Clinical trials: Widespread Chronic Pain
Ehlers-Danlos Syndrome (EDS), Complex Regional Pain Syndrome (CRPS)
Two Point Discrimination
SPECIFIC AIMS Pain in both youth and adults is a complex, subjective and personal experience, and remains poorly understood. One particularly perplexing dimension of some forms of pain is the tendency of pain to spread outside of…
- Conditions
- Ehlers-Danlos Syndrome (EDS), Complex Regional Pain Syndrome (CRPS), Amplified Musculoskeletal Pain Syndrome (AMPS), Low Back Pain
- Trial name
- TPD (NCT03686748)
- Testing
- Two-point discrimination training, One-point discrimination training
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Anxiety Disorder, Chronic Myeloproliferative Disorders
Music Therapy to Ease Pain and Emotional Distress in Patients With Hematologic Cancer Who Are Undergoing High-Dose Therapy and Stem Cell Transplantation
RATIONALE: Music therapy may be effective in relieving pain and emotional distress in patients who are undergoing cancer therapy.
- Conditions
- Anxiety Disorder, Chronic Myeloproliferative Disorders, Depression, Lymphoma
- Trial name
- NCT00014482
- Testing
- pain therapy, psychosocial assessment and care
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Chronic Pain, Widespread Chronic Pain
Nationwide Evaluation of Multimodal Rehabilitation in Patients With Chronic Musculoskeletal Pain
Chronic pain is a common health problem that causes enormous social costs. A common method for treating patients with chronic pain problems are multimodal rehabilitation (MMR), which consists of a combination of physical…
- Trial name
- NCT02248363
- Testing
- Multimodal rehabilitation
- Where
- Sweden
- Volunteers
- 6,500 people
- Sponsor
- Karolinska Institutet
Cancer
Ketamine Hydrochloride and Best Pain Management in Treating Cancer Patients With Neuropathic Pain
RATIONALE: Ketamine hydrochloride may lessen neuropathic pain in patients with cancer. It is not yet known whether ketamine hydrochloride given together with the best pain management is more effective than a placebo given…
- Trial name
- NCT01316744
- Testing
- ketamine hydrochloride, pharmacogenomic studies, questionnaire administration
- Where
- 3 sites in United Kingdom
- Volunteers
- 214 people
- Sponsor
- University of Glasgow
Fibromyalgia, Pain, Chronic
Psychobiological Mechanisms Underlying Chronic Pain
Pain is a powerful motivator of behavior and it is more than the perception of nociceptive input. It is a complex experience that comprises different components: sensory discriminative, emotional-motivational and cognitive…
- Conditions
- Fibromyalgia, Pain, Chronic, Chronic Pain, Widespread
- Trial name
- NCT04674670
- Testing
- Bromocriptine Mesylate Capsules, Amisulpride 400 MG
- Where
- Switzerland
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- susanne becker
Fibromyalgia (FM) OR Fibromyalgia Syndrome, Manuel Therapy
Effects of Adding Vagal Neuromodulation to Manual Therapy in Women With Fibromyalgia
The aim of this study is to investigate the effect of transcutaneous auricular vagus nerve stimulation (taVNS) added to manual therapy on pain, autonomic nervous system function, and illness perception in female patients…
- Conditions
- Fibromyalgia (FM) OR Fibromyalgia Syndrome, Manuel Therapy, Chronic Widespread Pain, Autonomic Nervous System Dysfunction
- Trial name
- NCT07894588
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation (taVNS), Manual Therapy Program, Diaphragmatic Breathing and Stretching Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Hasan Kalyoncu University
Chronic Pain
Reference Values and Clinical Screening Test of Diffuse Noxious Inhibitory Controls (DNIC)
Chronic pain (CP) is disabling for people triggering important costs for society. A deficit of diffuse noxious inhibitory controls (DNIC) is one of the CP mechanisms.
- Trial name
- DNIC (NCT03376867)
- Testing
- Conditioned pain modulation
- Where
- Canada
- Volunteers
- 468 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Chronic Widespread Pain, Fibromyalgia
Interdisciplinary Rehabilitation of Patients With Chronic Widespread Pain
The primary objective of the current study is to evaluate the outcome of an interdisciplinary multi-component rehabilitation programme customized to patients with chronic widespread pain (CWP) based on multidimensional diagnostic…
- Trial name
- IMPROvE (NCT01352052)
- Testing
- interdisciplinary rehabilitation
- Where
- 2 sites in Denmark
- Volunteers
- 192 people
- Sponsor
- Frederiksberg University Hospital
Migraine, Musculoskeletal Pain
Overlapping Pain Trajectory Study
The goal of this observational study is to learn about spatial and temporal nociceptive filtering in adolescents with chronic overlapping pain conditions (COPCs). The main questions it aims to answer are: 1.
- Conditions
- Migraine, Musculoskeletal Pain, Functional Abdominal Pain Disorders, Chronic Pain
- Trial name
- COPC (NCT05752396)
- Testing
- Conditioned Pain Modulation, Offset Analgesia, Spatial Summation
- Where
- United States
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Chronic Widespread Pain
Gut Microbiota in Adults With Chronic Widespread Pain
We aim to identify the gut microbiome composition in adults with CWP. We will collect the stool sample of 120 healthy individuals and 120 Chronic Widespread Pain patients.
- Trial name
- NCT05678387
- Where
- Hong Kong
- Volunteers
- 240 people
- Sponsor
- Chinese University of Hong Kong
Fibromyalgia
FIbromyalgia anD GenetIcs Subgroups (FIDGIS)
Fibromyalgia syndrome (FS) is characterized by widespread pain and affect 0.5 to 5 % of the general population, with a higher prevalence in women.
- Trial name
- FIDGIS (NCT04624581)
- Testing
- Electrophysiological measurement of reflex nociceptive flexion threshold (RIII reflex) using Nicolet Vicking device
- Where
- France
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Widspread Chronic Pain, Fibromyalgia
The Effect of Vagus Nerve Stimulation on Pain and Functional Activities in Individuals With Chronic Widespread Pain
The goal of this clinical trial is to examine the effect of vagus nerve stimulation (VNS) on chronic, widespread pain in adults.
- Trial name
- NCT07080749
- Testing
- Vagal nerve stimulation through deep exhalation exercise, Vagal nerve stimulation through ear electrical stimulation, No intervention (observational study)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of North Georgia
Fibromyalgia, Chronic Widespread Pain
Effects of and Exploring the Processes of Free Movement Dance as a Physical Therapy Intervention for Female Patients Diagnosed With Chronic Widespread Pain (Including Fibromyalgia).
The study has three parts: Part 1: To evaluate, for adult female patients diagnosed with chronic widespread pain (including fibromyalgia), the effects of Free Movement Dance as an add-on intervention after interdisciplinary pain…
- Trial name
- NCT05282758
- Testing
- Free Movement Dance, Modified person-centred progressive resistance exercise
- Where
- Sweden
- Volunteers
- 52 people
- Sponsor
- Göteborg University
Amplified Musculoskeletal Pain Syndrome, Reflex Sympathetic Dystrophy
Audio-Visual Relaxation Technology for Pediatric Amplified Musculoskeletal Pain Syndrome
A pilot randomized controlled trial to assess feasibility, acceptability and generate outcome domains for a future RCT testing the efficacy of immersive virtual reality on pain intensity in pediatric amplified musculoskeletal…
- Conditions
- Amplified Musculoskeletal Pain Syndrome, Reflex Sympathetic Dystrophy, Complex Regional Pain Syndromes
- Trial name
- NCT03762213
- Testing
- Oculus GO VR HMD, application Happy Place (© Mimerse), iPad, application Happy Place (© Mimerse)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Tufts Medical Center
Chronic Pain, Widespread
Effects of Social Presence and Perception in Virtual Reality on Pain
This experiment aims to examine the effects of transportation via social presence in "near" and "far" virtual environments, on pain threshold in two groups: 1. healthy volunteers in an induced pain task, and 2.
- Trial name
- SPP (NCT03157362)
- Testing
- Near Non-Social, Near Social, Far Non-Social
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Cornell University
Chronic Widespread Pain
Chronic Widespread Pain in HIV: Novel Mechanisms and Therapeutics
To determine if decreased production or release of endogenous opioid peptides by peripheral immune cells contributes to hypersensitivity in people with HIV
- Trial name
- NCT04787848
- Testing
- Relistor Injectable Product
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Florida International University
Low Back Pain, Chronic Widespread Pain
13-year Follow-up of Women With Chronic Low Back Pain in Primary Care - a Prospective Longitudinal Cohort Study
Background: Low back pain (LBP) is among the main causes of long-term sickness absence and is associated with considerable costs for both the individual and society.
- Conditions
- Low Back Pain, Chronic Widespread Pain, Predictors, Pain
- Trial name
- NCT03974191
- Testing
- Change in function, activity, participation and other health related factors in CLBP and to identify predictors for pain, activity and work ability after 13 years.
- Where
- 3 sites in Sweden
- Volunteers
- 87 people
- Sponsor
- Vastra Gotaland Region
Fibromyalgia, Whiplash
Diffuse Noxious Inhibitory Controls (DNIC): Nociceptive Modulation and Interaction With Neurocognitive Performance in Chronic Pain
Diffuse noxious inhibitory control In order to quantify central sensitization in chronic pain patients, the Diffuse Noxious Inhibitory Control (DNIC) model has been used frequently.
- Conditions
- Fibromyalgia, Whiplash, Chronic Pain
- Trial name
- NCT01172795
- Testing
- Relaxation session, Neurocognitive test battery
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Chronic Pain, Widespread, Obesity
Chronic Widespread Pain After Rapid Weight Loss in Non-Hispanic Black and Hispanic/Latino/a/x Adults
The goal of this observational study is to learn if surgical weight loss can improve chronic widespread pain in people living with higher BMI who self-identify as Hispanic/Latino ethnicity or non-Hispanic Black based on the…
- Conditions
- Chronic Pain, Widespread, Obesity, Bariatric Surgery Candidate
- Trial name
- NCT06795386
- Testing
- Bariatric Surgery
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- New York University
Knee Osteoarthritis, Widespread Chronic Pain
Prevalence and Characteristics of Widespread Pain in People With Knee Osteoarthritis
The goal is to evaluate whether the number of pain sites or pain estimation with Instant and Constant Osteoarthritis Pain (ICOAP) is related to functional impairment in the lower extremity in people with knee osteoarthritis…
- Trial name
- NCT06854237
- Where
- Sweden
- Volunteers
- 114 people
- Sponsor
- Vastra Gotaland Region