ultrasound Evaluation as a Predictor of Weaning
Several studies investigated the role of specific clinical predictors of weaning success, but it is determined by a combination of different aspects that can result in success or failure.
- Trial name
- NCT05539599
- Testing
- Comprehensive evaluation
- Where
- 2 sites in Italy
- Volunteers
- 89 people
- Sponsor
- Università degli Studi di Ferrara
Weaning From Mechanical Ventilation
Comparison of Weaning on Pressure Support vs. Proportional Assist Ventilation: A Pilot Study
The study hypothesis is that reducing patient-ventilator asynchrony will reduce time required to wean from mechanical ventilation.
- Trial name
- NCT01666054
- Testing
- PSV, PAV
- Where
- Canada
- Volunteers
- 54 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Perfusion Index, Weaning of Mechanical Ventilation
PPI in Weaning Prediction
The aim of this study is to evaluate the predictive role of the Peripheral Perfusion Index (PPI) in forecasting extubation success during the weaning process in intensive care unit (ICU) patients.
- Conditions
- Perfusion Index, Weaning of Mechanical Ventilation, ICU
- Trial name
- NCT07120672
- Testing
- patients were monitored for reentubation for 48 hours., weaning group
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Respiratory Failure
Effect of Inspiratory Muscle Training on Duration of Mechanical Ventilation Support
A growing body of knowledge has documented that the diaphragm, the primary muscle of breathing, atrophies and weakens within days of instituting mechanical ventilation support.
- Trial name
- NCT01108575
- Testing
- IMST
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- University of Florida
Prone Position, Supine Position
The Effect of the Position Given to the Child After Weaning from Noninvasive Mechanical Ventilation on Physiological Symptoms
The aim of this clinical trial was to investigate the effect of the position given to children after weaning from noninvasive mechanical ventilation on the physiological symptoms (heart rate, oxygen saturation, respiratory rate…
- Conditions
- Prone Position, Supine Position, Child
- Trial name
- NCT06580522
- Testing
- Prone Position Group, Supine Position Group
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Acibadem University
Weaning From Mechanical Ventilation
Comparison of the Impact of Three Programs of Inspiratory Muscles.
Ventilator-induced diaphragmatic dysfunction appears to contribute to slow weaning from mechanical ventilation. Several trials of inspiratory muscle training to facilitate weaning in intensive care have been performed, with…
- Trial name
- PREDRIC (NCT02855619)
- Testing
- Martin, Cader, EDRIC
- Where
- 2 sites in France
- Volunteers
- 92 people
- Sponsor
- University Hospital, Bordeaux
Critical Illness
Specialized Treatment, Rehabilitation and Outcome in Patients With Prolonged Critical Illness
This prospective observational study aims to describe the outcome for patients with persistent or chronic critical illness treated at Remeo, a clinic specialized for patients in need of prolonged intensive care and intensive care…
- Trial name
- CritillPro (NCT04247607)
- Where
- Sweden
- Volunteers
- 250 people
- Sponsor
- Remeo AB
DIAPHRAGM -Ultrasound -Weaning -Mechanical Ventilation
Diaphragm Training Ultrasound
Common neurological indications of intubation and initiation of mechanical ventilation (MV) include ischemic and hemorrhagic stroke, neurotrauma, and intracranial hemorrhage.
- Trial name
- DiaphUS (NCT04186325)
- Testing
- DIAPHRAGMATIC exercising
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Mansoura University
Weaning From Mechanical Ventilation
Assessment of Inspiratory Muscles Strength and Endurance Evolution on Difficult to Wean Patients in Intensive Care Unit
Ventilator-induced diaphragmatic dysfunction appears to contribute to slow weaning from mechanical ventilation. Several trials of inspiratory muscle training to facilitate weaning in intensive care have been performed, with…
- Trial name
- EFES (NCT03140267)
- Testing
- Difficult to wean patients
- Where
- 2 sites in France
- Volunteers
- 22 people
- Sponsor
- University Hospital, Bordeaux
Chronic Respiratory Failure
Is Optimal Minute Ventilation a Predictor of Weaning in Patients With Prolong Mechanical Ventilation?
1. purpose of study: optimal minute could be the prediction of successful weaning and become the new weaning parameter. 2. study design: inclusion criteria: investigators will perform this study at our respiratory care center.
- Trial name
- NCT03348085
- Testing
- No intervention
- Volunteers
- 120 people
- Sponsor
- Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Weaning From Mechanical Ventilation
Physiological Effects of Non-invasive Mechanical Ventilation Versus High-flow Nasal Cannula in Critically Ill Patients at High Risk of Extubation Failure
Weaning is one of the most complex challenges in mechanically ventilated patients. Increased work of breathing after extubation would play a central role in weaning failure.
- Trial name
- NCT05012696
- Testing
- Non-invasive ventilation (NIV), High-flow nasal cannula
- Where
- Chile
- Volunteers
- 22 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Ventilator Weaning
Automatic Control of Pressure Support Ventilation in Surgical Intensive Care Units
This bicentric, randomized, controlled trial examines the effectiveness of an automatic control of pressure support ventilation (SmartCare/PS) in critically ill patients.
- Trial name
- ASOPI (NCT00445289)
- Testing
- SmartCare/PS
- Where
- 2 sites in Germany
- Volunteers
- 300 people
- Sponsor
- University Hospital Schleswig-Holstein
Dysphagia, NeuroMuscular Electrical Stimulation
Effectiveness of Transcutaneous NMES as an Adjunct for Swallowing Disorders in Tracheotomized Patients
Dysphagia can reach a prevalence of up to 80% in intensive care patients. The implementation or prolonged presence of medical devices such as the intubation tube, tracheostomy, or nasogastric tube alters the physiology of…
- Trial name
- SWALEC (NCT07529210)
- Testing
- Neuromuscular Electrical Stimulation (NMES)
- Volunteers
- 238 people
- Sponsor
- Hopital Forcilles
Mechanical Ventilation, Following Heart or Abdominal Surgery
Cardiac, Pulmonary and Diaphragm Sonography for the Early Diagnosis of the Different Etiologies Underlying Failure of Weaning From Mechanical Ventilation
Weaning patients off ventilation in an ICU is sometimes difficult, because of three major inter-related etiologies: impaired lung, heart and diaphragm function.
- Trial name
- WEAN US (NCT03261440)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Weaning Invasive Mechanical Ventilation
Multidimensional Correlation Analysis of Heart Rate Variability and Weaning Assessment Parameters in Critically Mechanically Ventilated Patients
Background： Conventional weaning assessments are widely used but often affected by factors such as poor patient cooperation, neuromuscular issues, or unstable consciousness, leading to uncertainty in extubation timing.
- Trial name
- NCT07455214
- Testing
- BEATINFO ECG Sensor
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Fu Jen Catholic University Hospital