Clinical trials: Withdrawal
Contraception
To Compare SH T00658ID Over Ortho Tri-Cyclen Lo (US/Canada)
The objective of the study is to compare the oral contraceptive (OC) SH T00658ID over Ortho Tri-Cyclen Lo administered for 13 cycles to healthy female volunteers between 18 and 50 years of age who request oral contraceptive…
- Trial name
- NCT00754065
- Testing
- Estradiol valerate, Dienogest (Natazia, Qlaira, BAY86-5027), Ortho Tri Cyclen Lo
- Where
- 59 sites in United States, Canada
- Volunteers
- 409 people, healthy volunteers welcome
- Sponsor
- Bayer
Caffeine Use Disorder (DSM-5 Condition for Further Study)
Treatment for Caffeine Dependence
Recent research has shown that some individuals become addicted to or dependent on caffeine and are unable to quit or reduce caffeine consumption despite a persistent desire to do so.
- Trial name
- NCT01951872
- Testing
- Manual-based treatment for caffeine dependence
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Johns Hopkins University
Opioid Withdrawal, Chronic Pain
ACTION: Trial of Adding Buprenorphine, CBT, and TMS to Improve Outcomes of Long-Term Opioid Therapy for Chronic Pain
This study will sequentially evaluate three novel and scalable interventions for at-risk individuals on long term opioid therapy for chronic pain: (1) low-dose transdermal buprenorphine initiation without a period of opioid…
- Trial name
- ACTION (NCT06442566)
- Testing
- Buprenorphine Patch, Transcranial Magnetic Stimulation (TMS)
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Colonic Polyp
Position Changes During Colonoscope Withdrawal and Polyp Detection
The purpose of this study is to determine whether position changes during colonoscope withdrawal affects polyp detection rate. We hypothesize that positions change during scope withdrawal will increase polyp detection rate.
- Trial name
- NCT01395173
- Testing
- Position change, Standard
- Where
- Canada
- Volunteers
- 776 people
- Sponsor
- University of British Columbia
Central Sensitisation
Differences in Pain Processing Between Men and Women
Many chronic pain conditions show clear differences between between men and women, such as reported pain intensities or treatment effects, with chronic pain conditions being generally more frequent in women.
- Trial name
- NCT05031286
- Testing
- Cutaneous thermal stimuli
- Where
- Switzerland
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Balgrist University Hospital
Methamphetamine Dependence
Studying Amphetamine Withdrawal in Humans
Methamphetamine use is very common in the US and is associated with serious medical and psychiatric problems. There has also been a significant increase in the number of patients entering treatment for methamphetamine dependence…
- Trial name
- NCT01215929
- Testing
- Dextroamphetamine
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Arkansas
Juvenile Idiopathic Arthritis
Withdrawal of Etanercept After Successful Treatment of Juvenile Idiopathic Arthritis
The purpose of this study is to determine whether etanercept can be withdrawn successfully (i.e. no occurrence of flares) in juvenile idiopathic arthritis (JIA) patients in whom disease remission is reached. Goals: 1.
- Trial name
- ABC-STOP (NCT01287715)
- Testing
- etanercept
- Where
- 10 sites in Netherlands
- Volunteers
- 50 people
- Sponsor
- Erasmus Medical Center
Alcohol Use Disorder, Alcohol Withdrawal
Baclofen in Managing Acute Alcohol Withdrawal
The study goal is to investigate whether administration of oral baclofen forms an adequate treatment option in the management of acute alcohol withdrawal.
- Trial name
- NCT03293017
- Testing
- Diazepam 10 MG, Baclofen 30mg, Baclofen 60mg
- Where
- Belgium
- Volunteers
- 90 people
- Sponsor
- Universitair Ziekenhuis Brussel
Opioid-Related Disorders
Lofexidine for Opiate Withdrawal - 1
The purpose of this study is to evaluate lofexidine for opiate withdrawal.
- Trial name
- NCT00032942
- Testing
- Lofexidine
- Where
- 3 sites in United States
- Volunteers
- 66 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Neonatal Opioid Withdrawal, Neonatal Opioid Withdrawal Syndrome
Cerebral Physiology of NOWS
This study will use a new device to measure blood flow and oxygen levels in the brains of newborn infants who have had exposure to opioid medications in the womb, compared to newborns who have not had any exposure.
- Conditions
- Neonatal Opioid Withdrawal, Neonatal Opioid Withdrawal Syndrome, Opioid Use Disorder, Intrauterine Exposure
- Trial name
- NIRS for NOWS (NCT07610746)
- Testing
- FD-NIRS and DCS
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Indiana University
Heart Failure With Reduced Ejection Fraction, Heart Rhythm Disorder
Withdrawal of Treatment for Heart Failure Patients With Recovery From Tachycardia-induced Cardiomyopathy
New onset heart failure (HF) is observed in up to 25% of patients with incident atrial fibrillation or flutter (AF). Current guidelines suggest that both conditions (AF \& HF) be addressed with guideline directed medical therapy…
- Trial name
- WEAN-HF (NCT06128980)
- Testing
- GDMT
- Where
- Denmark
- Volunteers
- 348 people
- Sponsor
- Herlev and Gentofte Hospital
Drug Overdose, Opioid Withdrawal
Feasibility of the Utilization of Buprenorphine in the Emergency Room to Treat Clinical Opioid Withdrawal
The investigators are trying to determine whether they can effectively treat patients suffering from acute opioid withdrawal in the Emergency Department at Virginia Commonwealth University Health System (VCUHS) and subsequently…
- Conditions
- Drug Overdose, Opioid Withdrawal, Opioid-use Disorder
- Trial name
- NCT03489161
- Testing
- Buprenorphine
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Virginia Commonwealth University
Asthma
An Evaluation Of PF-03715455 In Moderate To Severe Uncontrolled Asthma
The study proposes to evaluate the safety and efficacy of PF-03715455 in moderate to severe asthma when added to standard of care and during staged withdrawal of background therapy.
- Trial name
- NCT02219048
- Testing
- PF-03715455
- Where
- 28 sites in United States
- Volunteers
- 51 people
- Sponsor
- Pfizer
Tobacco Use Disorder
Treating Schizophrenic Smokers: Effects on Craving, Cues and Withdrawal
This is a clinical research protocol to study the efficacy of combined varenicline (Chantix) and motivational interviewing (MI) for smoking cessation in a sample of smokers who have been diagnosed with schizophrenia or…
- Trial name
- NCT00781755
- Testing
- varenicline, Adaptation of Motivational Interviewing
- Where
- United States
- Sponsor
- VA Boston Healthcare System
Neonatal Abstinence Syndrome
Clonidine to Treat Iatrogenic-induced Opioid Dependence in Infants
Thousands of critically ill infants (and children) are exposed to opioids and benzodiazepines to achieve sedation and analgesia as part of routine care in neonatal and pediatric intensive care units.
- Trial name
- NCT01360450
- Testing
- Clonidine HCL, saline
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Johns Hopkins University
Organ Donation After Circulatory Death
Brain-based Prediction of the Dying Duration in Humans After Withdrawal of Life Sustaining Therapies to Inform Donation After Circulatory Death
The purpose of this study is to develop a new tool that uses information collected before life-sustaining treatments are withdrawn to better predict whether a patient will die within the time needed for organ donation to be…
- Trial name
- NeuroDCD (NCT07698262)
- Where
- 13 sites in Canada
- Volunteers
- 102 people
- Sponsor
- University of British Columbia
Narcolepsy Type 1 (NT 1)
A Study of TAK-994 in Adults With Narcolepsy
Adults with narcolepsy who have completed the TAK-994-1501 study will be able to take part in this study. The main aim of this study is to check if participants have side effects from TAK-994.
- Trial name
- NCT04820842
- Testing
- TAK-994
- Where
- 70 sites in United States, Canada and 8 more
- Volunteers
- 26 people
- Sponsor
- Takeda
Disorder Related to Renal Transplantation
Efficacy of Certican® in Combination With Myfortic® in Renal
The primary objective is to demonstrate the superiority of everolimus plus Myfortic® plus corticosteroids following CNI withdrawal at week 16 compared to tacrolimus plus Myfortic® plus corticosteroids as measured by the change in…
- Trial name
- HUSJ1 (NCT01399242)
- Testing
- Certican
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hospital Universitário São José
Patient Scheduled for Surgery
Evaluation of Pupillometry as a Predictor of Pain Intensity Upon Withdrawal of Sedation in the Postoperative Period Following Cardiac Surgery: A Prospective Cohort Study
Postoperative pain is a significant issue following surgery, and pain that is either inadequately treated or, conversely, overtreated can increase morbidity.
- Trial name
- PUPREA (NCT07648342)
- Testing
- Pupilometry, VAS
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Liver Transplantation
Withdrawal of Immunosuppression in Long Term Stable Liver Transplant Recipients
Long-term immunosuppression carries potential adverse effects such as risk of infection, malignancy, renal insufficiency, diabetes and hypertension.
- Trial name
- tolerance (NCT01198314)
- Testing
- immunosuppression withdrawal, continue of taking immunosuppressant
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The Catholic University of Korea
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