Clinical trials: Wound and Injuries
Brain Injuries
CDP-Choline and Working Memory After TBI: A Neuroimaging Study
The purpose of this study is to determine whether an investigational drug, called "CDP-Choline", improves memory in people with traumatic brain injury (TBI).
- Trial name
- NCT00727246
- Testing
- CDP-Choline
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Patricia M. Arenth
Risk Assessment, Parenting
Randomized Controlled Trial of a Risk Reframing Tool to Change Mothers' Parenting Associated With Children's Risky Play
Children's risky play is associated with a variety of positive developmental, physical and mental health outcomes, including greater physical activity, self-confidence and risk management skills.
- Trial name
- NCT03374683
- Testing
- RR Digital Tool, RR In-Person Workshop, Position Statement on Active Outdoor Play
- Where
- Canada
- Volunteers
- 451 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Cisplatin Ototoxicity, Hearing Loss
Randomized Trial Comparison of Ototoxicity Monitoring Programs
This study involves research. Some chemotherapeutic drugs that can permanently reduce hearing are termed "ototoxic". One such drug is the chemotherapy called cisplatin.
- Trial name
- COMP-VA (NCT02099786)
- Testing
- COMP-VA, Standard of care
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Complications Wounds, Negative Pressure Wound Therapy
Incisional Negative Pressure Wound Therapy in High Risk Patients Undergoing Panniculectomy: A Prospective Randomized Controlled Trial
Incisional negative pressure therapy (INPWT) has previously been shown in certain patient populations to decrease wound healing complications, decrease the rate of hematomas and seromas, as well as have better scar quality.
- Conditions
- Complications Wounds, Negative Pressure Wound Therapy, Wound Healing Delayed, Incisional
- Trial name
- NCT03010137
- Testing
- Incisional Negative Pressure Wound Therapy, Standard Closure with Skin Glue, PICO (Smith&Nephew)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Preterm Birth, Injuries
Nurse-Family Partnership Impact Evaluation in South Carolina
This study evaluates the effects of the Nurse Family Partnership (NFP), an established home-visiting program, using a scientifically rigorous individual-level randomized controlled trial.
- Conditions
- Preterm Birth, Injuries, Maternal Behavior
- Trial name
- NFP (NCT03360539)
- Testing
- Nurse-Family Partnership
- Where
- 9 sites in United States
- Volunteers
- 5,670 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Foot Injuries and Disorders
SCANREP: Reliability of 3D Lower Limb Scanning
3D limb scanning systems have recently been implemented for the clinical fitting of prosthetic and orthotic devices due to substantial decreases in costs.
- Trial name
- NCT04032041
- Testing
- Structure Sensor, Caliper
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Stress Disorders, Posttraumatic
Veteran Stress and Learning Study
This is a research study examining the use of two medications, Hydrocortisone and D-Cycloserine, compared to an inactive substance (placebo), on their ability to reduce fear responses and memory of fear in Veterans with symptoms…
- Trial name
- VSL (NCT00674570)
- Testing
- Hydrocortisone, D-Cycloserine
- Where
- United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Surgical Site Infection
Topical Treatment and Prevalence of P. Acnes
This study is about preventing surgical site infections of the shoulder. We hope to learn if clindamycin alone, benzoyl peroxide alone, or clindamycin and benzoyl peroxide together can affect growth of Propionibacterium acnes in…
- Trial name
- NCT03257202
- Testing
- Clindamycin 1% Gel, Benzoyl peroxide 5% gel, BenzaClin 5%-1% Topical Gel
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Arthritis, Rheumatoid Arthritis
Wright Foot & Ankle Post-Market Observational Study
WRIGHT FOOT \& ANKLE POST-MARKET OBSERVATIONAL STUDY, Multi-Year, Multi-Site, Multi-Device, Post-Market Observational Study, 10 sites, a minimum of 40 patients per device
- Conditions
- Arthritis, Rheumatoid Arthritis, Fracture, Trauma Injury
- Trial name
- NCT04118894
- Testing
- Foot and Ankle Devices
- Where
- 5 sites in United States, France and 2 more
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Stryker Trauma and Extremities
Traumatic Brain Injury (TBI), Chronic Traumatic Encephalopathy (CTE)
The Effects of Fish Oil Supplementation on the Brain Health of Collegiate Football Athletes
Determine if the daily docosahexaenoic acid (DHA)/eicosapentaenoic acid (EPA) supplement will reduce serum levels of biomarkers of sub-concussion injuries over a course of American football season among collegiate football…
- Trial name
- NCT04796207
- Testing
- Fish Oil (DPA+EPA 2:1 ratio) Capsules, High Oleic Safflower Oil Capsules
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Acute Musculoskeletal Disease, Sprains
Efficacy of Lidocaine Patch in Acute Musculoskeletal Pain in the Emergency Department
This study evaluates the addition of a lidocaine patch to ibuprofen in the treatment of acute musculoskeletal pains. Half of the participants will get only ibuprofen for their pain, while other half will receive lidocaine patch…
- Conditions
- Acute Musculoskeletal Disease, Sprains, Sprains and Strains, Injuries
- Trial name
- NCT03571737
- Testing
- Ibuprofen, Lidocaine Patch 4%
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- East Carolina University
Chlorhexidine Gluconate Cloths, Infection; Cesarean Section
STRIPES Study: Study To Reduce Infection Post cEsarean Section
The objective of this study is to determine if the use of chlorhexidine gluconate cloths prior to cesarean section reduce the rate of infectious morbidity (i.e. surgical site infections, endometritis).
- Conditions
- Chlorhexidine Gluconate Cloths, Infection; Cesarean Section, Infectious Morbidity, Surgical Site Infections
- Trial name
- NCT02402907
- Testing
- 2% chlorhexidine gluconate (CHG) cloth
- Where
- United States
- Volunteers
- 1,356 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Attendance at Treatment, PTSD, Substance Use, and Attendance at Treatment
Evaluation and Treatment of Substance Abuse in Veterans With PTSD Disability Claims
Veterans can apply for compensation and pension (C \& P) benefits for a disability related to military service. The application exam for these benefits provides an opportunity for Veterans returning from service to access VA…
- Trial name
- SBIRT-PTSD (NCT01597856)
- Testing
- SBIRT
- Where
- 2 sites in United States
- Volunteers
- 346 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Spinal Cord Injury
Biomechanical Validation of the Transfer Assessment Instrument (TAI)
The purpose of this research study is to further develop and refine the Transfer Assessment Instrument (TAI). The TAI is a clinical tool to be used by therapists to evaluate transfer techniques and performance.
- Trial name
- NCT01183546
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury
Noninvasive Modulation of Motivational Brain Regions in Healthy Volunteers
21 healthy control participants will be recruited. On Day 1 they will complete reward-guided decision making tasks and questionnaires followed by a functional magnetic resonance imaging (fMRI) scan.
- Trial name
- NCT04972786
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Cesarean Section, Wound Complications
Cesarean Trial of Staples vs. Sutures
To determine whether the rate of wound complications differs based on method of closure of skin incision (staples vs. suture) after cesarean delivery.
- Conditions
- Cesarean Section, Wound Complications, Patient Satisfaction, Pain Measurement
- Trial name
- CROSS (NCT01211600)
- Testing
- Staples, Suture
- Where
- 2 sites in United States
- Volunteers
- 746 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Low Level Laser Therapy, Healthy
Effect of GaAlAs 940 Laser on Pain and Wound Healing After Free Gingival Graft
This randomized controlled clinical trial aims to evaluate the biomodulatory effects of a 940-nm GaAlAs diode laser on postoperative pain control and wound healing at the palatal donor site following free gingival graft…
- Conditions
- Low Level Laser Therapy, Healthy, Postoperative Pain Management, Wound Healing
- Trial name
- NCT07308912
- Testing
- 940 nm GaAlAs diode laser, palatal stent
- Where
- Vietnam
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Scar, Skin Scarring
Scar Appearance After Postoperative Hydrocolloid Dressing Versus Standard Petrolatum Ointment
Patients will be randomized either to receive standard daily dressing or hydrocolloid dressing using a randomization generator. After closing the wound with the sutures,the scar will be covered by a hydrocolloid dressing, which…
- Conditions
- Scar, Skin Scarring, Skin Cancer, Wound Heal
- Trial name
- NCT05618912
- Testing
- Hydrocolloid dressing, Petrolatum jelly dressing
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Indiana University
Anxiety, Lacerations
Intranasal Midazolam for Treatment of Anxiety in Children Undergoing Suturing in the Pediatric Emergency Department
Laceration repair can cause significant anxiety in children. As open wounds account for 21-25% of injuries in children presenting to the emergency department, the management of anxiety is of great importance.
- Trial name
- NCT02618772
- Testing
- Midazolam, Saline
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Infant, Newborn, Infant, Low Birth Weight
Multi-dose Pharmacokinetics and Dose Ranging of Inositol in Premature Infants (INS-2)
This pilot study is a randomized, placebo-controlled, clinical trial to measure changes in blood and urine levels of inositol in premature infants at high risk for retinopathy of prematurity (ROP) following repeated doses of…
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- INS-2 (NCT01030575)
- Testing
- Inositol lower volume, Inositol mid-level volume, Inositol high volume
- Where
- 17 sites in United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- NICHD Neonatal Research Network