Clinical trials: White Blood Cells
Eosinophilic Esophagitis
Use of Topical Budesonide in the Treatment of Eosinophilic Esophagitis
This study is designed to evaluate whether or not oral viscous budesonide is effective in treating children with Eosinophilic Esophagitis.
- Trial name
- NCT00638456
- Testing
- Budesonide plus Prevacid
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Ranjan Dohil
Chemotherapy-induced Neutropenia, Febrile Neutropenia, Drug-Induced
Granulocyte Colony Stimulating Factor for for the Prevention of Febrile Neutropenia in Epithelial Ovarian Cancer
This study aims to analyze the effects of long-acting versus short-acting granulocyte colony stimulating factor (G-CSF) on the prevention febrile neutropenia (FN) in epithelial ovarian cancer patients.
- Conditions
- Chemotherapy-induced Neutropenia, Febrile Neutropenia, Drug-Induced, Epithelial Ovarian Cancer, Colony Stimulating Factors Adverse Reaction
- Trial name
- NCT04101760
- Testing
- Long-acting granulocyte colony stimulating factor, Short-acting granulocyte colony stimulating factor
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Lei Li
Healthy Volunteers
Pharmacokinetic Comparability Study in Healthy Participants - PF-06881894 On-Body Injector Relative to Prefilled Syringe
This will be an open-label, randomized, 2-treatment, 2-period, crossover single-dose study in approximately 134 healthy adult participants.
- Trial name
- NCT05194579
- Testing
- PF-06881894 by on-body injector, PF-06881894 by prefilled syringe
- Where
- 4 sites in United States
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Pfizer
Renal Function Disorder
Indoxyl Sulfate Induces Leukocyte-endothelial Interactions Through Up-regulation of ICAM-1 in Acute Kidney Injury
Indoxyl sulfate (IS) is an anionic uremic toxin that is accumulated in the serum of patients with uremia. In previous study, the investigators successfully induced AKI animal model.
- Trial name
- NCT02061566
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
End Stage Renal Disease on Dialysis
pH, Hypoxia and Haemodialysis
End-stage renal disease typically requires haemodialysis to help replace kidney function. However, changes in oxygen uptake during haemodialysis have been linked to increased all-cause mortality.
- Trial name
- pHHd (NCT04501159)
- Testing
- blood sample pre, during and post HD, Non invasive cardiac output assessment
- Where
- 2 sites in United Kingdom
- Volunteers
- 100 people
- Sponsor
- Coventry University
Eosinophilic Esophagitis
MRI to Assess Fibrosis in Eosinophilic Esophagitis Patients
Can an MRI detect and monitor the inflammatory and fibrotic possess in patients with Eosinophilic Esophagitis
- Trial name
- EoE (NCT03446118)
- Testing
- MRI to detect inflammation and fibrosis in subjects with EoE
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Mayo Clinic
Inflammation
Immune Cell Response to Stimuli
This study will investigate the response of immune cells (neutrophils, monocytes) to various signals in the test tube to determine how they sense the signals in the body and what substances they produce in response to them.
- Trial name
- NCT00397280
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Granulomatous Disease, Chronic
Chronic Granulomatous Disease Study in China
CGD is a rare inherited primary immunodeficiency which is caused by the defect in one of the subunits of NADPH oxidase complex.We tend to collect and analyze Chinese CGD patients who are diagnosed in hospitals affiliated to…
- Trial name
- NCT02231996
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanghai Children's Medical Center
Leukocyte Adhesion Deficiency
An Extension Study Assessing the Safety and Efficacy of AVTX-803 in Subjects With Leukocyte Adhesion Deficiency Type II
The primary objective of this extension study is to assess the long-term safety and efficacy of AVTX-803 in subjects with LAD II (SLC35C1-CDG).
- Trial name
- NCT05754450
- Testing
- AVTX-803
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- AUG Therapeutics
Wiskott-Aldrich Syndrome (WAS)
Gene Therapy for Wiskott-Aldrich Syndrome
This is phase I/II protocol to evaluate the safety and efficacy of WAS gene transfer into hematopoietic stem/progenitor cells for the treatment of Wiskott Aldrich Syndrome.
- Trial name
- TIGET-WAS (NCT01515462)
- Testing
- TLT003
- Where
- Italy
- Volunteers
- 8 people
- Sponsor
- Fondazione Telethon
Postoperative Cognitive Dysfunction
Correlation Between Postoperative Cognitive Dysfunction and Telomere Length in Patients With Non-cardiac Surgery
To study on the Postoperative Cognitive Dysfunction: Correlations With Leukocyte telomere length。
- Trial name
- NCT03703973
- Testing
- Neuropsychology test
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Xuzhou Medical University
Hematologic Neoplasms, Neutropenia
The Relationship of Defeverscence and Itraconazole Plasma Level Study in Immunocompromised Participants
The purpose of this observational study is to investigate whether a sufficient concentration of itraconazole can influence disappearance of a fever (defeverscence) when intravenous (into the vein) itraconazole is administered for…
- Conditions
- Hematologic Neoplasms, Neutropenia, Fever
- Trial name
- NCT01021683
- Testing
- Itraconazole
- Volunteers
- 203 people
- Sponsor
- Janssen Korea, Ltd., Korea
IFN-Gamma Therapy, CGD Gene Mutation
Biochemical Response to Interferon-Gamma in Subjects With Specific Gene Mutation in Chronic Granulomatous Disease
Background: Chronic granulomatous disease (CGD) is an immunodeficiency disease in which white blood cells are unable to kill certain bacteria and fungi.
- Conditions
- IFN-Gamma Therapy, CGD Gene Mutation, CGD Response to IFNg, CGD - Chronic Granulomatous Disease
- Trial name
- NCT01147042
- Testing
- IFN-gamma
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Graft Versus Host Disease
Cryopreservation of White Blood Cells Before Their UVA Irradiation for Graft Versus Host Disease Treatment
Extracorporeal photopheresis (ECP) is a worldwide recognized treatment of acute and chronic mild to moderate graft versus host disease (GVHD), in second or further line of treatment.
- Trial name
- cryo-ECP (NCT03361254)
- Testing
- cryopreservation
- Volunteers
- 5 people
- Sponsor
- Central Hospital, Nancy, France
Eosinophilia
Specific Versus Empirical Anthelminthic Treatment in Eosinophilia
There are a few guidelines recommend about management of eosinophilia worldwide, most of guielines recommend a thorough history-taking and physical examination.
- Trial name
- Eosinophilia (NCT06265870)
- Testing
- Albendazole, Ivermectin or albendazole
- Where
- Thailand
- Volunteers
- 700 people
- Sponsor
- Prince of Songkla University
Leukemia, CART Therapy
Early Versus Late Stopping of Antibiotics in Adults With High-risk Hematological Malignancies/Receiving Cellular Therapies and Fever
Pre-neutropenic fever (PNF) (fever following chemotherapy but before developing low white cells) and neutropenic fever (NF) (fever in the setting of low white cells) are very common after chemotherapy for acute leukemia, bone…
- Conditions
- Leukemia, CART Therapy, Transplantation, Stem Cell, Infections, Bacterial
- Trial name
- ELSA-Adult (NCT07051525)
- Testing
- Early antibiotic cessation alert
- Where
- 2 sites in Australia
- Volunteers
- 214 people
- Sponsor
- Peter MacCallum Cancer Centre, Australia
CMV Infection, CMV
Letermovir vs Valganciclovir in CMV R+ Kidney Transplant
The purpose of this study is to find out whether letermovir can help prevent cytomegalovirus (CMV) infection in kidney transplant recipients who are CMV seropositive.
- Conditions
- CMV Infection, CMV, CMV Viremia, CMV Disease
- Trial name
- NCT07571135
- Testing
- Letermovir, Valganciclovir CMV Prophylaxis
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Elisabeth Kincaide
Organ Transplant Recipients
Complement-activating Anti-human Leucocyte Antigen Donor Specific Antibodies in Solid Organ Transplantation
This project will involve a systematic literature review and meta-analysis of studies assessing the impact of complement-activating anti-Human Leukocyte Antigen (HLA) donor specific antibodies (DSA) on the allograft survival rate…
- Trial name
- NCT03438058
- Testing
- Graft survival and/or Rejection appearance
- Volunteers
- 7,547 people
- Sponsor
- Paris Translational Research Center for Organ Transplantation
Eosinophilic Esophagitis
Fibrostenotic Eosinophilic Esophagitis: Assessment Tools
This protocol addresses a central hypothesis that fibrostenotic Eosinophilic Esophagitis (EoE) is characterized by abnormal esophageal structure and compliance compared to non fibrostenotic EoE and that distinctive cellular and…
- Trial name
- NCT02453126
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Colorado, Denver
Neutropenia, Sickle Cell Disease
Decitabine for High-Risk Sickle Cell Disease
Background: In sickle cell disease (SCD), the proteins in the red blood cells that carry oxygen do not behave normally. In parts of the body where there are low levels of oxygen or where oxygen is used more, the sickle hemoglobin…
- Trial name
- NCT01375608
- Testing
- Decitabine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.