Clinical trials: White Blood Cells
Eosinophilic Esophagitis, Respiratory Allergy
Survey About the Relationship Beetween Allergic Rhinitis and Seasonal EOE Exacerbations
Eosinophilic esophagitis (EoE) is a chronic inflammatory esophagus disease that is presented in patients with a history of recurrent dysphagia.
- Trial name
- NCT05755477
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Nucera Eleonora
Leukocyte Function, Anesthesia
The Determination of the Effect of Volatile Anesthetics on Leukocyte Function ex Vivo
One of the most common side effects of a surgical procedure is infection. In order to lower the number of infections that occur after surgery, it is important for physicians to know how medications used during surgery affect the…
- Trial name
- NCT02207842
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Boston Children's Hospital
Lung Cancer, Adenocarcinoma
Combination Immunotherapy of GM.CD40L Vaccine With CCL21 in Lung Cancer
The purpose of this study is to find out what effects (good and bad) a tumor vaccine used in combination with GM.CD40L and CCL21 have on the patient and their cancer.
- Trial name
- NCT01433172
- Testing
- Phase I - GM.CD40L.CCL21 Vaccinations, Phase II - GM.CD40L cells Vaccinations, Phase II - GM.CD40L.CCL21 Vaccinations
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Neutropenia
Bioavailability Study of Lozanoc™ 65 mg Itraconazole Capsules in Patients Requiring Prophylaxis
This open-labelled, single arm study is a follow-on from Study MPG010 to compare the relative bioavailability of Lozanoc 65 mg Capsules against Lozanoc 50 mg Capsules and Sporanox 100 mg Capsules in patients requiring…
- Trial name
- NCT02755857
- Testing
- Lozanoc
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- Mayne Pharma International Pty Ltd
Neovascular Maculopathy, Age Related Macular Degeneration
Anti-VEGFR Vaccine Therapy in Treating Patients With Neovascular Maculopathy
The purpose of this study is to evaluate the safety and time to progression of HLA-A*2402 or A*0201 restricted epitope peptides VEGFR1 and VEGFR2 emulsified with Montanide ISA 51 in patients with Neovascular Maculopathy…
- Trial name
- NCT00791570
- Testing
- VEGFR1 and VEGFR2
- Where
- Japan
- Volunteers
- 17 people
- Sponsor
- Osaka University
Sepsis
Role of RNA Metabolism Alterations in Persistent Immune Dysfunction After Sepsis
This study includes adult ICU patients with sepsis (according to SEPSIS 3.0) or critically ill non-septic patients with severe non-infectious conditions at Louis Mourier Hospital.
- Trial name
- SEPSI-splice (NCT07418801)
- Where
- 2 sites in France
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Eosinophilic Esophagitis
Risk Factors and Biomarkers for Diagnosis and Treatment of EoE
Purpose: To validate our previously developed model of risk factors for diagnosis of eosinophilic esophagitis (EoE), and to assess the utility of serum levels of biomarkers in diagnosis and monitoring of treatment of EoE.
- Trial name
- NCT01988285
- Testing
- Specimen Collection, Questionnaires
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- University of North Carolina, Chapel Hill
Intra-bony Pockets, Periodontitis
Biologicals in Management of Intra-Bony Defects
The aim is of this study is to evaluate and compare the effects (clinical and radiological) of different biomaterials on the repair of bone defects around the teeth.
- Trial name
- NCT07292870
- Testing
- Minimally invasive surgical treatment of the intra-bony defects, Use of the xenograft Bio-Oss® Collagen during the surgery, Use of enamel matrix derivative (Emdogain®)
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Asthma; Eosinophilic
Efficacy of Reslizumab Dose Escalation in Patients With Severe Asthma
Dose escalation of reslizumab can ameliorate sputum eosinophilia in severe asthmatics who have persistent sputum eosinophilia despite treatment with reslizumab at the standard dose.
- Trial name
- NCT04710134
- Testing
- Reslizumab
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- McMaster University
MIS-C Associated With COVID-19, COVID-19
Study of Virus-specific Lymphocytic Cell Populations in Non-invasive Nasal Mucosa Samples of MIS-C Patients
The aim of the study is to make an accurate assessment of immune cells obtained from nasal mucosa and peripherial blood of MIS-C patients during the disease and the period of health.
- Trial name
- NCT05560906
- Where
- Poland
- Volunteers
- 20 people
- Sponsor
- Medical University of Warsaw
Glioblastoma
Feasibility of Lymphocyte Reinfusion in Newly Diagnosed High Grade Gliomas
This research study is being done to see if lymphocytes can be collected from patients with high grade gliomas before they start standard radiation and chemotherapy.
- Trial name
- NCT01653834
- Testing
- Lymphocyte harvesting & reinfusion
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Chronic Myelogenous Leukemia, Acute Lymphoblastic Leukemia (Philadelphia Chromosome Positive)
A Study of Oral AMN107 in Adults With Chronic Myelogenous Leukemia (CML) or Other Hematologic Malignancies
The purpose of this trial is to assess the efficacy, safety, tolerability, biologic activity, and pharmacokinetics of AMN107 in six groups of patients with one of the following conditions: Relapsed/refractory Ph+ Acute…
- Conditions
- Chronic Myelogenous Leukemia, Acute Lymphoblastic Leukemia (Philadelphia Chromosome Positive), Hypereosinophilic Syndrome, Systemic Mastocytosis
- Trial name
- NCT00109707
- Testing
- Nilotinib
- Where
- 101 sites in United States, Australia and 20 more
- Volunteers
- 507 people
- Sponsor
- Novartis Pharmaceuticals
Eosinophilic Esophagitis, EoE
The Immune Directed Individualized Elimination Therapy (iDIET) Study
This is a randomized, double blind, sham-controlled, pilot/feasibility trial of individualized dietary elimination treatment.
- Trial name
- iDIET (NCT05543512)
- Testing
- Algorithm to diagnose food allergens
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of North Carolina, Chapel Hill
Eosinophilic Esophagitis
Value of Patch Testing in Direct Diet Therapy for Eosinophilic Esophagitis
This study is being done to see if allergy patch testing (APT) can help predict effective dietary therapy in patients with eosinophilic esophagitis.
- Trial name
- EoE (NCT02227836)
- Testing
- Allergy Patch Testing
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Mayo Clinic
Febrile Neutropenia
Comparing Ciprofloxacin (CPFX) With Cefepime (CFPM) in Febrile Neutropenic Patients With Hematologic Diseases
The aim of this study is to investigate whether intravenous ciprofloxacin is as effective as cefepime for the initial treatment of febrile neutropenia developed in patients with hematologic diseases.
- Trial name
- NCT00137787
- Testing
- ciprofloxacin, cefepime
- Where
- Japan
- Volunteers
- 51 people
- Sponsor
- Center for Supporting Hematology-Oncology Trials
Rheumatoid Arthritis
Study of Human Leukocyte Antigen (HLA) Polymorphisms in Patients With Rheumatoid Arthritis
Rheumatoid arthritis (RA), affects between 0.3% and 1.0% of the population, it can lead to progressive joint destruction and severe disability.
- Trial name
- HLAPRPA (NCT01111357)
- Testing
- Collect of 10 ml of peripheric blood for DNA extraction
- Where
- Martinique
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Hospital Center of Martinique
Prostate Hyperplasia, Coagulation; Intravascular
The Effect of Human Prostate Tissue on Platelet Activation
Transurethral resection of the prostate (TURP) is a common and standard urological surgical procedure for managing benign prostatic hyperplasia (BPH).
- Conditions
- Prostate Hyperplasia, Coagulation; Intravascular, Thrombotic Disorder
- Trial name
- NCT05059431
- Volunteers
- 8 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Breast Cancer, Neutropenia
Neulasta-controlled Trial of F-627 in Women With Breast Cancer Receiving Myelotoxic Chemotherapy
This is a randomized, multi-center, single dose, open-label and Neulasta controlled phase 3 study to evaluate the efficacy and safety of F-627 in women with Stage I - III invasive breast cancer receiving chemotherapy treatment.
- Trial name
- NCT03252431
- Testing
- F-627, Neulasta
- Where
- United States
- Volunteers
- 393 people
- Sponsor
- EVIVE Biotechnology
Eosinophilic Esophagitis
Radiation Dose in Humans From Orally Administered Tc99m-Heparin
This is a research study of a new agent used for evaluation of inflammation in the GI tract. This agent is investigational and thus is being studied to determine appropriate dosing and administration in both normal controls (i.e.
- Trial name
- NCT04069429
- Testing
- Computerized Tomography scan, Single Photon Emission Computed Tomography scans, Technetium Tc 99M
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Utah
Children Under 3 Months of Age With Fever
Diagnostic Performance of a Combination of Leukocyte Cell Surface Markers in Predicting the Risk of Severe Bacterial Infection in Febrile Children Under Three Months of Age in the Emergency Department: a Pilot Study.
Fever is a frequent reason for emergency department (ED) visits in infants under 3 months of age. Although viral infections are the most common etiologies, the prevalence of severe bacterial infections (SBI) is high (10%).
- Trial name
- CYTOFEB (NCT06618989)
- Testing
- Blood sampling and follow-up call
- Where
- 2 sites in France
- Volunteers
- 180 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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