Clinical trials: Withdrawal
Alcohol Use Disorder
Anxiety During Abstinence in AUD
The goal of this study is to better understand the underlying neurobiological basis of anxiety that emerges during abstinence in patients with alcohol use disorder (AUD). The main questions it aims to answer are: 1.
- Trial name
- NCT06793488
- Testing
- Disulfiram 250 mg, functional MRI
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Columbia University
Alcohol Use Disorder, Alcohol Withdrawal
Effects of Ketone Supplementation on Acute Alcohol Withdrawal
The goal of this study is to study the effects of the ketone supplement Kenetik compared to placebo (an inactive beverage) on alcohol withdrawal symptoms during the 5 days of clinical alcohol withdrawal management treatment at…
- Conditions
- Alcohol Use Disorder, Alcohol Withdrawal, Alcohol Dependence, Ketosis
- Trial name
- NCT06173973
- Testing
- Kenetik; Ketone Concentrate
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Pennsylvania
RheumatoId Arthritis
Comparison of Two Strategies of Glucocorticoid Withdrawal in Rheumatoid Arthritis Patients
The purpose of this study is to compare the proportion of patients who could withdraw from prednisone and hydrocortisone one year after a progressive decrease of GC (GC tapering) or a hydrocortisone replacement therapy in…
- Trial name
- STAR (NCT02997605)
- Testing
- GlucoCorticoid
- Where
- 17 sites in France
- Volunteers
- 102 people
- Sponsor
- University Hospital, Toulouse
Wilson Disease
Study to Assess Long-Term Outcomes of Trientine in Wilson Disease Patients Withdrawn From Therapy With d-Penicillamine
A study to review Wilson disease patients who have previously been prescribed d- Penicillamine but were changed to trientine as treatment for their disease, and to follow them for a further 12 months.
- Trial name
- NCT02426905
- Testing
- trientine dihydrochloride
- Where
- 4 sites in Germany, Greece and 2 more
- Volunteers
- 90 people
- Sponsor
- Univar BV
Addiction
Progressive Muscle Relaxation and Cigarette Craving
Cigarette craving usually occurs with unpleasant feelings, including stress. Progressive Muscle Relaxation (PMR) may reduce level of cigarette craving and/or withdrawal symptoms.
- Trial name
- NCT02153775
- Testing
- Progressive Muscle Relaxation
- Where
- Thailand
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Surgery, Angiotensin Hypertension
Management of Angiotensin Inhibitors During the Perioperative Period
This is a multicenter randomized clinical trial to determine the effect of continuation versus withdrawal of angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) in the perioperative period on…
- Conditions
- Surgery, Angiotensin Hypertension, Perioperative Complication
- Trial name
- AIPOP (NCT04506372)
- Testing
- Perioperative withdrawal of angiotensin converting enzyme inhibitors and angiotenin receptor blockers, Blood draw, Diary to register drug adherence
- Where
- 7 sites in Canada, Netherlands
- Volunteers
- 342 people
- Sponsor
- UMC Utrecht
Hypertension
Dose Response of Valsartan on Sitting Systolic Blood Pressure in Children 6 Months - 5 Years of Age With High Blood Pressure
The purpose of this study is to evaluate the safety and efficacy of three doses of valsartan (0.25, 1.0, and 4.0 mg/kg) on mean sitting systolic blood pressure (MSSBP) and mean sitting diastolic blood pressure (MSDBP) in 6 months…
- Trial name
- NCT00435162
- Testing
- Valsartan 0.25 mg/kg, Valsartan 1.0 mg/kg, Valsartan 4.0 mg/kg
- Where
- 11 sites in United States, Belgium and 9 more
- Volunteers
- 74 people
- Sponsor
- Novartis Pharmaceuticals
Liver Diseases
Induction Treatment Followed by Immunosuppression Withdrawal in Liver Transplantation: A Comparative Trial
This is a randomized, controlled trial in liver transplantation in which conventional immunosuppressive treatment will be compared with a therapeutic strategy consisting in pre-transplant antibody-mediated T cell depletion…
- Trial name
- ATEGE-LIVER (NCT00436722)
- Testing
- ATG (Fresenius Biotech)
- Where
- Spain
- Volunteers
- 72 people
- Sponsor
- Hospital Clinic of Barcelona
Nicotine Dependence
Zonisamide Augmentation of Varenicline Treatment for Smoking Cessation
Randomized trial to evaluate whether zonisamide can enhance varenicline-induced smoking cessation.
- Trial name
- 1207 (NCT01685996)
- Testing
- zonisamide
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Johns Hopkins University
Trigeminal Neuralgia
An Efficacy and Safety Study of Basimglurant (NOE-101) in Patients With Trigeminal Neuralgia.
Trigeminal neuralgia (TN), also called "tic douloureux", is the most common form of craniofacial neuropathic pain and is considered the cause of one of the most painful afflictions known in medical practice.
- Trial name
- NCT05217628
- Testing
- Basimglurant
- Where
- 34 sites in United States, Denmark and 6 more
- Volunteers
- 166 people
- Sponsor
- Noema Pharma AG
Cocaine-Related Disorders
Effectiveness of Amantadine and Propranolol for Treating Cocaine Dependence - 2
Cocaine addiction is a serious health problem with no available medical treatment for preventing relapse. Amantadine, a medication that improves muscle control, and propranolol, a medication that lowers blood pressure, may be…
- Trial name
- NCT00158132
- Testing
- Propranolol, Amantadine
- Where
- United States
- Volunteers
- 199 people
- Sponsor
- University of Pennsylvania
Smoking Cessation
Nicotine Patch Trial in Syrian Primary Care Settings
The study is a two-arm, parallel group, randomized, placebo-controlled, double blind trial, conducted at four primary health care centers in Aleppo, Syria, to test the efficacy of transdermal nicotine patch therapy vs.
- Trial name
- NCT01085032
- Testing
- Transdermal Nicotine
- Where
- Syria
- Volunteers
- 269 people, healthy volunteers welcome
- Sponsor
- University of Memphis
Heart Failure
Medication Withdrawal in Stable HF With Improved LVEF
The goal of this clinical trial is to evaluate the safety and feasibility of withdrawing mineralocorticoid antagonists (MRA) in patients with stable heart failure with improved left ventricular ejection fraction (HFimpEF).
- Trial name
- SIMPLIFY-HF (NCT07489547)
- Testing
- Discontinuation of MRAs, Continue MRAs
- Where
- Brazil
- Volunteers
- 90 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
COVID-19
Impact of Long COVID-19 on the Health and Quality of Life of Military Personnel (Active or Retired) and Their Families
Severe and sometimes irreversible sequelae are observed in people who have developed a severe form of COVID-19 (pulmonary, cardiovascular, renal, neurological sequelae among others).
- Trial name
- IMP@LA (NCT05200832)
- Testing
- Online questionnaire, Semi-structured interview
- Where
- France
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Lymphoma, Chronic Hepatitis B
Hepatitis B Virus Reactivation After Withdrawal of Preemptive Antiviral Therapy in Hematologic Malignancy
Previous studies dealt with patients who maintained antiviral drugs for 2 ~ 6 months after final chemotherapy and they revealed that many of the patients who stopped preemptive antiviral drug within 6 months experienced viral…
- Trial name
- NCT02056548
- Volunteers
- 126 people
- Sponsor
- Seoul St. Mary's Hospital
Attention Deficit Hyperactivity Disorder
Efficacy & Safety of KAPVAY™ Extended-Release in Children & Adolescents With Attention Deficit Hyperactivity Disorder
The purpose of this study is to determine the long-term efficacy and safety of KAPVAY™ (clonidine hydrochloride) extended-release in children and adolescents with Attention Deficit Hyperactivity Disorder (ADHD)
- Trial name
- NCT01439126
- Testing
- clonidine hydrochloride
- Volunteers
- 135 people
- Sponsor
- Concordia Pharmaceuticals Inc., Barbados
Restless Legs Syndrome
A Study in Patients Suffering From Idiopathic Restless Legs Syndrome Who Responded to a Preceding, 6-month Treatment With Open-label Pramipexole Including Titration (0.125, 0.25, 0.5, 0.75 mg Orally q.n.)
The primary objective is to assess sustained efficacy in patients who have responded to a 6 month treatment with open-label pramipexole.
- Trial name
- NCT00152958
- Testing
- Pramipexole
- Where
- 12 sites in Germany
- Volunteers
- 224 people
- Sponsor
- Boehringer Ingelheim
Alcohol Withdrawal
Gabapentin vs Chlordiazepoxide for Ambulatory Alcohol Withdrawal
A randomized, double-blind controlled trial comparing treatment outcomes between chlordiazepoxide, or gabapentin to treat alcohol withdrawal syndrome in alcohol dependent veteran subjects.
- Trial name
- NCT01573052
- Testing
- Chlordiazepoxide, Gabapentin
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- VA Salt Lake City Health Care System
Schizophrenia, Schizoaffective Disorder
The Effects of Nicotine Withdrawal on Reward Responsivity in Schizophrenia
It has been suggested that patients with schizophrenia smoke in order to produce amelioration of dysfunctional dopaminergic pathways allowing them to experience pleasure and satisfaction and overcome anhedonia.
- Trial name
- NCT00373126
- Testing
- transdermal nicotine patch
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- North Suffolk Mental Health Association
Chronic HBV Infection, Drug Withdrawal
Effects of T-bet B Cells in Persistent Virus Control After Discontinuance of NAs in CHB Patients
The immune mechanism of the nucleos(t)ide analogs (NAs) in inhibiting HBV replication effectively while having a low sustained virus control rate after drug withdrawal is unclear.
- Trial name
- NCT06029634
- Testing
- T-bet B cell
- Where
- China
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
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