Clinical trials: Wounds
Spinal Cord Diseases, Spinal Cord Injuries
An Open-Label Long-Term Study Of Pregabalin For The Treatment Of Central Neuropathic Pain
The purpose of this study is to assess the safety of the long-term use of pregabalin at doses up to 600 mg/day in patients with central neuropathic pain (post spinal cord injury pain, post stroke pain, and multiple sclerosis…
- Conditions
- Spinal Cord Diseases, Spinal Cord Injuries, Neuralgia, Pain
- Trial name
- NCT01202227
- Testing
- pregabalin
- Where
- 26 sites in Japan
- Volunteers
- 104 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Surgical Wound
RESPECT Trial - (Rapid Extravascular Sealing Via PercutanEous Collagen ImplanT)
The objective of this trial is to demonstrate the safety and effectiveness of the Cardiva VASCADE™ Vascular Closure System (VCS) in sealing femoral arterial access sites.
- Trial name
- RESPECT (NCT01297322)
- Testing
- Manual compression, Cardiva VASCADE™ Vascular Closure System
- Where
- 21 sites in United States, Australia
- Volunteers
- 420 people
- Sponsor
- Cardiva Medical, Inc.
Fractures, Bone, Nausea and Vomiting, Postoperative
Quality of Recovery After Dexamethasone, Ondansetron or Placebo Intrathecal Morphine Administration
The aim of this study is to evaluate not only the occurrence of side effects, but the quality of the recovery (QoR-40 Questionnaire) of patients submitted to spinal anesthesia with administration of low doses (0.1 mg) of…
- Conditions
- Fractures, Bone, Nausea and Vomiting, Postoperative, Pruritus, Morphine Adverse Reaction
- Trial name
- NCT03035942
- Testing
- Dexamethasone, Ondansetron, Saline
- Where
- Brazil
- Volunteers
- 135 people
- Sponsor
- Pontificia Universidade Catolica de Sao Paulo
Ototoxicity
SPI-1005 for Prevention and Treatment of Tobramycin Induced Ototoxicity
The primary objective of this study is to determine the safety and efficacy of SPI-1005 treatment in CF patients with active pulmonary exacerbation that are receiving an IV course of tobramycin, determined by comparing hearing…
- Trial name
- NCT02819856
- Testing
- SPI-1005 Ebselen 200mg Capsule x1, SPI-1005 Ebselen 200mg Capsule x2, SPI-1005 Ebselen 200mg Capsule x3
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Sound Pharmaceuticals, Incorporated
Spinal Cord Injury, Urinary Tract Infection
Colonizing Neurogenic Bladders With Benign Flora
The purpose of the research is to determine whether we can get harmless bacteria to live in the bladders of persons with spinal cord injury who practice intermittent bladder catheterization.
- Trial name
- NCT00371631
- Testing
- Insertion of urinary catheters coated with E. coli 83972
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- US Department of Veterans Affairs
Trauma, Opioid Use
Relieving Acute Pain (RAP) Study: A Pilot Study
The United States (US) faces a crisis of pain management. According to the 2012 National Health Interview Survey, almost 50 million adults in the US reported having significant chronic or severe pain (Nahin 2015).
- Conditions
- Trauma, Opioid Use, Spine Fusion
- Trial name
- NCT03426137
- Testing
- Oxycodone, Ketorolac
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Maryland, Baltimore
Osteoarthritis Shoulder, Fracture
Multi Centre Study on TESS V2 Shoulder System
This study is a Post Market Clinical Follow-up study to fulfill the post market surveillance requirements. The data collected from this study will serve the purpose of confirming safety and performance of the TESS Shoulder System.
- Conditions
- Osteoarthritis Shoulder, Fracture, Rheumatoid Arthritis, Avascular Necrosis
- Trial name
- NCT03431857
- Testing
- TESS V2
- Where
- 2 sites in Belgium, France
- Volunteers
- 106 people
- Sponsor
- Zimmer Biomet
TBI (Traumatic Brain Injury)
Improving Functions in MTBI Patients With Headache by rTMS
Due to recent wars in Afghanistan and Iraq, the number of Veteran suffering from Mild traumatic brain(MTBI) injury and PTSD increases rapidly.
- Trial name
- NCT01948947
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- VA Office of Research and Development
Alcohol Use Disorder, Post Traumatic Stress Disorder
Piloting "Signs of Safety": A Deaf-Accessible Therapy Toolkit for Alcohol Use Disorder and Trauma
The U.S. Deaf community - more than 500,000 Americans who communicate using American Sign Language (ASL) - experiences nearly triple the rate of lifetime problem drinking and twice the rate of trauma exposure as compared to the…
- Trial name
- NCT03845985
- Testing
- Seeking Safety + Signs of Safety toolkit
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Massachusetts, Worcester
Shock, Hemorrhagic, Injury Penetrating
Feasibility of Evaluating XSTAT Use in the Prehospital Setting
This study evaluates the prehospital use of the XSTAT device to control bleeding in junctional wounds. Participants will be randomized to the use of XSTAT versus standard care.
- Conditions
- Shock, Hemorrhagic, Injury Penetrating, Hemorrhage
- Trial name
- PhoXSTAT (NCT04663087)
- Testing
- XSTAT, Standard of Care
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Alabama at Birmingham
Hip Dysplasia, Postoperative Complications
High vs Low Dose Dexamethasone on Complications in the Immediate Postoperative Phase
The aim of this study is to investigate the effect of a single preoperative high-dose steroid injection on complications in the immediate postoperative phase after periacetabular osteotomy.
- Trial name
- DEX-GANZ (NCT03161938)
- Testing
- Dexamethasone
- Where
- Denmark
- Volunteers
- 64 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Brain Injuries, Traumatic, Sleep Initiation and Maintenance Disorders
The Feasibility of Home-Based Measurement of Circadian Timing for Veterans With TBI and Insomnia
Veterans with traumatic brain injury (TBI) frequently experience insomnia, which is linked with delayed TBI recovery, more severe functional impairment, and exacerbation of disabling TBI after-effects such as depression, chronic…
- Trial name
- Home DLMO (NCT05665764)
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- VA Office of Research and Development
Post-Concussion Syndrome
The Effectiveness of Biofeedback for Individuals With Long-term Post-concussive Symptoms
Most concussions resolve within 7-10 days, but approximately 40% of individuals do not fully recover and suffer from persistent post-concussive symptoms.
- Trial name
- NCT03338036
- Testing
- Heart Rate Variability Biofeedback, Neurofeedback
- Where
- Canada
- Volunteers
- 31 people
- Sponsor
- Western University, Canada
ACL Injury, Post Operative Pain
iPACK for Post-op Pain Following ACL Reconstruction
This study will consist of patients 12 years and older undergoing ACL reconstruction using a quadriceps or bone-patella tendon bone (BTB) graft.
- Trial name
- NCT05498870
- Testing
- Adductor Canal Block (ACB) Only, Adductor Canal Block (ACB) + iPACK Block
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Medical University of South Carolina
Spinal Cord Injury
Effects of Salsalate on Prandial-Induced Vascular Inflammation After Spinal Cord Injury (SCI)
The overall study objectives are to examine whether: 1. Persons with spinal cord injury (SCI) having elevated body mass are at greater cardiovascular disease (CVD) risk for fasting and postprandial lipidemia, glycemia, and…
- Trial name
- NCT01201759
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Miami
Obstruction of Pelviureteric Junction
The Efficacy and Safety of Local Anesthetic Infusion With Ropivacaine
The investigators propose a prospective blinded randomized control trial (RCT) to assess the efficacy and safety of a simple method of continuous infusion of a local anesthetic, ropivacaine, via a surgical wound to control pain…
- Trial name
- NCT00930046
- Testing
- Ropivacaine wound catheter, Saline wound catheter
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Boston Children's Hospital
Spinal Cord Injury, Acute, Neurogenic Bladder
Sacral Nerve Stimulation in Improving Bladder Function After Acute Traumatic Spinal Cord Injury
The purpose of this study is to see what effects sacral neuromodulation has on bladder function and quality of life in patients with acute spinal cord injury.
- Conditions
- Spinal Cord Injury, Acute, Neurogenic Bladder, Incontinence, Urinary Tract Infections
- Trial name
- NCT03083366
- Testing
- PrimeAdvanced Surescan 97702 Neurostimulator - Medtronic (Minneapolis, MN)
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- University of Utah
Arthralgia
Changes in Knee Articular Cartilage Volume in Women on Aromatase Inhibitors
Many women with breast cancer are treated with a class of drugs called aromatase inhibitors (mainly letrozole or anastrozole), which lowers the amount of estrogen being produced in the body.
- Trial name
- NCT00111241
- Testing
- aromatase inhibitors (letrozole, anastrozole)
- Where
- Australia
- Volunteers
- 115 people
- Sponsor
- Monash University
Sleep Initiation and Maintenance Disorders, Anxiety
HIRREM Developmental Study
The purpose of this study is to explore the functional and physiological effects associated with the use of High-resolution, relational, resonance-based, electroencephalic mirroring (HIRREM), as supplemental care, for symptoms of…
- Conditions
- Sleep Initiation and Maintenance Disorders, Anxiety, Post-Traumatic Stress Disorder, Hot Flashes
- Trial name
- NCT02709369
- Testing
- HIRREM
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Wake Forest University Health Sciences
Hip Fractures
Surgical Treatment of Hip Fractures Under Peripheral Regional Anesthesia
The study investigates whether treatment of proximal femoral fractures is possible using a peripheral regional anesthesia technique.
- Trial name
- NCT04005404
- Testing
- Ropivacaine (sciatic nerve block), Ropivacaine (lumbar plexus block L2-L4), Ropivacaine (lumbar plexus block Th12-L1)
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Helios Research Center
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