Clinical trials: Wound Healing and Prevention
Endometrial Adenocarcinoma, Endometrial Carcinoma
Universal Endometrial Cancer DNA Sequencing for Detection of Lynch Syndrome and Personalized Care
This clinical trial studies universal screening for deoxyribonucleic acid (DNA) mismatch repair deficiency in patients with endometrial cancer, mutations in the genes responsible for Lynch syndrome (inherited forms of endometrial…
- Conditions
- Endometrial Adenocarcinoma, Endometrial Carcinoma, Lynch Syndrome, Relatives
- Trial name
- OPTEC (NCT03460483)
- Testing
- Genetic Counseling, Genetic Testing, Laboratory Biomarker Analysis
- Where
- 9 sites in United States
- Volunteers
- 1,001 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Lower Leg Wound
A Pilot Study of the WoundWand™ Debridement Device on Infection Prevention
A Pilot Study of the WoundWand™ Debridement Device on Infection Prevention
- Trial name
- WoundWand (NCT01924806)
- Testing
- WoundWand™ Debridement Device, Standard of Care sharp debridement
- Where
- 2 sites in France, United Kingdom
- Volunteers
- 11 people
- Sponsor
- Smith & Nephew, Inc.
Cleft Palate
The Role of Antibiotic Prophylaxis in Cleft Palate and Velopharyngeal Insufficiency Repair
Cleft Lip and Palate surgical repair is one of the most common procedures performed by Plastic and Reconstructive Surgeons in the World.
- Trial name
- Cleft Palate (NCT02688634)
- Testing
- Amoxicillin
- Where
- 2 sites in United States
- Sponsor
- University of Florida
Surgical Site Infection Prevention, Episiotomy Infection
Effect of Topical Diltiazem Plus Fusidic Acid Versus Fusidic Acid Alone on Episiotomy Healing, Pain, and Resumption of Sexual Activity: A Randomized Controlled Trial in Azadi Teaching Hospital
The goal of this clinical trial is to learn if diltiazem gel combined with fucidic acid cream works better than fucidic acid cream alone to prevent surgical site infection following episiotomy repair.
- Conditions
- Surgical Site Infection Prevention, Episiotomy Infection, Episiotomy Wound, Normal Vaginal Delivery
- Trial name
- NCT07545187
- Testing
- Group 1 received sequential topical diltiazem gel 2% followed by fusidic acid cream, and Group 2 received topical fusidic acid cream alone
- Where
- Iraq
- Volunteers
- 100 people
- Sponsor
- Alaa Nadhim Hameed
Colon Cancer, Rectal Cancer
Adherence to Colon Cancer Screening (ACCS)
This randomized clinical trial studies website access or genetic counseling with or without patient navigators on adherence to colorectal cancer screening recommendations in patients with newly diagnosed colorectal cancer and…
- Trial name
- NCT02112747
- Testing
- Patient Navigator
- Where
- United States
- Volunteers
- 1,900 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Familial Breast Cancer, Familial Colorectal Cancer
Direct Information to At-risk Relatives
This study evaluates if uptake of genetic counselling in high-risk families is increased when patients at cancer genetics clinics are being offered healthcare-assisted disclosure to at-risk relatives compared to current standard…
- Conditions
- Familial Breast Cancer, Familial Colorectal Cancer, Hereditary Breast and Ovarian Cancer Syndrome, Hereditary Breast Cancer
- Trial name
- DIRECT (NCT04197856)
- Testing
- Standard care encouraging family-mediated disclosure of hereditary cancer risk, Offer of health-care assisted disclosure by sending direct letters to at-risk relatives
- Where
- Sweden
- Volunteers
- 490 people
- Sponsor
- Umeå University
Wound Healing and Prevention, Oral Inflammation
Impact of Nd:YAG Laser Photobiostimulation on Healing of Gingiva
The intervention in this study is to determine whether multiple applications of photobiostimulation with Nd-YAG laser improve wound healing following tooth extraction and alveolar ridge preservation.
- Conditions
- Wound Healing and Prevention, Oral Inflammation, Photobiomodulation, Post-operative Pain Management
- Trial name
- NCT07095556
- Testing
- Low-level laser therapy
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Ventral Hernia
Microlyte in Prevention of SSI After Open Ventral Hernia Repair
Participants who are scheduled to have open ventral hernia repair (OVHR) will be asked to take part in this study. The purpose of this study is to find out if placing Microlyte (which is a dissolvable sheet coated in silver) on…
- Trial name
- NCT05093894
- Testing
- Group 1
- Where
- 3 sites in United States
- Sponsor
- Prisma Health-Upstate
Incisional Hernia of Midline of Abdomen, Surgical Wound
Onlay Mesh in Abdominal Aortic Aneurysm Repair.
The aim of the study was to compare the incidence of IH after abdominal aortic aneurysm (AAA) open repair according to the abdominal wall closure technique used.
- Trial name
- NCT07416422
- Testing
- Abdominal Ultrasound or computed tomography
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Hospital Universitario Ramon y Cajal
Tendon Injuries
Prevention of Adhesions Following Flexor Tendon Injury Within Zone II With Vascularized Finger Dorsal Fascial Flap
The purpose of this study was to report a new method of flexor tendon repair in zone II with combined standard modified Kessler technique and vascularized finger dorsal fascial flap pedicled with dorsal cutaneous branch of proper…
- Trial name
- NCT01726855
- Testing
- vascularized finger dorsal fascial flap
- Where
- China
- Volunteers
- 1 people
- Sponsor
- The Second Hospital of Tangshan
Surgical Site Infection
Surgical Site Infection After Episiotomy Repair Related to Routine Use of Antibiotic Prophylaxis in Low-Risk Population
Bacterial infections occurring during labor, childbirth, and the puerperium may be associated with considerable maternal and perinatal morbidity and mortality.
- Trial name
- NCT06154720
- Testing
- Antibiotics
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Breast Cancer Surgery
Long-term Safety of Nipple Sparing Mastectomy in Women With High Penetrance Breast Cancer Susceptibility Genes in Breast Cancer
Patients with a germline pathogenic variant (GPV) in high-penetrance breast cancer susceptibility genes who are considering risk reducing mastectomy (RRM) often strongly desire to keep their nipple areola complex but inquire as…
- Trial name
- NSM (NCT06888388)
- Testing
- Nipple Sparing Mastectomy (NSM), Skin-Sparing Mastectomy (SSM), Total (Simple) Mastectomy
- Where
- 16 sites in United States, Australia and 6 more
- Volunteers
- 4,700 people
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Colorectal Cancer
Mesalamine for Colorectal Cancer Prevention Program in Lynch Syndrome
Multicenter, multinational, randomized, 3-arm, double-blind, phase II clinical study with 2400mg mesalamine, 1200mg mesalamine or placebo for prevention of colorectal neoplasia in Lynch Syndrome patients for 2 years.
- Trial name
- MesaCAPP (NCT03070574)
- Testing
- mesalamine 2400 MG (5-ASA), mesalamine 1200 MG
- Where
- 6 sites in Austria, Germany and 4 more
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Christoph Gasche
Caesarean Wound, Hypertrophic Surgical Scar
: Protescal: Prevention of Hypertrophic Scar and Keloid Formation Post Caesarean Section
This study aimed to evaluate the effectiveness of Protescal in preventing post caesarean section hypertrophic scar and keloid formation.
- Conditions
- Caesarean Wound, Hypertrophic Surgical Scar, Keloid Scar Following Surgery
- Trial name
- NCT04951869
- Testing
- Protescal gel
- Where
- Malaysia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Delayed Healing
PICO Breast Reduction Clinical Study Looking at Incision Healing Complications
The purpose of this study is to see if the use of a single-use negative pressure wound therapy system (NPWT) will have an effect on the reduction of post-surgical incision healing complications following breast reduction surgery…
- Trial name
- NCT01640366
- Testing
- PICO
- Where
- 6 sites in United States, France and 2 more
- Volunteers
- 200 people
- Sponsor
- Smith & Nephew, Inc.
Kidney Transplant, Overweight or Obese Adults
Feasibility and Plausible Effectiveness of a Lifestyle Intervention in Kidney Transplant Recipients (HEAL)
The goal of this clinical trial is to learn whether if it is feasible to implement a study of patients receiving kidney transplantation, to learn if these patients will complete selective outcomes measurements, and to examine if…
- Conditions
- Kidney Transplant, Overweight or Obese Adults, Glucose Control
- Trial name
- HEAL (NCT06640179)
- Testing
- Standard medical care, Monitoring Contacts, Behavioral Sessions
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Kansas Medical Center
Lynch Syndrome
First in Human Pilot Study to Assess the Safety and Efficacy of Dendritic Cells Loaded With Frameshift Derived Neopeptides for the Prevention of Cancer in of Lynch Syndrome Carriers
Tha aim of this clinical trial is to evaluate safety and tolerability of autologous peripheral blood differentiated and matured adult dendritic cells. Immunogenicity of the prduct(DC-DELAY) will be evaluated also.
- Trial name
- DELAY (NCT07163403)
- Testing
- Autologous Tolerogenic Dendritic cells
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Familial Ovarian Cancer, Familial Breast Cancer
Clinical, Genetic, Behavioral, Laboratory and Epidemiologic Characterization of Individuals and Families at High Risk of Breast/Ovarian Cancer
Individuals and families with known or suspected syndromes that include breast, ovarian or genetically-related cancers are enrolled in this family study, which is a syndrome-specific sub-set of the long-standing DCEG Human…
- Conditions
- Familial Ovarian Cancer, Familial Breast Cancer, BRCA1-associate Malignancies, BRCA2-associated Malignancies
- Trial name
- NCT00040222
- Where
- United States
- Volunteers
- 377 people
- Sponsor
- National Cancer Institute (NCI)
Ventral Hernia
Repair of Large Incisional Hernias - To Drain or Not to Drain Randomised Clinical Trial
The aim of this study was to perform a randomised clinical trial comparing the use of closed-suction tubular drains and progressive tension sutures in individuals with large incisional hernias subjected to onlay mesh repair to…
- Trial name
- NCT02163460
- Testing
- Drain, Progressive Tension Sutures
- Where
- Brazil
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual do Oeste do Paraná
Colorectal Carcinoma, Colorectal Neoplasm
Testing a Combination of Vaccines for Cancer Prevention in Lynch Syndrome
This phase IIb trial tests whether Tri-Ad5 in combination with N-803 works to prevent colon and other cancers in participants with Lynch syndrome.
- Conditions
- Colorectal Carcinoma, Colorectal Neoplasm, Lynch Syndrome
- Trial name
- NCT05419011
- Testing
- Adenovirus 5 CEA/MUC1/Brachyury Vaccine Tri-Ad5, Biopsy Procedure, Biospecimen Collection
- Where
- 14 sites in United States, Puerto Rico
- Volunteers
- 186 people
- Sponsor
- National Cancer Institute (NCI)