Clinical trials: Wound Infection, Surgical
Rheumatoid Arthritis
Anti-TNFα Use During Elective Foot and Ankle Surgery in Patients With Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a frequent inflammatory arthritis that can lead to severe joint deformity and often requires orthopaedic surgical interventions.
- Trial name
- NCT02242474
- Testing
- Anti-TNF suspended perioperatively, Anti-TNFα continued perioperatively
- Where
- Canada
- Volunteers
- 660 people
- Sponsor
- CHU de Quebec-Universite Laval
Smoking Cessation
A Pilot Study Of Smoking Cessation Treatment Including Varenicline In Patients Scheduled For Planned Surgery
It is possible to offer smoking cessation treatment including varenicline to patients scheduled for elective surgery. This study will evaluate whether or not this will enable some patients to quit smoking for up to 4 weeks prior…
- Trial name
- NCT00889720
- Testing
- Varenicline
- Where
- 2 sites in France, Italy
- Volunteers
- 16 people
- Sponsor
- Pfizer
Wound Infection
Antiseptic Sutures and Wound Infection
The aim of this study was to ascertain if the use of Vicryl plus® reduced the number of wound infections after transverse laparotomy comparing to polydioxanon suture.
- Trial name
- NCT00932503
- Testing
- Vicryl plus
- Where
- Germany
- Volunteers
- 839 people
- Sponsor
- University Hospital, Saarland
Colorectal Cancer, Nutritional Deficiency
PeRioperative Omega Three and the Effect on ImmuNity
Bowel cancer is the second most common cause of cancer-related death in the UK, with 50,000 new cases and over 15,000 deaths annually.
- Conditions
- Colorectal Cancer, Nutritional Deficiency, Infected Wound, Surgical Site Infection
- Trial name
- PROTEIN (NCT03598413)
- Testing
- Omega-3
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Royal Surrey County Hospital NHS Foundation Trust
Congenital Heart Diseases, Aortic Valve Disorder
Pre-operative Prophylaxis With Vancomycin and Cefazolin in Pediatric Cardiovascular Surgery Patients
The investigators hope to learn 1) if the addition of prophylaxis with vancomycin will decrease the rate of cefazolin non-susceptible surgical site infections (SSI), in high risk population 2) to develop better understanding of…
- Trial name
- NCT01619982
- Testing
- Cefazolin 25 mg/kg body weight and Vancomycin hydrochloride, Cefazolin 30 mg/kg body weight
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Stanford University
Staphylococcal Infections, Surgical Site Infection
Effect of Exeporfinium Chloride (XF-73) Gel on Nasal S.Aureus in Patients at Risk of Post-op Staphylococcal Infection
This study looks at the difference between XF-73 and placebo in reducing the carriage of a bacteria S. aureus in the nose before, during and after heart surgery.
- Trial name
- NCT03915470
- Testing
- XF-73
- Where
- 21 sites in United States, Georgia and 1 more
- Volunteers
- 124 people
- Sponsor
- Destiny Pharma Plc
Laparotomy Closure After Abdominal Surgery, Suture Materials
Comparison of Vicryl Versus Prolene for Midline Rectus Sheath Closure After Elective Laparotomy
This randomized controlled trial compared two commonly used suture materials, Prolene and Vicryl, for closing the midline rectus sheath after elective laparotomy.
- Conditions
- Laparotomy Closure After Abdominal Surgery, Suture Materials, Complications Wounds
- Trial name
- NCT07451990
- Testing
- Vicryl (Polyglactin 910) Suture, Prolene (Polypropylene) Suture
- Where
- Pakistan
- Volunteers
- 152 people
- Sponsor
- Hayatabad Medical Complex
Uncomplicated Cutaneous Abscess
A Randomized Blinded Trial of Abscess Management With Packing vs No Packing
Adult patients presenting to the emergency department with superficial cutaneous abscesses will be randomized after incision and drainage to standard care with wound packing or no packing to determine if there is a difference in…
- Trial name
- NCT01698996
- Testing
- Packing vs No Packing
- Where
- Canada
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Cesarean Section; Infection
Evaluation of Triclosan Coated Suture in Obstetrical Surgery
A prospective comparative randomized blinded study conducted in the obstetrics gynecology department of Ben Arous hospital over an eight-month period between November 2020 and June 2021.
- Trial name
- NCT05330650
- Testing
- Coated Vicryl+, Vicryl
- Where
- Tunisia
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- Tunis University
Sepsis, Surgery
Inflammatory Mediators of Acute Kidney Injury in Intensive Care
Acute kidney injury (AKI) affects more than 50% of patients admitted to the intensive care unit. The most common underlying cause is sepsis. Severe AKI in combination with sepsis is associated with high mortality.
- Conditions
- Sepsis, Surgery, Acute Kidney Injury
- Trial name
- PronMed (NCT03720860)
- Where
- Sweden
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Pain, Wound Healing Disturbance of
Periodontal Dressing After Surgical Crown Lengthening
Background: There is controversy regarding the postoperative effects of periodontal dressing on the periodontium, pain and discomfort.
- Conditions
- Pain, Wound Healing Disturbance of, Periodontal Infection
- Trial name
- NCT01986959
- Testing
- With Periodontal dressing, Without Periodontal dressing
- Where
- Brazil
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Franciscan University Center
Necrotizing Soft Tissue Infection, Necrotizing Fasciitis
Biomarkers in Patients With Flesh-eating Bacterial Infections
The purpose of this study is to investigate the immune response in patients with necrotizing soft tissue infections (NSTI). The investigation will focus on inflammatory and vasoactive biomarkers as prognostic markers of severity…
- Conditions
- Necrotizing Soft Tissue Infection, Necrotizing Fasciitis, Gas Gangrene, Fournier Gangrene
- Trial name
- BIONEC (NCT02180906)
- Where
- Denmark
- Volunteers
- 169 people
- Sponsor
- Ole Hyldegaard
Acute Fracture Surgery, Alcohol Cessation Intervention
Alcohol Cessation Intervention in an Acute Surgical Setting
Hazardous alcohol intake is an independent risk factor for postoperative complications after major and minor operations, elective and emergency procedures for men and women.
- Conditions
- Acute Fracture Surgery, Alcohol Cessation Intervention, Postoperative Complications, Infection
- Trial name
- NCT00986791
- Testing
- GSP-A
- Where
- 3 sites in Denmark
- Volunteers
- 70 people
- Sponsor
- Bispebjerg Hospital
Staphylococcal Aureus Infection, Surgical Site Infection (SSI)
Gene Expression Analysis of Biofilm Formation and Antimicrobial Resistance in Clinical Methicillin-Resistant Staphylococcus Aureus
Staphylococcus aureus are Gram-positive cocci that asymptomatically colonize the skin and mucosal surfaces of approximately 20-30% of healthy individuals . Although they commonly exist as a harmless commensal organisms, S.
- Trial name
- NCT07796555
- Testing
- swab from lesion, Biochemical reactions, Antibiotic sensitivity
- Volunteers
- 100 people
- Sponsor
- Sohag University
Surgical Site Infection
Benefit of a Single Preoperative Dose of Antibiotics for the Prevention of Surgical Site Infections
In a rural hospital in Tanzania the rate of surgical site infections (SSI) was 21.6%. Inappropriate choice of antibiotics and of administration time were determined as sole risk factors in this setting.
- Trial name
- SSI2 (NCT00801099)
- Testing
- Amoxicillin/Clavulanic Acid
- Where
- Switzerland
- Volunteers
- 276 people
- Sponsor
- Swiss Tropical & Public Health Institute
Post Traumatic Stress Disorder, Postoperative Complications
PTSD of Surgeons or Anesthesiologists on Prognosis of Surgical Patients
The objective of this prospective cohort study is to explore the association between the development of post-traumatic stress disorder (PTSD) in surgeons and anesthesiologists and postoperative prognosis in surgical patients they…
- Conditions
- Post Traumatic Stress Disorder, Postoperative Complications, COVID-19
- Trial name
- NCT05732116
- Testing
- PTSD
- Where
- 2 sites in China
- Volunteers
- 356 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Wound
Staples Versus Suture for Cesarean Wound Closure
The objective of this randomized controlled trial is to compare wound morbidity (including disruption and infection) in surgical staples versus absorbable subcuticular suture for wound closure in cesarean deliveries.
- Trial name
- SVS (NCT01008449)
- Testing
- Surgical staples, Absorbable Surgical Suture
- Where
- United States
- Volunteers
- 398 people
- Sponsor
- University of Alabama at Birmingham
Pancreatic Diseases
Effect of an Artificial Pancreas in Patients Undergoing Pancreatic Resection
This study evaluated that strict control of perioperative blood glucose following pancreatic resection by using an artificial pancreas would improve postoperative surgical site infection.
- Trial name
- NCT00661648
- Testing
- the closed-loop STG-22 system (Nikkiso Inc, Tokyo, Japan)
- Where
- Japan
- Volunteers
- 50 people
- Sponsor
- Kochi University
Surgical Site Infection
Disposable Versus Reusable DrApes and Gowns for Green OperatiNg Theatres
Multicentre non-inferiority cluster randomised trial testing Disposable versus Reusable drApes and Gowns for green OperatiNg theatres.
- Trial name
- DRAGON (NCT06164444)
- Testing
- Intervention: Reusable drapes and gowns, Comparator: Disposable (single-use) drapes and gowns
- Where
- Mexico
- Volunteers
- 26,800 people
- Sponsor
- University of Birmingham
Surgical Wound Infection, Cystitis
The Role of Synbiotics in Reducing Post-Operative Infections in Patients Undergoing Cardiac Surgery: A Pilot Study
All surgical procedures carry with them the risk of infection. Even a minor infection can extend the hospitalization after cardiac surgery. The average minimum increase in length of stay for a single infection is three days.
- Conditions
- Surgical Wound Infection, Cystitis, Bacteremia, Pneumonia
- Trial name
- NCT00164099
- Testing
- Synbiotic 2000
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Beth Israel Medical Center
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