Clinical trials: Wound Infections
Community-acquired Pneumonia
Accuracy of Lung Injury Biomarkers in the Initial Investigation of Patients With Suspected Pneumonia
The aim of this study is to investigate the diagnostic and prognostic value of surfactant protein D, Krebs von den Lungen (KL-6), and Chitinase-3-like protein 1 (YKL-40) in the initial investigation of patients hospitalized with…
- Trial name
- NCT04686331
- Testing
- Biomarkers for pneumonia
- Where
- Denmark
- Volunteers
- 411 people
- Sponsor
- University of Southern Denmark
Acute Kidney Injury, Probiotics
Effect of Probiotics and Prebiotics in Renal Function in Septic Acute Kidney Injury Patients
Septic acute kidney injury is a condition associated with highly related to inflammatory molecules. Prebiotics and probiotics have shown to improve inflammatory cascade in animal model; In this study, the investigators propose…
- Conditions
- Acute Kidney Injury, Probiotics, Sepsis
- Trial name
- NCT03877081
- Testing
- Probiotics
- Where
- Mexico
- Volunteers
- 90 people
- Sponsor
- Hospital Civil de Guadalajara
Surgical Wound Infections
Prevention of Neurosurgical Wound Infections
The goal of this study is to determine whether injecting the antibiotic vancomycin directly into surgical wounds can decrease the rate of infection following implantation of neurosurgical devices.
- Trial name
- POWI (NCT00915967)
- Testing
- Vancomycin
- Where
- United States
- Volunteers
- 214 people
- Sponsor
- Oregon Health and Science University
Septic Shock, Stress Response
Effect of Dexmedetomidine vs Esmolol or Placebo on Cerebral Hemodynamics in Septic Shock
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Some researchers proposed that the dysregulated response or organ dysfunction can be lessened by reducing the stress…
- Conditions
- Septic Shock, Stress Response, Cerebral Hemodynamics
- Trial name
- NCT06169475
- Testing
- Dexmedetomidine Hydrochloride, Esmolol Hydrochloride
- Where
- China
- Volunteers
- 14 people
- Sponsor
- Xinchen Wang
Negative-Pressure Wound Therapy, Wound Heal
Compare Stoma Reversal Wound Outcomes Between NPWT and Secondary Intention Healing
This was a single-center, parallel-group randomized controlled trial conducted in 2025 at the General Surgery Ward of the Sindh Institute of Urology and Transplantation (SIUT), Karachi.
- Conditions
- Negative-Pressure Wound Therapy, Wound Heal, Stoma Site Infection, Surgical Site Infection
- Trial name
- NCT07258134
- Testing
- Negative Pressure Wound Therapy
- Where
- Pakistan
- Volunteers
- 72 people
- Sponsor
- Maryam Arbab
Lower Extremity Wound Infected, Venous Stasis Ulcers
V.A.C. VeraFlo™ Instillation Therapy vs V.A.C. Ulta™ Therapy on Biofilm in Chronically Infected Wounds
This study would like to determine if using negative pressure wound therapy with an instillation of .125% Dakins is more effective than using negative pressure wound therapy alone on biofilm removal, disruption and elimination in…
- Trial name
- NCT02009501
- Testing
- VAC VeraFlo with Dakins Instillation, VAC Ulta Therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Open Fracture, Pseudarthrosis
Septic Management and Outcome of Open Fracture
The aim is the study of the management and outcome of the open fractures. Some open fractures will become pseudarthrosis. Thoses pseudarthrosis may be septic or not.
- Conditions
- Open Fracture, Pseudarthrosis, Bone and Joint Infection
- Trial name
- NCT04418882
- Testing
- management and follow up of all open fractures
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Hospices Civils de Lyon
Suture, Complication, Wound
Split Scar Study to Assess Cosmetic Outcome From Differing Suture Spacing
The investigators wish to determine how suture spacing (5 mm vs. 10 mm) affects cosmetic outcome and development of "train tracking" in wounds.
- Conditions
- Suture, Complication, Wound, Wound Complication, Wound Dehiscence
- Trial name
- SFD (NCT03284983)
- Testing
- Suture spacing for wound closure
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Silver Falls Dermatology
COVID, Corona Virus Infection
RIC as an Adjunct Therapy for Severe COVID-19 Disease: a Prospective Randomized Pilot Study
This research aims to assess the use of an experimental and non-invasive procedure, Remote Ischemic Conditioning (RIC), as an adjunct therapy in attenuating severe COVID-19 disease.
- Conditions
- COVID, Corona Virus Infection, Acute Lung Injury, Ischemia Limb
- Trial name
- NCT04659460
- Testing
- Remote Ischemic Conditioning
- Volunteers
- 30 people
- Sponsor
- Unity Health Toronto
Surgical Site Infection
Checklist to Prevent MRSA Surgical Site Infections
The goals of this project are 1) to assess the effectiveness and cost-effectiveness of the checklist to prevent MRSA SSIs among Veterans undergoing TJA or cardiac surgery, and 2) to assess barriers and facilitators to checklist…
- Trial name
- NCT02216227
- Testing
- Mupirocin, Chlorhexidine gluconate, Cefazolin
- Where
- 11 sites in United States
- Volunteers
- 23,005 people
- Sponsor
- VA Office of Research and Development
Breast Cancer
Use of Clorhexidine Dressings to Reduce Surgical Site Infections in Breast Cancer Surgery. A Controlled Clinical Trial
Surgical site infection (SSI) after breast and axillary surgery occurs more often than for other clean surgical procedures. Infection in the setting of sick woman could delay the adjuvant therapy and result increase morbidity and…
- Trial name
- NCT03229824
- Testing
- Antiseptic occlusive dressing group
- Where
- Mexico
- Volunteers
- 116 people
- Sponsor
- National Institute of Cancerología
Wound Infection
Biofilm Correlation and Validation
This is a prospective, single-blind, controlled trial. There are two arms and 20 patients with acute or chronic wounds with clinical suspicion of biofilm (CSB+/CSB-) are allocated in each arm.
- Trial name
- NCT05196880
- Testing
- MolecuLight DX Imaging Device
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- MolecuLight Inc.
Acute Non Infected Wounds, Non Infected Post Surgical Wounds
A Prospective, Open, Non-controlled Clinical Investigation to Evaluate a New Negative Pressure Wound Therapy (NPWT) System to be Used in the Treatment of Acute Non-infected Wounds and Post Surgical Infected Wounds
The investigation is designed as a prospective, open, non-controlled clinical investigation.
- Trial name
- NCT01195896
- Testing
- New NPWT system
- Where
- Germany
- Volunteers
- 9 people
- Sponsor
- Molnlycke Health Care AB
Sepsis, Acute Renal Failure
The Membrane Adsorbing OXiris Filter in Septic Patients With AKI
Patients with Sepsis / Septic Shock and AKI are submitted to Continuous Renal Replacement Therapy with the oXiris filter . The pro- inflammatory mediators , the endotoxin , interleukin 10 , the main cardiorespiratory indices and…
- Trial name
- MOSAKI (NCT03914586)
- Testing
- oXiris filter
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- FRANCO TURANI
Hip Fractures (ICD-10 72.01-72.2)
Pre- and Postoperative Chest Therapy With Positive Expiratory Pressure (PEP) to Prevent Hospital-acquired Pneumonia
The goal of this clinical trial is to investigate whether pre- and postoperative treatment with systematic PEP therapy can prevent hospital-acquired pneumonia in patients with hip frac-ture.
- Trial name
- NCT07189260
- Testing
- positive expiratory pressure
- Where
- 2 sites in Denmark
- Volunteers
- 566 people
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Open Fracture
Evaluation of STIMULAN Device and AI Model in Preventing Fracture Infections
This is a prospective, single-center, double-blind randomized clinical trial aimed at evaluating the efficacy and safety of the extended-release antibiotic device, STIMULAN, in preventing infections in patients with open…
- Trial name
- NCT06033534
- Testing
- STIMULAN
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Università Vita-Salute San Raffaele
Cellulitis, Insect Bites
Point-of-Care Ultrasound Educational Initiative for Insect Bites
This pre-post study, designed to decrease unnecessary antibiotic prescribing, will use a prospective cohort of patients presenting to the Pediatric Emergency Department (PED).
- Conditions
- Cellulitis, Insect Bites, Insect Stings
- Trial name
- USED4BUGBITE (NCT03619746)
- Testing
- POCUS Educational Intervention
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- New York City Health and Hospitals Corporation
Fracture Nonunion, Infection
Smoking Cessation in Nonunion, Malunion, Osseous Infection
The Study Investigators have seen high rates of tobacco cessation success combining Chantix with the risk of no surgery, should tobacco use continue.
- Trial name
- nicotine (NCT00754299)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Gastrostomy, Methods
Gastrostomy Tube Placed After Gastropexy Versus Gastrostomy Tube Placed Using the Traditional Push/Pull Techniques
Endoscopic placement of a percutaneous gastrostomy tube is a safe, efficient and well standardized technique. Two variants of this maneuver - the pull and the push techniques - are widespread worldwide.
- Trial name
- NCT01463540
- Testing
- A 20 Fr gastrostomy tube, placed using push/pull techniques., A 20 Fr balloon type tube, placed after gastropexy.
- Where
- 3 sites in Italy
- Volunteers
- 206 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Critical Illness, COVID-19 Pneumonia
Acute Kidney Injury in Coronavirus Disease-19 (COVID-19) Patients Admitted to the Intensive Care Unit (ICU)
The aim of this study is to evaluate the rate and outcomes of COVID-19 associated acute kidney injury (AKI) and use of kidney replacement therapy (KRT) in critically ill COVID-19 patients in ICUs in several large hospitals in…
- Conditions
- Critical Illness, COVID-19 Pneumonia, Acute Kidney Injury
- Trial name
- COVID-AKI-B (NCT04997915)
- Testing
- Observational study exploring the epidemiology and outcomes of AKI in critical COVID-19 patients admitted to the ICU
- Where
- 9 sites in Belgium
- Volunteers
- 1,286 people
- Sponsor
- University Hospital, Ghent
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.