Clinical trials: White Spot Lesions
White Spot Lesions, Gingival Inflammation and Bleeding
Topical 10% Povidone-Iodine in Preventing White Spots
The goal of this clinical trial is to learn if topical application on the all surface of 10% Povidone Iodine (Povi-One) in healthy participants in transitional or permanent dentition (10-17 y) prevents new white spot lesions in…
- Trial name
- NCT06616207
- Testing
- Povidone-iodine solution
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Washington
White Spot Lesion of Tooth
Combined Application of Diode Laser and Different Remineralizing Agents on White Spot Lesions
Dental caries is a very common condition, and although it has become less common, it still represents a serious public health risk.
- Trial name
- Whitespot (NCT05871619)
- Testing
- Remin Pro, X Pur Remin, Fluoride varnish
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
White Spot Lesion of Tooth
Effect of Self Assembling Peptide on White Spot Lesion
During re-mineralization of white spot lesion, Will biomimetic self-assembling peptides improve the re-mineralizating effect of the post orthodontic white spot lesion compared to fluoride-based delivery systems?
- Trial name
- regeneration (NCT03930927)
- Testing
- Self Assembling peptide, remineralizing agent
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Raneen Ahmed
White Spot Lesion of Tooth
Color Stability of S-PRG Resin-Based Light-Cure Varnish and Prophylaxis Paste on White Spot Lesions
The aim of the study is to evaluate and compare the long-term color stability of two bioactive materials used in the management of white spot lesions: Surface Pre-Reacted Glass (S-PRG) containing resin-based light-cured varnish…
- Trial name
- NCT07126366
- Testing
- S-PRG Barrier coat, S-PRG Prophylaxis paste
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Cairo University
White Spot Lesion of Tooth
Caries Prevention Potential of Pearl Powder Versus CPP-ACP on Enamel White Spot Lesions
to evaluate the caries prevention potential of pearl powder against CPP-ACP in enamel white spot lesions.
- Trial name
- NCT03973554
- Testing
- pearl powder, CPP-ACP
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Ruba Alaa El Din Adel El Damarisy
Early Caries Lesions
A Prospective, Randomized Clinical Study on the Effects of Casein Phosphopeptide-amorphous Calcium Phosphate (CPP-ACP) Paste on Plaque, Gingivitis and White Spot Lesions in Orthodontic Patients - Part 1
Influence of CPP-ACP paste on the evolution and appearance of white spot lesions in orthodontic patients after removal of the fixed appliances.
- Trial name
- NCT00670670
- Testing
- CPP-ACP (GC Tooth Mousse), CPP-ACP (GC MI Paste Plus)
- Where
- Belgium
- Volunteers
- 325 people
- Sponsor
- University Hospital, Ghent
White Spot Lesion
Effect of CO2 Laser on Enamel White Spot Lesion Formation Around Orthodontic Brackets
This study aims to evaluate the clinical effect of CO2 laser on enamel resistance to white spot lesions formation around orthodontic brackets.
- Trial name
- NCT03114475
- Testing
- CO2 laser irradiation
- Where
- 2 sites in Syria
- Volunteers
- 25 people
- Sponsor
- Damascus University
Remineralization Effect of the Varnish on White Spot Lesions
Remineralization Potential of MI Varnish Versus Fluoride Varnish on White Spot Lesions in Maxillary Primary Incisors
Remineralization effect of CPP-ACP and Fluoride (MI varnish) versus Fluoride varnish on white spot lesions in maxillary primary incisors
- Trial name
- NCT03731403
- Testing
- MI varnish
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Gingival Hyperplasia, Dental Plaque
Clinical Efficacy of Chlorhexidine Varnish in Reducing Gingival Hyperplasia, Plaque Accumulation, and White Spot Lesions in Orthodontic Patients
This study investigates whether applying a chlorohexidine varnish (a dental coating) reduces gum overgrowth, plaque buildup, and early tooth decay (white spots) in patients with braces.
- Conditions
- Gingival Hyperplasia, Dental Plaque, Tooth Demineralization
- Trial name
- NCT07115784
- Testing
- Chlorhexidine Varnish
- Where
- Pakistan
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Khyber Medical University Peshawar
White Spot Lesion of Tooth
Incidence of White Spot Lesions Around Ceramic Brackets Compared With Metal Brackets
The main objective of this study was to investigate the relation between ceramic brackets and the development of white spot lesions (WSLs) compared to that associated with conventional metal brackets.
- Trial name
- NCT05764187
- Testing
- Orthodontic fixed appliance therapy
- Where
- Jordan
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Tooth Demineralization
Study of Treatments Used for White Spot Lesions After Orthodontic Treatment.
The purpose of this study is to learn more about the management of white spot lesions that occur after orthodontic treatment. White spot lesions generally improve slightly with time.
- Trial name
- NCT01059058
- Testing
- MI Paste Plus, PreviDent Fluoride Varnish, Normal Home Care
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Washington
Bracket Bonding, Orthodontic Treatment
A Split-Mouth Clinical Trial Evaluating the Bond Failure Rate of a New Etch-Free Orthodontic Adhesive
This randomized, split-mouth clinical trial will evaluate a new orthodontic adhesive that eliminates the need for acid etching before bracket bonding.
- Conditions
- Bracket Bonding, Orthodontic Treatment, Dental Adhesives/Restorations Performance, White Spot Lesion of Tooth
- Trial name
- NCT07091422
- Testing
- Etch-Free Adhesive, Conventional Etch-and-Bond Adhesive
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Dental Caries
Remineralizing Efficacy of Grape Seed Extract in Management of White Spot Lesion in Post Orthodontic Treated Patients.
This clinical trial will be conducted to compare the efficacy of grape seed extract oil versus sodium fluoride mouth wash in the management of remineralization in adult patients with white spot lesion over six months.
- Trial name
- NCT04357093
- Testing
- Grape seed extract mouthwash, Sodium fluoride mouthwash
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
White Spot Lesions
Effect of the Use of Self-Assembling Peptides Versus Resin Infiltration on Post Orthodontic White Spot Lesions: A Randomized Clinical Trial
This study aim was to Investigate color change of post orthodontic white spot lesion after using self- assembling peptide (CURODONT) and compare the color change of post orthodontic white spot lesion between CURODONT and ICON
- Trial name
- WSL (NCT07773714)
- Testing
- Self-Assembling Peptide (Curodont Repair)
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Suez Canal University
White Spot Lesion of Tooth
Artificial Intelligence Versus Clinical Examination in White Spot Lesions Detection, Identification, And Scoring
The goal of this observational study is to compare the diagnostic accuracy of Clinical examination as a standard for detection, identification and scoring of White Spot Lesions Versus Artificial intelligence analysis of intraoral…
- Trial name
- NCT07639749
- Testing
- Artificial Intelligence models (YOLO and MASK-RCNN)
- Volunteers
- 329 people
- Sponsor
- Cairo University
Caries; Initial, Caries Active
Clinical Effectiveness of Bioactive Silica Based With Calcium Toothpaste
This study will be conducted to Clinically evaluate Bioactive Silica Based with calcium booster (Refix technology) toothpaste and Sodium Fluoride varnish versus conventional fluoride toothpastes in management of white spot…
- Trial name
- NCT07120243
- Testing
- Toothpaste Product, Varnishes, Fluoride
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Rawda Hesham Abd ElAziz
White Spot Lesion
Resin Infiltration Vs Self-Assembling Peptide (P11-4) in Treating White Spot Lesions
Clinical assessment of the effectiveness of two treatment modalities (self-assembling peptide (P11-4) (alone or combined with fluoride) and resin infiltration) for treating white spot lesions
- Trial name
- NCT06708481
- Testing
- P11-4, a self-assembling peptide, P11-4, a self-assembling peptide with flouride, resin infilteration
- Where
- Egypt
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- October 6 University
White Spot Lesions [Initial Caries] on Smooth Surface of Tooth
Clinical Evaluation of the Efficacy of SPR-G Barrier Coat Versus Fluoride Varnish Versus MI Paste in the Treatment of Early White Spot Lesions in Pediatric Patients
In-Vivo randomized clinical trial to compare between the clinical performance of fluoride varnish versus MI paste (CPP_ACP) and the PRG- Barrier coat material concerning enamel remineralization, arrest of active early lesions…
- Trial name
- NCT05202821
- Testing
- PRG Barrier Coat, Fluoride varnish, MI paste
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Tooth; Lesion, White Spot Lesions
Remineralisation of White Spot Lesions by Elmex® gelée in Post-orthodontic Patients
The aim of this study is to monitor the effect of intraoral topical high fluoride application on the development of white spot lesions (WSL) after orthodontic treatment with multibracket appliances and to compare it to a placebo.
- Trial name
- NCT01329731
- Testing
- elmex® gelée
- Where
- Germany
- Volunteers
- 48 people
- Sponsor
- Gaba International AG