Clinical trials: Weight Management
Obesity
Effect of Recombinant Human Growth Hormone (rhGH) on Abdominal Fat and Cardiovascular Risk in Obese Girls
Teenagers and adults who are overweight or obese have an increase in fat in the abdomen, which increases their risk for diabetes and heart disease.
- Trial name
- NCT01169103
- Testing
- recombinant human growth hormone (rhGH)
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Massachusetts General Hospital
Obesity
Portion Size Strategies for Management of Body Weight
The primary aim of this research is to determine the efficacy of two portion-control strategies to achieve sustainable dietary and behavior changes and to promote weight loss and maintenance.
- Trial name
- NCT01474759
- Testing
- Advice on diet, physical activity, and behavior change, Instruction in food portion size, Provision of pre-portioned foods
- Where
- United States
- Volunteers
- 186 people
- Sponsor
- Penn State University
Healthy Participants
Assess the Safety, Tolerability, and Pharmacokinetics of AZD6234 Following Single Ascending Dose Administration to Healthy Subjects Who Are Overweight or Obese
A study in healthy male and female participants of non-childbearing potential who are overweight or obese.
- Trial name
- NCT05511025
- Testing
- AZD6234, Acetaminophen
- Where
- 2 sites in United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Obesity
Healthy Weight Management Project for Overweight and Obesity Children
Childhood obesity is a significant public health concern worldwide. In China, childhood obesity has dramatically increased as the economy has grown quickly over the past decades.
- Trial name
- NCT05482191
- Testing
- Lifestyle intervention
- Where
- China
- Volunteers
- 331 people, healthy volunteers welcome
- Sponsor
- Ningbo No. 1 Hospital
Overweight, Obesity
Weight and Metabolic Management Study
The goal of this clinical trial is to learn whether elénzia CONTROL®, a nutritional supplement, can support weight management in adults who have either never used GLP-1 weight-loss medications or have recently stopped using them.
- Conditions
- Overweight, Obesity, Weight Maintenance
- Trial name
- WMMS (NCT07789223)
- Testing
- elénzia CONTROL®
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Elenzia
Obesity, Childhood, Pediatric Obesity
Treatment Efforts Addressing Child Weight Management by Unifying Patients, Parents & Providers
The US Preventive Services Task Force (USPSTF) recommends that providers screen children aged 6 years and older for obesity and offer or refer them to a comprehensive behavioral intervention (≥26 hours over a period of up to 12…
- Conditions
- Obesity, Childhood, Pediatric Obesity, Childhood Obesity, Adolescent Obesity
- Trial name
- TEAM UP (NCT03843424)
- Testing
- eSOC program, FBT program
- Where
- 7 sites in United States
- Volunteers
- 1,460 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Obesity, Overweight
A Study of Aleniglipron in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2)
This is randomized, double-blind, placebo-controlled study of the long-term efficacy, safety, and tolerability of multiple doses of aleniglipron in participants living with overweight or obesity and T2DM.
- Conditions
- Obesity, Overweight, Chronic Weight Management, Type2 Diabetes Mellitus
- Trial name
- NCT07654374
- Testing
- aleniglipron
- Where
- 74 sites in United States
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics
Chronic Weight Management
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ASC35 Injection in Participants With Obesity or Overweight
This randomized, double-blind, placebo-controlled single ascending dose (SAD)/ multiple ascending dose (MAD) study is designed to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of ASC35 injection
- Trial name
- NCT07842640
- Testing
- ASC35 Injection B, for subcutaneous use, Tirzepatide
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Ascletis Pharma (China) Co., Limited
Obesity, Hypertension
Food as Medicine: A Quasi-Randomized Control Trial of Healthy Foods for Chronic Disease Management
The purpose of this study is to investigate the effect of providing healthy foods and nutrition education on participants' body weight, blood pressure, and average blood sugar level.
- Conditions
- Obesity, Hypertension, Pre-diabetes, Type 2 Diabetes
- Trial name
- NCT05174078
- Testing
- Medically-tailored meals, Produce box and recipes
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Cleveland Clinic Akron General
Pulmonary Aspiration During Anaesthetic Induction, Gastric Emptying Time
Gastric Emptying With Metoclopramide in GLP-1 Agonist Patients Undergoing Elective Surgery
This is a multicentre, investigator-blinded, randomised controlled trial evaluating whether the use of oral metoclopramide before surgery can reduce the amount of residual gastric content in patients who are taking glucagon-like…
- Conditions
- Pulmonary Aspiration During Anaesthetic Induction, Gastric Emptying Time, Preoperative Risk Assessment, Obesity (Disorder)
- Trial name
- GEM-GLP1RA (NCT07100691)
- Testing
- Metoclopramide
- Where
- 2 sites in Ireland
- Volunteers
- 80 people
- Sponsor
- Mater Misericordiae University Hospital
Obesity & Overweight
Multimodal Intervention for Weight Management and Health in the Elderly Population
Aging may be accompanied by changes in body composition, muscle strength, metabolic health, and well-being. In older adults with overweight or obesity, strategies that combine physical exercise, behavioral changes, and…
- Trial name
- NCT07820774
- Testing
- Nutritional guidance focused on adopting a high-protein diet., Group Cognitive Behavioral Therapy Intervention, Resistance Training Program
- Where
- Brazil
- Volunteers
- 54 people
- Sponsor
- Universidade Cesumar (UNICESUMAR)
Peripheral Nerve Block, Pain Management
Comparison of Conventional and Retroclavicular Approaches for Ultrasound-guided Infraclavicular Brachial Plexus Block
Forearm and hand surgeries are among the most frequently performed surgical interventions both in trauma patients and electively.In these procedures, alternative anesthesia methods such as general anesthesia, regional intravenous…
- Conditions
- Peripheral Nerve Block, Pain Management, Forearm Surgery, Hand Surgery
- Trial name
- NCT07151443
- Testing
- Conventional approach to infraclavicular block, Retroclavicular approach to the infraclavicular block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara Etlik City Hospital
Obesity, Overweight
The Peer Assisted Lifestyle Intervention
The PAL intervention uses a new software tool delivered on tablets to facilitate 5As-based weight management counseling with a peer health coach and the VA PACT healthcare team to promote goal-setting, behavior change, and weight…
- Trial name
- PAL (NCT03163264)
- Testing
- Peer Assisted Lifestyle, Enhanced Usual Care
- Where
- United States
- Volunteers
- 301 people
- Sponsor
- VA Office of Research and Development
Obesity
Impact of Probiotics on Weight Control and Body Composition in Overweight and Obese Individuals
The aim of the study is to evaluate the potential of probiotics on weight management. It is hypothesized that the consumption of 1 capsule of probiotics daily will modulate the intestinal gut microbiota thereby reducing body…
- Trial name
- NCT02893943
- Testing
- Probiotics
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Osteoarthritis, Overweight and Obesity
Effects of an Online Training Program for Physiotherapists About Weight Management for People With Osteoarthritis
A randomized controlled trial for which the primary objective is to evaluate the effects of an online training program on physiotherapist's self-reported confidence in knowledge about weight management for people with…
- Trial name
- NCT04574804
- Testing
- Online training program in weight management for osteoarthritis
- Where
- Australia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Melbourne
Pregnancy, Weight Gain
Development of a Pregnancy Weight Management Service Model
To develop a pregnancy weight management application and service model for pregnant women, and to evaluate its feasibility and effects on gestational weight management and health behaviors during pregnancy.
- Trial name
- NCT07814885
- Testing
- Pregnancy Weight Management Counseling
- Where
- Taiwan
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Mackay Medical College
Eating Disorders, Intermittent Fasting
Effect of Fasting and Calorie-Restricted Diets on Dopamine and Serotonin Levels Among Obese Women With BED and FA
Obesity presents a substantial economic burden in Jordan. Binge eating disorder (BED) and food addiction (FA) are the most common eating disorders associated with obesity.
- Conditions
- Eating Disorders, Intermittent Fasting, Obesity
- Trial name
- NCT04873648
- Testing
- caloric reduced -intermitted fasting diet, Daily calorie restriction, Control group
- Where
- Jordan
- Volunteers
- 100 people
- Sponsor
- University of Jordan
Breast-milk
Breast-milk Enema Administration to Stimulate Passage of Meconium
Lack of passage of meconium in preterm infants delays feeding advancement and may represent a risk factor for necrotizing enterocolitis (NEC) and spontaneous intestinal perforation (SIP).
- Trial name
- BEAM (NCT07661992)
- Testing
- breast milk
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Wake Forest University Health Sciences
Diabetes Mellitus, Type 2, Obesity
Weight Loss Clinical Decision Support
Despite steady increases in obesity prevalence, the more than 12 million obese U.S. adults with type 2 diabetes (T2DM) and severe obesity encounter a number of barriers to adopting effective surgical and pharmaceutical…
- Trial name
- WL-CDS (NCT05198765)
- Testing
- BMI-CDS
- Where
- United States
- Volunteers
- 10,120 people
- Sponsor
- HealthPartners Institute
Food Cravings, rTMS
The Effectiveness of rTMS on Improving Food Craving and Weight Control in Adults Without Serious Mental Illness
Department of Psychiatry | Li Ka Shing Faculty of Medicine The University of Hong Kong The Effectiveness of rTMS on Improving Food Cravings and Weight Control in Adults without Serious Mental Illness Introduction The…
- Trial name
- NCT07106398
- Testing
- repetitive transcranial magnetic stimulation
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- The University of Hong Kong