Clinical trials: Withdrawal
Gastroesophageal Reflux
Safety and Efficacy of Rabeprazole in Infants With Gastroesophageal Erosive Reflux Disease (GERD)
The purpose of this study is to assess the effectiveness and safety of rabeprazole sodium, an inhibitor of gastric acid secretion of the protein pump inhibitor (PPI) class, compared with placebo in the treatment of…
- Trial name
- NCT00992589
- Testing
- Rabeprazole sodium 5 mg, Rabeprazole sodium 10 mg
- Where
- 81 sites in United States, Australia and 8 more
- Volunteers
- 344 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Psychiatric Disorder, Benzodiazepine Withdrawal
Influence of Olfaction Essential Oils on the Consumption of Benzodiazepine Receptor Agonists & Z-Drugs (BZRAs) Prescribed as " if Needed " in Psychiatric Outpatients (HECBA-PSY).
The goal of this interventional study is to test the use of olfactory Essential Oils through a nasal stick as one of the non-medicinal strategies to propose to the patient to reduce the consumption of medication in a population…
- Trial name
- HECBA-PSY (NCT05583240)
- Testing
- Essences and Essential Oils
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Etablissement Public de Santé Barthélemy Durand
Major Depressive Disorder
Waitlist-Control Trial of Smartphone CBT for Major Depressive Disorder (MDD), Withdrawn
The investigators are testing the efficacy of Smartphone-delivered cognitive behavioral therapy (CBT) treatment for major depressive disorder (MDD).
- Trial name
- NCT03769350
- Testing
- Smartphone-delivered CBT for MDD
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Baclofen Withdrawal Syndrome
Oral and IV Baclofen in Adult Volunteers
The primary objective of this study is to characterize baclofen pharmacokinetics following oral and intravenous administration in patients who are on chronic oral baclofen therapy.
- Trial name
- NCT01749319
- Testing
- Oral baclofen, Intervenous baclofen
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Diabetic Neuropathy
A Safety and Efficacy Study for Tapentadol (CG5503) Extended Release for Patients With Painful Diabetic Peripheral Neuropathy
The purpose of this study is to evaluate the effectiveness (level of pain control) and safety of Tapentadol (CG5503) extended release (ER) (base) compared to placebo in patients with moderate to severe pain from diabetic…
- Trial name
- NCT00455520
- Testing
- CG5503
- Volunteers
- 395 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Alcoholism
Baclofen to Prevent Agitation in Alcohol Addicted Patients in ICU
Background: Alcohol is the leading psychoactive substance consumed in France, with about 15 million regular consumers. The National institute on Alcohol Abuse and Alcoholism (NIAAA) considers alcohol abuse to be more than 14…
- Trial name
- BACLOREA (NCT02723383)
- Testing
- BACLOFEN
- Where
- 18 sites in France
- Volunteers
- 314 people
- Sponsor
- Nantes University Hospital
Antibody-mediated Rejection
Efficacy and Safety of Human Plasma-derived C1-esterase Inhibitor as add-on to Standard of Care for the Treatment of Refractory Antibody Mediated Rejection (AMR) in Adult Renal Transplant Recipients
This is a double-blind, randomized-withdrawal, placebo-controlled study in kidney transplant patients with AMR to evaluate the efficacy and safety of human plasma-derived C1-esterase inhibitor as add-on to standard of care (IVIG).
- Trial name
- NCT03221842
- Testing
- C1-esterase inhibitor
- Where
- 26 sites in United States, Belgium and 5 more
- Volunteers
- 63 people
- Sponsor
- CSL Behring
Chronic Pain, Opiate Withdrawal Syndrome
Treatment of Withdrawal Symptoms With NADA Acupuncture in Chronic Pain Patients
This project aims at examining the following hypotheses: Treatment with NADA and clonidine reduces intensity of withdrawal symptoms to a greater extent than treatment with clonidine.
- Trial name
- NCT03397212
- Testing
- NADA acupuncture
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Single Transplant, 5 Years of Follow-up After Transplant, in Which an Attempt Was Made to Suspend IS
De Novo Metabolic Syndrome in Liver Transplant Patients After Immunosuppression Withdrawal
Evaluate de novo onset of metabolic syndrome, NAFLD and NASH in liver transplant recipients who have discontinued immunosuppressive therapy ("tolerant") and in those taking immunosuppressive therapy ("non-tolerant").
- Trial name
- NCT05808192
- Testing
- Immunosuppressive
- Where
- Italy
- Volunteers
- 92 people
- Sponsor
- University of Rome Tor Vergata
Substance Withdrawal Syndrome
The Effect of Melatonin Upon Post-Acute Withdrawal Among Males in a Residential Treatment Program
Individuals recovering from drug and/or alcohol addiction initially experience the symptoms of acute withdrawal before experiencing the symptoms of post-acute withdrawal (PAWS).
- Trial name
- M-PAWS (NCT02431728)
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Duquesne University
Hepatitis B, Chronic
Long-Term Lamivudine Therapy for Chronic Hepatitis B
This study will evaluate the long-term safety and effectiveness of lamivudine therapy and the possibility of stopping therapy in patients whose hepatitis B is chronic, that is, long lasting, and which has responded to treatment.
- Trial name
- NCT00120354
- Testing
- Blood Testing, Percutaneous Liver Biopsy, Lamivudine Therapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Anesthesia, General
Reduction of Rocuronium-induced Injection Pain With Aspiration of Blood
The goal of this clinical trial is to learn about reduction of rocuronium injection pain in participants receiving general anesthesia.
- Trial name
- NCT06150001
- Testing
- rocuronium-normal-saline mixture, rocuronium-lidocaine mixture, rocuronium-blood mixture
- Where
- Taiwan
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Hidradenitis Suppurativa
Extension Study to Assess Effects of Non-interrupted Versus Interrupted and Long Term Treatment of Two Dose Regimes of Secukinumab in Subjects With Hidradenitis Suppurativa
The purpose of this extension study is to evaluate maintenance of Hidradenitis Suppurativa Clinical Response (HiSCR response) in either continuous or interrupted therapy (using a randomized withdrawal period) of two dose regimens…
- Trial name
- NCT04179175
- Testing
- secukinumab
- Where
- 191 sites in United States, Argentina and 36 more
- Volunteers
- 702 people
- Sponsor
- Novartis Pharmaceuticals
Neonatal Abstinence Syndrome, Withdrawal
Feasibility of Auricular Acupressure as an Adjunct Treatment for Neonatal Abstinence Syndrome (NAS)
This study will assess the feasibility of implementing auricular acupressure as an additional non-pharmacologic therapy for neonates at risk for developing neonatal abstinence syndrome (NAS) at Monroe Carrell Jr Children's…
- Trial name
- NCT03973801
- Testing
- Auricular acupuncture
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Vanderbilt University Medical Center
Colonic Polyps
Efficacy of Segmental Examination Twice of the Proximal Colon on Adenoma Detection
Segmental examination twice of the proximal colon might be helpful to increase adenoma detection rate (ADR).
- Trial name
- NCT02581475
- Testing
- Extending withdrawal time in the proximal colon, Segmental examination twice of the proximal colon
- Where
- China
- Volunteers
- 386 people, healthy volunteers welcome
- Sponsor
- Yanqing Li
Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
Prevalence and Clinical Manifestations of Cannabis Withdrawal in Hospitalized Patients With Hematological Malignancies Undergoing Bone Marrow Transplant (BMT) or Chimeric Antigen Receptor T-Cell (CAR-T) Therapy
This study evaluates the prevalence of cannabis withdrawal and the clinical manifestations of cannabis withdrawal syndrome in patients hospitalized for BMT or CAR-T therapy.
- Trial name
- NCT07594496
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Mayo Clinic
Kidney Transplantation
REgulatory T Cell Therapy to Achieve Immunosuppression REduction
The goal of this multi-national, multi-center, open-label, randomized Phase 2 trial is to determine the safety and efficacy of administering expanded regulatory T cells (TRK-001) to prevent allograft rejection in living donor…
- Trial name
- RETIRE (NCT06552169)
- Testing
- Arm 1: SOC (mTOR + CNI), Arm 2A: TRACT/MONO mTOR, Arm 2B: TRACT/MONO CNI
- Where
- 7 sites in United States, Taiwan
- Volunteers
- 34 people
- Sponsor
- Singulera Therapeutics Inc.
Substance Withdrawal Syndrome
Process Evaluation Standardised Nurse-led Approach for Risk Screening and Decrease of Alcohol Withdrawal in ENT
In ear, nose, throat (ENT) and jaw surgery departments, up to 60% of patients suffer from alcohol dependence (Allen et al., 2009), and may develop an alcohol withdrawal syndrome (AWS) when undergoing sur-gery.
- Trial name
- NCT02782156
- Testing
- Process evaluation
- Where
- Switzerland
- Volunteers
- 89 people
- Sponsor
- University Hospital, Basel, Switzerland
Diabetes
Comparison of New-onset Diabetes After Transplantation Between Two Steroid Withdrawal Group With CellCept
With improvements in patient and graft survival, increasing attention has been placed on complications that contribute to long-term patient morbidity and mortality.
- Trial name
- NODAT (NCT02095418)
- Testing
- Mycophenolate mofetil, Corticosteroids, Corticosteroids, Mycophenolate mofetil
- Where
- 5 sites in South Korea
- Volunteers
- 152 people
- Sponsor
- Samsung Medical Center
Heart Failure With Normal Ejection Fraction, Chronotropic Incompetence
β-blockers Withdrawal in Patients With HFpEF and Chronotropic Incompetence: Effect on Functional Capacity (Preserve-HR)
The pathophysiology of heart failure with preserved ejection fraction (HFpEF) is complex and multifactorial. Chronotropic incompetence has emerged as a crucial mechanism, particularly in elderly patients.
- Trial name
- Preserve-HR (NCT03871803)
- Testing
- Controlled withdrawal of beta-blockers, Cardiopulmonary Exercise Testing
- Where
- Spain
- Volunteers
- 52 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
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