Clinical trials: White Blood Cells
Ocular Discomfort, Ocular Inflammation
Effects of Xiidra on Closed Eye Tear Film Leukocytes in Dry Eye Disease
Every night during sleep, there is an accumulation of white blood cells in the closed eye. The closed eye white blood cells are predominantly neutrophils, but there is a small population (3%) of T cells.
- Conditions
- Ocular Discomfort, Ocular Inflammation, Dry Eye, Contact Lens Complication
- Trial name
- NCT03408015
- Testing
- Lifitegrast
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Chronic Periodontitis, Diabetes Mellitus, Type 2
White Blood Cell Signaling and Defense Mechanisms in Patients With Diabetes Mellitus Type 2 and Periodontitis
White blood cell membrane and surface structures are affected by the metabolic disorders and complications found in diabetes mellitus.
- Trial name
- DMS (NCT01848379)
- Testing
- ADT+FD, FD
- Where
- Germany
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Zentrum fuer Zahn-, Mund- und Kieferheilkunde
Metastatic Cancer, Melanoma
Vemurafenib and White Blood Cell Therapy for Advanced Melanoma
Background: One possible treatment for advanced melanoma involves collecting white blood cells from the person with cancer and growing them in a laboratory. The cells can then be given back to the donor.
- Trial name
- NCT01585415
- Testing
- Vemurafenib, Young TIL, Cyclophosphamide
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Cancer Institute (NCI)
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Hematologic Disease and Disorders, Donors
Screening for Hematology Branch Protocols
This study allows the evaluation of subjects in order to determine their ability to safely participate in other active research studies.
- Conditions
- Hematologic Disease and Disorders, Donors, Healthy Volunteer
- Trial name
- NCT00001620
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Asthma, COPD
Asthma, Inflammation and G Protein-coupled Receptors (GPCR)
The G protein-coupled receptors (GPCRs) are a family of proteins expressed at the cell membrane. They are composed of 380 members involved in the important functions of the organism and are privileged therapeutic targets.Their…
- Trial name
- NCT00793676
- Testing
- spirometry, blood test
- Where
- 5 sites in France
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Eosinophilic Esophagitis
Confocal Laser Endomicroscopy in Patients With Eosinophilic Esophagitis
Confocal laser endomicroscopy enables in vivo microscopic imaging within the mucosa layer of the gut at a subcellular resolution.
- Trial name
- NCT01234376
- Testing
- Confocal laser endomicroscopy
- Where
- Germany
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Multiple Myeloma, Pneumococcal Infection
Pneumococcal Vaccination of Multiple Myeloma Patients on Novel Agents
Multiple myeloma is an incurable blood cancer of plasma cells that occurs in older individuals. Novel agents (proteasome inhibitors, immunomodulatory agents) have substantially improved the overall response rates…
- Conditions
- Multiple Myeloma, Pneumococcal Infection, Febrile Neutropenia, Pneumococcal Pneumonia
- Trial name
- NCT03619252
- Testing
- Vaccination with pneumococcal conjugate vaccine (PCV13), Standard Antibacterial Prophylaxis
- Where
- Belarus
- Volunteers
- 36 people
- Sponsor
- Minsk Scientific-Practical Center for Surgery, Transplantation and Hematology
Neutropenia
Late Neutropenia in VLBW Preterm Babies
There are rare reports regarding late neutropenua in very low birth weight preterm infants. The investigators wish to characterize it among our population, and assess its consequenses and the postnatal menagement of the infants.
- Trial name
- NCT04217811
- Testing
- No intervention
- Where
- Israel
- Volunteers
- 237 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Neutropenia (Low White Blood Cell Count)
A Research Study To Test How Multiple Doses Of Filgrastim Hospira Works In The Body Of Healthy Study Subjects When Given by Subcutaneous Injection (SC) (Shot) Compared To An Already U.S.-Approved Drug Neupogen® (Amgen)
This is a study comparing two study drugs, Filgrastim Hospira and Neupogen®. Neupogen® is approved by the US Food and Drug Administration (FDA) to treat low numbers of specific kinds of white blood cells (WBC) known as…
- Trial name
- NCT02766634
- Testing
- Filgrastim Hospira (US), U.S.-approved Neupogen®
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Pfizer
Platelet Refractoriness, Hematologic Malignancy
A Pilot Trial Using Isatuximab to Overcome Platelet Transfusion Refractoriness in Human Leukocyte Antigen Allo-Immunized Patients (SuppCare 001)
Some of the treatments for cancer can cause platelets (the part of the blood that helps with clotting) to decrease. If they are too low, then clinicians may recommend a transfusion (getting platelets from another person added to…
- Trial name
- NCT05284032
- Testing
- isatuximab 10 mg/kg
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Firas El Chaer, MD
Asthma, Eosinophilic Granulomatosis With Polyangiitis (EGPA)
Roll-over Study for Participants Who Have Completed a Previous Clinical Study With Benralizumab (Fasenra) and Benefit From Continued Treatment
The rationale of the roll-over study (ROSY) is to provide continuous access to study treatment for participants who have completed or exited a parent study and are deemed appropriate for continued benralizumab treatment, as…
- Conditions
- Asthma, Eosinophilic Granulomatosis With Polyangiitis (EGPA), Hypereosinophilic Syndrome (HES)
- Trial name
- ROSY-F (NCT07444567)
- Testing
- Benralizumab
- Where
- 47 sites in United States, Argentina and 12 more
- Volunteers
- 230 people
- Sponsor
- AstraZeneca
Kidney Failure, Presence of Donor Specific Antibodies
Nanoparticle for DSA Removal
Magnetic nanoparticles, coated with human leukocyte antigens (HLA) to capture anti-HLA antibodies with donor specificity (donor-specific antibodies, DSA), will be tested ex-vivo.
- Trial name
- NCT04277377
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University of Zurich
Hematological Malignancy, Neutropenia
Effect of Body Mass on Filgrastim Pharmacokinetics
Studies have shown that different percentages of body fat can alter the way drugs are distributed in the body. This study will use blood samples taken at different time points for patients taking Neupogen to determine if higher…
- Trial name
- NCT01719432
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Aaron Cumpston, PharmD, BCOP
Non-Small Cell Lung Cancer
Neulasta® in Subjects With Advanced Non-Small-Cell Lung Cancer (NSCLC) During Chemotherapy
The purpose of this study is to estimate the relationship between patient reported outcomes (PROs) and neutropenia (or its complications) in NSCLC subjects receiving chemotherapy with or without Neulasta® (pegfilgrastim).
- Trial name
- NCT00115206
- Testing
- Neulasta® (pegfilgrastim)
- Sponsor
- Amgen
Perianal Warts
Study of Leukocyte Interleukin, Injection for Treatment of Perianal Warts
Study is a dose escalation study. Fifteen patients will be enrolled in 2 treatment cohorts. Five participants (cohort A) will be treated with 200IU Multikine daily, 5 days/week for 2 weeks, off 2 weeks, then again 5 days/week for…
- Trial name
- PAW (NCT03038828)
- Testing
- Leukocyte Interleukin, Injection
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- CEL-SCI Corporation
Non-Myeloid Malignancy
Phase 3 Study to Evaluate the Safety and Efficacy of YPEG-rhG-CSF in Malignancies Receiving Chemotherapy
This phase 3 study is aimed to evaluate the safety and efficacy of YPEG-rhG-CSF in reducing the infection manifested by febrile neutropenia in patients with non-myeloid malignancy who receiving Myelosuppressive Chemotherapy which…
- Trial name
- NCT04466137
- Testing
- YPEG-rhG-CSF, rhG-CSF/PEG-rhG-CSF
- Where
- China
- Volunteers
- 398 people
- Sponsor
- Xiamen Amoytop Biotech Co., Ltd.
Eosinophilic Esophagitis (EoE)
Effect of Dupilumab on the Muscle Function of the Esophagus (food Pipe) in Participants with Eosinophilic Esophagitis (EoE)
The goal of this study is to research Dupilumab, an FDA approved medication in treating patients diagnosed with Eosinophilic esophagitis (EoE). The drug works by controlling allergic inflammation of the esophagus.
- Trial name
- NCT06665971
- Testing
- Dupilumab 300 MG/2 ML Subcutaneous Solution [DUPIXENT]
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Diego
Prostate Hyperplasia, Coagulation; Intravascular
The Effect of Human Prostate Tissue on Platelet Activation
Transurethral resection of the prostate (TURP) is a common and standard urological surgical procedure for managing benign prostatic hyperplasia (BPH).
- Conditions
- Prostate Hyperplasia, Coagulation; Intravascular, Thrombotic Disorder
- Trial name
- NCT05059431
- Volunteers
- 8 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Burns
The Relationship Between Cadaveric Allograft Skin and HLA-Sensitivity in Burn Patients
The purpose of this research study is to look at how the body's immune system reacts to temporary skin grafts from deceased donors.
- Trial name
- NCT04162639
- Testing
- Skin allograft
- Sponsor
- Virginia Commonwealth University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.