Clinical trials: Wound of Knee
ACL Tears
MRI Evaluation of Graft Maturation Following ACL Reconstruction
Post-surgical ACL Graft maturation will be assessed at 4.5, 6, 7.5, 9, 10.5, and 12 months with MRI.
- Trial name
- NCT07046000
- Testing
- MRI
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Skye Biologics Holdings, LLC
Wound Healing and Prevention
Performance, Safety and Efficacy of NPWT Device
Smith \& Nephew are assessing a new investigational single use NPWT system.
- Trial name
- NCT04102865
- Testing
- Negative-Pressure Wound Therapy (NPWT)
- Where
- 8 sites in United Kingdom
- Volunteers
- 90 people
- Sponsor
- Smith & Nephew, Inc.
Low Back Pain, Radicular Syndrome
Comparison of High-Intensity and Conventional Physical Therapy in Musculoskeletal Disorders
This pilot randomized controlled trial aims to compare the clinical effectiveness of advanced high-intensity physical therapy modalities with conventional physical therapy in patients suffering from musculoskeletal disorders.
- Conditions
- Low Back Pain, Radicular Syndrome, Sacroiliac Joint Dysfunction, Shoulder Impingement Syndrome
- Trial name
- NCT07903142
- Testing
- Repetitive Peripheral Magnetic Stimulation (rPMS), High-Intensity Laser Therapy (HIL), Extracorporeal Shockwave Therapy (ESWT)
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- BTL Industries Ltd.
Cartilage Injury, Osteochondritis Dissecans
A Randomized Controlled Trial Comparing Chondro-Gide® to Microfracture Alone for Treatment of Knee Cartilage Defects.
The purpose of this study is to evaluate the safety and effectiveness of using Chondro-Gide® collagen membrane either sutured or glued compared to microfracture alone in the treatment of symptomatic cartilage defects of the knee.
- Trial name
- NCT02993510
- Testing
- Microfracture, Chondro-Gide sutured, Chondro-Gide glued
- Where
- 7 sites in Germany
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Geistlich Pharma AG
Infection of Total Knee Joint Prosthesis
Evaluating Bactisure Wound Lavage in Orthopedic Wounds
To demonstrate a reduction of debris in knee synovial fluid as demonstrated by WBC cell counts before and after irrigation with Bactisure Wound Lavage.
- Trial name
- NCT03192124
- Testing
- Bactisure
- Where
- 5 sites in United States
- Volunteers
- 40 people
- Sponsor
- Zimmer Biomet
Pain, Acute, Pain, Chronic
Evaluation of the Effect of the AI500™ SINGLE-DOSE GEL Medical Device in Patients With Reduced Knee Function
Evaluation of the effect of the AI500™ SINGLE-DOSE GEL medical device in patients with reduced knee function
- Conditions
- Pain, Acute, Pain, Chronic, Knee Injuries, Knee Osteoarthritis
- Trial name
- NCT05886608
- Testing
- AI 500™ SINGLE-DOSE GEL
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- Contrad Swiss SA
Arthroplasty, Replacement, Knee, Knee Injuries
ALGRX 4975 After Total Knee Replacement
ALGRX 4975 or placebo will be dripped onto the cut muscles and soft tissues before the end of surgery for total replacement of the knee.
- Trial name
- NCT00132392
- Testing
- ALGRX 4975
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- AlgoRx Pharmaceuticals
Knee Injury
Evaluation of the CR Plug for Repair of Defects Created at the Harvest Site From an Autograft in the Knee.
The main objective of this study is to test the ability of an allograft plug to provide a successful repair of an osteochondral defect left at the harvest site during OATS procedure.
- Trial name
- CRB (NCT00821873)
- Testing
- CR Plug
- Where
- 4 sites in United States
- Volunteers
- 9 people
- Sponsor
- RTI Surgical
Lower Limb Amputation Below Knee (Injury), Lower Limb Amputation Above Knee (Injury)
Feasibility Study to Evaluate a New Energy Storage and Return Prosthetic Foot
A prospective, interventional, multicenter pilot study to characterize differences in performance and patient reported outcomes between the Taleo, Proflex XC, and the new Revo prosthetic foot.
- Conditions
- Lower Limb Amputation Below Knee (Injury), Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Knee
- Trial name
- NCT04239222
- Testing
- Revo-M, Taleo, Proflex XC
- Where
- 4 sites in United States
- Volunteers
- 27 people
- Sponsor
- Otto Bock Healthcare Products GmbH
Anterior Cruciate Ligament Injury, Anterior Cruciate Ligament Rupture
The BEAR III Trial for Bridge-Enhanced ACL (Anterior Cruciate Ligament) Restoration
Bridge-Enhanced ACL Restoration (BEAR) is a new procedure being developed to treat patients with ACL injuries. In the BEAR procedure, an implant is placed between the torn ends of the ACL and the patient's own blood is added to…
- Trial name
- NCT03348995
- Testing
- Bridge-Enhanced ACL Restoration (BEAR)
- Where
- 11 sites in United States
- Volunteers
- 250 people
- Sponsor
- Miach Orthopaedics
Cartilage Injury
Second Line Treatment of Knee Osteochondral Lesion With Treated Osteochondral Graft
Patient with IKDC score < 65, pretreated with mosaicplasty or ACI ( with matrix or not) within > 18 months, with one or two osteochondral lesions are recruited to have treated osteochondral allografts in mosaicplasty.
- Trial name
- ODPHOENIX2 (NCT02430558)
- Testing
- OD-PHOENIX
- Volunteers
- 10 people
- Sponsor
- TBF Genie Tissulaire
Anterior Cruciate Ligament Injury, Osteoarthritis
Safety and Efficacy Study of MSB-CAR001 in Subjects 6 Weeks Post an Anterior Cruciate Ligament Reconstruction
The purpose of this study is to evaluate safety and preliminary efficacy of MSB-CAR001 in subjects who have recently undergone an Anterior Cruciate Ligament Reconstruction
- Trial name
- NCT01088191
- Testing
- MSB-CAR001 Combined With Hyaluronan, Hyaluronan
- Where
- Australia
- Volunteers
- 17 people
- Sponsor
- Mesoblast, Ltd.
Articular Cartilage Disorder of Knee, Cartilage Damage
Human ECM Implanted Within Microfracture Interstices & the Cartilage Defect in the Knee to Regenerate Hyaline Cartilage
HST003 is a human extracellular matrix designed for injection into the subchondral bone following microfracture surgery by an injection into the interstices created by the surgical awl and filling the full defect to help…
- Conditions
- Articular Cartilage Disorder of Knee, Cartilage Damage, Microfractures
- Trial name
- hECM;HST003 (NCT05082831)
- Testing
- microfracture surgery + HST003
- Where
- 5 sites in United States
- Volunteers
- 1 people
- Sponsor
- Histogen
Osteoarthritis of the Knee, Degenerative Osteoarthritis
Platelet-Rich Plasma and the Effects of NSAIDs on Pain and Functional Scores in Knee Osteoarthritis
The primary research purpose is to determine if the use of a drug therapy intervention (each study participant will be randomly assigned to receive one of 3 study medications which will be blinded from everyone, including the…
- Conditions
- Osteoarthritis of the Knee, Degenerative Osteoarthritis, Knee Pain Chronic
- Trial name
- PRPNSAIDsKOA (NCT05742763)
- Testing
- Ibuprofen and PRP, Acetaminophen and PRP
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- QC Kinetix LLC
Osteoarthritis, Knee
Clinical Trial to Evaluate the Efficacy and Safety of MegaCarti® in Knee Cartilage Defects
The MegaCarti® is the decellularized allogeneic cartilage and acts as a cover after bone marrow stimulation to prevent the loss of blood clots and induces cartilage regeneration by assisting in the location of stem cells derived…
- Trial name
- NCT05440370
- Testing
- MegaCarti®, Microfracture
- Where
- 4 sites in South Korea
- Volunteers
- 90 people
- Sponsor
- L&C Bio