Clinical trials: Wounds
Spinal Cord Injury
The Relationship Between Irisin and Bone Health in Individuals With Spinal Cord Injury
This study will examine the relationship between circulating irisin and bone health individuals with spinal cord injury. Additionally, this study seeks to examine the influence of muscle fiber type on circulating irisin and…
- Trial name
- IBSCI (NCT05319522)
- Testing
- Acute Exercise
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Mastectomy
PEAK PlasmaBlade™ 4.0 Versus Traditional Electrosurgery in Mastectomy
The objective of this clinical study is to evaluate the incidence of partial skin necrosis following modified-radical mastectomy with or without same-day (two-stage) reconstruction with the PEAK PlasmaBlade 4.0; to monitor and…
- Trial name
- PRECISE (NCT00943605)
- Testing
- Scalpel and Traditional Electrosurgery, PEAK PlasmaBlade
- Where
- 4 sites in United States
- Volunteers
- 60 people
- Sponsor
- Medtronic Surgical Technologies
Occlusion
Comparison of EVD Catheter Diameter on Occlusion and Replacement
A randomized trial comparing small versus large catheters in terms of occlusion and need for replacement to confirm differential occlusion risk based on catheter size.
- Trial name
- NCT03248739
- Testing
- Clear Bactiseal 'large' catheter (EVD), Orange Bactiseal 'small' catheter (EVD)
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Wake Forest University Health Sciences
PTSD, Anxiety
EEG Biofeedback Therapy as an Adjunct Treatment for PTSD
The proposed study, "Placebo-controlled study of EEG biofeedback therapy as an adjunct treatment for PTSD, evaluating symptoms and EEG dynamics", will investigate the brain dynamics associated with PTSD symptom reduction…
- Conditions
- PTSD, Anxiety, Trauma, Sleep Disorders
- Trial name
- NCT01591408
- Testing
- EEG biofeedback
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- United States Naval Medical Center, San Diego
Macromastia
A Study to Evaluate Cutaneous Scar Quality Following Bilateral Breast Reduction With the PEAK PlasmaBlade 4.0
The objective of this clinical study is to evaluate scar quality following incision with the PEAK PlasmaBlade 4.0 using the Patient and Observer Scar Assessment Scale (POSAS), and to compare these results to equivalently-aged…
- Trial name
- PRECISE (NCT01284491)
- Testing
- PEAK PlasmaBlade 4.0, Traditional Electrosurgery with scalpel
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Medtronic Surgical Technologies
Brow Ptosis, Surgical Wound
An Analysis of Dermabond vs. Non-Absorbable Sutures in Skin Closure for Brow Ptosis Procedures
The goal of this clinical trial is to compare Dermabond with non-absorbable sutures in skin closure after brow ptosis surgery. The main questions it aims to answer are: if Dermabond provides equivalent wound healing compared to…
- Trial name
- NCT05981443
- Testing
- Dermabond, Non-Absorbable Sutures
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Cody Blanchard
Tibial Fractures
Use of a Reinforced Injectable Calcium Phosphate Bone Cement in the Treatment of Tibial Plateau Fractures
Case series of tibial plateau fractures using Norian Drillable.
- Trial name
- NCT01132508
- Testing
- Norian Drillable Bone Void Filler
- Where
- 6 sites in Australia, China and 2 more
- Volunteers
- 33 people
- Sponsor
- Synthes GmbH
Acute Wounds From Trauma, Dehiscence or Surgical Complications
Comparison of Two Methods of Negative Pressure Wound Therapy
The current standard for negative pressure wound therapy is the Vacuum Assisted Closure Device (VAC), a commercial system that utilizes a computerized suction pump to apply negative pressure to an open-cell poly-urethane foam…
- Trial name
- NCT00724750
- Testing
- Gauze suction (G-SUC), Vacuum Assisted Closure Device (VAC)
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- University of Chicago
Injuries, Spinal Cord
The WISE Trial - Walking Improvement for SCI With Exoskeleton
A randomized, controlled trial comparing exoskeleton gait training with standard gait training or no gait training in community-dwelling participants with chronic incomplete spinal cord injury
- Trial name
- WISE (NCT02943915)
- Testing
- Ekso GT Rehabilitation Therapy, Body Weight Supported (BWS) Treadmill Training
- Where
- 10 sites in United States
- Volunteers
- 45 people
- Sponsor
- Ekso Bionics
Intra-Articular Fractures
Effect of Early Saline Lavage on Synovial Fluid Composition Following Intra Articular Ankle Fractures
The purpose of this study is to examine the effect of early, percutaneous, intra-articular saline lavage on the undiluted synovial fluid microenvironment during the acute phase following intra-articular fracture of the human…
- Trial name
- NCT05465382
- Testing
- Saline Lavage, No intra-articular saline lavage, Lidocaine - intra-articular injection
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Duke University
Blast Injuries, Brain Injuries
Central Auditory Processing Deficits Associated With Blast Exposure
The current conflicts in Afghanistan and Iraq have resulted in unprecedented rates of exposure to high-intensity blasts and resulting brain injury.
- Conditions
- Blast Injuries, Brain Injuries, Age Factors
- Trial name
- NCT01567020
- Testing
- Diagnostic
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Tooth Fractures, Tooth Injuries
Comparative Volumetric Assessment of Alveolar Ridge Preservation Utilizing Different Bone Grafting Materials
This study is intended to provide statistically robust evidence that Symbios Demineralized Cortical-cancellous granule mix, Symbios OsteoGraf LD-300, and OsteoGraf/N-300 combined with Symbios OsteoShield Collagen Resorbable…
- Conditions
- Tooth Fractures, Tooth Injuries, Tooth Diseases
- Trial name
- NCT02532543
- Testing
- Allograft, Membrane, Alloplast, Membrane, Xenograft, Membrane
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Spasticity, Cerebrovascular Accident
Efficacy and Safety Study of MYOBLOC® in the Treatment of Adult Upper Limb Spasticity
Phase 2/3, randomized, double-blind, placebo-controlled, single-treatment, multicenter trial assessing the efficacy and safety of MYOBLOC for the treatment of upper limb spasticity in adults followed by an open-label extension…
- Conditions
- Spasticity, Cerebrovascular Accident, Multiple Sclerosis, Traumatic Brain Injury
- Trial name
- NCT04815967
- Testing
- Phase 2; Low Dose MYOBLOC (10,000 Units), Phase 2; High Dose MYOBLOC (20,000 Units), Phase 3; MYOBLOC
- Where
- 9 sites in United States, Hungary and 1 more
- Volunteers
- 32 people
- Sponsor
- Solstice Neurosciences, LLC, a subsidiary of MDD US Operations, LLC
Menopause, Fracture
Forteo for the Treatment of Unexplained Osteoporosis in Premenopausal Women
Idiopathic osteoporosis (IOP) is an uncommon disorder in which otherwise healthy young individuals sustain one or more low-trauma fractures.
- Conditions
- Menopause, Fracture, Osteoporosis
- Trial name
- IOPForteo (NCT00697463)
- Testing
- Teriparatide (PTH 1-34)
- Where
- 2 sites in United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Columbia University
Head Trauma, Image, Body
Rapid MRI for Acute Pediatric Head Trauma
Pediatric head trauma is a leading cause of morbidity and mortality for children/adolescents. The current standard of care regarding imaging modality when concerned for an acute head injury is CT.
- Trial name
- NCT03291964
- Testing
- Rapid Brain MRI
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Oregon Health and Science University
Diabetic Foot Ulcer
VA MERIT: A Comparative Efficacy Study: Treatment of Non-Healing Diabetic
The primary objective of this study is to assess the effectiveness of cellular dermal replacement tissue vs. non-viable extracellular matrix (ECM) for the treatment of non-healing diabetic foot ulcers.
- Trial name
- DOLCE (NCT01450943)
- Testing
- SECONDARY dressing gauze and tape, debridement, irrigation, Dermagraft
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- VA Office of Research and Development
Brain Injuries, Traumatic, Sleeplessness
AcuSleep in Mild Traumatic Brain Injury (TBI)
Objective: To evaluate real acupuncture, as compare to sham acupuncture, in improving persistent sleep difficulties in veterans with mild traumatic brain injury (mTBI) Design: Randomized, blinded, sham-controlled clinical trial…
- Trial name
- AcuTBI (NCT01162317)
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- VA Office of Research and Development
Abscess
Antibiotics Versus Placebo in the Treatment of Abscesses in the Emergency Department
The purpose of this study is to determine if there is a difference between an antibiotic, trimethoprim-sulfamethoxazole versus placebo in healing outcomes of soft tissue abscesses following incision and drainage.
- Trial name
- NCT00867789
- Testing
- Trimethoprim-sulfamethoxazole, Sugar pill
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Spinal Cord Injury
Development of Low Cost Devices to Increase Access to Treadmill Training
The goals of this Model System Program are to expand upon and advance the findings and outcomes of previous and current Model Systems clinical research, to continue to develop and study the effectiveness of innovative treatment…
- Trial name
- NCT02560506
- Testing
- Elastic assisted treadmill walking
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Shirley Ryan AbilityLab
Wound
Evaluation of the Safety and Effectiveness of ALLEVYN Gentle Border
The clinical study will evaluate the safety and effectiveness of the ALLEVYN Gentle Border. The study is a post-market clinical follow-up to assess clinical performance and safety of ALLEVYN Gentle Border with new wound contact…
- Trial name
- NCT03877484
- Testing
- ALLEVYN Gentle border
- Where
- 6 sites in France, Germany and 1 more
- Volunteers
- 43 people
- Sponsor
- Smith & Nephew Orthopaedics AG
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