Clinical trials: Weight Reduction
Individual Stress and Weight Loss
Intensive Longitudinal Assessment of Stress and Stress-related Concepts Across a Behavioral Weight Loss Intervention
Examine the association between variability in individual stress and related concepts with weight loss, physical activity, and sleep across a behavioral weight loss program
- Trial name
- INSTANT (NCT06668259)
- Where
- 2 sites in United States
- Volunteers
- 52 people
- Sponsor
- University of Kansas Medical Center
Obesity
Examining Cooking as a Health Behavior
The proposed pilot study will examine cooking as an intervention target for weight control in overweight adults. The study will also examine whether interventions designed to promote cooking at home can increase participants'…
- Trial name
- iChef (NCT03783962)
- Testing
- Active Intervention - Cooking, Demonstrations - Cooking
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Obesity, Type 2 Diabetes
The Effects of Weight Loss on Neuroadrenergic Function
Elevated subconscious nervous system activity is a characteristic of the obese state and contributes importantly to the risk of heart disease and diabetes.
- Conditions
- Obesity, Type 2 Diabetes, Metabolic Syndrome
- Trial name
- NCT01771042
- Testing
- Dietary weight loss at 25% energy deficit
- Where
- Australia
- Volunteers
- 120 people
- Sponsor
- Baker Heart Research Institute
Lymphedema
The Women In Steady Exercise Research (WISER) Survivor Trial
WISER Survivor is a one year weight loss and exercise study for sedentary breast cancer survivors who are overweight or obese with breast cancer related lymphedema.
- Trial name
- WISER Survivor (NCT01515124)
- Testing
- Exercise Intervention, Weight Loss Intervention
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Stage IV Non-small Cell Lung Cancer, Cachexia
Ruxolitinib for Cancer Cachexia
To assess toxicity with use of Ruxolitinib in NSCLC cachexia patients; to associate levels of JAK/STAT signaling in blood, adipose, and muscle pre- and post-ruxolitinib treatment with changes in cachexia and anorexia.
- Trial name
- NCT04906746
- Testing
- Identify any dose-limiting toxicity (DLT) when ruxolitinib is administered to NSCLC cachexia patients.
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Tu Dan
Gastric Bypass Surgery, Obesity
Mechanisms of Diabetes Control After Weight Loss Surgery
Obesity and type 2 diabetes (T2DM) are increasing in the US. One third of patients seeking bariatric surgery have T2DM. Although all surgeries result in significant weight loss and often 'cure' the T2DM, the rapid onset and the…
- Trial name
- NCT00571220
- Testing
- gastric bypass surgery, Diet induced weight loss
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Overweight , Obesity, Adults
Study to Assess the Effect and Safety of ALV-100 on Maintenance of Weight Loss
A study of ALV-100 to assess efficacy, safety and tolerability among participants with overweight or obesity who have previously achieved a body weight reduction of ≥10% while treated with incretin-based therapies.
- Trial name
- PRESERVE (NCT07837973)
- Testing
- ALV-100
- Where
- 20 sites in United States
- Volunteers
- 220 people
- Sponsor
- Alveus Therapeutics, Inc.
Obesity
Protein Eating Patterns and Weight Loss
The purpose of this study is to determine the effects of daily protein intake patterns on body composition and eating behaviors during weight loss.
- Trial name
- NCT03202069
- Testing
- Even protein, Skewed protein
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- USDA Grand Forks Human Nutrition Research Center
Obesity, Inflammation
Effect of Weight Reduction on Inflammatory Markers and Genes Expression in Obese Individuals
To investigate whether weight reduction by life style modification for 12 weeks will improve circulating inflammatory markers, adipocytokines as well as gene expression of proinflammatory protein obtained from circulating…
- Trial name
- NCT00416156
- Testing
- Lifestyle modification
- Where
- Taiwan
- Volunteers
- 25 people
- Sponsor
- Taichung Veterans General Hospital
Body Composition, Obesity
Efficacy of Liquid Versus Powder Protein Supplementation to Optimize Protein Intake After Bariatric Surgery
The goal of this randomized control trial is to compare the effect of a liquid formula rich in nutrients and low in calories (supplement) with the progressive diet with conventional foods that we usually recommend in patients…
- Conditions
- Body Composition, Obesity, Protein Supplementation, Bariatric Surgery Candidate
- Trial name
- NCT06267677
- Testing
- High protein liquid formula
- Volunteers
- 50 people
- Sponsor
- Hospital Clinic of Barcelona
Ductal Carcinoma In Situ, Breast Cancer
Effects of Diet and Exercise on Ductal Carcinoma in Situ
This pilot/feasibility trial seeks to explore whether an acute bout of negative energy balance prior to surgery affects biomarkers of neoplasia.
- Trial name
- DCIS (NCT02224807)
- Testing
- Active Comparator: Progressive Resistance Training (PRT) and a healthy diet, Experimental: PRT and a healthy diet, plus weight loss
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Alabama at Birmingham
Overweight and Obesity
Predictors of Lorcaserin-Induced Weight Loss
This two-phase study aims to explore ways to predict who will respond well to the weight loss drug lorcaserin and to understand the mechanisms that develop which limit drug efficacy.
- Trial name
- NCT03353220
- Testing
- Belviq
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Columbia University
Obesity
Pivotal Aspiration Therapy With Adjusted Lifestyle Therapy Study
This research study is being performed to find out if a new device, AspireAssist Aspiration Therapy System, can help people with obesity to lose weight without causing too many side effects.
- Trial name
- PATHWAY (NCT01766037)
- Testing
- Aspiration Therapy (AspireAssist), Lifestyle Therapy
- Where
- 10 sites in United States
- Volunteers
- 171 people
- Sponsor
- Aspire Bariatrics, Inc.
Weight Loss, Overweight
Rethinking Eating and FITness for Men
The purpose of this study is to test the effect of a new three-month behavioral weight loss program among adult men. Weight will be measured at three and six months post randomization.
- Trial name
- REFIT (NCT01843595)
- Testing
- REFIT Intervention
- Where
- United States
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Weight Loss
The Undernourished Patient: Prevention and Treatment
The purpose of this study is to determine whether a nutrition intervention during a rehabilitation stay followed by nutritional advice after discharge, can improve the nutritional status of the patients after 3 months.
- Trial name
- NCT01632072
- Testing
- Nutritional support
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- University of Oslo
Obesity
Reducing Energy Density by Different Methods to Decrease Energy Intake
The purpose of this research is to investigate how using different methods to reduce the energy density of entrees affects daily energy intake in adults.
- Trial name
- NCT01470300
- Testing
- Energy density feeding study
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Penn State University
Obesity, Weight Loss
The Big Breakfast Study
This weight loss study will investigate the impact of diet composition and meal size (large breakfast meals and smaller evening meals) on body weight, energy balance and eating behaviour, by altering calorie (meal) distribution.
- Trial name
- NCT03077295
- Testing
- High Fibre, High Protein
- Where
- United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Safety Issues
Safety Evaluation of Porous Silica in Men
The aim of the present study was to determine whether oral dosing, up to 9 grams/day, of porous silica administered as a food additive can be used safely in normal weight and obese male humans, without significant side effects on…
- Trial name
- NCT03667430
- Testing
- Porous silica
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Obesity Type 2 Diabetes Mellitus, Obesity & Overweight
Eating Behaviour Before, During, and After Obesity Medication
This study will examine how eating behaviour changes during the first 18 months of treatment with obesity medications in patients attending the St Vincent's Healthcare Group obesity service.
- Trial name
- NCT07636395
- Where
- Ireland
- Volunteers
- 30 people
- Sponsor
- University College Dublin
Obesity
Dairy Intervention in People With Obesity
Obesity is associated with increased morbidity and mortality, but weight reduction is difficult to achieve. In this randomized controlled trial we will include 120 obese subjects.
- Trial name
- DIPO (NCT04154475)
- Testing
- yogurt diet, dairy diet, standard diet
- Where
- Austria
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz