Clinical trials: White Spot Lesion
White Spot Lesions
"Clinical Evaluation of Self-Assembling Peptides Versus Tri-Calcium Phosphate Based Varnish in Treatment of White Spot Lesions; Split-Mouth Randomized Clinical Trial"
Brief Summary: This randomized controlled clinical trial will evaluate the effectiveness of two remineralizing agents in the treatment of white spot lesions (WSLs) in young adults.
- Trial name
- SAP VS TCP (NCT07289932)
- Testing
- Curodont Repair (SAP P11-4), Clinpro White Varnish (Tri-Calcium Phosphate, TCP)
- Where
- Egypt
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Dental Caries Tooth Demineralization, Post-Orthodontic Esthetic Defects
Evaluation of Self-assembling Peptides Versus Amorphous Calcium Phosphate in the Treatment of White Spot Lesions
This clinical trial aims to compare the effectiveness of two remineralizing treatments for white spot lesions (WSLs) on the enamel surfaces of the front teeth.
- Trial name
- NCT07146464
- Testing
- Self-Assembling Peptide P11-4 Self-Assembling Peptide P11-4 is a biomimetic material applied topically to white spot lesions on the enamel. It diffuses into the lesion body and forms a three-dimension
- Where
- Egypt
- Volunteers
- 18 people
- Sponsor
- Ain Shams University
Initial Dental Caries
Dentifrice With Innovative Remineralizing Technology
Objective: The aim of this study is to evaluate in vivo dentifrices containing different active ingredients in fluoride (F) retention in saliva and dental biofilm.
- Trial name
- REFIX (NCT04730908)
- Testing
- DENTIFRICE
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Federal University of Paraíba
White Spot Lesion of Tooth
Incidence of White Spot Lesions Around Ceramic Brackets Compared With Metal Brackets
The main objective of this study was to investigate the relation between ceramic brackets and the development of white spot lesions (WSLs) compared to that associated with conventional metal brackets.
- Trial name
- NCT05764187
- Testing
- Orthodontic fixed appliance therapy
- Where
- Jordan
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
White Spot Lesions
Remineralization Capacity and Patient Satisfaction of Self-Assembling Peptide With Fluoride Versus Tooth Protective Coating With Surface Pre-Reacted Glass on White Spot Lesions
Cosmetics and esthetics are current trends of our society, as more and more patients are demanding for minimally invasive cosmetic enhancement without anesthesia, drilling and less expensive restorations.
- Trial name
- NCT07086235
- Testing
- self-assembling peptide, S-PRG Barrier Coat
- Where
- Egypt
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Nahda University
Dental Caries, White Spot Lesion
A Randomized Controlled Trial of Vitamin D Supplementation on Salivary Biomarkers and Cariogenic Oral Microbiome
The goal of this clinical trial is to compare the treatment effect of vitamin D supplementation and topical fluorides in the population having vitamin D deficiency and Initial Carious Lesions (ICL) on the progression of ICL in…
- Conditions
- Dental Caries, White Spot Lesion, Initial Caries, Incipient Enamel Caries
- Trial name
- Incipient (NCT06172764)
- Testing
- Vitamin D supplements along with behavioral modification, Topical fluoride application and Vitamin D supplements along with behavioral modification, Topical fluoride application along with behavioral modification
- Where
- Pakistan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
White Spot Lesion
Remineralization Potential of Bioactive Varnish
This randomized controlled trial is held to investigate the effectiveness of two remineralizing agents surface pre-reacted glass-ionomer (S-PRG) filler and fluoride in management of white spot lesions.
- Trial name
- NCT07602660
- Testing
- S-PRG barrier coat, Profluorid Varnish
- Volunteers
- 60 people
- Sponsor
- Future University in Egypt
Early Caries Lesions
A Prospective, Randomized Clinical Study on the Effects of Casein Phosphopeptide-amorphous Calcium Phosphate (CPP-ACP) Paste on Plaque, Gingivitis and White Spot Lesions in Orthodontic Patients - Part 2
Influence of CPP-ACP paste and Elmex Medical Gel on the prevention of white spot lesions in orthodontic patients during fixed appliances.
- Trial name
- NCT00670618
- Testing
- CPP-ACP (GC Tooth Mousse), CPP-ACP (GC MI Paste Plus), Fluoride (Elmex Medical Gel)
- Where
- Belgium
- Volunteers
- 325 people
- Sponsor
- University Hospital, Ghent
White Spot Lesion
Effect of Casein Phosphopeptide Amorphous Calcium Phosphate Fluoride Varnish on Remineralization of White Spot Lesion in Primary Teeth
The aim of this study is to evaluate the effectiveness of Casein phosphopeptide-amorphous calcium phosphate fluoride varnish (CPP-ACP FV) in comparison to fluoride varnish (FV) as a remineralizing agent for white spot lesions in…
- Trial name
- NCT03865680
- Testing
- CPP-ACP, Duraphat
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Nourhan M.Aly
Oral Hygiene, White Spot Lesion
Effects of Active Reminders and Motivational Techniques on Oral Hygiene and Gingival Health in Orthodontic Patients
This study will compare the use of text message reminders versus multiple in-person sessions of oral hygiene instructions and motivation on improving oral hygiene measurements.
- Conditions
- Oral Hygiene, White Spot Lesion, Gingivitis
- Trial name
- NCT03841825
- Testing
- Oral hygiene instructions
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Dental Caries, White Spot Lesions
QLF and Digital Imaging for Caries Activity Assessment After Orthodontic Treatment
This prospective longitudinal observational study aims to evaluate the diagnostic performance and agreement of Smartphone photography, intraoral 3D imaging, Quantitative Light-Induced Fluorescence Digital (QLF-D), and ICDAS…
- Conditions
- Dental Caries, White Spot Lesions, Caries Lesion Activity, Post-Orthodontic Enamel Demineralization
- Trial name
- NCT07608471
- Volunteers
- 30 people
- Sponsor
- Universidad El Bosque, Bogotá
White Spot Lesion
White Spot Lesions Treatment in Orthodontic
The study aims to investigate the effectiveness of a new treatment for demineralized white spot lesions (WSLs) after fixed appliance therapy.
- Trial name
- WSL (NCT06051981)
- Testing
- 5% sodium fluoride, Intensive 5% sodium fluoride, Casein Phosphopeptide-Amorphous Calcium Phosphate
- Volunteers
- 88 people
- Sponsor
- Riyadh Elm University
Dental Caries
Remineralization Effect of Eggshell Powder on Post-orthodontic White Spot Lesions Compared to CPP-ACP
This research is conducted to compare the remineralization efficacy of eggshell powder gel and CPP-ACP (MI paste) on post-orthodontic white spot lesions.
- Trial name
- REEPP-WSC (NCT03963791)
- Testing
- Eggshell powder gel, CPP-ACP crème
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
White Spot Lesion
The Remineralization of Early Enamel Caries in Permanent Teeth
Evaluate clinically the remineralizing potential of self-assembling peptide ( P11-4) fluoride plus in early enamel carious lesions of permanent anterior teeth.
- Trial name
- NCT06358066
- Testing
- self assembling peptide p11-4 with fluoride, 5% sodium fluoride varnish
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Tanta University
Dental Caries
Development and Validation of a Multi-Mineral Fluoride Mouthrinse
The primary goals of this project are to determine the anticaries benefits of a prototype multi-mineral mouthrinse containing 225 ppm fluoride and 30 ppm of a Ca through the remineralization of enamel white-spots (non-cavitated…
- Trial name
- NCT00642252
- Testing
- Fluoride
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Indiana Nanotech, LLC
White Spot Lesion of Tooth, Orthodontic Treatment
S-PRG Filler for Preventing White Spot Lesions During Orthodontic Treatment
White spot lesions are early areas of enamel demineralization that may develop during orthodontic treatment with fixed braces. This study aims to evaluate the effectiveness of S-PRG Barrier Coat in preventing white spot lesions…
- Conditions
- White Spot Lesion of Tooth, Orthodontic Treatment, Enamel Demineralization, Fluoride Varnishes
- Trial name
- SPRG-WSL (NCT07839780)
- Testing
- S-PRG Barrier Coat, S-PRG Barrier Coat + 5% Sodium Fluoride Varnish, 5% sodium fluoride varnish
- Where
- Malaysia
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Malaligned Teeth, Crowding of Teeth
Effect of Different Adhesive Systems on White Spot Lesions During Fixed Orthodontic Treatment
The primary goal of this study is to compare the number of white spot lesions during fixed appliance therapy between self-etch and one-step bonding systems.
- Trial name
- NCT07753512
- Testing
- Self-etch adhesive, One-Step Adhesive, Conventional Bonding Technique
- Where
- Pakistan
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Foundation University Islamabad
White Spot Lesion
Evaluation of White Spot Lesion Development Using 3 Orthodontic Adhesive Systems
The gaol of this randomized clinical trial was to compare the effect of self-etching primer bonding system and one step adhesive bonding system on the development of white spot lesions (WSLs) during fixed orthodontic therapy in…
- Trial name
- NCT05738356
- Testing
- Adhesive bonding systems
- Where
- Jordan
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
White Spot Lesions
Effect of Nanohydroxyapatite Paste After Different Pretreatment Techniques on White Spot White Spot Lesions
forty teeth diagnosed with white spot lesions in children aged between 10-14 years old were selected to compare between the effect of using nanohydroxyapatite paste applicatio either alone or preceded by the application of HCl…
- Trial name
- NCT06834464
- Testing
- Nanohydroxyapatite paste, HCl liquid, microabrasion
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Research Centre, Egypt
Caries,Dental, Remineralization
Remineralization Efficacy of Gum Arabic Varnish.
The aim of this study is to evaluate the remineralizing capacity of Gum Arabic varnish and its implementation into clinical practice.
- Conditions
- Caries,Dental, Remineralization, White Spot Lesion
- Trial name
- NCT04422860
- Testing
- Gum Arabic varnish, Proflourid Varnish,VOCO, MI Varnish,GC Japan Inc.
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Cairo University