Clinical trials: Wound Infections
Laparotomy, Dehiscence Wound
Barbed Suture vs Non-Barbed Closure for Emergency Exploratory Laparotomy RCT
This randomized control trial aims to compare the efficacy of triclosan-coated barbed suture (TCB) versus conventional non-barbed polydioxanone (PDS) suture in the closure of the abdominal fascia after emergency exploratory…
- Conditions
- Laparotomy, Dehiscence Wound, Surgical Site Infections, Trauma Abdomen
- Trial name
- NCT06043414
- Testing
- triclosan-coated barbed suture, triclosan-coated non-barbed suture, Non-coated non-barbed suture
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Southern California
Wound Complication, Surgical Wound Infection
Electrocautery Versus Scalpel for Skin Incisions
The aim of this research project is to compare electrocautery to scalpel for laparotomy skin incisions, with the following objectives: 1. To investigate whether electrocautery produces a cosmetically inferior surgical scar. 2.
- Conditions
- Wound Complication, Surgical Wound Infection, Post-operative Pain
- Trial name
- NCT01496404
- Testing
- Electrocautery, Scalpel
- Where
- Canada
- Volunteers
- 66 people
- Sponsor
- St. Paul's Hospital, Canada
Wound Infection
A Randomized Trial of Ostomy Closure Techniques
Stoma closure has been associated with a high rate of surgical site infection (SSI). The rate for SSI following stoma closure has been noted to be 7-41%; a rate that is higher than expected for a clean-contaminated operative…
- Trial name
- NCT01713452
- Testing
- Purse string closure, Primary closure
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- University of Minnesota
COVID-19, Chilblains
Analysis of Chilblains pROfile During coVID-19 Epidemic (ACROVID)
Cases of chilblains have been reported with an unusual frequency in France in the context of the COronaVirus Infectious Disease 2019 (COVID-19) epidemic.
- Trial name
- ACROVID (NCT04387955)
- Testing
- Biological Sample Collection
- Where
- France
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Oral Health Related Quality of Life (OHRQoL), Early Childhood Caries (ECC)
Assessment of Oral Health-Related Quality of Life in Preschool-Aged Children in Alto Alentejo
The observational study aims to improve understanding of Oral Health-Related Quality of Life (OHRQoL) among preschool children in the District of Portalegre, Portugal, by examining the roles of sociodemographic, behavioral, and…
- Conditions
- Oral Health Related Quality of Life (OHRQoL), Early Childhood Caries (ECC), Traumatic Dental Injuries, Gingivitis
- Trial name
- NCT07648121
- Where
- Portugal
- Volunteers
- 454 people, healthy volunteers welcome
- Sponsor
- University of Lisbon
Burns, Sepsis
Comparison Between Interleukin 6 and Procalcitonin in Detecting Sepsis and Incidence of Mortality in Burn ICU Patients
The investigators will compare the efficacy of Interleukin-6 (IL-6) as a better indicator than procalcitonin in burn patients with sepsis or septic shock regarding success of treatment and early ICU discharge.
- Conditions
- Burns, Sepsis, Septic Shock, Death
- Trial name
- NCT06915974
- Testing
- Interleukin 6
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Wound Infection
Biofilm Correlation and Validation
This is a prospective, single-blind, controlled trial. There are two arms and 20 patients with acute or chronic wounds with clinical suspicion of biofilm (CSB+/CSB-) are allocated in each arm.
- Trial name
- NCT05196880
- Testing
- MolecuLight DX Imaging Device
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- MolecuLight Inc.
Radiation; Adverse Effect, Pneumonitis
Predictors of Radiation Pneumonitis in Locally Advanced Lung Cancer Treated With Chemoradiation
Lung cancer [LC] is the leading cause of cancer death worldwide. The standard treatment of locally advanced lung cancer unresectable or marginally resectable is combination therapy with radical or preoperative chemoradiation.
- Trial name
- NCT01580579
- Where
- Mexico
- Volunteers
- 62 people
- Sponsor
- Instituto Nacional de Cancerologia de Mexico
Spinal Cord Injuries
Intravesical Glycosaminoglycan Instillation and Urinary Tract Infection in Acute Spinal Cord Injury
The purpose of this study is to assess the safety and feasibility of administering glycosaminoglycan (GAG) therapy, iAluRil®, intravesically in individuals with acute spinal cord injury (SCI), commencing within the first ten days…
- Trial name
- NCT03945110
- Testing
- iAluRil® intravesical instillations
- Where
- Australia
- Volunteers
- 10 people
- Sponsor
- The University of Western Australia
Covid19, Sars-CoV2
Description of Ophthalmologic Injuries in Intensive Care During the SARS-CoV2 Epidemic - COVID19
The management of patients with SARS-CoV2 in respiratory distress can expose to corneal or retinal lesions induced by the stay in intensive care.
- Trial name
- DOCOV (NCT04385810)
- Testing
- Ophthalmologic exam
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Bone and Joint Infection
Comparison of Two Empirical Antimicrobial Therapies of Prosthetic Joint Infection
The empirical use of vancomycin in combination with a broad-spectrum beta-lactam is currently recommended after the initial surgery of prosthetic joint infection (PJI).
- Trial name
- NCT03850860
- Testing
- empirical antibiotherapy
- Where
- France
- Volunteers
- 178 people
- Sponsor
- Hospices Civils de Lyon
Surgical Site Infection
De-Implementation of Unnecessary Surgical Antibiotic Prophylaxis in Children
The overall objective of this study is to identify the best strategy to eliminate unnecessary antibiotic use after surgery in pediatric surgical procedures considered low-risk for an SSI.
- Trial name
- OPerAtiC (NCT04366440)
- Testing
- Order set review and modification with facilitation, Order set review and modification
- Where
- 10 sites in United States
- Volunteers
- 18,267 people
- Sponsor
- Washington University School of Medicine
Cirrhosis, Liver, Bacterial Infections
Bacterial Infections in Cirrhotic Patients With Acute Severe Liver Injury
Acute hepatic insults including hepatitis flare-up, active alcohol assumption and hepatotoxic drug use are common in patients with cirrhosis especially in Eastern countries.These patients are at high risk of developing…
- Conditions
- Cirrhosis, Liver, Bacterial Infections, Acute Liver Injury
- Trial name
- NCT03204591
- Testing
- No intervention
- Where
- China
- Volunteers
- 500 people
- Sponsor
- The Zhejiang Study Group for Organ Failure in Cirrhosis
Cardiac Disease, Covid19
Validation of Quantitative Myocardial Tissue Characterization Through Non-gated CT
The main aim is to validate non-gated 5-min computed tomography myocardial relative enhancement (CT-MRE), which can be readily estimated via contrast-enhanced non-gated chest CT, as a tool for estimating myocardial extracellular…
- Conditions
- Cardiac Disease, Covid19, Cardiotoxicity, Extracellular Space Alteration
- Trial name
- NCT04880317
- Testing
- Cardiac Magnetic Resonance, Additional CT acquisition, Blood tests
- Where
- Italy
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Dysphagia, Peristomal Wound Infection
The Influence of Oral Hygiene on Local Wound and Systemic Infection in Patients With Percutaneous Endoscopic Gastrostomy Placement
Percutaneous endoscopic gastrostomy (PEG) is commonly used for long term enteral feeding of patients with severe dysphagia. The most common complication is peristomal wound infection.
- Trial name
- PEG (NCT00859235)
- Testing
- Chlorhexidine gluconate 0.2%, Plain water
- Volunteers
- 50 people
- Sponsor
- Hillel Yaffe Medical Center
Surgical Site Infection, Difference in Surgical Site Infection According to Gender and Age Groups
COMPARISON OF PURSE-STRING CLOSURE VERSUS CONVENTIONAL PRIMARY CLOSURE FOLLOWING STOMA REVERSAL TO REDUCE SURGICAL SITE INFECTION RATE"
The study will be carried out in Surgical Unit-III, Lahore General Hospital, Lahore for one year . . Patients undergoing surgery for Ileostomy will be randomly divided into two groups, Group-A (Purse-string closure) and Group-B…
- Trial name
- NCT04757623
- Testing
- Purse string closure of Ileostomy
- Where
- 2 sites in Pakistan
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Combined Military Hospital, Pakistan
COVID-19
Assessment of Mental Health in Healthcare Workers Exposed to COVID-19 Patients
The recent COVID-19 outbreak has put the health care workers on the frontline to interact and provide support to the patients. Based on previous disease outbreak-associated studies, it is evident that these individuals are at a…
- Trial name
- BADS-PTSD (NCT04473118)
- Testing
- Survey
- Where
- Qatar
- Volunteers
- 25,000 people
- Sponsor
- Hamad Medical Corporation
Myocardial Injury, COVID-19
Myocardial Injury and Dysfunction Associated With COVID-19 Vaccination
The overall goal of the study is to investigate the characteristics and potential mechanisms responsible for myocardial injury and dysfunction in patients after COVID-19 vaccination.
- Conditions
- Myocardial Injury, COVID-19, Vaccine Reaction
- Trial name
- MIDAVAX (NCT05359250)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Colorado, Denver
Septic Shock
Continuous Hemodialysis With an Enhanced Middle Molecule Clearance Membrane
This study aims to demonstrate equivalence in terms of molecule removal between continuous hemodialysis using an "enhanced middle molecule clearance" membrane(Ultraflux EMiC2) and continuous hemofiltration using a standard…
- Trial name
- NCT01067313
- Testing
- Dialyzer Ultraflux EMiC2, Dialyzer Ultraflux AV1000S
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Fresenius Medical Care France
Surgical Wound Infection
Prophylactic Negative Wound Pressure Therapy (PICO-7) Following Groin Incisions in Vascular Surgery (PICO-Vasc Study)
Comparison between waterproof sterile dressing OPSITE Post-Op Visible, Smith \& Nephew, UK and PICO-7, Smith \& Nephew, UK in terms of inguinal surgical wound infection and complications after lower limb revascularization.
- Trial name
- PICO-Vasc (NCT04840576)
- Testing
- Regular waterproof sterile dressing., Prophylactic Negative Pressure Dressing
- Where
- Spain
- Volunteers
- 132 people
- Sponsor
- Corporacion Parc Tauli
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