Clinical trials: Wounds and Injuries
Traumatic Haemorrhagic Shock
An Observational Pilot Study of the Effects of Traumatic Haemorrhagic Shock and Resuscitation on the Microcirculation
Haemorrhage following major trauma is an important preventable cause of death. Those patients who survive may have a prolonged period of debility caused by failure of key body organs.
- Trial name
- MICROSHOCK (NCT02111109)
- Testing
- Side Stream Dark Field Microscopy
- Where
- 3 sites in United Kingdom
- Volunteers
- 58 people
- Sponsor
- King's College Hospital NHS Trust
Injury of Anterior Cruciate Ligament
Comparison of Infiltration Analgesia With Femoral Nerve Block After Hamstrings Anterior Cruciate Ligament Reconstruction
Pain treatment after anterior cruciate ligament reconstruction - Comparison of infiltration analgesia with femoral nerve block after.
- Trial name
- NCT01260363
- Testing
- Femoral nerve block, Local infiltration analgesia
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- University of Aarhus
Spinal Cord Injuries, Neurogenic Bladder
Dorsal Genital Nerve Stimulation for Bladder Management After SCI
Following spinal cord injury signals between the brain and the bladder are disrupted. As a result the bladder often becomes overactive which can lead to the need for frequent trips to the toilet, regular incontinence episodes and…
- Conditions
- Spinal Cord Injuries, Neurogenic Bladder, Neurogenic Detrusor Overactivity, Neurogenic Bladder Dysfunction
- Trial name
- NEUROMOD UCon (NCT05502614)
- Testing
- Neuromodulation
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- University College, London
Traumatic Brain Injury
Advanced MRI in Blast-related TBI
Thousands of soldiers, marines, and other military personnel have had injuries to the brain due the wars in Iraq and Afghanistan.
- Trial name
- NCT00785304
- Where
- 2 sites in United States, Germany
- Volunteers
- 100 people
- Sponsor
- Washington University School of Medicine
ACL Reconstruction, Meniscus Tears
A Comparison of Outcomes After Anterior Cruciate Ligament (ACL) or Anterior Cruciate Ligament and Meniscus (ACL+Meniscus) Surgery Using Semiconductor Fabric Products
The goal of this clinical trial is to determine the effect of semiconductor sleeves on the treatment of Anterior Cruciate Ligament (ACL) or Anterior Cruciate Ligament and Meniscus (ACL+Meniscus) arthroscopic surgery.
- Conditions
- ACL Reconstruction, Meniscus Tears, Anterior Cruciate Ligament Rupture
- Trial name
- NCT06979804
- Testing
- Semiconducting fabric sleeves, Non-semiconducting fabric sleeves
- Where
- United States
- Volunteers
- 135 people
- Sponsor
- Illinois Center for Orthopaedic Research and Education
Pregnant Women Undergoing Cesarean Delivery
Dexmedetomidine for Cesarean Delivery
Regional anesthesia has become the anesthetic of choice for cesarean section in most countries; however, some women still prefer general anesthesia techniques.
- Trial name
- NCT01005433
- Testing
- Dexmedetomidine
- Where
- Saudi Arabia
- Volunteers
- 68 people
- Sponsor
- King Faisal University
Burn
Determining Elements of Anti-Fungal Immunity in BURN Patients
Scientific justification Invasive fungal diseases (IFDs) pose a substantial threat, especially in immunocompromised patients, necessitating urgent research focus and therapeutic advancements.
- Trial name
- DEFI-BURN (NCT06828458)
- Testing
- Biological sampling
- Where
- France
- Volunteers
- 327 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acquired Brain Injury
Effect of Telehealth Mindfulness on Sleep and Anxiety in Acquired Brain Injury Population
The goal of this study is to learn the effect of a telehealth mindfulness meditation program on sleep quality and anxiety in individuals with brain injury living in the community.
- Trial name
- NCT06717399
- Testing
- Mindfulness meditation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Saint Joseph's University, Philadelphia
Spinal Cord Injuries
The Effect of FES and Therapeutic Exercise on SCI Patients Skeletal Muscles, Sitting Balance, Posture and Quality of Life
Aim of the current study is to evaluate the effect functional electrical stimulation and therapeutic exercise on traumatic spinal cord injured participants'skeletal muscle characteristics, sitting balance, lung function and…
- Trial name
- NCT03517787
- Testing
- FES+TE, TE, REF-FES+TE
- Where
- Estonia
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Tartu University Hospital
Hypothermia, Trauma
Zero Heat Flux Temp Monitor on Discharge Hypothermia Among Trauma Patients (RUZIT Trial)
Hypothermia amongst trauma patients is a persistent problem that increases the relative risk of transfusion as well as morbidity and mortality.
- Conditions
- Hypothermia, Trauma, Temperature Change, Body
- Trial name
- RUZIT (NCT03313258)
- Testing
- Standard of Care Group, Active Warming Group
- Where
- Canada
- Sponsor
- Dr. Asim Alam
Elderly, Wrist Fracture
Evaluation of Health and Social Interventions Aimed to Old People Discharged From Hospital After a Hip or Wrist Fracture Due to a Fall
Objectives: To describe social and health care provided to our older patients who have been admitted in the emergency department (ED) after suffering from a hip or wrist fracture due to a fall.
- Conditions
- Elderly, Wrist Fracture, Hip Fracture
- Trial name
- NCT02802358
- Testing
- Surgery or non-invasive procedure (reduction of the fracture, immobilization, stabilization)
- Volunteers
- 1,824 people
- Sponsor
- Hospital Galdakao-Usansolo
Anterior Cruciate Ligament Rupture
Effect of Tunnel Placements on Clinical and MRI Findings Two Years After ACL Reconstruction With DB Technique
Purpose: To find out whether the clinical and MRI findings two years after anterior cruciate ligament (ACL) reconstruction were associated with each other so that MRI-based graft invisibility in the anteromedial (AM) graft would…
- Trial name
- NCT02000258
- Testing
- Double-bundle ACL reconstruction, Magnetic resonance imaging (MRI)
- Where
- Finland
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Tampere University Hospital
Spinal Cord Injuries, Neurogenic Bowel
Prebiotics for Spinal Cord Injury Patients With Bowel and Bladder Dysfunction
An investigator initiated pilot study: two arm, double blind, placebo controlled, randomized, group of approximately 60 patients with spinal cord injury, and who have evidence of neurogenic bladder.
- Conditions
- Spinal Cord Injuries, Neurogenic Bowel, Bladder Dysfunction
- Trial name
- NCT03987126
- Testing
- Human Milk Oligosaccharides (HMO)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Cardiac Toxicity, Unspecified Childhood Solid Tumor, Protocol Specific
Oblimersen Plus Combination Chemotherapy and Dexrazoxane in Treating Children and Adolescents With Relapsed or Refractory Solid Tumors
Phase I trial to study the effectiveness of oblimersen plus combination chemotherapy and dexrazoxane in treating children and adolescents who have relapsed or refractory solid tumors.
- Trial name
- NCT00039481
- Testing
- oblimersen sodium, dexrazoxane hydrochloride, doxorubicin hydrochloride
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Cancer Institute (NCI)
Humeral Fractures, Proximal
Determinants of Function and Clinically Important Outcomes in Proximal Humerus Fractures
The proposed project will be a multi-centre, prospective observational study to determine the prognosis and determinants of functional outcomes of patients with proximal humerus fractures.
- Trial name
- NCT02212600
- Testing
- Observational
- Where
- 2 sites in Canada
- Volunteers
- 500 people
- Sponsor
- London Health Sciences Centre
Humerus Fracture, Humerus
RSA vs. Nonop for 3 & 4-Part Proximal Humerus Fractures
There is currently no consensus amongst orthopedic specialists on the best way to treat 3- and 4-part proximal humerus fractures.
- Conditions
- Humerus Fracture, Humerus, Shoulder Fractures, Shoulder Arthropathy Associated With Other Conditions
- Trial name
- NCT03599336
- Testing
- Reverse Total Shoulder Arthroplasty (rTSA), Nonoperative Treatment
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Mayo Clinic
White Matter Injury, Brain Injury, Fetus and Neonate
Neonatal White Matter Injury Trial (WRAP)
The researchers are investigating a new treatment for white matter injury, which is a common type of brain injury in premature babies. The drug, clemastine, is experimental.
- Conditions
- White Matter Injury, Brain Injury, Fetus and Neonate, Neonatal Brain Injury, Periventricular Leukomalacia
- Trial name
- WRAP (NCT07688746)
- Testing
- Clemastine fumarate
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Bridget LaMonica Ostrem, M.D., Ph.D.
Carpal Tunnel Syndrome, Compare Steroids Versus PRP in Dissection of Median Nerve by Ultrasound
Ultrasound Guided Activated and Non Activated Platelet Rich Plasma Injection Versus Hydro Dissection by Steroids.
PRP represents a promising, nonsurgical option for patients with carpal tunnel syndrome (CTS) with improvement in symptoms compared to placebo, conservative treatment, and local corticosteroid injections at 3-months…
- Trial name
- PRP (NCT06249503)
- Testing
- platelet rich plasma
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Ankle Sprain, Ankle Sprain 1St Degree
Effectiveness of a Telerehabilitation Program in Ankle Sprain
Ankle sprain is the most common sprain. Their care entails a high cost due to the incapacity for work that it generates. An early and timely intervention for the treatment of ankle sprain reduces the days of disability and…
- Conditions
- Ankle Sprain, Ankle Sprain 1St Degree, Ankle Sprain 2Nd Degree
- Trial name
- NCT05217173
- Testing
- telerehabilitation
- Where
- Mexico
- Volunteers
- 82 people
- Sponsor
- Instituto Mexicano del Seguro Social
Shoulder Injury
Blood Flow Restriction Therapy Following Acute Shoulder Injury Patients
Atrophy and weakness of the shoulder are a common problem following treatment of a number of shoulder and elbow pathologies. Even with relatively short periods of reduced activity, the magnitude of muscle loss can be quite…
- Trial name
- BFR (NCT06223373)
- Testing
- Blood Flow Restriction
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Wake Forest University Health Sciences