Clinical trials: Wound Infections
Wounds
Clinical Investigation to Evaluate the Safety and Performance of ConnettivinaBio Plus Cream Compared to ConnettivinaBio Cream in the Management of Wounds in Patients at High Risk of Infection
The clinical investigation plan will include a Screening/Baseline visit (V1) in which patients will be screened on the basis of inclusion/exclusion criteria and clinically evaluated.
- Trial name
- NCT04936204
- Testing
- ConnettivinaBio Plus cream, ConnettivinaBio cream
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Fidia Farmaceutici s.p.a.
Cesarean Section, Wound Complications
Cesarean Trial of Staples vs. Sutures
To determine whether the rate of wound complications differs based on method of closure of skin incision (staples vs. suture) after cesarean delivery.
- Conditions
- Cesarean Section, Wound Complications, Patient Satisfaction, Pain Measurement
- Trial name
- CROSS (NCT01211600)
- Testing
- Staples, Suture
- Where
- 2 sites in United States
- Volunteers
- 746 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Surgical Procedure, Unspecified, Soft Tissue Infections
Three-dimensional Bone Regeneration Using Custom-made Meshes With and Without Collagen Membrane
The presence of alveolar ridge deficiencies is considered major limitation to achieve an implant-prosthetic restoration with high aesthetics and stability over time.
- Conditions
- Surgical Procedure, Unspecified, Soft Tissue Infections, Surgical Wound Dehiscence, Bone Density
- Trial name
- NCT04286334
- Testing
- Bone augmentation with cad-cam laser-sintered mesh
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- GBR Academy
Obesity, Morbid, Obesity
CiNPT for Abdominoplasties in Post-bariatric Patients Study
The overarching goal of this research is to assess whether the post-operative use of closed-incision Negative Pressure Therapy (ciNPT) accelerates healing of surgical wounds, improves surgical outcomes, and reduces the rate of…
- Conditions
- Obesity, Morbid, Obesity, Obesity, Abdominal, Wound
- Trial name
- CAPS (NCT04214236)
- Testing
- ciNPT group, Control group
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera, Ospedale Civile di Legnano
Bacterial Infections, Wounds
Effects of MRSA Bactericidal Gel To Promote Healing and Eliminate MRSA in cSSTI Vancogel(TM)
Based on personal experience and the literature it is reasonable expectation that Vancomycin is a viable treatment in a direct contact form to eliminate MRSA from open wounds in order to heal the wounds by conventional means.
- Trial name
- Vancogel(R) (NCT00945152)
- Testing
- Vancomycin 1.25-1.50% in a complex gel formulation trademarked Vancogel(R)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Robert S Berman MD
Pulmonary Alveolar Proteinosis, COPD
Use of cSVF Via IV Deployment for Residual Lung Damage After Symptomatic COVID-19 Infection
COVID-19 Viral Global Pandemic resulting in post-infection pulmonary damage, including Fibrotic Lung Disease due to inflammatory and reactive protein secretions damaging pulmonary alveolar structure and functionality.
- Conditions
- Pulmonary Alveolar Proteinosis, COPD, Idiopathic Pulmonary Fibrosis, Viral Pneumonia
- Trial name
- GARM-COVID19 (NCT04326036)
- Testing
- Microcannula Harvest Adipose Derived tissue stromal vascular fraction (tSVF), Centricyte 1000, IV Deployment Of cSVF In Sterile Normal Saline IV Solution
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Black Tie Medical, Inc.
Operation Wound; Infection, Bacterial Infections
Nudging Effect of Timer on Surgical Rub
To study whether a device has a nudging effect on the time spend on surgical rub.
- Conditions
- Operation Wound; Infection, Bacterial Infections, Surgical Procedure, Unspecified
- Trial name
- NCT04609384
- Testing
- Alcohol rub timer device
- Where
- Denmark
- Volunteers
- 400 people
- Sponsor
- Sygehus Lillebaelt
Middle Ear Effusion, Tympanic Membrane Perforation
PneuMum: Pneumococcal Vaccination of Australian Indigenous Mothers
PneuMum is a randomised controlled trial that aims to find out if pneumococcal vaccination for Australian Indigenous mothers, in the last few months of pregnancy or at delivery, can prevent ear disease in infants.
- Conditions
- Middle Ear Effusion, Tympanic Membrane Perforation, Acute Otitis Media, Pneumococcal Infections
- Trial name
- PneuMum (NCT00714064)
- Testing
- 23vPPV, dTpa (Pneumovax, Boostrix)
- Where
- Australia
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- Menzies School of Health Research
Acute Lung Injury, Sepsis
Extracardiac Complications After Cardiac Surgery
Hypothesis of the study is that patients undergoing major cardiac surgery can develop extracardiac complications correlated to cardiopulmonary by pass.
- Conditions
- Acute Lung Injury, Sepsis, Infections, Acute Kidney Injury
- Trial name
- NCT01187004
- Where
- Italy
- Volunteers
- 164 people
- Sponsor
- University of Turin, Italy
Cognitive Disorders, HIV Infections
A Study of Decreased Mental Function Associated With HIV
The purpose of this study is to compare pictures of the brain of HIV-infected people with memory problems before and after treatment with selegiline. Selegiline is the study drug received through A5090.
- Trial name
- NCT00027040
- Testing
- Selegiline hydrochloride
- Where
- 12 sites in United States
- Volunteers
- 90 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Stress, Stress Disorder
The Professional Peer Resilience Initiative
The Professional Peer Resilience Initiative (PPRI) study is an observational study aimed at understanding how symptoms of traumatic stress and resilience evolve over time in the University of Minnesota (UMN) healthcare workforce…
- Conditions
- Stress, Stress Disorder, Stress, Psychological, Trauma, Psychological
- Trial name
- PPRI (NCT04396600)
- Testing
- MinnRAP Peer Support Program
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Sepsis
The Effect and Mechanism of lncRNA NBR2 Regulating Endothelial Pyroptosis by Targeting GSDMD in Sepsis
Sepsis is a life-threatening disease characterized by multi-organ failure due to dysregulated host response to infection, with high global mortality of 30-50%.
- Trial name
- NCT04427371
- Testing
- the levels of pyroptosis
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Jianfeng Xie
Appendicitis, Cholecystitis
NOVOsyn® for Trocar Incision After Laparoscopic Appendectomy and Cholecystectomy
The aim of this study is to evaluate if the application of a Chlorhexidine coated suture (Novosyn® CHD) will reduce the colonization of bacteria in comparison to an uncoated suture (Novosyn®) used for the closure of trocar wounds…
- Trial name
- NOVOTILAC (NCT04033211)
- Testing
- Novosyn® CHD for fascia and skin closure, Novosyn® for fascia and skin closure
- Where
- 4 sites in Germany, Spain
- Volunteers
- 316 people
- Sponsor
- Aesculap AG
Surgical Complication
The Effect of Local Application of Tranexamic Acid Versus Placebo on Postoperative Complications in Plastic Surgery
Study objective: This is a study to investigate whether applying the drug tranexamic acid (TXA) onto a surgical wound surface may affect the incidence of surgical complications such as re-bleeding needing intervention, wound…
- Trial name
- TRANOP (NCT06270407)
- Testing
- Tranexamic Acid 100 MG/ML, 0.9%sodium chloride
- Where
- 11 sites in Denmark, Finland and 1 more
- Volunteers
- 3,000 people
- Sponsor
- St. Olavs Hospital
Surgical Site Infection (SSI)
Skin Adhesive Plus Intra-cuticular Suture Versus Suture Alone for Cesarean Skin Closure
The goal of this randomized control trial is to compare two skin closure techniques after cesarean section. Both techniques are currently in wide use but no comparison between the two was reasserted yet.
- Trial name
- NCT07483411
- Testing
- Dermabond
- Where
- Israel
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Doron Kabiri
COVID-19, Psychological Distress
Psychological Impact of COVID-19 on Intensive Care Survivors
Psychological distress is commonly experienced by survivors of an intensive care admission, including patients treated during previous pandemics.
- Conditions
- COVID-19, Psychological Distress, Depression, Anxiety
- Trial name
- PIM-COVID (NCT05092529)
- Where
- 50 sites in United Kingdom
- Volunteers
- 1,620 people
- Sponsor
- Royal Liverpool University Hospital
Gastric Cancer, Surgical Wound Infection
Fatigue and QoL Among Gastric Cancer Patients Undergoing Abdominal Surgery
Background: Cancer-related fatigue (CRF), one of the indicators of QoL, is one of the most common side effects of cancer and its treatment.
- Conditions
- Gastric Cancer, Surgical Wound Infection, Fatigue, Quality of Life
- Trial name
- NCT03766945
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Taiwan University Hospital
Acute Kidney Injury, Probiotics
Effect of Probiotics and Prebiotics in Renal Function in Septic Acute Kidney Injury Patients
Septic acute kidney injury is a condition associated with highly related to inflammatory molecules. Prebiotics and probiotics have shown to improve inflammatory cascade in animal model; In this study, the investigators propose…
- Conditions
- Acute Kidney Injury, Probiotics, Sepsis
- Trial name
- NCT03877081
- Testing
- Probiotics
- Where
- Mexico
- Volunteers
- 90 people
- Sponsor
- Hospital Civil de Guadalajara
Trauma
Inflammation and Infection in Trauma, Role in Posttraumatic Complications
The purpose of this study is to investigate the relationship between trauma, the immune system, biochemical changes in the first 24 h and subsequent complications and mortality
- Trial name
- NCT00192907
- Where
- Denmark
- Volunteers
- 380 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Noninvasive Ventlation, COVID-19 Respiratory Infection
Effects of Body Position on Diaphragmatic Activity in Patients Requiring Noninvasive Ventilation for Acute Respiratory Failure COVID-19 Related
The present investigation aims to assess the diaphragmatic thickening fraction, reflecting the diaphragmatic activity, during supine (baseline) and at 1 hour following prone position in patients assisted through non invasive…
- Conditions
- Noninvasive Ventlation, COVID-19 Respiratory Infection, Diaphragm Injury
- Trial name
- DiaCOVIDProne (NCT04904731)
- Testing
- Prone position
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Azienda Ospedaliera di Perugia
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