Clinical trials: Withdrawal
Chronic Headache
Feasibility Study of Normobaric Oxygen Delivered by a High Flow Concentrator in the Treatment of Chronic Headache
Chronic headache is most often associated with drug abuse and medication overuse headache (MOH) is the main complication of migraine disease results in chronic daily headache.
- Trial name
- O214 (NCT02302027)
- Testing
- platinium IRC9LXO2AWQ
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Association pour la Recherche au Centre d'Urgence des Céphalées
Opioid Use Disorder, Opioid Withdrawal
Suboxone Dispenser for OUD
The goal of this study is to evaluate the usability and acceptability of the Addinex system with patients receiving Suboxone in OUD treatment.
- Trial name
- NCT05790551
- Testing
- Addinex
- Where
- United States
- Sponsor
- Addinex Technologies, Inc.
Deep Venous Thrombosis
D-Dimer Guided Oral Anticoagulant Treatment (OAT)
This clinical trial will investigate the hypothesis that D-Dimer testing can be successfully used to tailor the duration of OAT in patients after an unprovoked episode of deep venous thrombosis (DVT) using a prospective…
- Trial name
- DDOAT2006 (NCT00895505)
- Testing
- Phenprocoumon, Warfarin-Natrium
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- University Hospital, Bonn
Hepatic Encephalopathy
A Study of Controlled Lactulose Withdrawal
After resolution of the initial episode of hepatic encephalopathy (HE), lactulose is routinely continued indefinitely as maintenance therapy.
- Trial name
- NCT00914056
- Testing
- lactulose
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Hunter Holmes Mcguire Veteran Affairs Medical Center
Chronic Pain, Low Back Pain
A Research Study of an Investigational Drug ALO-02 (Oxycodone Hydrochloride and Naltrexone Hydrochloride) in Patients With Moderate to Severe Chronic Low Back Pain
The primary objective of the study is to determine the analgesic efficacy and safety of ALO-02 extended-release capsules, when compared to placebo, in subjects with moderate to severe chronic low back pain.
- Conditions
- Chronic Pain, Low Back Pain, Analgesia
- Trial name
- NCT01571362
- Testing
- ALO-02
- Where
- 52 sites in United States
- Volunteers
- 410 people
- Sponsor
- Pfizer
Marijuana Abuse, Substance-Related Disorders
Effectiveness of Bupropion in Treating Marijuana Dependent Individuals
A definable and significant withdrawal syndrome occurs upon cessation of chronic, heavy marijuana use. Bupropion (Zyban) is a medication currently used to treat withdrawal symptoms associated with tobacco use.
- Trial name
- NCT00142870
- Testing
- Bupropion
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Alcohol Dependence, Alcohol Abuse
A Smartphone Based Intervention for the Prevention of Relapse in Alcohol Dependence
The rate of relapse following an inpatient alcohol rehabilitation program has been around 50% for a number of years. Offered treatments mainly focus on conscious and controllable aspects of behaviour, but research has found that…
- Conditions
- Alcohol Dependence, Alcohol Abuse, Alcohol Use Disorder
- Trial name
- SPIRA (NCT03952429)
- Testing
- Anti Alcohol App with Active Cognitive Bias, Inactive Cognitive Bias Modification
- Where
- Germany
- Volunteers
- 600 people
- Sponsor
- Salus Klinik Lindow
Major Depressive Disorder
Quetiapine Fumarate as Monotherapy in the Maintenance Treatment of Patients With Major Depressive Disorder
The purpose of this study is to determine safety \& efficacy of SEROQUEL SR™ in the treatment of major depressive disorder compared to placebo \& to evaluate quality of sleep, overall quality of life, and effect, if any, on…
- Trial name
- AMETHYST (NCT00278941)
- Testing
- Quetiapine Fumarate Sustained Release
- Where
- 168 sites in United States, Bulgaria and 6 more
- Volunteers
- 3,000 people
- Sponsor
- AstraZeneca
Heart Failure (HF)
Systematic Withdrawal of Neurohumoral Blocker Therapy in Optimally Responding CRT Patients
The primary objective of this study is to demonstrate that in patients with recuperated/normalized left ventricular function, defined as an ejection fraction (EF) ≥ 50%, after implantation of cardiac resynchronization therapy…
- Trial name
- STOP-CRT (NCT02200822)
- Testing
- beta blockers, RAAS blockers
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Hasselt University
Nicotine Withdrawal
Sensorimotor Replacement With Electronic and De-nicotinised Cigarettes
There are currently two sensorimotor replacement products which may be of benefit in smoking cessation: de-nicotinised cigarettes (denics) and electronic cigarettes (ECs), and the purpose of this project is to investigate whether…
- Trial name
- SenRep (NCT01414998)
- Testing
- Stress Ball vs Nicotine-free E-Cigarette, Nicotine-free E-Cigarette vs De-nicotinised Cigarette
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Adenomatous Polyp of Colon
The Utility of Time Segmental Withdrawal During Screening Colonoscopy for Increasing Adenoma Detection Rate.
Colonoscopy( examining the colon with a flexible tube and a camera ) is usually done for screening purposes to find any precancerous lesions (polyps) at an early stage.
- Trial name
- NCT02538406
- Testing
- Segmental withdrawal
- Where
- United States
- Volunteers
- 232 people
- Sponsor
- Baylor College of Medicine
Electronic Cigarettes
Effects of e-Cigarettes on Nicotine Withdrawal
This behavioral pharmacology laboratory experiment will assess whether sweet (vs. non-sweet) flavored e-cigarette solutions reduce tobacco withdrawal symptoms and motivation to smoke among 40 smokers interested in trying…
- Trial name
- NCT03098004
- Testing
- e-Cigarette
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Irritable Bowel Syndrome
Multicenter Withdrawal Clinical Trials of N-acetyl Glucosamine Capsule for IBS-D Treatment
This study is a withdrawal randomized clinical trail to evaluate the clinical efficacy and safety of 1.1 chemical drugs N-acetyl glucosamine on Chinese IBS-D patients coming from four centers in chongqing.
- Trial name
- NCT01893606
- Testing
- N-acetyl-D-glucosamine
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Third Military Medical University
Intestinal Polyps
A Comparison of Two Colonoscopic Withdrawal Techniques
This study will compare two strategies for colonoscope withdrawal, using polyp detection as the primary outcome measure, to determine the optimal withdrawal strategy.
- Trial name
- NCT01554098
- Testing
- Strategy : Supine first, Strategy : dynamic first
- Where
- United Kingdom
- Volunteers
- 130 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Parkinson's Disease
Psychiatric and Cognitive Manifestations of Parkinson's Disease
Parkinson's Disease (PD) is often thought of as affecting movement only. In fact, most patients also experience psychiatric and cognitive symptoms, sometimes from the disease itself, and sometimes as a side-effect of PD…
- Trial name
- NCT00360633
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Schizophrenia
Efficacy & Safety of SCH 900435 in Schizophrenia (Study P06079)(WITHDRAWN)
The purpose of this study is to assess whether SCH 900435 (Org 25935) 16 mg twice daily is more effective than placebo in the treatment of patients with schizophrenia, using olanzapine 15 mg once daily as active control.
- Trial name
- GUEST (NCT00988728)
- Testing
- SCH 900435 (Org 25935), Olanzapine
- Sponsor
- Merck Sharp & Dohme LLC
MMR on 12 Month
Withdrawal or Reduction TKIs in CML-CP
Compare MMR on 12 month treated with half TKIs(including imatinib, dasatinib, and nilotinib) or TKIs withdrawal.
- Trial name
- NCT04143087
- Testing
- withdrawal TKIs or halve TKIs
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Respiratory Physiotherapy, Resuscitation
Does Respiratory Physiotherapy Allow for Earlier Withdrawal of Mechanical Ventilation in Respiratory Resuscitation Service?
Respiratory physiotherapy is not routinely prescribed in the resuscitation department and few studies deal with this subject, especially in respiratory resuscitation
- Trial name
- KISEVEN (NCT03114787)
- Testing
- Study on patients with respiratory resuscitation
- Where
- France
- Volunteers
- 17 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Nicotine Dependence, Cigarettes, With Withdrawal
A Dietary Supplement for Early Cigarette Withdrawal
The purpose of this study is to determine whether a dietary supplement (DS) is effective in protecting against sad mood during early cigarette withdrawal.
- Trial name
- CIGAR (NCT02042521)
- Testing
- Dietary Supplement
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- Centre for Addiction and Mental Health
Spondylitis, Ankylosing
Etanercept Withdrawal And Retreament Study In Subjects With Nr-ax SpA
The purpose of this study is to study the benefits and risks of etanercept withdrawal in patients who have achieved a significant clinical response.
- Trial name
- RE-EMBARK (NCT02509026)
- Testing
- Etanercept
- Where
- 82 sites in United States, Australia and 12 more
- Volunteers
- 210 people
- Sponsor
- Pfizer
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