Clinical trials: Wound
Musculoskeletal Pain
Vitamin D to ENhance TraUma REcovery
The main objective of this study is to determine whether the administration of a single dose of Vitamin D in the Emergency Department following a motor vehicle collision can improve musculoskeletal pain severity as well as reduce…
- Trial name
- VENTURE (NCT05458024)
- Testing
- Vitamin D 2
- Where
- 4 sites in United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Brain Concussion
Enhanced Problem-Solving Training
Mild traumatic brain injury (mTBI) is among the most common injuries sustained by Veterans of Operations Enduring and Iraqi Freedom.
- Trial name
- E-PST (NCT03759223)
- Testing
- Enhanced Problem-Solving Training (E-PST), Healthy Living Messages (HLM), Enhanced Problem-Solving Training (E-PST) (non-randomized)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- VA Office of Research and Development
Endometritis, Wound Infection
Study of Effectiveness and Safety of Azithromycin-based Extended-spectrum Prophylaxis to Prevent Post Cesarean Infection
The Cesarean Section Optimal Antibiotic Prophylaxis (C/SOAP) study is a large pragmatic multi-center randomized clinical trial designed to evaluate the comparative effectiveness and safety of azithromycin-based extended-spectrum…
- Conditions
- Endometritis, Wound Infection, Abscess, Surgical Site Infection
- Trial name
- C/SOAP (NCT01235546)
- Testing
- Azithromycin and standard of care
- Where
- 9 sites in United States
- Volunteers
- 2,013 people
- Sponsor
- Alan Tita
Rotator Cuff Injuries, Shoulder Disease
Feasibility of an Analgesic Device Enabling Local Anesthetic Delivery and Neuromodulation After Shoulder/Foot Surgery
Postoperative pain remains undertreated with inadequate analgesic options. Opioids have well-known limitations for both individuals and society; single-injection and continuous peripheral nerve blocks provide intense analgesia…
- Conditions
- Rotator Cuff Injuries, Shoulder Disease, Hallux Valgus, Ankle Arthropathy
- Trial name
- NCT06818708
- Testing
- Experimental Treatment
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Diego
Anxiety Symptoms, Anxiety Disorders
TMS for Anxiety and Trauma-related Disorders
The present pilot study will apply accelerated intermittent theta burst stimulation (aiTBS) to a novel transcranial magnetic stimulation (TMS) target for anxiety derived via causal network mapping.
- Trial name
- NCT06475040
- Testing
- transcranial magnetic stimulation
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Shanghai Mental Health Center
Prematurity, Apnea
Caffeine to Reduce Mechanical Ventilation in Preterm Infants
Most premature infants require mechanical ventilation for prolonged periods of time and a significant proportion of them develop Bronchopulmonary Dysplasia (BPD).
- Conditions
- Prematurity, Apnea, Respiratory Failure
- Trial name
- NCT01751724
- Testing
- Caffeine citrate, Normal saline
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- University of Miami
Osteoporosis, Postmenopausal, Osteoporosis
Early Effects of Abaloparatide on Tissue-Based Indices of Bone Formation and Resorption
The objective of this study is to measure the early effects of abaloparatide on tissue-based bone formation using samples obtained by transiliac crest bone biopsy after quadruple fluorochrome labeling.
- Conditions
- Osteoporosis, Postmenopausal, Osteoporosis, Osteoporosis Vertebral, Osteoporosis Risk
- Trial name
- NCT03710889
- Testing
- Abaloparatide
- Where
- 4 sites in United States
- Volunteers
- 23 people
- Sponsor
- Radius Health, Inc.
Traumatic Brain Injury
Prehospital Tranexamic Acid Use for Traumatic Brain Injury
Primary aim: To determine the efficacy of two dosing regimens of TXA initiated in the prehospital setting in patients with moderate to severe TBI (GCS score ≤12).
- Trial name
- TXA (NCT01990768)
- Testing
- 1 gram Tranexamic Acid (TXA), 2 grams TXA, 0.9% Sodium Chloride injectable
- Where
- 12 sites in United States, Canada
- Volunteers
- 967 people
- Sponsor
- University of Washington
Surgical Wound Infection
Negative Pressure Wound Therapy for Prevention of Poststernotomy Infection
This prospective study evaluates the role of negative pressure wound therapy or wound VAC as a dressing over the incision to prevent poststernotomy wound infection in high risk patients.
- Trial name
- NCT02020018
- Testing
- Prevena Incision Management System, Conventional sterile dry wound dressing
- Where
- United States
- Volunteers
- 1,869 people
- Sponsor
- Mayo Clinic
Coma, Traumatic Brain Injury
Continuous Quantified EEG in NeuroIntensive Care
To evaluate the ability of NICU (NeuroIntensive Care Unit) staff to interpret, before and after a training period, symmetry, sedation level, seizures activities and artefact on continuous cEEG/qEEG (continuous…
- Conditions
- Coma, Traumatic Brain Injury, Subarachnoid Hemorrhage, Ischemic Stroke
- Trial name
- CrazyEEG (NCT02901262)
- Where
- 2 sites in Italy
- Volunteers
- 30 people
- Sponsor
- Azienda Ospedaliera San Gerardo di Monza
Insomnia, Traumatic Brain Injury
Non-Pharmacological Treatments for Insomnia in Chronic Traumatic Brain Injury
The purpose of this clinical trial is to assess the relative efficacy of two non-pharmacological interventions for insomnia in Veterans suffering from chronic mild traumatic brain injury (mTBI).
- Trial name
- NCT03261674
- Testing
- CBT-I, ABT-I
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- VA Office of Research and Development
Tendinopathy
Achilles Tendon Repair With Bioinductive Implant
To evaluate bioinduction of new tissue and tendon healing after implantation of the Rotation Medical Bioinductive Implant used as adjunct to surgical repair in the treatment of insertional Achilles tendonitis.
- Trial name
- NCT02811003
- Testing
- Rotation Medical Bioinductive Implant
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Smith & Nephew, Inc.
Wound Healing and Scar Quality Following Mohs Surgery and Excisional Dermatologic Surgery
Porcine Xenograft Versus Second Intention Healing
The purpose of this research study is to test whether it is better to allow patients with post- operative wounds on the legs to heal on their own without a covering or to use a porcine xenograft (skin graft that is made from pig…
- Trial name
- NCT03931746
- Testing
- Porcine xenograft
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- Northwell Health
Rupture, Venous Thromboembolism
Compression Treatment Effects on Complications and Healing of Achilles Tendon Rupture
This prospective randomized study aims to determine whether intermittent pneumatic compression (IPC), 75 patients, beneath functional bracing compared to treatment-as-usual in plaster cast, 75 patients, can reduce the Venous…
- Conditions
- Rupture, Venous Thromboembolism, Venous Thrombosis, Surgical Wound Infection
- Trial name
- NCT01317160
- Testing
- Intermittent pneumatic compression (IPC)
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Karolinska University Hospital
Radiographic Contrast Agent Nephropathy
Contrast Media Reduction and Removal in Patients With Chronic Kidney Disease (CKD) (PRESERV)
The purpose of this clinical trial is to demonstrate the efficacy and safety of the Osprey Medical CINCOR™ Contrast Removal System.
- Trial name
- NCT01168024
- Testing
- CINCOR™ System and contrast conservation unit (CCS-1), Standard of Care plus peri-procedural hydration
- Where
- 21 sites in United States, Germany
- Volunteers
- 16 people
- Sponsor
- Osprey Medical, Inc
Aging, Accidental Fall
Reducing CNS-Active Medications to Prevent Falls and Injuries in Older Adults
The overall objective of STOP-FALLS is to test whether a patient-centered deprescribing intervention that focuses on CNS-active medications reduces medically treated falls among older adults.
- Trial name
- STOP-FALLS (NCT05689554)
- Testing
- STOP Falls Educational Intervention
- Where
- United States
- Volunteers
- 2,367 people, healthy volunteers welcome
- Sponsor
- University of Washington
Concussion
Q-collar and Brain Injury Biomarkers
Significant morbidity, mortality, and related costs are caused by traumatic brain injury (TBI). A simple, effective, and lightweight device worn by athletes or war fighters in the field, designed to mitigate TBI resulting from…
- Trial name
- NCT02271451
- Testing
- Q collar
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Traumatic Brain Injury
Vasopressin Versus Catecholamines for Cerebral Perfusion Pressure Control in Brain Injured Trauma Patients
Traumatic brain injury (TBI) is among the leading causes of trauma death and disability in both civilian and military populations.
- Trial name
- AVP (NCT00795366)
- Testing
- arginine vasopressin, Standard catecholamine
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- University of Miami
Combat Disorders, Posttraumatic Stress Disorder
Exposure Therapy for Chronic PTSD: Efficacy and Mechanisms
The goals of the proposed research are to produce preliminary evidence of PE with OEF/OIF veterans with PTSD and to examine cognitive, psychophysiological, and neuroendocrine mechanisms of change in PTSD treatment.
- Trial name
- NCT00475241
- Testing
- Prolonged Exposure therapy for PTSD, Present centered therapy for PTSD
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder
Enhancement of PTSD Treatment With Computerized Executive Function Training
This study focuses on helping Iraq and Afghanistan Veterans with posttraumatic stress disorder (PTSD) benefit fully from therapy by first enhancing their thinking abilities.
- Trial name
- NCT03260127
- Testing
- Computerized executive function training plus CPT (CEFT-CPT), Word game training plus CPT (WT-CPT)
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- VA Office of Research and Development
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