Clinical trials: Withdrawal
Colonic Polyp, Colonic Neoplasms
Combined Forward and Retroflexion Withdrawal in the Detection of Polyps and Adenoma During Colonoscopy
Colonoscopy is the standard of care for the detection of colorectal polyps and adenoma, and colorectal cancer detection. Despite a meticulous evaluation of the colonic mucosa during colonoscopy, a substantial number of colorectal…
- Conditions
- Colonic Polyp, Colonic Neoplasms, Colonic Adenoma
- Trial name
- NCT03901651
- Testing
- Colonoscopy with Retroview scope combing forward and retroflexed withdrawal technique, Colonoscopy with standard colonoscope and forward withdrawal technique
- Where
- Ecuador
- Volunteers
- 203 people
- Sponsor
- Instituto Ecuatoriano de Enfermedades Digestivas
Heart Rate Variability, Biofeedback, Nicotine Dependence, Nicotine Withdrawal, Anxiety, Depression, Insomnia
Effects of HRV Biofeedback on Autonomic Function and Nicotine Withdrawal Symptoms and Dependence in Smoking Cessation Adults
This study is a randomized controlled trial. It is estimated that 80 quitters will be recruited, and they will be randomly included in the experimental group and 40 in the control group.
- Trial name
- NCT04679636
- Testing
- heart rate variability biofeedback
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Defense Medical Center, Taiwan
Alcohol Use Disorder, Supplementation
Administration of Fiber as a Dietary Supplement to Improve the Management of Alcohol Withdrawal
The goal of this clinical trial is to demonstrate that a fiber-enriched diet (with a high proportion of inulin and pectin) combined with standard care can reduce intestinal permeability in patients with alcohol use disorder (AUD)…
- Conditions
- Alcohol Use Disorder, Supplementation, Intestinal Permeability
- Trial name
- FIB-ALC (NCT07371286)
- Testing
- Administration of fibers as a dietary supplement
- Volunteers
- 138 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Opioid Dependence, Acute Opioid Withdrawal Syndrome
Efficacy, Safety and Dose-Response Study Followed by Open-Label Study of Lofexidine Treatment of Opioid Withdrawal
The purpose of this study is to look at the efficacy and safety for lofexidine hydrochloride, an alpha-2 adrenergic agonist under development for the treatment of acute withdrawal from short-acting opioids.
- Trial name
- NCT01863186
- Testing
- Lofexidine HCl, Open Label Lofexidine HCL
- Where
- 18 sites in United States
- Volunteers
- 603 people
- Sponsor
- USWM, LLC (dba US WorldMeds)
Neonatal Abstinence Syndrome
Assessing the Effects of Auricular Acupressure on Newborns With NAS
This study will determine the feasibility of using auricular acupressure as an intervention in newborns with neonatal abstinence syndrome(NAS).
- Trial name
- NCT03890562
- Testing
- Auricular acupressure
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Virginia Commonwealth University
Gastroesophageal Reflux
Study Evaluating the Efficacy and Safety of Pantoprazole in Infants With Symptomatic Gastroesophageal Reflux Disease (GERD)
To assess the efficacy of pantoprazole for the treatment of infants with symptomatic Gastroesophageal Reflux Disease (GERD).
- Trial name
- NCT00365300
- Testing
- pantoprazole
- Where
- 38 sites in United States
- Volunteers
- 129 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Opiate Withdrawal Syndrome
Neurostimulation for Opiate Withdrawal in the PICU
This is a prospective pilot study to investigate the effects of Percutaneous Electrical Nerve Field Stimulation (PENFS) on symptoms of opioid withdrawal in pediatric patients in the intensive care unit.
- Trial name
- NOW (NCT03975192)
- Testing
- Percutaneous Electrical Nerve Field Stimulation
- Where
- United States
- Sponsor
- Medical College of Wisconsin
Cannabis Dependence, Tobacco Use
Characterization of the Pattern of Consumption and Withdrawal Syndrome From Dual Cannabis and Tobacco Use
Aims: To characterize the pattern of cannabis and tobacco use and withdrawal symptoms in people who start treatment for cannabis use disorders (exclusive cannabis, concurrent and/or simultaneous with various tobacco products)…
- Conditions
- Cannabis Dependence, Tobacco Use, Withdrawal Syndrome, Substance Abuse
- Trial name
- DuCATA_GAMCaT (NCT05512091)
- Volunteers
- 282 people
- Sponsor
- Cristina Martínez Martínez
Major Depressive Disorder, Anxiety
Brexpiprazole (OPC-34712) as an Adjunctive Treatment in Adults With Major Depressive Disorder and Anxiety Symptoms
The purpose of this study is to investigate the efficacy and safety of flexibly dosed adjunctive brexpiprazole treatment in subjects with major depressive disorder and anxiety symptoms, who are experiencing an inadequate…
- Trial name
- NCT02013531
- Testing
- Brexpiprazole
- Where
- 21 sites in United States
- Volunteers
- 37 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Opiate Addiction
Safety Study of Intravenous 6β-Naltrexol (AIKO-150) in Opioid-Dependent Subjects
The purpose of this study is to evaluate the safety and efficacy of intravenous 6β-Naltrexol administered to opiate dependent subjects
- Trial name
- AIKO-150 (NCT00829777)
- Testing
- 6β-Naltrexol escalating doses from 0.05-0.5 mg IV
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- California Pacific Medical Center Research Institute
Alcohol Withdrawal
Study of Exploratory Plasmatic Markers of Alcohol Withdrawal
This research focuses on alcohol withdrawal in hospitals and its potential neurological consequences. Alcohol withdrawal is an event that induces physical symptoms, such as tremors, sweating, anxiety and requires medical support.
- Trial name
- STEP-AW (NCT05216705)
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Opioid Use Disorder
Impact of Bridge™ Device to Treat Opioid Withdrawal Symptoms
The purpose of this prospective study is to investigate the efficacy of the Bridge™ device in reducing the symptoms of opioid withdrawal in a blind comparison to a sham device.
- Trial name
- NCT05924945
- Testing
- Bridge™ active device
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Masimo Corporation
Retirement
Residual Athletic Identity, Body Image, and Emotional Symptoms in Retired Rhythmic Gymnasts
Background. Rhythmic gymnastics is a sport characterized by high physical and aesthetic demands and typically early competitive retirement.
- Trial name
- NCT07408752
- Testing
- Adult retired rhythmic gymnasts
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Oviedo
Social Withdrawal of Childhood or Adolescence, Preterm Infant
The Effect of a Neonatologist's Standardized Guidance Intervention on Preterm Infants With Relational Withdrawal.
The objective of this project is to determine the effect of the verbal intervention on the decrease in sustained social withdrawal in late and moderately late preterm infants.
- Trial name
- NCT03212547
- Testing
- Verbal Intervention
- Where
- 2 sites in Chile
- Volunteers
- 110 people
- Sponsor
- Clinica Alemana de Santiago
Substance Use Disorder, Cocaine Dependence
Cannabidiol and Cocaine Craving/Dependence
In this study, the investigators seek to evaluate the effects of cannabidiol (CBD) on cocaine craving and relapse. Cocaine addiction is characterized by compulsive substance use and repetitive urges to consume the drug even after…
- Conditions
- Substance Use Disorder, Cocaine Dependence, Withdrawal From Addictive Substance; Detoxification
- Trial name
- CBD (NCT02559167)
- Testing
- Cannabidiol
- Where
- Canada
- Volunteers
- 79 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Smoking
Genetic Differences in Limbic Activation Associated With Nicotine Withdrawal
Objectives: To evaluate neural correlates associated with emotional processing during nicotine withdrawal preferentially involving the amygdala and associated areas within the corticolimbic and mesolimbic circuitry.
- Trial name
- NCT00664404
- Testing
- Functional Magnetic Resonance Imaging (fMRI)
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Crohn Disease
Crohn Disease Exclusion Diet After Single Medication De-escalation
The primary objective of this study is to determine whether pediatric Crohn Disease (CD) patients in long-standing remission remain in remission longer after stopping medications if they follow the Crohn's Disease Exclusion Diet…
- Trial name
- CEASE (NCT02472457)
- Testing
- Crohn Disease Exclusion Diet, Free Diet
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Children's Hospital of Philadelphia
suspensión Completa Del Tratamiento Con Benzodicepinas, Disminución Del Consumo Benzodiacepinas
Evaluation of the Effectiveness of a Psychoeducational Intervention on Benzodiazepine Use in the Population Over 64 Years Old in Primary Care
The goal of this pragmatic, multicenter, randomized controlled trial is to determine whether a multidisciplinary psychoeducational intervention combined with therapeutic exercise is more effective than a minimal educational…
- Trial name
- BENZOS-AP (NCT06950567)
- Testing
- psycho-educational intervention and therapeutic activity, Control
- Where
- Spain
- Volunteers
- 122 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Cannabis Dependence, Cannabis Withdrawal
Clinical and Neurobiological Effects of Cannabis Dependence in Young Adults
The purpose of this study is to find out more about cognitive functioning in people who are cannabis dependent, relative to people who do not use cannabis, and how their brains process information after one month of not using…
- Trial name
- SCCAN (NCT00656487)
- Testing
- rimonabant
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- The Scripps Research Institute
Cardiovascular Disease Other, Bleeding
Transfusion of Cold-stored Platelet Concentrates
This study will investigate the effects of Leukocyte reduced cold-stored platelet transfusions used in treatment of immediate postoperative blood loss in patients undergoing thoracic surgery in combination with extracorporal…
- Conditions
- Cardiovascular Disease Other, Bleeding, Surgery
- Trial name
- 4CPLT (NCT02495506)
- Testing
- Cold stored platelets, Room temperature platelets
- Where
- Norway
- Volunteers
- 65 people
- Sponsor
- Haukeland University Hospital
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