Clinical trials: White Blood Cells
Inflammatory Response, Pain, Postoperative
Dexamethasone and Robotic-assisted Hysterectomy
Robotic-assisted hysterectomy is an alternative to laparoscopic surgery as part of a minimal invasive regimen. Several treatment strategies are followed to improve the overall outcome and minimize surgical stress.
- Conditions
- Inflammatory Response, Pain, Postoperative, Nausea, Postoperative, Incontinence
- Trial name
- NCT04762381
- Testing
- Dexamethasone phosphate
- Where
- Denmark
- Volunteers
- 109 people
- Sponsor
- Herning Hospital
Wiskott-Aldrich Syndrome
Post-transplant Cyclophosphamide in Wiskott-Aldrich Syndrome
A protocol named as "CIP-2015" for patients with Wiskott-Aldrich Syndrome may reduce the rate of GvHD. The details of the protocal followed with: 1. Conditioning regimen Busulfan 16 mg/kg in total, Fludarabine 160 mg/m2 in total.
- Trial name
- NCT03198195
- Testing
- cyclophosphamide
- Volunteers
- 5 people
- Sponsor
- Capital Research Institute of Pediatrics
Community-Acquired Pneumonia (CAP), Acute Respiratory Distress Syndrome (ARDS)
Study of Nogapendekin Alfa Inbakicept and iNKT Cells in Critically Ill Adults With Severe Community-Acquired Pneumonia
This is a Phase 3, randomized, blinded, and placebo-controlled clinical trial investigating a new combination treatment for critically ill adults who have severe community-acquired pneumonia, especially if they also have sepsis…
- Conditions
- Community-Acquired Pneumonia (CAP), Acute Respiratory Distress Syndrome (ARDS), Sepsis, Lymphopenia
- Trial name
- NCT07492875
- Testing
- Nogapendekin alfa inbakicept (NAI), agenT-797
- Sponsor
- ImmunityBio, Inc.
Eosinophilic Esophagitis
Pediatric Eosinophilic Esophagitis (pedEoE): Effect of Allergen Heat Denaturation on EoE Remission: a Pilot Trial
The objective of the study is to study whether the introduction of heated food products (more specifically heated hen's egg and/or cow's milk) in children with EoE would be possible without re-occurrence of the eosinophilic…
- Trial name
- NCT06381219
- Testing
- Implementation of cow's milk in decreasingly heated forms, Implementation of hen's egg in decreasingly heated forms
- Where
- Belgium
- Volunteers
- 36 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Kidney Cancer, Leukemia
Voriconazole in Preventing Fungal Infections in Children With Neutropenia After Chemotherapy
RATIONALE: Voriconazole may be effective in preventing systemic fungal infections following chemotherapy. PURPOSE: Phase II trial to study the effectiveness of voriconazole in preventing systemic fungal infections in children who…
- Conditions
- Kidney Cancer, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00066599
- Testing
- voriconazole
- Where
- 7 sites in United States
- Sponsor
- National Cancer Institute (NCI)
Respiratory Syncytial Virus Infections, Immunocompromised Host
RSV, Influenza, and SARS-CoV-2 Outcomes in Severely Immunosuppressed Adults
Respiratory syncytial virus (RSV), influenza, and SARS-CoV-2 are common respiratory viruses. In healthy adults they usually cause mild, cold-like illness, but in people whose immune system is severely weakened - such as people…
- Conditions
- Respiratory Syncytial Virus Infections, Immunocompromised Host, Influenza, COVID - 19
- Trial name
- NCT07816471
- Volunteers
- 350 people
- Sponsor
- Hospital Italiano de Buenos Aires
Asthma; Eosinophilic
Functional Lung MRI for Early Treatment Response Assessment for Patients With Eosinophilic Asthma
Patients with severe eosinophilic asthma will be placed on biologics if they continue to be uncontrolled despite maximized inhalation therapy or if they are only controlled under oral corticosteroids.
- Trial name
- FUNLUM (NCT04512521)
- Testing
- Mepolizumab
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Hannover Medical School
Asthma
A Dose Ranging Placebo-controlled Double-blind Study to Evaluate the Safety, Pharmacokinetics and Efficacy of 610 in Participants With Severe Eosinophilic Asthma
This study will assess the safety, tolerability, pharmacokinetics and preliminary efficacy of 610 as an adjunctive therapy in adult subjects with severe eosinophilic asthma.
- Trial name
- NCT05584306
- Testing
- 610 30mg group, 610 100mg group, 610 300mg group
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd.
Eosinophilic Gastroenteritis, Eosinophilic Esophagitis
Immunopathogenesis of Food Allergy and Eosinophilic Gastrointestinal Disorders
Background: Food allergies are characterized by abnormal immune system responses to certain foods, such as peanuts, strawberries, and shellfish.
- Trial name
- NCT01212016
- Where
- United States
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Eosinophilic Asthma
A Pragmatic Study to Investigate the Efficacy and Safety of Mepolizumab in Severe Uncontrolled Asthma in Brazil
The anti-interleukin-5 monoclonal antibody mepolizumab is approved as an add-on therapy in Europe, Canada, USA, and other countries, to standard of care for the treatment of patients with severe eosinophilic asthma.
- Trial name
- NCT04228588
- Testing
- Mepolizumab 100 MG [Nucala]
- Where
- Brazil
- Volunteers
- 18 people
- Sponsor
- University of Sao Paulo General Hospital
Febrile, Neutropenia
Assessment of New Blood Culture Methods on the Microbiological Documentation of Febrile Neutropenia
Febrile neutropenia are microbiologically documented in only 30% of the cases, and almost exclusively by blood cultures. The reasons for this low documentation are likely multiple: (1) some of these fevers are of non-infectious…
- Conditions
- Febrile, Neutropenia, Post-chemotherapy
- Trial name
- HEMATOCPLUS (NCT00913042)
- Testing
- sample blood
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Leukemia in Remission
Fludarabine Phosphate, Cyclophosphamide, Total Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Blood Cancer
This phase II trial studies how well fludarabine phosphate, cyclophosphamide, total body irradiation, and donor stem cell transplant work in treating patients with blood cancer.
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Leukemia in Remission, Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia
- Trial name
- NCT03333486
- Testing
- Cyclophosphamide, Fludarabine Phosphate, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Roswell Park Cancer Institute
Asthma, Asthma; Eosinophilic
Asthma Control in a Dutch Primary Care Population
Rationale: Despite the availability of effective treatment to reach symptom control, nearly half of the asthma patients remain inadequately controlled.
- Conditions
- Asthma, Asthma; Eosinophilic, Asthma Chronic, Asthma; Status
- Trial name
- NCT04456270
- Where
- Netherlands
- Volunteers
- 222 people
- Sponsor
- General Practitioners Research Institute
Neutropenia, Febrile, Hematologic Cancer
CEFtolozane-Tazobactam for the Empiric Anti-bacterial Treatment of Neutropenic Fever in Hematology Patients
Patients with blood cancers and those who received a bone marrow transplant frequently have low circulating white blood cell countS.
- Trial name
- CEF-10 (NCT05061654)
- Testing
- Ceftolozane-tazobactam IV
- Where
- Qatar
- Sponsor
- Hamad Medical Corporation
Methemoglobinemia, Linear IgA Bullous Dermatosis
Pharmacokinetics and Distribution of Dapsone in Leucocytes After Single-dose and Multiple-dose Administration
The objectives of the study are to evaluate pharmacokinetics, distribution in blood leucocytes, metabolism and methemoglobinemia after single-dose and repeated-dose administration of 100 mg of dapsone in healthy subjects…
- Trial name
- NCT02493283
- Testing
- Dapsone single dose, Dapsone multiple dose, leucocytes
- Where
- Germany
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Eosinophilic Esophagitis, Gastroesophageal Reflux
Phenotypic Characterization and Biomarkers Investigation for Eosinophilic Esophagitis in Pediatric Patients
The purpose of this study is to find out some potential biomarkers for the Eosinophilic Esophagitis (EoE) in pediatric patients through the prospective clinical characterization and assessment of samples collected during the…
- Trial name
- NCT03069573
- Where
- Brazil
- Volunteers
- 110 people
- Sponsor
- Federal University of Uberlandia
Eosinophilic Esophagitis
Evaluation of Efficacy, Safety and Patient' Satisfaction of Therapeutic Switch From Off-Steroids to Budesonide
Eosinophilic esophagitis (EoE) is a chronic, immune-mediated, esophageal-restricted disease characterized clinically by symptoms related to esophageal dysfunction and histologically by an eosinophil-predominant inflammation.A…
- Trial name
- Switch (NCT05594849)
- Testing
- Budesonide Orodispersible Tablets (Jorveza)
- Where
- Italy
- Volunteers
- 31 people
- Sponsor
- Istituto Clinico Humanitas
Periodontitis
Effect of Periodontitis on the Quality and Quantity of Leukocyte- and Platelet-Rich Fibrin (L-PRF)
Periodontitis is a chronic inflammatory disease that destroys the supporting tissues of the teeth and may also increase systemic inflammatory burden.
- Trial name
- NCT07693725
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Suleyman Demirel University
Chronic Heart Failure
Human Leucocyte Antigen G and Chronic Heart Failure
The Human leukocyte antigen G (HLA-G) is a non-classical, major histocompatibility complex class I (MHC-I) protein that modulates the immune response, inhibiting it in most cases.
- Trial name
- NCT03655925
- Testing
- plasmatic HLA-G
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Piera Boschetto
Carotid Atherosclerosis, Cerebrovascular Accident
Potential Risk Factors for Stroke
Early studies have shown that the immune system may play a role in the development of strokes. Conditions such as high blood pressure, high cholesterol, diabetes, and old age can activate the immune system and increase the risk…
- Conditions
- Carotid Atherosclerosis, Cerebrovascular Accident, Diabetes Mellitus, Hypercholesterolemia
- Trial name
- NCT00001368
- Testing
- cytokine and leukocyte activation profile
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
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