Clinical trials: White Spot Lesion
Obesity & Overweight, Orthodontic Treatment
Impact of Increased Body Mass Index on Adolescent Fixed Orthodontic Treatment. A Prospective Longitudinal Study
The goal of this prospective observational study is to assess the influence of increased body mass index (BMI) on various oral health and orthodontic-related parameters in adolescents undergoing orthodontic therapy (OT) with…
- Trial name
- NCT07217756
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Rochester
White Spot Lesion
White Spot Lesions Treatment in Orthodontic
The study aims to investigate the effectiveness of a new treatment for demineralized white spot lesions (WSLs) after fixed appliance therapy.
- Trial name
- WSL (NCT06051981)
- Testing
- 5% sodium fluoride, Intensive 5% sodium fluoride, Casein Phosphopeptide-Amorphous Calcium Phosphate
- Volunteers
- 88 people
- Sponsor
- Riyadh Elm University
White Spot Lesions
P11-4 and Fluoride Varnish for Remineralization of Post-orthodontic Lesions
This clinical study aims to compare the remineralizing effects of self-assembling peptide P11-4 (SAP11-4) with fluoride varnish in the treatment of post-orthodontic non-cavitated carious lesions (NCLs).
- Trial name
- NCT06749977
- Testing
- Remineralization with SAP11-4, Remineralization with sodium fluoride varnish
- Where
- Bulgaria
- Volunteers
- 45 people
- Sponsor
- Medical University of Sofia
White Spot Lesion
The Effect of Probiotic Lozenges on White Spot Lesion Development in Orthodontic Patients
The goal of this randomized clinical trial was to investigate the effect of probiotic lozenges on the development of white spot lesions (WSLs) compared to a positive control, and no treatment.
- Trial name
- NCT05738369
- Testing
- Biogaia L. reuteri Prodentis® lozenges, Hersheyland Ice Breakers Mints sugar free lozenges
- Where
- Jordan
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
White Spot Lesion
The Remineralization of Early Enamel Caries in Permanent Teeth
Evaluate clinically the remineralizing potential of self-assembling peptide ( P11-4) fluoride plus in early enamel carious lesions of permanent anterior teeth.
- Trial name
- NCT06358066
- Testing
- self assembling peptide p11-4 with fluoride, 5% sodium fluoride varnish
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Tanta University
Dental Caries
The Prevalence of White Spot Lesions During Orthodontic Treatment With Fixed Appliances
This study investigates how often cavities develop on the permanent teeth of patients with braces (orthodontic treatment). The hypothesis is that there is no difference in the number of cavities on the permanent teeth of patients…
- Trial name
- WSLs (NCT04186065)
- Where
- United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Hiroko Nagaoka
Caries
Effect of CPP-ACP With/Without Fl on White Spot Lesion,Salivary pH and fl Release in High Caries Risk Patients
Effect of CPP-ACP pastes with/without Fluoride on White spot lesion progression, salivary pH and fluoride release in high caries risk Patients, over 3 month period using VistaCam, Digital pH meter and Selective ion electrode.
- Trial name
- NCT03656432
- Testing
- CPP-ACP paste
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Cairo University
White Spot Lesion
Effect of Different Remineralization Gels
The aim of the study is to treat white spot lesions that occur after orthodontic treatment. Different gels will be used for remineralization. The study will consist of 45 people between the ages of 15-18.
- Trial name
- NCT05868603
- Testing
- Remineralization gel
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Marmara University
Tooth Crowding, Tooth; Lesion, White Spot Lesions
Comparison Of Different Orthodontic Aligner Systems Applied On Single Stage And Three Stage
Applying to the Orthodontics Department of the Faculty of Dentistry of Erciyes University for orthodontic treatment, a periodontally healthy 16-26 year-old periodontally healthy, non-congenital or congenital anomaly in the…
- Trial name
- NCT04678596
- Testing
- EonAligner, Clearfix
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Oral Hygiene, White Spot Lesion
Effects of Active Reminders and Motivational Techniques on Oral Hygiene and Gingival Health in Orthodontic Patients
This study will compare the use of text message reminders versus multiple in-person sessions of oral hygiene instructions and motivation on improving oral hygiene measurements.
- Conditions
- Oral Hygiene, White Spot Lesion, Gingivitis
- Trial name
- NCT03841825
- Testing
- Oral hygiene instructions
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
White Spot Lesion of Tooth, Orthodontic Malocclusion
A Comparative Assessment of Orthodontic Treatment Outcomes Using the Quantitative Light-Induced Fluorescence Method
The aim of this 2-arm parallel trial was to evaluate enamel demineralization after an indirect bonding technique in comparison to a direct bonding technique group using the quantitative light-induced fluorescence method.
- Trial name
- QLF (NCT03738839)
- Testing
- Quantitative Light-Induced Fluorescence, Direct bonding, Indirect bonding
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
White Spot Lesion of Tooth
Effect of Diode Laser With Dye and Remineralizing Agent on Surface Area of White Spot Lesions by Using Digital Subtraction Radiograph Techniques.
The current study was conducted to compare effect of diode laser and perio green dye with reminerlizing agent on surface area white spot lesions by using digital subtraction radiographic techniques.
- Trial name
- NCT07818655
- Testing
- remin pro
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Demineralisation, White Spot Lesions
A Trial of Tooth Mousse to Remineralise Post-orthodontic Treatment White Spot Lesions
Fixed dental braces are associated with the risk of developing White Spot Lesions (WSLs), which appear as white chalky marks on the teeth.
- Conditions
- Demineralisation, White Spot Lesions, Orthodontic Treatment
- Trial name
- NCT01344473
- Testing
- Tooth Mousse creme (Casein Phosphopeptide)(RECALDENT)
- Where
- 2 sites in United Kingdom
- Volunteers
- 90 people
- Sponsor
- University of Dundee
Dental Caries Tooth Demineralization, Post-Orthodontic Esthetic Defects
Evaluation of Self-assembling Peptides Versus Amorphous Calcium Phosphate in the Treatment of White Spot Lesions
This clinical trial aims to compare the effectiveness of two remineralizing treatments for white spot lesions (WSLs) on the enamel surfaces of the front teeth.
- Trial name
- NCT07146464
- Testing
- Self-Assembling Peptide P11-4 Self-Assembling Peptide P11-4 is a biomimetic material applied topically to white spot lesions on the enamel. It diffuses into the lesion body and forms a three-dimension
- Where
- Egypt
- Volunteers
- 18 people
- Sponsor
- Ain Shams University
White Spot Lesion, Caries
Clinical Effectiveness of Various Professionally Applied Fluoride Prophylaxes in Groups at High Risk
The study is to compare the prophylactic and therapeutic clinical effectiveness of two fluoride varnishes in children at high caries risk.
- Trial name
- NCT02027922
- Testing
- Fluor Protector S
- Where
- Poland
- Volunteers
- 180 people
- Sponsor
- Medical University of Warsaw
Demineralization, Tooth, White Spot Lesion of Tooth
Preventive Effects of Silver Diamine Fluoride on Early Enamel Caries
Fixed orthodontic patients are at risk of developing dental caries. Topical application of fluoride varnish (FV) around the orthodontic brackets and using fluoridated mouth rinses have been suggested to prevent the formation of…
- Conditions
- Demineralization, Tooth, White Spot Lesion of Tooth, Fixed Appliances, Early Caries Lesions
- Trial name
- NCT06797882
- Testing
- Silver diamine fluoride- potassium iodide, Fluoride varnish, 0.9 % saline
- Where
- Malaysia
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
White Spot Lesion of Tooth, Tooth Color
Toothpastes With Different Contents and Tooth Color
This study aims to investigate the color tone and fluorescence changes that may occur during fixed orthodontic treatment with brackets in patients' teeth using toothpaste with different properties.
- Conditions
- White Spot Lesion of Tooth, Tooth Color, Dentistry, Orthodontic Appliances, Fixed
- Trial name
- NCT06833970
- Testing
- Colgate use, Curaprox use, ROCS use
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Taner OZTURK, DDS, MS
Dental Caries, Early Caries Lesions
A Randomized Split-Mouth Clinical Trial Comparing Resin Infiltration and Microabrasion for Early Caries Lesions
This study aims to evaluate and compare the clinical characteristics and treatment outcomes of early caries lesions using resin infiltration (Icon) and microabrasion (Opalustre).
- Conditions
- Dental Caries, Early Caries Lesions, White Spot Lesions[Initial Caries]on Smooth Surface of Tooth
- Trial name
- ICON-CTU (NCT07544849)
- Testing
- Resin Infiltration, Microabrasion
- Where
- Vietnam
- Volunteers
- 30 people
- Sponsor
- Can Tho University of Medicine and Pharmacy
White Spot Lesions
Preventive Potential of Fluoride Sealants in Adolescent Orthodontic Patients
The aim of this trial is to investigate the potential of using an adhesive bonding agent that also acts as a fluoride sealant when placing fixed orthodontic appliances in adolescent patients, as an alternative to regular bonding…
- Trial name
- NCT07691879
- Testing
- Use of a bonding agent to place the orthodontic appliance, Use of fluoride releasing bonding agent to place the orthodontic appliance
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sigmund Freud PrivatUniversitat
White Spot Lesion of Tooth
Effect of Different Pastes on Remineralization of Early Caries Lesions in Primary Teeth
This study is a randomized controlled trial involving 118 children ages between 4 and 5 years to assess the remineralization effect of Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP) on white spot lesions in primary…
- Trial name
- NCT03526276
- Testing
- CPP-ACP paste, Fluoride toothpaste, Both (Fluoride and CPP-ACP)
- Where
- Jordan
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology