Clinical trials: Weight Changes
HIV-1-infection, Metabolic Syndrome
Assessing Virologic Success and Metabolic Changes in Patients Switching From a TDF to TAF Containing Antiretroviral Therapy Regimen
Switching patients with HIV infection from tenofovir disoproxil fumarate (TDF) to a tenofovir alafenamide (TAF) based drug regimen can provide many safety benefits including preserving bone mineral density and kidney function.
- Conditions
- HIV-1-infection, Metabolic Syndrome, Cardiovascular Diseases, Weight Gain
- Trial name
- NCT03646370
- Testing
- Tenofovir Alafenamide
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Thomas Jefferson University
Food Insecurity, Stunting
Scaling up Small-Scale Food Processing to Promote Food Security Among Women Farmers in Rural Vietnam
This repeated measures, cluster randomized, cohort trial design was carried out in three provinces in the northern mountainous area of Vietnam.
- Conditions
- Food Insecurity, Stunting, Wasting, Underweight
- Trial name
- NCT03847662
- Volunteers
- 799 people, healthy volunteers welcome
- Sponsor
- National Institute of Nutrition, Vietnam
Weight Loss
Long-term Follow up After SG vs RYGB vs OAGB
A prospective randomized clinical study of all morbidly obese patients undergoing SG, RYGB and OAGB, as primary bariatric procedures, was performed.
- Trial name
- NCT03467646
- Testing
- Sleeve Gastrectomy, Roux-en-Y gastric bypass, One-Anastomosis Gastric Bypass
- Volunteers
- 600 people
- Sponsor
- Hospital General Universitario Elche
Diabetes, Pre Diabetes
Diabetes Prevention and Education
Type 2 diabetes mellitus is one of the fastest growing public health problems in developed and developing countries and imposes a large financial burden on health-care systems.
- Conditions
- Diabetes, Pre Diabetes, Fatty Liver, Body Weight Changes
- Trial name
- NCT05769127
- Testing
- Diabetes Prevention Program (DPP), Diabetes Self-Management Training (DSMT)
- Where
- United States
- Sponsor
- University of Maryland, Baltimore
Obese
Changes in Intrahepatic Lipids With Exercise
Individuals with obesity and particular type 2 diabetes have abnormally high levels of fat in liver cells and are at increased risk for cardiovascular and liver-related mortality.
- Trial name
- NCT02181270
- Testing
- high intensity exercise, continuous moderate exercise
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Overweight, Weight Loss
Weight Loss Interventions for Obesity
Numerous barriers towards weight management among Singaporeans with obesity exists, which involves environmental and self-regulation factors (i.e. motivation and hunger).
- Conditions
- Overweight, Weight Loss, Ketogenic Dieting, Obesity
- Trial name
- NCT06022796
- Testing
- Healthy Ketogenic Ready-to-Eat Meals, Healthy Ketogenic Diet
- Where
- Singapore
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Power, Metabolic Disturbance
Effect of 8-week Intake of 2S-hesperidin on Performance, Body Composition and Biochemicals Markers in Amateur Cyclists
This clinical study evaluates the effect of 500 mg of 2S-hesperidin for 8 weeks on performance (power generated in different metabolic zones), body composition (fat and muscle mass) and biochemical (antioxidant, inflammatory…
- Conditions
- Power, Metabolic Disturbance, Change, Body Weight, Changes Fatty
- Trial name
- HESPERFORMAN (NCT04597983)
- Testing
- 2S-hesperidin
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Francisco Javier Martínez Noguera
Obstructive Sleep Apnoea, Overweight
A Brief Lifestyle Modification Programme in Overweight Subjects With Obstructive Sleep Apnoea - Needs Assessment
Obstructive sleep apnea (OSA) is a common chronic disease and associated with cardiovascular and neurocognitive sequelae. Overweight is a common, reversible risk factor of OSA, and the rapid rise in obesity worldwide may lead to…
- Trial name
- NCT04262986
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- The University of Hong Kong
Diabetes Mellitus, Weight Loss
A Study to Evaluate the Pharmacokinetics of HRS9531 Injection in Participants With Mild, Moderate, and Normal Hepatic Function
This is a Phase I clinical study to compare the pharmacokinetics (PK) of HRS9531 Injection in participants with mild/moderate hepatic impairment and participants with normal hepatic function, and to evaluate the safety of HRS9531…
- Trial name
- NCT07540754
- Testing
- HRS9531 Injection
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
ICU Survivors
Integrated Recovery Program for Critical Illness
This study aims to investigate the effects of the Integrated Critical Illness Aftercare and Recovery Enhancement (I-CARE) program on reducing healthcare burden and improving functional outcomes in ICU survivors.
- Trial name
- iCARE (NCT06997822)
- Testing
- LINE Bot-Based Remote Care Combined with In-Person Post-ICU Clinic
- Where
- Taiwan
- Volunteers
- 240 people
- Sponsor
- National Taiwan University Hospital
Obesity
Pharmacokinetic Comparison of Multiple Formulations of Topiramate and Phentermine in Obese Adults
The primary objective of this study is to describe the single- and multiple-dose pharmacokinetic profiles of two novel formulations of topiramate and commercially available immediate release topiramate, all dosed with immediate…
- Trial name
- NCT00518466
- Testing
- topiramate, phentermine
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- VIVUS LLC
Obesity, Ketogenic Dieting
Impact of a Ketogenic Diet on Metabolic and Psychiatric Health in Patients With Bipolar or Schizophrenia Illness
To initiate a low-carbohydrate, high-fat (LCHF) or ketogenic dietary (KD) intervention among a cohort of outpatients with either schizophrenia or bipolar illness who also have metabolic abnormalities, overweight/obesity, and/or…
- Conditions
- Obesity, Ketogenic Dieting, Metabolic Syndrome, Bipolar Disorder
- Trial name
- NCT03935854
- Testing
- LCHF, Ketogenic Diet
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Stanford University
Overweight, Obese
Weight Loss and Healthy Diet Through Mobile Phone-enabled Social Interactions
A randomized controlled trial comparing the effects of the social-enabled internet weight loss and diet change intervention with the delayed treatment group for 3 months.
- Trial name
- NCT01957800
- Testing
- Website, Usual Care
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Milton S. Hershey Medical Center
Severe Obesity
Enhancing Weight Loss Maintenance With GLP-1RA (BYDUREON™) in Adolescents With Severe Obesity
Long-term weight loss maintenance is seldom achieved by individuals with obesity owing to numerous biological adaptations involving appetite, satiety, and energy expenditure in the post- weight loss setting.
- Trial name
- NCT02496611
- Testing
- Weight loss with pharmacotherapy, Weight loss without pharmacotherapy
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Obesity
Weight Gain in First-year University Students
The transition to university from secondary school comes with many changes to living arrangements, dietary and alcohol intake, physical activity, and stress.
- Trial name
- NCT05856734
- Testing
- Weight and body composition change, Change in dietary intake, Change in physical activity
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Obesity and Overweight, Diabetes Mellitus
FAMily-centered WEight Loss for Black Adults (FAM WEL B-ing)
The goal of this clinical trial is to learn the best combination of family components that yields optimal weight loss among Black adults.
- Conditions
- Obesity and Overweight, Diabetes Mellitus, Weight Loss, Behavior Change
- Trial name
- FAM WEL B-ing (NCT06724406)
- Testing
- Family Skills Training Session Quantity: 5, Family Skills Training Session Mode: In-person, Family Skills Training Content: Communication
- Where
- United States
- Volunteers
- 256 people
- Sponsor
- University of North Carolina, Chapel Hill
Obesity, Overweight
Evaluating a Remotely Delivered Plant-Based Behavioral Weight Loss Treatment
Many individuals do not achieve clinically significant weight loss following traditional lifestyle modification interventions, potentially because weight loss is dependent upon calorie tracking compliance (to achieve calorie…
- Trial name
- NCT04892030
- Testing
- Whole Food Plant-Based Behavioral Weight Loss Treatment
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Drexel University
Prader-Willi Syndrome, Obesity
Improving Care of Prader-Willi Syndrome : Evaluation of a New Care Program Combining Adapted Physical Activity, Nutrition and Therapeutic Education
Prader-Willi syndrome (PWS) is a rare and complex genetic disease characterized by hypothalamic-pituitary axis dysfunction combining eating disorders associated with hyperphagia and satiety deficiency, mild intellectual deficit…
- Trial name
- APHYNET (NCT05249998)
- Testing
- Program combing APA, Nutrition, and Therapeutic Education
- Where
- France
- Volunteers
- 128 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Weight Loss
Active Nutrition Program on Weight Loss
The study will evaluate the impact of the Active Nutrition 60-day program from USANA on weight loss and related measures, such as body composition, physical appearance/body shape, perceived wellness, and biochemical markers of…
- Trial name
- NCT06249698
- Testing
- meal replacements and supplements
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Memphis
Weight Loss, Health Economics
Investigating Remote Access, Group-based Functional Imagery Training in the Community
The rise in obesity over the last two decades has led to an increased need to support individuals to lose weight but also reduce costs for healthcare settings.
- Conditions
- Weight Loss, Health Economics, Quality of Life
- Trial name
- NCT04953299
- Testing
- Functional Imagery training, NHS 12 week weight loss programme
- Volunteers
- 150 people
- Sponsor
- University of Plymouth