Clinical trials: Weight Reduction and Insulin Sensitivity
Obesity, Diabetes Mellitus, Type 2
The Effect of Bariatric Surgery on Insulin Sensitivity and Energy Metabolism
The purpose of this study is: 1. To explore to what extent insulin sensitivity, energy metabolism and ectopic lipid storage can be improved by bariatric surgery 2.
- Trial name
- BARIA-DDZ (NCT01477957)
- Testing
- surgery
- Where
- Germany
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- German Diabetes Center
Obesity in Diabetes, Obesity/Therapy
Semaglutide Treatment in Type 1 Diabetes
The goal of this clinical trial is to investigate the efficacy of semaglutide on body weight, insulin dose requirements and improvements in glucose control and safety aspects in regards to risk of hypoglycemia and diabetic…
- Conditions
- Obesity in Diabetes, Obesity/Therapy, Type 1 Diabetes Mellitus (T1DM), Insulin Sensitivity/Resistance
- Trial name
- OBES1TY (NCT06909006)
- Testing
- Semaglutide 2.4mg
- Where
- Denmark
- Volunteers
- 122 people
- Sponsor
- Nordsjaellands Hospital
Sensitivity to Thyroid Hormones, Metabolic Parameters
Effects of Intermittent Fasting on Fatty Liver Disease
Eighty subjects with FLD were recruited from the endocrinology clinic at Beijing Chao-yang Hospital. All of the following inclusion criteria needed to be met: hepatic fat content (HFC) were upper 5.0% evaluated by upper abdominal…
- Conditions
- Sensitivity to Thyroid Hormones, Metabolic Parameters, in Patients With FLD
- Trial name
- NCT04795973
- Testing
- 5:2 intermittent fasting
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Beijing Chao Yang Hospital
Type 2 Diabetes Mellitus
Dietary Fatty Acids As Complementary Therapy in Type 2 Diabetes Mellitus
The purpose of the study is to see how a dietary oil called conjugated linoleic acid, or CLA, might be useful in combination with diabetes medication. Some studies show that CLA can modestly reduce body weight and body fat.
- Trial name
- FACT (NCT00607945)
- Testing
- Rosiglitazone (Avandia) OR other diabetes medication currently prescribed to participant, conjugated linoleic acid (CLA)
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Ohio State University
Childhood Obesity, NAFLD (Non-alcoholic Fatty Liver Disease)
Metabolic Syndrome and Gen-polymorphs Influence on Weightloss Among Children in Treatment for Overweight
Definition: the overall objective is to examine childhood obesity with focus on NAFLD and its treatment. Further, we aimed to investigate the impact of genetic variation on obesity.
- Conditions
- Childhood Obesity, NAFLD (Non-alcoholic Fatty Liver Disease), Hypertension, Hyperlipidemia
- Trial name
- NCT00823277
- Testing
- Chronic care multidisciplinary intervention of childhood obesity
- Where
- Denmark
- Volunteers
- 517 people, healthy volunteers welcome
- Sponsor
- Holbaek Sygehus
Insulin Sensitivity
Physical Training Per se
The investigators aimed to evaluate the health benefits of physical training per se, weight loss per se and exercise-induced weight loss in young, overweight men.
- Trial name
- TPS (NCT01090869)
- Testing
- 12 weeks of lifestyle change
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Obesity
Physical Activity Following Surgery Induced Weight Loss
The primary objective of this study will be to determine the effects of physical activity in patients during substantial surgery-induced weight loss.
- Trial name
- NCT00692367
- Testing
- Physical Activity
- Where
- 2 sites in United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Insulin Sensitivity, Obesity
Comparative the Effect of Metformin and Acupuncture on Weight Loss and Insulin Sensitivity
The investigators designed this randomized double blind (patients/ assessor) clinical trial to compare the therapeutic effects of Metformin monotherapy with Metformin and acupuncture combined therapy on weight loss and insulin…
- Trial name
- NCT02438540
- Testing
- metformin, acupuncture
- Volunteers
- 43 people
- Sponsor
- Amir Firouzjaei
Type 2 Diabetes
Surgery Or Lifestyle Intervention for Type 2 Diabetes (SOLID)
This research study will investigate the safety and effectiveness of weight loss surgery for overweight persons with type 2 diabetes.
- Trial name
- SOLID (NCT01040468)
- Testing
- Roux-en-Y Gastric Bypass surgery, Laparoscopic Adjustable Gastric Banding surgery, Intensive Lifestyle Modification
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Pennsylvania
Overweight, Obesity
Can We Achieve 'high-quality' Weight Loss Through Supplementation and Exercise? the TRIM MUSCLE Study
The purpose of this study is to determine whether the combination of two dietary supplements: MUSCLE 5, which contains protein, creatine and vitamin D and TRIM 7, which contains beet extract, caffeine, coenzyme Q10, alpha lipoic…
- Trial name
- NCT05384431
- Testing
- Muscle5 and TRIM7, Mixed exercise
- Where
- Canada
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Exerkine Corporation
Metabolic Syndrome X
Sympathetic Activity in Individuals With the Metabolic Syndrome: Benefits of Lifestyle Interventions
An abdominal distribution of fat is associated with the greatest heart disease risk, because commonly, several risk factors of metabolic origin (high blood pressure, unfavourable cholesterol profile, elevated blood sugar…
- Trial name
- NCT00163943
- Testing
- Dietary weight loss +/- aerobic exercise
- Where
- Australia
- Volunteers
- 66 people
- Sponsor
- Bayside Health
Obesity, Liver Diseases
Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled Trial
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease globally. While weight loss through lifestyle modification is the standard treatment, most patients regain weight limiting…
- Conditions
- Obesity, Liver Diseases, Liver Fibrosis, Liver Fat
- Trial name
- NCT06138821
- Testing
- ESG + lifestyle modification, Lifestyle modification
- Where
- 2 sites in United States
- Volunteers
- 132 people
- Sponsor
- Pichamol Jirapinyo, MD, MPH
Morbid Obesity
Glucose Homeostasis Pre and Post Bariatric Surgery
The investigators wish to study the effects of three forms of bariatric surgery: Roux-en-Y gastric bypass, Sleeve Gastrectomy, and Gastric Banding. The surgery is not part of the clinical trial.
- Trial name
- RB (NCT00981500)
- Testing
- gastric bypass, gastric banding, sleeve gastrectomy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Washington University School of Medicine
Diabetes, Pre-diabetes
Weight Loss and/or Exercise Training to Discover Muscle Lipids Related to Insulin Sensitivity
The investigators will use exercise training and weight loss to discover localized lipid species related to diabetes risk in people.
- Trial name
- NCT02043405
- Testing
- Weight loss and exercise training intervention, Weight loss Only Intervention
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Obesity, Severe Obesity
Energy Expenditure From ECAL Indirect Calorimeter in a Multicomponent Weight Management Service
Whether greater weight loss is as a result of a smaller reduction in energy expenditure with caloric restriction is not known. Resting energy expenditure and 24-hour energy expenditure vary substantially between individuals.
- Conditions
- Obesity, Severe Obesity, Sleep Apnoea
- Trial name
- ECAL (NCT03638895)
- Testing
- ECAL Indirect Calorimeter, Diet, exercise & behaviour modification therapy
- Where
- United Kingdom
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Liverpool
Weight Loss, Obesity
Effects of Negative Energy Balance on Muscle Mass Regulation
The investigators here propose to perform a prospective randomized intervention trial in post-menopausal women to investigate the endocrine network, which contributes to the changes in skeletal muscle mass during weight loss.
- Conditions
- Weight Loss, Obesity, Skeletal Muscle, Insulin Sensitivity/Resistance
- Trial name
- NCT01105143
- Testing
- multimodal lifestyle intervention
- Where
- Germany
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Overweight, Obesity
Effects of Obex in Overweight and Obese Patients
Obesity is an important and growing public health worldwide Obesity is highly related to the development of metabolic syndrome, diabetes, cardiovascular diseases and cancer An extensive body of evidence from efficacy trials has…
- Trial name
- NCT02145442
- Testing
- Obex
- Where
- Cuba
- Volunteers
- 40 people
- Sponsor
- Catalysis SL
Type2 Diabetes, Weight Loss
Improving Glucose and Lipid Metabolism Through Caloric Restriction Using Diet or Surgery (CRUDOS)
In this explorative randomized clinical study, the investigators aim to study metabolic, cellular, and molecular changes that occur during weight loss in obese subjects with and without type 2 diabetes.
- Conditions
- Type2 Diabetes, Weight Loss, Insulin Sensitivity, Metabolism and Nutrition Disorder
- Trial name
- CRUDOS (NCT02988011)
- Testing
- Gastric by-pass surgery, Low-caloric diet
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Uppsala University
Overweight and Obesity
SIT LESS 4: How Does Reducing Sitting Time Improve Glucose and Lipid Metabolism?
Research has shown that replacing sitting time with low intensity physical activity (such as slowly walking and standing) has beneficial effects on metabolic health, like insulin sensitivity, comparable to improvements after…
- Trial name
- SITLESS4 (NCT03912922)
- Testing
- Activity regime
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Weight Reduction and Insulin Sensitivity
Fatty Acid Quality and Overweight (FO-study)
The purpose of this study is to study the health effects of fatty acid quality in healthy, overweight individuals.
- Trial name
- NCT01034436
- Testing
- fatty acid quality and overweight
- Where
- Norway
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Oslo Metropolitan University