Clinical trials: Withdrawal
Colonoscopy
Artificial-intelligence-based Reporting Technology for Endoscopy Monitoring and Imaging System
Properly documenting withdrawal time in colonoscopy is essential for quality assessment and cost allocation. However, reporting withdrawal time has significant interobserver variability.
- Trial name
- ARTEMIS (NCT06094270)
- Testing
- EndoMind
- Where
- Germany
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Wuerzburg University Hospital
Drug Withdrawal Headache
Postoperative Headache in Elective Surgery Patients
To evaluate the association of anaesthesia and surgery with postoperative headache in elective surgery patients By multiple logistic regression analysis of data collected during a six-month period from 446 patients undergoing…
- Trial name
- NCT02374346
- Volunteers
- 494 people
- Sponsor
- Attikon Hospital
Withdrawal; Therapeutic Substance
Protocolized Initiation of Clonidine to Prevent Dexmedetomidine Withdrawal
The purpose of this study is to determine if the protocolized use of clonidine will reduce dexmedetomidine withdrawal symptoms, reduce PICU length of stay, and reduce costs related to sedation during hospital admission.
- Trial name
- NCT05575219
- Testing
- Clonidine (without protocolized initiation), Clonidine (protocolized initiation)
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- The University of Texas Health Science Center, Houston
Rheumatoid Arthritis
The Role of Tofacitinib in Steroid Withdrawal in Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a systemic chronic arthritis characterized by systemic inflammation, persistent synovitis and final joint destruction Inflammatory diseases can lead to decreased productivity and impaired…
- Trial name
- NCT04927000
- Testing
- Tofacitinib
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Obstructive Sleep Apnea
"Six-week Study of the Safety and Efficacy of JZP-110 in the Treatment of Excessive Sleepiness in OSA"
This trial is a 6-week, double-blind, placebo-controlled, randomized-withdrawal, multicenter study of safety and efficacy of JZP-110 in the treatment of excessive sleepiness in adult subjects with OSA.
- Trial name
- OSA (NCT02348619)
- Testing
- JZP-110
- Where
- 30 sites in United States, Finland and 3 more
- Volunteers
- 174 people
- Sponsor
- Jazz Pharmaceuticals
Opioid-Related Disorders, Drug Addiction
Medication Treatment for Opioid Use Disorder in Expectant Mothers: Conceptual Model Assessments Sub-study
This is a sub-study of NIDA CTN Protocol 0080: Medication Treatment for Opioid Use Disorder in Expectant Mothers (MOMs; Unique protocol ID: 2019-0429-1).
- Conditions
- Opioid-Related Disorders, Drug Addiction, Pregnancy Related, Substance Abuse
- Trial name
- MOMs-CMA (NCT03911466)
- Testing
- Buprenorphine Injection, Buprenorphine Sublingual Product
- Where
- 12 sites in United States
- Volunteers
- 97 people
- Sponsor
- T. John Winhusen, PhD
Autoimmune Diseases
Withdraw Drug in Stable IgG4-Related Disease
Evaluation and prediction of relapse risk after glucocorticoid or immunosuppressant withdrawal in patients with stable IgG4 related disease: a prospective cohort study from china.
- Trial name
- NCT04124861
- Testing
- Drug free, IS monotherapy and GC combined with IS
- Where
- China
- Volunteers
- 138 people
- Sponsor
- Peking Union Medical College Hospital
Schizophrenia
A Physical Dependence Study in Schizophrenia
The purpose of this study is to determine whether or not people with schizophrenia who take LY2140023 become physically dependent on it, and experience a series of symptoms such as craving to have the drug when they stop using…
- Trial name
- NCT01452919
- Testing
- LY2140023
- Where
- 10 sites in United States, Greece
- Volunteers
- 123 people
- Sponsor
- Denovo Biopharma LLC
Kidney Failure, Graft Rejection
Study Evaluating Two Different Sirolimus-based Immunosuppressive Regimens in Elderly Kidney Transplant Recipients
The purpose of this study is to test two different sirolimus-based immunosuppressive regimens for elderly kidney transplant recipients.
- Conditions
- Kidney Failure, Graft Rejection, Aged
- Trial name
- NCT00254709
- Testing
- Sirolimus
- Volunteers
- 66 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Cigarette Smoking, Nicotine Dependence
Nicotine Withdrawal and Reward Processing
This study is designed to find out how smoking affects the way the brain responds to pleasure and how this impacts smokers' behavior. Participants will complete three sessions.
- Conditions
- Cigarette Smoking, Nicotine Dependence, Nicotine Withdrawal
- Trial name
- NicWith (NCT05041959)
- Testing
- Smoking Abstinence, Ad Lib Smoking
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Benzodiazepines
The Contribution of Melatonin Vs. Placebo in Benzodiazepine Withdrawal in Methadone Maintenance Treatment Patients
We hypothesized that patient will success in benzodiazepine withdrawal if they get melatonin to solve sleep-problems which commonly occur during benzodiazepine withdrawal.
- Trial name
- NCT00261183
- Testing
- Melatonin
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Marijuana Dependence
Effect of Baclofen on Marijuana Withdrawal and Relapse
The purpose of this study is to determine if baclofen dose-dependently decreases marijuana's direct effects and symptoms of marijuana withdrawal and thus decreases marijuana relapse.
- Trial name
- NCT00373295
- Testing
- Baclofen, Marijuana
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Pulmonary Disease, Chronic Obstructive
Inhaled Corticosteroid Withdrawal in Patients With Chronic Obstructive Pulmonary Disease
This is a randomised study to be conducted in patients with severe to very severe Chronic Obstructive Pulmonary Disease (COPD) to establish whether there is a need for these patients to be continuously treated with an inhaled…
- Trial name
- NCT00975195
- Testing
- tiotropium inhalation, salmeterol xinafoate, fluticasone propionate
- Where
- 222 sites in Australia, Belgium and 21 more
- Volunteers
- 2,488 people
- Sponsor
- Boehringer Ingelheim
Spondylitis, Ankylosing, Recurrence
Relapse of Ankylosing Spondylitis Patients Withdrawal Etanercept After Clinical Remission: a Following-up Study
The inclusion criteria was patients who aged 18 or older with ankylosing spondylitis, fulfilled the 1984 modified New York criteria for AS.
- Trial name
- NCT02915354
- Testing
- Etanercept
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Sun Yat-sen University
Smoking, Sleep Disturbance
Racial Differences in Circadian and Sleep Mechanisms for Nicotine Dependence, Craving, and Withdrawal
The number one preventable cause of death in the world is tobacco use. Cigarette smoking in particular, costs an estimated $300 billion due to expenses related to medical care and lost productivity.
- Conditions
- Smoking, Sleep Disturbance, Nicotine Dependence
- Trial name
- NCT03968900
- Testing
- Sleep restriction condition, Sleep extension condition
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Alabama at Birmingham
Juvenile Idiopathic Arthritis (JIA)
Toward Personalized Medicine to Guide Drug Withdrawal in Children with Juvenile Idiopathic Arthritis in Clinical Remission
Biologic therapies made clinical remission an achievable goal for most juvenile idiopathic arthritis (JIA) patients. Nevertheless, antirheumatic drugs have side effects and are costly.
- Trial name
- Re-JIA (NCT06618937)
- Testing
- Treatment medication withdrawal strategy
- Where
- Italy
- Volunteers
- 166 people
- Sponsor
- Istituto Giannina Gaslini
Vascularized Composite Allotransplantation
Withdrawal of Immunosuppression in Recipients of Face and Extremity Transplants
Many patients suffer from devastating injuries to vascularized composite tissues. Vascularized composite tissues are blocs of functional tissue that can contain multiple tissue types such as bone, muscle, nerves, blood vessels…
- Trial name
- NCT01853111
- Testing
- Interleukin-2
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Brigham and Women's Hospital
Alcohol Withdrawal, Psychophysiologic Reaction
Auricular Vagal Stimulation in Alcohol Craving
Background: The cause of the vegetative symptoms is a sympathetic driven misbalance of the autonomous nervous system. To restore vegetative balance in alcohol withdrawal syndrome new neuro-modulatory methods, such as percutaneous…
- Trial name
- VNS_CRAV (NCT05131334)
- Testing
- auriStim, for auricular vagal stimulation
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Post-Concussion Syndrome
ATCell™ Expanded Autologous, Adipose-Derived Mesenchymal Stem Cells Deployed Via Intravenous Infusion
This is a Phase 1 Clinical Safety Study intended to provide preliminary assessments of the safety, tolerability, and clinical alleviation of symptoms associated with Post Concussion Syndrome (PCS), also known as Chronic…
- Trial name
- NCT04744051
- Testing
- 50 Adipose Derived Stem Cell Infusion, 150 Adipose Derived Stem Cell Infusion, 300 Adipose Derived Stem Cell Infusion
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- American CryoStem Corporation
Alcoholism
Comparing Gabapentin and Lorazepam for Treating Alcohol Withdrawal
This study will evaluate a safe and useful medication for outpatient detoxification that is as effective as benzodiazepines in the short-term, and more effective in the protracted withdrawal period.
- Trial name
- NCT00011297
- Testing
- gabapentin (Neurontin), lorazepam (Ativan)
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
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