Clinical trials: Withdrawal
Cannabis Use, Cannabis Dependence
Neuroimaging of Adolescent Cannabis Use Treatment
This study is testing whether brain activity related to learning can help predict how well teens respond to a treatment program designed to reduce cannabis use.
- Conditions
- Cannabis Use, Cannabis Dependence, Cannabis Use Disorder, Cannabis Abuse
- Trial name
- ACT (NCT07340554)
- Testing
- Contingency Management, Elastic Net Regression
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Indiana University
Pain, Pain, Acute
Assessing Opioid Care Practices Using CPV Patient Simulation Modules
This study will test the quality of opioid-related physician care decisions using a patient-simulation based measurement and feedback approach that combines multiple-choice care decisions with real-time, personalized scoring and…
- Conditions
- Pain, Pain, Acute, Pain, Chronic, Pain, Neuropathic
- Trial name
- NCT04080037
- Testing
- Quality IQ Patient Simulations
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Qure Healthcare, LLC
Tobacco Use Disorder
Project 4, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Pregnant Women
Study 2 will evaluate the effects of extended exposure to cigarettes with varying levels of nicotine in pregnant smokers who have less than an Associate's degree. This study will be limited to two conditions: usual brand vs.
- Trial name
- NCT04033237
- Testing
- Very low nicotine content cigarettes
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Hypogonadism, Hypogonadism, Male
A Randomized, Double-blinded, Clinical, Placebo-controlled Trial on the Effects of Therapy With Letrozole and hUman Choriongonadotropin in Male Hypogonadism Induced by Illicit Use of Anabolic Androgenic Steroids- The LUCAS Trial
The overall objective of this randomized trial is to investigate the effects of treatment of AAS- induced male hypogonadism with combined therapy of letrozole and hCG compared with placebo on reproductive hormone levels…
- Conditions
- Hypogonadism, Hypogonadism, Male, Hypogonadotropic Hypogonadism
- Trial name
- NCT05205837
- Testing
- Letrozole 2.5mg, hCG
- Where
- Denmark
- Volunteers
- 8 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Critical Care, Palliative Care
An Algorithmic Approach to Ventilator Withdrawal at the End of Life
The proposed study is an important, under-investigated area of ICU care for terminally ill patients undergoing terminal ventilator withdrawal.
- Trial name
- NCT03121391
- Testing
- Ventilator withdrawal algorithm
- Where
- 5 sites in United States
- Volunteers
- 165 people
- Sponsor
- Wayne State University
Differentiated Thyroid Carcinoma, TCM Syndrome Type
Correlation Between TCM Syndrome Factors and TSH Changes of Thyroid Hormone Withdrawal Before Iodine Therapy in Postoperative Patients With Thyroid Cancer
The purpose of this study is to make a dialectical classification of patients who will receive 131I treatment after operation of thyroid cancer from the point of view of dialectics of syndrome elements of traditional Chinese…
- Trial name
- NCT04916262
- Volunteers
- 160 people
- Sponsor
- Qianfoshan Hospital
Brain Health Retired Elite Athletes
Long-term Brain Health of Retired Professional Rugby Players, With a History of Concussion/Head Impact Exposure
There has been significant recent interest on the issue of brain health in athletes. Participation in sports is generally viewed as extremely positive.
- Trial name
- NCT03544346
- Testing
- Exploratory brain and general health assessment
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Dublin, Trinity College
Cocaine Dependence
Effect of Zonisamide on Cocaine Reinforcement, Craving, and Relapse
This is a residential pilot trial to evaluate the pharmacodynamic interaction between zonisamide and cocaine, with the goal of evaluating zonisamide's potential for the treatment of cocaine dependence.
- Trial name
- NCT01137890
- Testing
- Zonisamide, Cocaine Hydrochloride, Neurocognitive and Performance Battery
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Johns Hopkins University
Renal Transplant
Calcineurin Inhibitor Based Immunosuppression Withdrawal
Damage and scarring of a transplanted kidney has become the most common cause of loss of the transplanted kidney. This kidney damage is a complex process caused by many factors including injury during obtaining and transplanting…
- Trial name
- CNI-W (NCT02117596)
- Testing
- Sirolimus
- Where
- 4 sites in United States
- Volunteers
- 52 people
- Sponsor
- Pediatric Nephrology of Alabama
Kidney Transplantation
Safety/Efficacy of Induction Agents With Tacrolimus, MMF, and Rapid Steroid Withdrawal in Renal Transplant Recipients
The purpose of this study is to compare the safety and efficacy of different induction agents (alemtuzumab, basiliximab or rabbit anti-thymocyte globulin) in renal transplant recipients treated with tacrolimus, mycophenolate…
- Trial name
- INTAC (NCT00113269)
- Testing
- basiliximab, rabbit anti-thymocyte globulin, tacrolimus
- Where
- 29 sites in United States
- Volunteers
- 501 people
- Sponsor
- Astellas Pharma Inc
Heart Failure
The Assessment of Partial Guideline-Directed Medical Therapy Down Titration in Heart Failure in Remission.
Heart failure (HF) is a chronic condition that is characterized by a weakened and enlarged heart. It typically causes symptoms such as breathlessness and swelling of the legs, and it is a serious illness that shortens life…
- Trial name
- TAPERED-HF (NCT07513883)
- Testing
- Down-titration, Continuation of guideline-directed heart failure therapy
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Ziekenhuis Oost-Limburg
Hepatitis C, Chronic, Hepatitis C
An Observational Study of Patients With Chronic Hepatitis C Undergoing Treatment With PegIntron and Rebetol in Clinical Practice in Belgium (Study P05494)(WITHDRAWN)
This is an observational study of patients undergoing treatment with PegIntron and Rebetol for chronic hepatitis C in clinical practice in Belgium. Treatment will not be administered as part of the study.
- Trial name
- PEGIMPACT (NCT00704756)
- Testing
- PegIntron (peginterferon alfa-2b; SCH 54031), Rebetol (ribavirin; SCH 18908)
- Sponsor
- Merck Sharp & Dohme LLC
END STAGE RENAL DISEASE
ESTEROID WITHDRAWAL STUDY, SAFETY AND EFFICACY IN RENAL TRANPLANTATION
BACKGROUND: Non-steroid maintenance immunosuppression after transplantation can improve long-term lipid and hemodynamic profiles without severe acute rejection (AR) events that alter graft function or survival.
- Trial name
- ESWMEX001 (NCT02328222)
- Testing
- ESW group
- Where
- Mexico
- Volunteers
- 71 people
- Sponsor
- Unidad de Investigacion Medica en Enfermedades Renales
Schizophrenia
Clinical Trial Evaluating the Efficacy, Safety, and Tolerability of Cariprazine in a Dose-Reduction Paradigm in the Prevention of Relapse in Participants With Schizophrenia
1. To evaluate the efficacy and safety of cariprazine at a target dose of 4.5 milligram per day (mg/d) compared with placebo in prevention of relapse in patients with schizophrenia 2.
- Trial name
- NCT03593213
- Testing
- Cariprazine
- Where
- 97 sites in United States, Bulgaria and 9 more
- Volunteers
- 587 people
- Sponsor
- AbbVie
Social Anxiety Disorder
RESCCUE4 - Group CBT for Social Anxiety in Adolescents
This randomized controlled trial aims to evaluate the efficacy of a 2-month group Cognitive Behavioral Therapy (CBT) intervention compared to a structured psychoeducational treatment as usual (TAU) in adolescents diagnosed with…
- Trial name
- NCT07464561
- Testing
- Group Cognitive Behavioral Therapy, Psychoeducational Group Intervention
- Where
- Italy
- Volunteers
- 34 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Healthy
Fit & Active Retirement: A Physical Function Programme for Young-old Retirees
Physical inactivity is the fourth leading cause of mortality in the world; as such, the World Health Organization (WHO) recommends that adults engage in at least 150 minutes of moderate-intensity physical activity every week.
- Trial name
- Fit&Active (NCT06972342)
- Testing
- education
- Where
- Hong Kong
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Non-24-Hour Sleep-Wake Disorder
Withdrawal Study to Demonstrate the Maintenance Effect in the Treatment of Non-24-Hour Sleep-Wake Disorder
The purpose of this study is to evaluate the maintenance effect and safety of 20 mg tasimelteon versus placebo in subjects suffering from Non-24-Hour Sleep-Wake Disorder.
- Trial name
- NCT01430754
- Testing
- tasimelteon
- Where
- 22 sites in United States
- Volunteers
- 20 people
- Sponsor
- Vanda Pharmaceuticals
Liver Transplant Recipients, Liver Transplantation
Immunosuppression Withdrawal for Stable Pediatric Liver Transplant Recipients
The primary objective of this study is to assess the efficacy of immunosuppression withdrawal (ISW) in pediatric liver transplant (tx) recipients.
- Conditions
- Liver Transplant Recipients, Liver Transplantation, Immunosuppression
- Trial name
- iWITH (NCT01638559)
- Testing
- Immunosuppression withdrawal
- Where
- 12 sites in United States, Canada
- Volunteers
- 161 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Kidney Transplant Rejection, Kidney Transplant; Complications
Added Value of 18 FDG Pet-scanner in Diagnosis and Management of Subclinical Rejection in Kidney Transplant Patients
The renal biopsy (RB) represents the gold-standard for the diagnosis of acute renal transplant rejection (AR), and allows early verification of a so-called "subclinical" rejection, ie without any clinical or biological…
- Trial name
- NCT04702022
- Testing
- 18FDG PET / CT
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- University of Liege
Smoking, Smoking Cessation
Mindfulness Training Plus Oxytocin Effects on Smoking Behavior
The purpose of this study is to examine the effects of mindfulness training and a drug called oxytocin on smoking.
- Trial name
- MOXY (NCT03819231)
- Testing
- Oxytocin, Mindfulness, Saline Solution
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Southern California
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