Clinical trials: Wound Infection, Surgical
Endometritis, Wound Infection
Study of Effectiveness and Safety of Azithromycin-based Extended-spectrum Prophylaxis to Prevent Post Cesarean Infection
The Cesarean Section Optimal Antibiotic Prophylaxis (C/SOAP) study is a large pragmatic multi-center randomized clinical trial designed to evaluate the comparative effectiveness and safety of azithromycin-based extended-spectrum…
- Conditions
- Endometritis, Wound Infection, Abscess, Surgical Site Infection
- Trial name
- C/SOAP (NCT01235546)
- Testing
- Azithromycin and standard of care
- Where
- 9 sites in United States
- Volunteers
- 2,013 people
- Sponsor
- Alan Tita
Sepsis, Trauma
BIA Assessment of Polymyoneuropathy in Critically Ill Patients
The aim of the study is to monitor and evaluate changes in body composition, with a special emphasis on muscle mass, in the context of polyneuromyopathy of critically-ill patients at ICU, on artificial ventilation (duration of…
- Conditions
- Sepsis, Trauma, Respiratory Insufficiency, Surgery
- Trial name
- NCT04758676
- Testing
- Nutritional and physiotherapy protocol, BIA, Standard of care
- Where
- 2 sites in Czechia
- Volunteers
- 60 people
- Sponsor
- University Hospital Ostrava
Infections
Effectiveness for Interventions to Minimize Surgical Site Infections
The purpose of this study is to evaluate two different simple and inexpensive extra treatments during colorectal surgeries to see if this will reduce the rate of post operative infections
- Trial name
- NCT01153191
- Testing
- Normal saline pressurized irrigation, sub-q gentamicin
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Dallas VA Medical Center
Incisional Hernia, Surgical Wound Infection
Prophylactic Negative Pressure Wound Therapy for Patients Undergoing Incisional Hernia Repair
The study will examine the effect of using Negative Pressure Wound Therapy (NPWT) compared with standard wound dressing among patients undergoing elective open surgery for incisional hernia.
- Conditions
- Incisional Hernia, Surgical Wound Infection, Surgical Site Infection, Quality of Life
- Trial name
- PROPRESS (NCT05050786)
- Testing
- Negative Wound Pressure Therapy (Prevena(TM)), Standard Wound Dressing
- Where
- Denmark
- Volunteers
- 110 people
- Sponsor
- Kristian Kiim Jensen
Otitis Media Chronic, Tympanic Membrane Perforation
Use of Autologous Plasma Rich in Platelets and Extracellular Vesicles in the Surgical Treatment of Chronic Middle Ear Infections
This clinical study evaluates the efficacy of the autologous blood-derived product called platelet- and extracellular vesicle-rich plasma as a supplement to the surgical treatment of chronic tympanic membrane perforations.
- Trial name
- NCT04761562
- Testing
- Platelet- and extracellular vesicle-rich plasma, Control group
- Where
- Slovenia
- Volunteers
- 100 people
- Sponsor
- University Medical Centre Ljubljana
Esophageal Cancer, Radiation Pneumonitis
Neoadjuvant Therapy for Esophageal Cancer and Cardiopulmonary Physiology
Although recent global trends indicate reduced postoperative mortality after esophagectomy, major morbidity, in particular pulmonary, remains high, with considerable health and economic costs.
- Conditions
- Esophageal Cancer, Radiation Pneumonitis, Pulmonary Fibrosis, Respiratory Failure
- Trial name
- NCT03462524
- Testing
- Esophagectomy
- Where
- 2 sites in Ireland
- Volunteers
- 384 people
- Sponsor
- St. James's Hospital, Ireland
Plastic Surgery, Mammaplasty
Single Dose Versus 24 Hours Antibiotic Prophylaxis in Reduction Mammaplasty
Setting: Translacional Surgery Graduation Program - Universidade Federal de São Paulo and Hospital das Clínicas Samuel Libânio - Universidade do Vale do Sapucaí.
- Conditions
- Plastic Surgery, Mammaplasty, Anti-bacterial Agents, Prophylaxis
- Trial name
- NCT04079686
- Testing
- Cephazolin, Sterile saline
- Where
- Brazil
- Volunteers
- 146 people
- Sponsor
- Daniela Francescato Veiga
Surgical Wound Infection
Antibiotic Prophylaxis for Revision, Clean Head and Neck Surgery
We hypothesized that revision clean head \& neck surgery may have a higher rate of wound infection that may be lowered with prophylactic antibiotic treatment.
- Trial name
- NCT01980082
- Testing
- Cefazolin
- Where
- Israel
- Volunteers
- 53 people
- Sponsor
- Rabin Medical Center
Surgical Site Infection, Colorectal Cancer
Comparison of Method for Skin Closure in Colorectal Cancer.
Compared to tissue adhesives and skin stapling devices, tissue adhesives are reported to have advantages in terms of wound infection and cost competitiveness.
- Trial name
- NCT06549803
- Testing
- skin bond, skin stapler
- Where
- South Korea
- Volunteers
- 304 people
- Sponsor
- Yoon Suk Lee
Limb Edema, Surgical Site Infections
Prevention of Edema After Coronary Artery Bypass Graft by Customized Pressure-guided Elastic Bandages
The study aimed to assess the efficacy of customized pressure-guided elastic bandages (CPG-EB) in preventing postoperative edema and complications in Coronary Artery Bypass Graft (CABG) patients.
- Conditions
- Limb Edema, Surgical Site Infections, Leg Swelling, Compression Bandages
- Trial name
- PEACCE (NCT06603961)
- Testing
- CPG-EB group
- Where
- 2 sites in Thailand
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Siriraj Hospital
Surgical Site Infection (SSI), Central Nervous System Tumor
A Clinical Prediction Model for Surgical Site Infection After Central Nervous System Tumor Surgery
1. Study Background For patients undergoing brain or spinal tumor surgery, postoperative surgical wound infection (known as "surgical site infection," SSI) is a recognized risk.
- Trial name
- NCT07378683
- Testing
- ML-Based Enhanced Intervention Package for SSI Prevention, Standard Postoperative Care
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Ming Yang
Appendicitis Acute, Safety Issues
Review of Efficacy of Used ultraSonic Energy Device
Single-use medical instruments are intended by the manufacturers for single-use only or for single-patient-use only. Nevertheless, single-use instruments are being reused more than once in many countries around the world.
- Conditions
- Appendicitis Acute, Safety Issues, Complication of Surgical Procedure, Device Induced Injury
- Trial name
- REUSED (NCT04226482)
- Testing
- New Device, Used Device
- Where
- 2 sites in Croatia
- Volunteers
- 100 people
- Sponsor
- University of Split, School of Medicine
Pancreatic Surgery, Antibiotic Prophylaxis
Impact of Antibiotic Prophylaxis Change on Surgical Site Infections After Pancreaticoduodenectomy
Patients undergoing pancreaticoduodenectomy after preoperative biliary drainage are at increased risk of surgical site infections (SSI) due to bile colonization.
- Conditions
- Pancreatic Surgery, Antibiotic Prophylaxis, Surgical Site Infection (SSI), Surgical Site Infection Prevention
- Trial name
- ICADI (NCT07531420)
- Where
- France
- Volunteers
- 117 people
- Sponsor
- Central Hospital, Nancy, France
Cesarean Wound Disruption With Postnatal Complication
Impact of Preoperative Bathing on Post Caesarean Section Surgical Site Infection
Surgical site infection (SSI) is the commonest hospital-acquired infection globally, and prevalence is much higher in the low-income countries. Caesarean delivery carries a 5-20 fold risk for developing postpartum sepsis.
- Trial name
- SSI-MUST (NCT03544710)
- Testing
- preoperative bathing with antiseptic
- Where
- Uganda
- Volunteers
- 96 people
- Sponsor
- Mbarara University of Science and Technology
Postoperative Complications
Integrating Data, Algorithms and Clinical Reasoning for Surgical Risk Assessment
Brief Summary: The goal of this study is to implement and test an intelligent perioperative system (IPS) that in real-time predicts risk for postoperative complications using routine clinical data collected in electronic health…
- Trial name
- IDEALIST (NCT02741986)
- Testing
- Risk estimation
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of Florida
Infection, Surgery
Topical Vancomycin for Neurosurgery Wound Prophylaxis
This study is a collaboration between New York Presbyterian (NYP)-Columbia and NYP-Cornell that seeks to evaluate the use of topical vancomycin and its reduction on surgical site infection (SSI) in neurosurgical procedures.
- Conditions
- Infection, Surgery, Nervous System Diseases
- Trial name
- Vanguard (NCT02284126)
- Testing
- Vancomycin
- Where
- United States
- Volunteers
- 1,103 people
- Sponsor
- Columbia University
Surgical Site Infections, Post Operative Complication
2% Chlorhexidine Gluconate Skin Cloths to Prevent SSI in Spine Surgery Patients
Surgical site infection (SSI) following spinal surgery is a frequent complication and results in higher morbidity, mortality and healthcare costs.
- Trial name
- DeSSI (NCT02490631)
- Testing
- 2% chlorhexidine gluconate cloths
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- Vanderbilt University
Spinal Fusion, Spinal Stenosis
Vancomycin Powder Combined With Autogenous Bone Graft as a Prevention for Post-operative Infection for Spine Surgery
Deep surgical site infection (DSSI) is one of the most challenging complications for spinal surgeons and can lead to a poor clinical outcome.
- Conditions
- Spinal Fusion, Spinal Stenosis, Spondylolisthesis
- Trial name
- NCT03883022
- Testing
- with U-VANCO (vancomycin hydrochloride), without U-VANCO (vancomycin hydrochloride)
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Pancreatic Disease, Pancreatic Neoplasms
Early (4 Days) Versus Standard Drainage of the Abdominal Cavity After Pancreaticoduodenectomy
Around two thousand pancreaticoduodenectomy (PD) are performed each year in France. This intervention is associated with a high rate of postoperative complications including: pancreatic fistulas (PF); surgical site infections…
- Trial name
- DRAINAGE DPC (NCT01368094)
- Testing
- Drain removal at D4, Standard drain removal
- Where
- 5 sites in France
- Volunteers
- 141 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Orthopedic Surgery
Biofilm Formation and Antibiotic Sensitivity Patterns
Detection of bacteria that form biofilm and its sensitivity to antibiotics in patients with surgical site infection after orthopedic surgery.
- Trial name
- NCT05181163
- Testing
- swab
- Volunteers
- 100 people
- Sponsor
- Sohag University
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