Clinical trials: White Blood Cells
Infertility
Maternal and Fetal Compatibility in Assisted Reproductive Technology (ART)-Oocyte Donor Influences Live Birth Rate
Has the maternal KIR haplotype an impact in pregnancy, miscarriage and live birth rates per embryo transfer in donor oocytes -ART by paternal and oocyte donor HLA-C?
- Trial name
- NCT02718105
- Testing
- KIR HLAC determinations
- Where
- Spain
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- IVI Madrid
Post-Operative Pain
The Correlation of COX-2 Expression in Human Polymorphonuclear Leukocytes/Macrophages (PMNL/MP) and Postoperative Pain
To investigate the dose-effect relations among the expression of COX-2 in polymorphonuclear leukocytes (PMNL) and macrophages, systemic and local inflammatory response and postoperative pain
- Trial name
- NCT01186159
- Testing
- Parecoxib Sodium
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Xianwei Zhang
Wiskott-Aldrich Syndrome (WAS)
Gene Therapy for Wiskott-Aldrich Syndrome
This is phase I/II protocol to evaluate the safety and efficacy of WAS gene transfer into hematopoietic stem/progenitor cells for the treatment of Wiskott Aldrich Syndrome.
- Trial name
- TIGET-WAS (NCT01515462)
- Testing
- TLT003
- Where
- Italy
- Volunteers
- 8 people
- Sponsor
- Fondazione Telethon
Neutropenia, Febrile, Pediatric Cancer
Early Stoppage Versus Continuation of Antimicrobial Therapy in Low Risk Pediatric Cancer Patients With Febrile Neutropenia, Before Recovery of Counts: -DALFEN Study
Pediatric patients with febrile neutropenia coming to Department of Medical Oncology with low risk features (culture awaited), will be started on intravenous antibiotics (Inj Cefoperazone+ Sulbactam ± Amikacin) on outpatient…
- Trial name
- DALFEN (NCT03003273)
- Testing
- stoppage of antibiotics, amoxycillin/clavulanic acid, levofloxacin
- Where
- India
- Volunteers
- 142 people
- Sponsor
- All India Institute of Medical Sciences
Extracranial Atherosclerosis
Images in Extracranial Artery Stenosis
The goals of this trial are: 1. To compare the sensitivity and specificity of various tools including Doppler and magnetic resonance imaging (MRI) for diagnosing vertebral artery stenosis and carotid artery stenosis.
- Trial name
- NCT00173927
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Eosinophilic Esophagitis
A Study in Adult Participants With EoE to Evaluate Vonoprazan 20 mg Compared to Placebo After 12 Weeks and to Evaluate Vonoprazan 20 mg Up to 24 Weeks
The primary objective of this study is to assess the efficacy of vonoprazan 20 mg once daily (QD) compared to placebo QD in the number of participants with a peak eosinophilic histologic response <15 eosinophils per high-power…
- Trial name
- NCT06851559
- Testing
- Vonoprazan
- Where
- 41 sites in United States
- Volunteers
- 95 people
- Sponsor
- Phathom Pharmaceuticals, Inc.
Neutropenia, Agranulocytosis
Natural History Study for BEN
In recent decades, hematologists have noticed that persons of African descent sometimes have lower white blood cell counts of a certain type, called granulocytes. These cells help to fight infections.
- Conditions
- Neutropenia, Agranulocytosis, Hematologic Diseases, Leukocyte Disorders
- Trial name
- NCT00059423
- Where
- United States
- Volunteers
- 178 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Acute Respiratory Distress Syndrome
Influence of NEP Inhibition on Vascular Leak and Inflammation (NEPi-INFLAMMATION)
Acute Respiratory Distress Syndrome (ARDS) is a severe type of lung injury that affects 10% of patients admitted to Intensive Care Units worldwide, with an unacceptably high mortality of up to 48% in those with the most severe…
- Trial name
- NCT05600062
- Testing
- Racecadotril 100 milligram (MG) Oral Capsule
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Infection, Bacterial Infection
Leukocyte Depletion of Autologous Whole Blood
Leukocyte depletion of autologous whole blood prior to storage does not reduce infection rate (wound, urinary tract, other), use of antibiotic treatment and length of hospital stay but may increase retransfusion perioperatively…
- Conditions
- Infection, Bacterial Infection, Sepsis
- Trial name
- LDAWB-2001 (NCT00176124)
- Testing
- leukocyte depletion of whole blood, Leukocyte filtration/Depletion
- Where
- 3 sites in Germany
- Volunteers
- 1,089 people
- Sponsor
- Heidelberg University
Neutropenia, Fungal Disease
Micafungin Prevention Study for Invasive Fungal Disease in Pediatric & Adolescent Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation
This study is to evaluate safety and prophylaxis effect of micafungin after hematopoietic stem cell transplantation. Micafungin is administered until confirmation of neutrophil engraftment or treatment failure.
- Trial name
- NCT01417169
- Testing
- micafungin
- Where
- South Korea
- Volunteers
- 112 people
- Sponsor
- Seoul National University Hospital
Chronic Granulomatous Disease
Lentiviral Gene Therapy for CGD
This is a Phase I/II clinical trial of gene therapy for treating Chronic Granulomatous Disease using a high-safety, high-efficiency, self-inactivating lentiviral vector TYF to functionally correct the defective gene.
- Trial name
- NCT03645486
- Testing
- Infusion of lentiviral TYF-CGD-modified autologous stem cells
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Shenzhen Geno-Immune Medical Institute
Lymphoma
Combination Chemotherapy Followed By Autologous Stem Cell Transplant, and White Blood Cell Infusions in Treating Patients With Non-Hodgkin's Lymphoma
RATIONALE: Drugs used in chemotherapy, such as carmustine, etoposide, cytarabine, and melphalan work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00244946
- Testing
- therapeutic autologous lymphocytes, carmustine, cytarabine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Barbara Ann Karmanos Cancer Institute
Hematologic Malignancies, Hematopoietic Stem Cell Transplantation
Effects of Resistance Training on Recovery During Hematopoietic Stem Cell Transplantation
This study investigates whether a resistance training program can help patients recovering from hematopoietic stem cell transplantation (HSCT) for hematologic malignancies.
- Conditions
- Hematologic Malignancies, Hematopoietic Stem Cell Transplantation, Resistance Training, Neutropenia
- Trial name
- NCT07872813
- Testing
- 8-week Elastic Band Resistance Training Program
- Where
- Taiwan
- Volunteers
- 86 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Post-transplant Lymphoproliferative Disorder, Mononucleosis
Early Detection of Epstein-Barr Virus Related Disease.
Epstein-Barr virus (EBV) is one of several herpesviruses that cause disease in humans. EBV virus has an oncogenic potential, and it has been associated with the development of a wide range of cancers.
- Conditions
- Post-transplant Lymphoproliferative Disorder, Mononucleosis, Epstein-Barr Virus Infections, Epstein-Barr Virus Related Malignancy
- Trial name
- NCT03546101
- Where
- Denmark
- Volunteers
- 1,527 people
- Sponsor
- University of Aarhus
Chronic Granulomatous Disease
Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Granulomatous Disease (CGD) With an Alemtuzumab, Busulfan and TBI-based Conditioning Regimen Combined With Cytokine (IL-6, +/- IFN-gamma) Antagonists
Background: Chronic granulomatous disease (CGD) affects the immune system. People with CGD are more likely to get infections. Drugs can help control infections, but these treatments can cause side effects including kidney failure…
- Trial name
- NCT05463133
- Testing
- Sirolimus, Cyclophosphamide, Alemtuzumab
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hypercholesterolemia, Hyperbilirubinemia
Study of Efficacy and Safety of the Plasmapheresis Method With Albumin Compensation Compared With the Plasmapheresis Method Without Albumin Compensation for Aging Biomarkers Correction in Men and Women Aged 40 to 55 Years Old
Reaching active aging makes it important to implement new methods affecting the biological age of a person. Biochemical parameters of a blood test are aging biomarkers that are ones of the most accessible for testing.
- Conditions
- Hypercholesterolemia, Hyperbilirubinemia, Hyper IgE Syndrome, Hyper Beta Lipoproteinemia
- Trial name
- NCT04897113
- Testing
- plasma exchange with albumin, plasma exchange without albumin
- Where
- 2 sites in Russia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Medical Research Center for Rehabilitation and Balneology
Febrile Neutropenia, Sarcoma
Acupuncture as add-on to G-CSF for Febrile Neutropenia-related Hospitalization in Doxorubicin-treated Patients With Sarcoma
Chemotherapy-induced febrile neutropenia (CIFN) is a dangerous complication of many chemotherapy drugs, with current treatment with granulocyte colony-stimulating factors (G-CSFs) accompanied by adverse effects, primarily muscle…
- Conditions
- Febrile Neutropenia, Sarcoma, Doxorubicin Adverse Reaction, Hospitalization-Associated Infection
- Trial name
- NCT06500715
- Testing
- Acupuncture
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Shaare Zedek Medical Center
Hematologic Diseases
Evaluation, Treatment, and Training for Patients With Blood Disorders
This study is designed to allow the evaluation, follow-up, and medical care of patients with blood disorders not currently participating in a research study being conducted by the Hematology Branch of the National Heart, Lung and…
- Trial name
- NCT00001397
- Where
- United States
- Volunteers
- 1,452 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Strains, Acute Lymphoblastic Leukemia
Effect of Simvastatin on Sepsis and Febrile Neutropenia in Patients With Acute Lymphoblastic Leukemia
In general, the percentage of complete remissions is 85 - 90 % for acute lymphoid leukemia (ALL). In developing countries, percentages are lower secondary to higher sepsis-related mortality.
- Conditions
- Strains, Acute Lymphoblastic Leukemia, Sepsis
- Trial name
- NCT05133310
- Testing
- Simvastatin
- Where
- Mexico
- Volunteers
- 108 people
- Sponsor
- Hospital General de Mexico
Leukocyte Adhesion Deficiency Syndrome
Gene Therapy for Patients With Leukocyte Adherence Deficiency (Follow-Up of Phase 1 Trial)
This study will provide long-term monitoring of two patients who received gene therapy for leukocyte adherence deficiency (LAD) under the Food and Drug Administration investigational new drug study BB-IND-7949.
- Trial name
- NCT00023010
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- National Cancer Institute (NCI)
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