Clinical trials: Weight Changes
Chronic Diseases, Obesity
Home-Based Exercise and Weight Control Program for Pain Control in Overweight Elderly With Osteoarthritis of the Knee
The purpose of this study is to determine whether a home-based exercise and weight control program applied to elderly overweight individuals with painful osteoarthritis of the knee, would result in pain reduction.
- Conditions
- Chronic Diseases, Obesity, Osteoarthritis, Pain
- Trial name
- NCT00126737
- Testing
- Weight Control Nutritional Program, Home-based exercise program
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- US Department of Veterans Affairs
Obstructive Sleep Apnea, Overweight
Influence of Exercise, Weight Loss, and Exercise Plus Weight Loss on Sleep Apnea
Obstructive sleep apnea (OSA) is highly prevalent among Veterans, and is associated with significant mortality and multiple morbidities.
- Trial name
- NCT02721251
- Testing
- Exercise, Weight Loss, Exercise + Weight Loss
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Weight Loss, Obesity
Testing the Effectiveness of WW Clinic GLP1
The study objective is to evaluate the efficacy of the WeightWatchers (WW) GLP-1 behavioral program + WW Clinic (formerly known as Sequence medical weight management program) on weight loss and related outcomes.
- Trial name
- WW Clinic (NCT06034457)
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- The Cleveland Clinic
Obesity, Sleep Apnea, Obstructive
Pragmatic Obstructive Sleep Apnea Weight Loss Trial Assessing Effectiveness and Reach
Prevalent obesity related conditions like obstructive sleep apnea (OSA) represent an important opportunity to improve population health. OSA reduces quality of life and is associated with greater risk for cardiovascular disease.
- Trial name
- POWER (NCT05104450)
- Testing
- lifestyle intervention
- Where
- United States
- Volunteers
- 696 people
- Sponsor
- VA Office of Research and Development
Weight Change, Body, Smoking Cessation
Efficacy of Two Novel Behavioral Post-cessation Weight Gain Interventions
The study aims to randomize 400 participants to 1 of 3 arms: a) a weight stability intervention prior to smoking cessation (Group 1); b) a weight loss intervention prior to smoking cessation (Group 2); or c) a self-guided weight…
- Trial name
- NCT03156660
- Testing
- Weight gain prevention (Group 1), Weight loss intervention (Group 2), Self-guided intervention (Group 3)
- Where
- United States
- Volunteers
- 305 people, healthy volunteers welcome
- Sponsor
- University of Tennessee
Obesity
ENDObesity® II Study: TransPyloric Shuttle® System for Weight Loss
The purpose of this clinical research trial is to study safety and effectiveness of the TransPyloric Shuttle System (TPSS) for weight reduction in patients who are considered medically obese.
- Trial name
- NCT02518685
- Testing
- TransPyloric Shuttle, Lifestyle Counseling
- Where
- 9 sites in United States
- Volunteers
- 302 people
- Sponsor
- BaroNova, Inc.
Pregnancy; Nutritional Diseases
Growth and Adiposity in Newborns: The Influence of Prenatal Docosahexaenoic Acid (DHA) Supplementation
The purpose of this study is to learn if participants in the ADORE study (NCT02626299), who took a DHA supplement during pregnancy, see favorable body fat in their infants from birth to 24 months, and if excessive or appropriate…
- Trial name
- ADORE-GAINS (NCT03310983)
- Where
- United States
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Metastatic Pancreatic Cancer
Anamorelin Study for Advanced Pancreatic Cancer
Multicenter, double-blind, randomized, placebo-controlled study to evaluate the efficacy and safety of anamorelin HCl. Approximately 100 subjects with advanced PDAC and cachexia will be randomized 1:1 to anamorelin HCl 100 mg or…
- Trial name
- NCT04844970
- Testing
- Anamorelin Hydrochloride
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Lahey Clinic
Male Infertility, Obesity
Investigating the Physiological Effects of Weight Loss on Male Fertility
The purpose of this study is to determine the physiological effects of weight loss on seminal parameters in male participants with reduced reproductive capacity.
- Conditions
- Male Infertility, Obesity, Weight Loss
- Trial name
- NCT03553927
- Testing
- Low Energy Diet, NHS advice on healthy eating
- Where
- United Kingdom
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Binge Eating, Weight Loss
Reducing Binge Eating to Prevent Weight Gain in Black Women
The purpose of the proposed study is to pilot a 6-month, cognitive-behavioral binge eating intervention, Appetite Awareness Training (AAT) to reduce binge eating and prevent weight gain for Black women with a BMI > 25 kg/m^2 and…
- Conditions
- Binge Eating, Weight Loss, Weight Gain Prevention
- Trial name
- NCT03531112
- Testing
- Appetite Awareness Treatment + Lifestyle Modification
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Obesity, Morbid Obesity
Bariatric Embolization of Arteries With Imaging Visible Embolics (BEATLES)
The BEATLES study is an investigator-initiated, prospective, double-blinded, randomized, sham-controlled study that will assess the impact of bariatric embolization on the systemic levels of obesity-related hormones and, as a…
- Conditions
- Obesity, Morbid Obesity, Weight Loss
- Trial name
- BAE2 (NCT04197336)
- Testing
- Bariatric Embolization of Arteries with imaging visible Embolics
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Obesity
Internet Assisted Obesity Treatment Enhanced With Financial Incentives
The investigators propose a randomized controlled trial to evaluate whether the addition of financial incentives to a high-quality, online behavioral weight loss intervention produces better weight losses than the online…
- Trial name
- iREACH3 (NCT02688621)
- Testing
- Internet Only, Internet + Incentives
- Where
- 2 sites in United States
- Volunteers
- 418 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Gestational Weight Gain, Maternal Fat Accretion
Preventing Excessive Weight Gain and Maternal and Infant Fat Accretion
The purpose of this study is to learn if consuming a high fiber diet will reduce gestational weight gain and maternal and infant fat accretion.
- Conditions
- Gestational Weight Gain, Maternal Fat Accretion, Infant Fat Accretion
- Trial name
- SPROUT (NCT04868110)
- Testing
- High fiber diet
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Cachexia, Non-Small Cell Lung Cancer
Anamorelin HCl in the Treatment of Non-Small Cell Lung Cancer-Cachexia (NSCLC-C): An Extension Study (ROMANA 3)
The administration of Anamorelin HCl in patients with Non-Small Cell Lung Cancer-Cachexia (NSCLC-C) is expected to increase appetite, lean body mass, weight gain, and muscle strength.
- Trial name
- NCT01395914
- Testing
- Anamorelin HCl
- Where
- 72 sites in United States, Australia and 15 more
- Volunteers
- 513 people
- Sponsor
- Helsinn Therapeutics (U.S.), Inc
Obesity, Morbid, Gastric Bypass
Effects of Gastric Bypass Surgery and Calcium Metabolism and the Skeleton
Obesity is a chronic illness of staggering proportions. Because weight loss through diet and exercise is difficult to attain and maintain, there has been escalating interest in bariatric surgery, including Roux-en-Y gastric…
- Trial name
- NCT01330914
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- VA Office of Research and Development
Obesity
Behavioral Weight Loss and Stigma Reduction
This is a randomized controlled trial to test the effects on long-term weight loss of a novel stigma-reduction intervention combined with standard BWL treatment, as compared to BWL alone.
- Trial name
- NCT03704064
- Testing
- Stigma-Reduction Intervention, Behavioral Weight Loss (BWL)
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- University of Pennsylvania
Loss-of-control Eating, Obesity/Overweight
Pharmacological and Behavioral Treatment After Bariatric Surgery: Medication Change for Non-Responders (Stage 2b)
This study will test the effectiveness of lisdexamfetamine medication as a treatment for loss-of-control eating and weight following bariatric surgery.
- Trial name
- NCT04599504
- Testing
- Lisdexamfetamine Dimesylate (Medication)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Yale University
Weight Gain
Study of Novel Approaches for Prevention
The Study of Novel Approaches for Prevention (SNAP) is randomized trial designed to test whether behavioral interventions based on self-regulation can prevent weight gain in young adults (18-35 years; body mass index (BMI) 21-30…
- Trial name
- SNAP (NCT01183689)
- Testing
- Small Behavior Changes, Large Behavior Changes
- Where
- 2 sites in United States
- Volunteers
- 599 people, healthy volunteers welcome
- Sponsor
- Wake Forest University
Weight Loss, Bone Health
Incorporating Nutrition, Vests, Education, and Strength Training in Bone Health (INVEST in Bone Health)
The main goal of the proposed study is to compare the effects of weight loss (WL) alone with WL plus weighted vest use or WL plus resistance exercise training (RT) on indicators of bone health and subsequent fracture risk.
- Trial name
- INVEST (NCT04076618)
- Testing
- Vest, Resistance Exercise Training, weight loss program
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Wake Forest University Health Sciences
Body Weight Changes, Overweight
Lifestyle Education for Activity and Nutrition for a Leaner You
Although weight loss programs are effective in the short-term, maintaining weight loss is more challenging. Regularly tracking and logging physical activity (PA) and diet is related to greater improvements in PA and diet and to…
- Trial name
- LEAN (NCT00957008)
- Testing
- Group weight loss program, Group weight loss program plus use of the Senseware Armband, Use of the senseware armband alone program
- Where
- United States
- Volunteers
- 197 people, healthy volunteers welcome
- Sponsor
- University of South Carolina