Clinical trials: Wound Infection, Surgical
Opioid Consumption, Multimodal Analgesia
Magnesium Sulfate in Children Undergoing Laparoscopic Appendectomy
Magnesium sulfate is one of the most commonly used co-analgetics. Its antinociceptive effect is related to antagonizing NMDA (N-methyl-D-aspartate) receptors of the nervous system, has an anti-inflammatory effect by reducing the…
- Conditions
- Opioid Consumption, Multimodal Analgesia, Acute Appendicitis, Complication of Treatment
- Trial name
- NCT06563349
- Testing
- Intravenous magnesium sulfate, Normal saline infusion
- Where
- Poland
- Volunteers
- 188 people
- Sponsor
- Medical University of Warsaw
Surgical Site Infection, Colon Surgery
Gut Decolonisation With Neomycin/Metronidazole or Rifaximin Before Colon Surgery
The goal of this clinical trial is to find out if a gut cleaning using Rifaximin works as well as the usual treatment with Neomycin and Metronidazole to prevent infections after colon surgery.
- Conditions
- Surgical Site Infection, Colon Surgery, Surgical Site Infections
- Trial name
- NeoRiDe (NCT07180615)
- Testing
- Rifaximin (Xifaxan), Metronidazole, Neomycin Sulfate
- Where
- 4 sites in Switzerland
- Volunteers
- 458 people
- Sponsor
- Universität Luzern
Surgical Wound Infection, Vascular Surgery
Supplemental Oxygen in Vascular Surgery
The purpose of this study was to test the hypothesis that supplemental postoperative oxygen reduces the risk of surgical wound infection in patients following lower limb vascular surgery.
- Trial name
- NCT00873704
- Testing
- supplemental postoperative oxygen
- Where
- 6 sites in Finland
- Volunteers
- 274 people
- Sponsor
- North Karelia Central Hospital
Surgical Site Infection, Dementia
Tranexamic Acid to Reduce Delirium After Gastrointestinal Surgery: the TRIGS-D Trial
Prophylactic TxA administration in patients undergoing major gastrointestinal surgery reduces the incidence of delirium after surgery when compared with placebo.
- Conditions
- Surgical Site Infection, Dementia, Cognition
- Trial name
- TRIGS-D (NCT05470816)
- Testing
- Tranexamic Acid 100Mg/ml Inj Vial 10ml
- Where
- Australia
- Volunteers
- 826 people
- Sponsor
- Bayside Health
Surgical Site Infection
Decolonization to Reduce After-Surgery Events of Surgical Site Infection
The DECREASE SSI Trial (Decolonization to Reduce After-Surgery Events of Surgical Site Infection) is a two-arm multi-center individual placebo-controlled randomized (2,700 participants randomized 1:1) clinical trial to reduce…
- Trial name
- DECREASE SSI (NCT05586776)
- Testing
- 4% Chlorhexidine Gluconate, 2% Mupirocin
- Where
- 4 sites in United States
- Volunteers
- 2,700 people
- Sponsor
- University of California, Irvine
Surgical Site Infection, Brain Tumor
Infection Prevention Bundle in Brain Tumor Surgery
This study aimed to evaluate the effectiveness of an infection prevention bundle on surgical site infections in patients undergone brain tumor surgery.
- Trial name
- NCT04285697
- Testing
- infection prevention bundle
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Surgical Wound, Wound Dehiscence, Surgical
Prophylactic Negative Pressure Wound Therapy for High Risk Laparotomy Wounds. A Randomized Prospective Clinical Trial.
Negative pressure wound closure technique (NPWT) has been widely introduced in different clinical settings. Most of the studies report it as an effective and cost-effective method to treat complicated surgical wounds or even open…
- Conditions
- Surgical Wound, Wound Dehiscence, Surgical, Surgical Site Infection, Dehiscence of Internal Surgical Wound
- Trial name
- NCT03716687
- Testing
- Prophylactic negative pressure wound dressing after laparotomy
- Where
- Hungary
- Volunteers
- 100 people
- Sponsor
- St. Borbala Hospital
Ventilator Associated Pneumonia (VAP)
Serial, Non-invasive Analysis of Exhaled Breath Condensate in Ventilated Trauma Patients
To determine if the analysis of exhaled breath condensate correlates with the development \& resolution of pneumonia.
- Trial name
- NCT02652247
- Testing
- molecular analysis of exhaled breath condensate, molecular analysis of mini-bronchoalveolar lavage (BAL) aspirate, molecular analysis of bronchoalveolar lavage (BAL) aspirate
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Vanderbilt University Medical Center
Negative-Pressure Wound Therapy, Wound Heal
Compare Stoma Reversal Wound Outcomes Between NPWT and Secondary Intention Healing
This was a single-center, parallel-group randomized controlled trial conducted in 2025 at the General Surgery Ward of the Sindh Institute of Urology and Transplantation (SIUT), Karachi.
- Conditions
- Negative-Pressure Wound Therapy, Wound Heal, Stoma Site Infection, Surgical Site Infection
- Trial name
- NCT07258134
- Testing
- Negative Pressure Wound Therapy
- Where
- Pakistan
- Volunteers
- 72 people
- Sponsor
- Maryam Arbab
Fracture Related Infection
Incidence of Fracture-Related Infection Among Adult Trauma Patients Undergoing Operative Fracture Fixation A Prospective Cohort Study at the Orthopaedic and Trauma Surgery Unit, Assiut University Hospital
Fracture-related infection (FRI) is an infection occurring after operative or non-operative management of a fracture, and it represents one of the most serious complications encountered in orthopaedic trauma surgery.
- Trial name
- NCT07853404
- Volunteers
- 375 people
- Sponsor
- Assiut University
Colorectal Surgery, Wound Infections
REDWIL: Reduction of Wound Infections in Laparoscopic Colon Resections by Wound Protectors
Surgical site infection is common in colorectal surgery leading to increased postoperative pain, longer hospital stay, delayed wound healing and increased re-operation rates.
- Trial name
- REDWIL (NCT01049971)
- Testing
- wound protector, no wound protector
- Where
- Germany
- Volunteers
- 109 people
- Sponsor
- Charite University, Berlin, Germany
Pain, Infection
Safety of Coronectomy vs Excision of Wisdom Teeth
The purpose of this study is to compare the surgical complications and neurosensory disturbance of coronectomy and conventional excision of wisdom teeth with roots in close proximity to inferior alveolar nerve.
- Conditions
- Pain, Infection, Alveolar Nerve Injury
- Trial name
- coronrct (NCT00752284)
- Testing
- Coronectomy, Total Excision
- Where
- China
- Volunteers
- 349 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Cesarean Section Complications, Wound Breakdown
Antimicrobial Dressing Versus Standard Dressing in Obese Women Undergoing Cesarean Delivery
This will be an open label pilot randomized controlled clinical trial. Women undergoing cesarean delivery will be randomized to have standard wound dressing care or chlorohexidine gluconate (CHG) impregnated wound dressing…
- Conditions
- Cesarean Section Complications, Wound Breakdown, Wound Infection, Satisfaction
- Trial name
- NCT03887299
- Testing
- ReliaTect™ Post-Op Dressing (contains chlorohexidine gluconate or CHG), Standard Wound Care
- Where
- United States
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Surgical Site Infection, Surgical Wound Infection
Floraseal Versus Iodine Impregnated Adhesive Drapes
Infection after total joint arthroplasty can have devastating consequences. Adhesive drapes have been traditionally used at our institution to help reduce the risk of wound contamination and infection by superficial skin flora.
- Trial name
- NCT03466489
- Testing
- Floraseal
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Miami
Post Operative Surgical Site Infection
Evaluation of a New Strategy for Protocolized Antibiotic Care for Severe Open Fractures: SEXTANT 2
The PRCT evaluates infection outcomes as well as fracture and antibiotic-related complications to include the emergence of resistant bacteria associated with two different antibiotic strategies in the treatment of Gustilo type…
- Trial name
- SEXTANT 2 (NCT04678154)
- Testing
- Standard of care, Vancomycin and Tobramycin
- Where
- 31 sites in United States
- Volunteers
- 600 people
- Sponsor
- Major Extremity Trauma Research Consortium
Surgery
Operating Room Air Filtration/Sterilization
Determine whether operating room air filtration and sterilization with the ActivePure system reduces a composite of serious surgical site infections, infection-related complications, and death within 30 days after surgery.
- Trial name
- ORACLE (NCT04610294)
- Testing
- Functioning Aerus air filtration/sterilization, Deactivated Aerus air filtration/sterilization
- Where
- United States
- Volunteers
- 66,273 people
- Sponsor
- The Cleveland Clinic
Suture Line Infection
Subcutaneous Continuous Versus Interrupted Sutures During Cesarean Section.
A comparison of the rate of surgical site infections after cesarean section depending on the type of suture used for subcutaneous closure-continuous versus interrupted.
- Trial name
- NCT04220294
- Testing
- Subcutaneous tissue closure
- Where
- Israel
- Volunteers
- 1,238 people
- Sponsor
- Rambam Health Care Campus
Surgical Site Infection
Roles of Prophylactic Subcutaneous Drain in Preventing Surgical Site Infection in Surgical Wound After Abdominal Surgery
Surgical site infections (SSI) pose a common challenge in the field of surgery. Current evidence and literature do not provide clear consensus whether the use of subcutaneous drainage will help reduce the incidence of SSI in…
- Trial name
- NCT06063629
- Testing
- Subcutaneous drain, No drain
- Volunteers
- 180 people
- Sponsor
- Queen Savang Vadhana Memorial Hospital, Thailand
Surgical Site Infection, Groin Hernia
Prophylactic Antibiotics in Groin Hernioplasty
The role of prophylactic antibiotics in preventing surgical site infections (SSI) for clean procedures like groin hernia repair remains controversial.
- Conditions
- Surgical Site Infection, Groin Hernia, Hernioplasty
- Trial name
- NCT07111702
- Testing
- Cefazolin
- Where
- Yemen
- Volunteers
- 100 people
- Sponsor
- Sana'a University
Surgical Site Infections, Nosocomial Infection
Nasal Photodisinfection in All Patients Presenting for Surgery for a Wide Range of Surgical Procedures
This is a Phase 2 single-center, open-label, single-arm, study of a microbiological endpoint using antimicrobial photodynamic therapy (aPDT) for nasal disinfection in all patients (universal) presenting for surgery at an acute…
- Conditions
- Surgical Site Infections, Nosocomial Infection, Healthcare Associated Infections
- Trial name
- BENEFIT-PDT (NCT05090657)
- Testing
- methylene blue 0.01%/chlorhexidine gluconate 0.25% + light activation
- Where
- United States
- Volunteers
- 322 people
- Sponsor
- Ondine Biomedical Inc.
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.