Clinical trials: Wide Spectrum of Diseases
Cervical Cancer, Vulvar Cancer
Long-term Follow-up of Broad Spectrum Human Papillomavirus (HPV) Vaccine Study in Women (V503-021)
Protocol V503-021 is a long-term follow-up study of the V503-001 base study (NCT00543543) to evaluate the safety, immunogenicity, and long-term effectiveness of V503 vaccine in preventing cervical cancer and related precancers…
- Conditions
- Cervical Cancer, Vulvar Cancer, Vaginal Cancer, Genital Warts
- Trial name
- NCT02653118
- Testing
- V503, GARDASIL
- Volunteers
- 4,453 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Drug Resistance, Microbial, Biomarkers
INterest of the Negative Predictive Value of Integrons in the reduCtion of Large Broad-spectrum anTibiotics Consumption for Urinary Tract infectionS
Urinary tract infections (UTI), mainly driven by Gram-negative bacteria (GNB) are a frequent cause of hospitalization and the second cause of antibiotic prescription after lower respiratory tract infections.
- Conditions
- Drug Resistance, Microbial, Biomarkers, Urinary Tract Infections (UTI's), Antibacterial Agents
- Trial name
- INVICTUS (NCT07675018)
- Testing
- Detection of integrons, Gold standard
- Where
- 7 sites in France
- Volunteers
- 204 people
- Sponsor
- University Hospital, Limoges
COVID-19
SA55 Injection: a Potential Therapy for the Prevention and Treatment of COVID-19
In this first-in-humans dose escalation study, SA55 will be evaluated for safety, tolerability, and pharmacokinetics. The study is intended to enable future studies of SA55-injection's efficacy in preventing and treating COVID-19.
- Trial name
- NCT06050460
- Testing
- SA55 Injection
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sinovac Life Sciences Co., Ltd.
Wide Spectrum of Diseases, Hematologic Diseases
Data Collection of Standard Care and Evaluation of NHLBI Patients and Donors
Background: Researchers seek ways to study people s medical problems in order to teach and further general knowledge. The ability to assess and treat people with a wide range of diseases is critical to training people to be good…
- Trial name
- NCT04450927
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
COVID-19
SA55 Novel Coronavirus Broad-spectrum Neutralizing Antibody Nasal Spray in Health People
To evaluate the safety, tolerance, local drug content and neutralization activity in nasal cavity, systemic exposure level and immunogenicity of novel coronavirus broad-spectrum neutralizing antibody SA55 nasal spray.
- Trial name
- NCT06048393
- Testing
- SA55 nasal spray
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sinovac Life Sciences Co., Ltd.
Traumatic Brain Injury
Broad-spectrum Cognitive Remediation: Effects of a Brain Plasticity-based Program in Mild Traumatic Brain Injury
The primary objective of this study is to evaluate the effects of plasticity-based, adaptive cognitive remediation on the cognitive abilities, functional status and quality of life of soldiers and veterans diagnosed with…
- Trial name
- BRAVE (NCT01640158)
- Testing
- Computerized Plasticity-based Adaptive Cognitive Training, Commercially available computerized training
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Posit Science Corporation
Influenza
Systems Biology of Flu Vaccine in Healthy Adults With and Without the Use of Antibiotics
The purpose of the study is to better understand how the use of antibiotics changes micro-organisms in the intestines. The change to micro-organisms in the intestines may change the body's vaccine immune response and alter the…
- Trial name
- VAX-002 (NCT02154061)
- Testing
- IIV Flu Vaccine, Metronidazole, Neomycin
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Emory University
Schizophrenia
Expanding Rapid Ascertainment Networks of Schizophrenia Families in Taiwan
This proposal responds to Request for Applications RFA ( Rapid Founding Award)-MH ( Mental Health)-08-131, which seeks applications that propose to enrich pre-existing resources for schizophrenia in the NIMH ( National Institute…
- Trial name
- S-TOGET (NCT01077687)
- Where
- Taiwan
- Volunteers
- 1,050 people
- Sponsor
- National Taiwan University Hospital
COVID-19 Prevention
Safety, Tolerability, and Pharmacokinetics of Q-Griffithsin Intranasal Spray
The purpose of this study is to test the safety of multiple doses of a Q-GRFT nasal spray in healthy volunteers. This Q-GRFT nasal spray is "investigational and not approved by the FDA for general use" and is being developed to…
- Trial name
- NCT05437029
- Testing
- Q-Griffithsin 3.0, Q-Griffithsin 6.0
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Kenneth Palmer
Acute Otitis Media, Acute Sinusitis
Comparative Effectiveness of Antibiotics for Respiratory Infections
The purpose of this study is to identify and use patient centered outcomes to compare narrow-spectrum and broad-spectrum antibiotics for the treatment of common acute respiratory tract infections (ARTIs) in children.
- Conditions
- Acute Otitis Media, Acute Sinusitis, Group A Streptococcal Pharyngitis
- Trial name
- CEARI (NCT02297815)
- Testing
- Broad-spectrum antibiotics, Narrow-spectrum antibiotics
- Where
- United States
- Volunteers
- 2,472 people
- Sponsor
- Children's Hospital of Philadelphia
Cervical Cancer, Vulvar Cancer
Broad Spectrum HPV (Human Papillomavirus) Vaccine in 16 to 26 Year Old Women (V505-001)
The purpose of this study is to evaluate the safety and immunogenicity of V505 in comparison to GARDASIL (TM)
- Conditions
- Cervical Cancer, Vulvar Cancer, Vaginal Cancer, Genital Warts
- Trial name
- NCT00520598
- Testing
- Comparator: V505 formulation 1, Comparator: V505 formulation 2, Comparator: V505 formulation 3
- Volunteers
- 511 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Febrile Neutropenia
Adjustment of Antibiotic Dosage in Pediatric Oncology Patients With Febrile Neutropenia and Augmented Renal Clearance
This clinical trial focuses on children with cancer who face infections after receiving chemotherapy. Chemotherapy affects the bone marrow, leading to a decrease in the production of certain white blood cells, particularly those…
- Trial name
- DAR-ARC (NCT06293677)
- Testing
- Dosage Adjustment Rules for Augmented Renal Clearance (DAR-ARC) for piperacillin-tazobactam and meropenem, Standard dosages of piperacillin-tazobactam or meropenem
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Autism Spectrum Disorder
Effect of a Wide Spectrum Nutritional Supplement on Mitochondrial Function in Children With Autism Spectrum Disorder
The objective of this study is to evaluate the metabolic effects of a comprehensive wide-spectrum supplement for children with ASD to determine whether it physiologically targets mitochondrial pathways known to be abnormal in…
- Trial name
- NCT03835117
- Testing
- Wide-spectrum nutritional supplement
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Rossignol Medical Center
Tuberculosis, Respiratory Tract Infections
Accuracy and Consequences of Using Trial-of-antibiotics for TB Diagnosis (ACT-TB Study)
This is a three-arm, open-label individually randomised controlled clinical trial investigating the benefits of the diagnostic use of broad-spectrum antimicrobials during the diagnostic process for tuberculosis (TB) and the risk…
- Conditions
- Tuberculosis, Respiratory Tract Infections, Pneumonia
- Trial name
- ACT-TB (NCT03545373)
- Testing
- Azithromycin, Amoxicillin
- Where
- Malawi
- Volunteers
- 1,583 people
- Sponsor
- London School of Hygiene and Tropical Medicine
COVID-19 Prevention
PREVENT-COVID-19: A Q-Griffithsin Intranasal Spray
This is the first-in-human clinical study to see if a single dose of an investigational nasal spray made from a modified plant protein called Q-Griffithsin is safe, tolerated and acceptable for use by healthy adults 18 to 60…
- Trial name
- NCT05122260
- Testing
- Q-Griffithsin
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Kenneth Palmer
Intestinal Failure
Spectral Lighting and Metabolism
The goal of this exploratory n-of-1-study is to compare markers of metabolism in infants in a Level IV Neonatal Intensive Care Unit (NICU) between two lighting environments.
- Trial name
- NCT06094504
- Testing
- Spectral Lighting
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Chronic Lymphocytic Leukaemia (CLL)
CLL Empirical Antibiotic Regimen
The purpose of this study is to evaluate whether patients with previously untreated, early stage CLL respond to empirical broad spectrum antibiotics and therefore test the hypothesis that occult bacterial infections are involved…
- Trial name
- CLEAR (NCT01279252)
- Testing
- metronidazole, clarithromycin, ciprofloxacin and lansoprazole
- Where
- United Kingdom
- Volunteers
- 71 people
- Sponsor
- King's College Hospital NHS Trust
Critical Illness, Intensive Care Unit Delirium
The Gut Microbiome - Source of Sepsis and Novel Target in Intensive Care Units?
Here, the investigators propose to study host responses to reduced microbiome complexity driven by treatment with broad spectrum antibiotics in patients with severe infections or sepsis.
- Conditions
- Critical Illness, Intensive Care Unit Delirium, Neurocognitive Deficit, Microbiome,immune Function, Critically Ill
- Trial name
- MS-ICU (NCT06749483)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Jena University Hospital
Intestinal Microbiome, Febrile Neutropenia
Choosing the Best Antibiotic to Protect Friendly Gut Bacteria During the Course of Stem Cell Transplant
The purpose of this study is to see how different antibiotics affect the community of friendly bacteria existing in the intestinal tract (gut).
- Trial name
- NCT03078010
- Testing
- Piperacillin-tazobactam, cefepime
- Where
- 2 sites in United States
- Volunteers
- 347 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Overweight, Obesity
Correlation of Irisin and Adipokine Levels With Body Mass Index and Risk Factors for Metabolic Syndrome in Hispanic Children
Childhood obesity is one of the most serious global public health challenges of the 21st century (Daniels et al., 2009). Mexico has the highest prevalence of obesity, (Secretaría de Salud, 2009); 34.4% of children and 35% of…
- Conditions
- Overweight, Obesity, Thinness
- Trial name
- NCT02320110
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Instituto Tecnologico y de Estudios Superiores de Monterey