Clinical trials: Withdrawal
Cannabis Use Disorder
Effect of Clonazepam on Cannabis Withdrawal and Relapse in Treatment-seeking Patients
The proposed protocol is a double-blind, placebo-controlled inpatient and outpatient study,looking at the clinical treatment of cannabis use disorder. The treatment study is a total of 12 weeks.
- Trial name
- NCT02913924
- Testing
- Clonazepam
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- New York State Psychiatric Institute
Graves Disease, Hyperthyroidism
Remission Induction and Sustenance in Graves' Disease 2
ATD therapy for Graves' disease is one of the commonly used options for therapy of the hyperthyroidism. The investigators study how to optimally keep patients in remission.
- Trial name
- NCT00796913
- Testing
- Stop medication
- Volunteers
- 139 people
- Sponsor
- Aalborg University Hospital
Oral Contraceptive
Comparative Trial in Hormone Withdrawal Associated Symptoms
This clinical research study will examine whether an oral contraceptive pill taken with a monthly hormone-free interval of 4 days reduces hormone withdrawal associated symptoms compared to an oral contraceptive pill taken with a…
- Trial name
- NCT01076582
- Testing
- EE20/DRSP (YAZ, BAY86-5300), Ethinylestradiol (EE) and desogestrel (DSG) (Mercilon)
- Where
- 44 sites in Argentina, Chile and 12 more
- Volunteers
- 592 people
- Sponsor
- Bayer
Cannabis Dependence, Marijuana Dependence
Combination of Dronabinol and Clonidine for Cannabis Dependence in Patients With Schizophrenia
Cannabis use disorders are an important public health problem in the United States, but no effective pharmacotherapies are available to treat these disorders.
- Trial name
- DCCS (NCT01598896)
- Testing
- Dronabinol, Clonidine
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Mclean Hospital
Opioid Dependence, Buprenorphine Withdrawal Syndrome
Pharmacokinetic & Pharmacodynamic Interaction of Lofexidine and Buprenorphine in Buprenorphine Maintained Patients
The primary objective of this study is to assess lofexidine related effects on QTc (an interval of the heart rhythm) in subjects receiving buprenorphine maintenance.
- Trial name
- NCT01820442
- Testing
- Lofexidine HCl, Lofexidine-matching sugar pill
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- USWM, LLC (dba US WorldMeds)
Tobacco Use, Smoking Cessation
Overcoming Nicotine Dependence to Enable Quitting
Tobacco use disorder is a chronic, relapsing health condition that necessitates a chronic care approach. However, traditional smoking cessation treatment programs allocate nearly all their resources only to those smokers who are…
- Conditions
- Tobacco Use, Smoking Cessation, Smoking Behaviors, Nicotine Dependence
- Trial name
- ON-DEQ (NCT05513872)
- Testing
- Nicotine Replacement Therapy (NRT) Sampling, Practice Quitting (PQ) Counseling, Motivational Interviewing (MI) Counseling
- Where
- United States
- Volunteers
- 780 people
- Sponsor
- Rush University Medical Center
Chronic Inflammatory Demyelinating Polyradiculopathy
Interest of Mycophenolate for CIDP Weaning
The main objective is to study if the mycophenolate could decrease the proportion of patients who relapse during the IVIG tapering period and after the IVIG withdrawal.
- Trial name
- MYCOPID (NCT02494505)
- Testing
- Mycophenolate Mofetil
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Essential Tremor
A Study to Evaluate SAGE-217 in Participants With Essential Tremor
This study is a three-part, multicenter, Phase 2a study to evaluate the efficacy, safety, tolerability, and pharmacokinetics of SAGE-217 in adult participants with essential tremor.
- Trial name
- NCT02978781
- Testing
- SAGE-217
- Where
- 26 sites in United States
- Volunteers
- 34 people
- Sponsor
- Biogen
Alcohol Withdrawal, Nutrition Disorders
Riboflavin for Glutamate Reduction in Alcohol Withdrawal
This RCT intends to investigate the use of oral Riboflavin (Vitamin B2) for reduction of blood glutamate levels in the setting of acute alcohol withdrawal.
- Conditions
- Alcohol Withdrawal, Nutrition Disorders, Alcohol Use Disorder
- Trial name
- RGRAW (NCT04232800)
- Testing
- Riboflavin
- Volunteers
- 40 people
- Sponsor
- Oregon Health and Science University
Opioid Use Disorder, Opioid Withdrawal
Evaluating Buspirone to Treat Opioid Withdrawal
The investigators propose a rigorous, Phase II, three-group, placebo-controlled double-blind randomized controlled trial (RCT) to evaluate the efficacy of buspirone for both withdrawal and craving among individuals with opioid…
- Conditions
- Opioid Use Disorder, Opioid Withdrawal, Opioid Craving, Anxiety
- Trial name
- NCT05511909
- Testing
- Buspirone, Lofexidine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Maryland, Baltimore
Substance Withdrawal Syndrome
Efficacy of XYZ for Withdrawal Syndrome
This is a randomized controlled clinical trial to explore the efficacy and mechanism of Tiaozhong-Yiqi Decoction (TZYD) in treating substance withdrawal syndrome, combining network pharmacology analysis and clinical validation.
- Trial name
- TZYT-WS (NCT07543809)
- Testing
- Tiaozhong-Yiqi Decoction, routine care
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Chongqing Jiangbei Hospital of Traditional Chinese Medicine
Renal Transplantation
Belatacept Early Steroid Withdrawal Trial
The study purpose is to determine the safety and efficacy of a belatacept-based immunosuppressive regimen (calcineurin inhibitor free) with alemtuzumab or rabbit antithymocyte globulin (rATG) induction and early glucocorticoid…
- Trial name
- NCT01729494
- Testing
- Alemtuzumab, rabbit antithymocyte globulin, Belatacept
- Where
- 8 sites in United States
- Volunteers
- 316 people
- Sponsor
- University of Cincinnati
Posttraumatic Osteoarthritis, Anterior Cruciate Ligament (ACL) Rupture
Synovial Fluid Withdrawal or PRP Injection For Acute ACL Tears and Cytokines
The purpose of this study is to determine what effects the withdrawal of excess knee joint fluid or the injection of a factor from the blood has on swelling after a sudden anterior cruciate ligament (ACL) rupture of the knee.
- Trial name
- NCT07142369
- Testing
- Synovial Fluid withdrawal at the preoperative clinic visit, Platelet-Rich Plasma (PRP) preparation and injection, Synovial fluid withdrawal at the time of surgery
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Rush University Medical Center
Chronic Cluster Headache
A First-in-human Study to Assess the Initial Safety, Tolerability, and Effectiveness of the ONSS Bilateral Occipital Nerve Field Stimulation System for the Prophylactic Treatment of Chronic Cluster Headache in Difficult-to-treat Subjects.
The purpose of this clinical trial is to evaluate the safety and effectiveness of the Occipital Nerve Stimulation System (ONSS) in treating chronic cluster headache in adults.
- Trial name
- ONFIELD (NCT07677137)
- Testing
- Occipital Nerve Stimulation System
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Man and Science, SA
Attention Deficit Hyperactivity Disorder
A Pivotal Efficacy Trial to Evaluate HLD200 in Children With ADHD in a Classroom Setting
This Phase 3 pivotal efficacy trial will examine the effects of HLD200 (methylphenidate) in patients aged 6-12 years with ADHD in a laboratory classroom setting.
- Trial name
- NCT02493777
- Testing
- HLD200 methylphenidate hydrochloride (MPH) Capsules
- Where
- 7 sites in United States
- Volunteers
- 125 people
- Sponsor
- Ironshore Pharmaceuticals and Development, Inc
Chronic Obstructive Lung Disease
Vitamin D and Chronic Obstructive Lung Disease
The purpose of this study is to examine the effect of vitamin D intervention in patients with chronic obstructive pulmonary disease (COPD) undergoing rehabilitation.
- Trial name
- NCT01416701
- Testing
- Vitamin D (D3, cholecalciferol)
- Where
- 2 sites in Denmark
- Sponsor
- Jorgen Vestbo
Opioid Withdrawal, Opioid Use Disorder
Assessing a Clinically-meaningful Opioid Withdrawal Phenotype
Evaluate individual differences in the expression of opioid withdrawal symptoms in persons with opioid use disorder (OUD) while completing a clinically-indicated medication taper.
- Conditions
- Opioid Withdrawal, Opioid Use Disorder, Opioid Craving
- Trial name
- NCT05027919
- Testing
- Hydromorphone, Naloxone + lofexidine pretreatment, Lofexidine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Maryland, Baltimore
Tobacco Use Disorder, Substance-Related Disorders
Behavioral Economic Purchasing Decisions for Cigarettes of Varied Compositions
The purpose of this study is to determine whether the abuse liability of cigarettes with altered composition (cigarettes differing in composition; e.g., tar levels, amount of sugar, casings) is reduced relative to standard…
- Trial name
- NCT02888249
- Testing
- Altered composition cigarette
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Johns Hopkins University
Traumatic Brain Injury, Concussion
Enhancing Cognitive and Neurobehavioral Functions After Repetitive Traumatic Brain Injuries (rTBI) in Retired NFL Players and Military Veterans.
The purpose of this study is to compare different combinations of cognitive training in retired professional football players and military veterans with a history of repeated concussions and persistent symptoms of impaired…
- Conditions
- Traumatic Brain Injury, Concussion, Mild Cognitive Disorder
- Trial name
- NCT02699476
- Testing
- Psycho-Social Therapy, Cognitive Behavioral Computer Training, Interactive Trainer-Subject Sessions
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Brain & Body Health Foundation
Kidney Transplant Rejection
Belatacept With Early Steroid Withdrawal rATG and Everolimus in Renal Transplantation (BETTER Trial)
This study is designed to determine the safety and efficacy of two calcineurin inhibitor free treatment groups 1) a belatacept, everolimus and early corticosteroid withdrawal (ECSWD) immunosuppressive regimen with rabbit…
- Trial name
- BETTER (NCT04849533)
- Testing
- Belatacept, Everolimus, mycophenolate mofetil
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of Cincinnati
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