Clinical trials: White Blood Cells
Hyper-IgE Syndrome, Job's Syndrome
Omalizumab to Treat Hyper-IgE (Job's) Syndrome
This study will evaluate the safety and effectiveness of a laboratory-made antibody called omalizumab in patients with Job's syndrome, or hyper-IgE syndrome (HIES).
- Trial name
- NCT00260702
- Testing
- Omalizumab (Xolair)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Asthma
Pharmacokinetics and Pharmacodynamics of Mepolizumab Administered Subcutaneously in Children
Mepolizumab is a humanized immunoglobulin G (IgG1) monoclonal antibody (mAb) that exhibits dose proportional and time-independent pharmacokinetics. The study will be conducted in 2 parts.
- Trial name
- NCT02377427
- Testing
- Mepolizumab
- Where
- 16 sites in United States, Japan and 2 more
- Volunteers
- 36 people
- Sponsor
- GlaxoSmithKline
Febrile Neutropenia
Caspofungin or Micafungin as Empiric Antifungal Therapy for Persistent Fever and Neutropenia
Invasive fungal infections are an important cause of morbidity and mortality in patients with neutropenia who are receiving chemotherapy for cancer. Early diagnosis of these infections is difficult and fever may be the only sign.
- Trial name
- NCT00723073
- Where
- United States
- Volunteers
- 323 people
- Sponsor
- Brigham and Women's Hospital
Acute Respiratory Distress Syndrome, Severe Community-Acquired Pneum
Nogapendekin Alfa-Inbakicept and iNKT Cells for Critically Ill Adults With Severe Community-Acquired Pneumonia (With or Without Sepsis/ARDS)
This Phase 2 study tests whether adding two immune therapies - nogapendekin alfa-inbakicept (NAI) and off-the-shelf iNKT cell infusions - to standard care can safely help critically ill adults with severe community-acquired…
- Conditions
- Acute Respiratory Distress Syndrome, Severe Community-Acquired Pneum, Sepsis, Lymphopenia / Immunoparalysis in Critically Ill Adults
- Trial name
- NCT07492888
- Testing
- Nogapendekin Alfa-Inbakicept (NAI), Allogeneic invariant Natural Killer T (iNKT) Cells (AgenT-797)
- Sponsor
- ImmunityBio, Inc.
Myocardial Infarction, Inflammation
Effects of Oxygen Treatment on Mechanisms Involved in Ischemia-reperfusion Injury: A Pilot Study in Healthy Volunteers
Oxygen treatment is widely used in acutely ill patients. In particular, oxygen treatment is routinely used in acute coronary syndrome (ACS) patients with suspected acute myocardial infarction and variably recommended in…
- Conditions
- Myocardial Infarction, Inflammation, Acute Coronary Syndrome (ACS), Reperfusion Injury
- Trial name
- NCT02286544
- Testing
- Salmonella typhi vaccine (Typhim Vi®), Oxygen (Oxymask®), Atorvastatin
- Where
- Sweden
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Platelet Refractoriness, Hematologic Malignancy
A Pilot Trial Using Isatuximab to Overcome Platelet Transfusion Refractoriness in Human Leukocyte Antigen Allo-Immunized Patients (SuppCare 001)
Some of the treatments for cancer can cause platelets (the part of the blood that helps with clotting) to decrease. If they are too low, then clinicians may recommend a transfusion (getting platelets from another person added to…
- Trial name
- NCT05284032
- Testing
- isatuximab 10 mg/kg
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Firas El Chaer, MD
Eosinophilia, Hypereosinophilic Syndrome
Steroid Treatment for Hypereosinophilic Syndrome
Background: Hypereosinophilic syndrome (HES) is a disorder in which the body has too many eosinophils (a type of white blood cell). Too many eosinophils in HES can cause damage to the heart, nerves, or skin.
- Conditions
- Eosinophilia, Hypereosinophilic Syndrome, Leukocyte Disorder, Hematologic Diseases
- Trial name
- NCT01524536
- Testing
- prednisone
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Deglutition Disorders, Esophageal Diseases
Development, Validation and Evaluation of an Adult and Pediatric Eosinophilic Esophagitis Activity Index
Eosinophilic Esophagitis (EoE) is a chronic inflammatory disease of the esophagus affecting children and adults. The most frequent symptoms are swallowing difficulties and thoracic pain.
- Conditions
- Deglutition Disorders, Esophageal Diseases, Eosinophilia
- Trial name
- EEsAI (NCT00939263)
- Testing
- assessment of disease activity using the EEsAI
- Where
- 25 sites in United States, Canada and 2 more
- Volunteers
- 650 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia Responds to Dermal Chelation
The purpose of this clinical trial is to identify 50 participants with Chronic Lymphocytic Leukemia (CLL) and follow their total white blood cell (WBC) counts and absolute lymphocyte counts after performing dermal chelation and…
- Trial name
- NCT03495492
- Testing
- Dermal Chelation, Nutritional Therapy
- Volunteers
- 50 people
- Sponsor
- Optimum Health, Natural Healthcare Center
Atherosclerosis, Chronic Granulomatous Disease (CGD)
Non-Invasive Assessment of Atherosclerosis in Patients With CGD and Other Disorders of the Immune System
Background: Atherosclerosis, the arterial plaques or blockages that cause heart disease, develops in many people by the time they are in their mid-20s.
- Trial name
- NCT01063309
- Where
- United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Febrile Neutropenia, Sarcoma
Acupuncture as add-on to G-CSF for Febrile Neutropenia-related Hospitalization in Doxorubicin-treated Patients With Sarcoma
Chemotherapy-induced febrile neutropenia (CIFN) is a dangerous complication of many chemotherapy drugs, with current treatment with granulocyte colony-stimulating factors (G-CSFs) accompanied by adverse effects, primarily muscle…
- Conditions
- Febrile Neutropenia, Sarcoma, Doxorubicin Adverse Reaction, Hospitalization-Associated Infection
- Trial name
- NCT06500715
- Testing
- Acupuncture
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Shaare Zedek Medical Center
Eosinophilic Esophagitis (EoE)
Trans-Cervical and Trans-abdominal Ultrasound for Monitoring Esophageal Thickness in Eosinophilic Esophagitis
Eosinophilic Esophagitis (EoE) is a chronic inflammatory disease characterized by eosinophilic infiltration of the esophageal mucosa, leading to symptoms of dysphagia and food impaction.
- Trial name
- NCT07057986
- Testing
- Trans cervical or abdominal ultrasound
- Volunteers
- 100 people
- Sponsor
- Sheba Medical Center
Neutropenia
A Study of Empirical Antifungal Therapy With Itraconazole
The purpose of this study is to investigate the overall success rate of itraconazole intravenous treatment for a period of more than 7 days.
- Trial name
- NCT01706562
- Testing
- Itraconazole
- Volunteers
- 138 people
- Sponsor
- Janssen Korea, Ltd., Korea
Leucogen, Ribociclib
the Efficacy of Leucogen in Preventing the Risk of Ribociclib-Associated Neutropenia in Early Breast Cancer
This study is a multicenter, single-arm, open-label Phase II exploratory clinical trial designed to evaluate whether prophylactic use of leucogen can reduce the incidence of Grade 3 or higher neutropenia in early-stage HR+/HER2…
- Conditions
- Leucogen, Ribociclib, Neutropenia (Low White Blood Cell Count), Breast Cancer
- Trial name
- NCT07380646
- Testing
- Treat Regimen
- Where
- China
- Volunteers
- 97 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Severe Eosinophilic Asthma
A Real World Study to Capture Clinical and Patient Centered Outcomes in Adults With Severe Eosinophilic Asthma Treated With Benralizumab.
Severe eosinophilic asthma (SEA) is associated with poor disease control and compromised health-related quality of life (HRQoL), leading to a substantial psychosocial and economic disease burden.
- Trial name
- EMPOWAIR (NCT05440656)
- Testing
- Cohort
- Where
- 13 sites in Greece
- Volunteers
- 152 people
- Sponsor
- AstraZeneca
Organ Transplantation
Re-evaluation of Donor-specific Anti-HLA Alloantibodies Immunoassay After Organ Transplantation, From Antigen Level to Epitope Level
Transplantation is the only treatment for end-stage organ dysfunction, with dialysis for the kidney. However, donor / recipient (D / R) tissue incompatibility accounts for the majority of long-term graft losses, through the…
- Trial name
- ACORG-HLA (NCT03861962)
- Testing
- DNA sequencing called "new generation" (or NGS)
- Volunteers
- 20,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Febrile Neutropenia
A Trial of Fosfomycin vs Ciprofloxacin for Febrile Neutropenia
Randomized phase 3 trial to compare efficacy and safety of oral fosfomycin versus ciprofloxacin to prevent febrile neutropenia in patients with acute leukemia or recipients of hematopoietic stem cell transplant.
- Trial name
- FOVOCIP (NCT05311254)
- Testing
- Fosfomycin Calcium
- Where
- Spain
- Volunteers
- 156 people
- Sponsor
- Fundación para la Investigación Biosanitaria del Principado de Asturias
X-Linked Chronic Granulomatous Disease
Gene Therapy for X-linked Chronic Granulomatous Disease
X-linked chronic granulomatous disease (X-CGD) is a rare genetic disorder, which affects boys. It is a primary immunodeficiency disorder which results from an inability of the white blood cells called phagocytic cells (or…
- Trial name
- NCT02757911
- Testing
- X vivo gene therapy
- Where
- France
- Volunteers
- 3 people
- Sponsor
- Genethon
Solid Cancer, Lymphopenia
Evaluation of the Effect of Cordycepin on CD8+ Lymphocytopenia in Patients With Solid Tumors
The goal of this clinical trial is to evaluate the effectiveness of PRaG-1 in improving CD8+ lymphocytopenia in patients with solid tumors who are tumor-free for more than six months after completing radiotherapy and/or…
- Trial name
- NCT07258160
- Testing
- PRaG-1
- Where
- China
- Volunteers
- 127 people
- Sponsor
- Second Affiliated Hospital of Soochow University
Chronic Granulomatous Disease
Role of Interferon-gamma 1-b (IFN-γ) on Cells of the Innate Immune System: Functional, Biochemical and Gene Expression Studies in Patients With Chronic Granulomatous Disease
The overall goal of the study is to investigate the functional, biochemical, and gene expression effects of Interferon-gamma 1-b (IFN-γ) on the neutrophils of patients with Chronic Granulomatous Disease (CGD).
- Trial name
- NCT03548818
- Testing
- Interferon Gamma-1B
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Colorado, Denver
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