Clinical trials: Wounds and Injury
Breast Carcinoma, Pain
Prophylactic Topical Agents in Reducing Radiation-Induced Dermatitis in Patients With Non-inflammatory Breast Cancer
This randomized pilot phase II trial studies and compares prophylactic topical agents in reducing radiation-induced dermatitis in patients with non-inflammatory breast cancer or breast cancer in situ.
- Conditions
- Breast Carcinoma, Pain, Radiation-Induced Dermatitis, Stage 0 Breast Cancer
- Trial name
- Curcumin-II (NCT02556632)
- Testing
- Curcumin-based Gel, Dermatologic Complications Management, Laboratory Biomarker Analysis
- Where
- 6 sites in United States
- Volunteers
- 191 people
- Sponsor
- Gary Morrow
Low Back Pain, Musculoskeletal Pain
Soft Active Back Exosuit to Reduce Workplace Back Pain
The goal of this clinical trial is to determine if a wearable back exosuit can make it safer and easier for workers who bend, lift, and lower objects in an industrial setting.
- Conditions
- Low Back Pain, Musculoskeletal Pain, Low Back Injury
- Trial name
- NCT05802914
- Testing
- Back Exosuit
- Where
- United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Wyss Institute at Harvard University
Acute Blunt Soft Tissue Injuries/Contusions
Efficacy and Safety of Diclofenac Sodium Topical Gel 1% Compared to Placebo in Subjects With Acute Blunt Trauma Injuries
This study will assess the analgesic efficacy of DSG 1% compared to placebo in the reduction of the pain associated with acute blunt trauma injuries.
- Trial name
- NCT02290821
- Where
- 10 sites in United States
- Volunteers
- 215 people
- Sponsor
- Novartis
Lung Cancer, Lung Metastases
Study to Evaluate the Efficacy and Safety of Nintedanib (BIBF 1120) + Prednisone Taper in Patients With Radiation Pneumonitis
The purpose of this study is to find out what effects, good and/or bad, the drug nintedanib in combination with steroids, has on the lungs. Furthermore, such treatments' side effects will be studied together with quality of life.
- Trial name
- NCT02496585
- Testing
- Nintedanib, Prednisone
- Where
- 12 sites in United States
- Volunteers
- 34 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Inflammatory Myelopathies
CNS Growth Factors Release and Changes in the Inflammatory Environment in Response to Electrical Stimulation in Subjects With Inflammatory Myelopathies
This research is being done to see how different amounts of Functional Electrical Stimulation (FES) affect cycling on factors in blood and spinal cord in people with spinal cord inflammation.
- Trial name
- FIRST-STIM (NCT01440452)
- Testing
- FES Cycling, Cycling without FES, Lumbar puncture
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Johns Hopkins University
Anterior Cruciate Ligament Rupture, Deficiency of Anterior Cruciate Ligament
Comparison of Three Methods for Anterior Cruciate Ligament Reconstruction
The purpose of this randomized clinical trial is to determine the difference in quality of life outcome at two years, in patients undergoing an Anterior Cruciate Ligament (ACL) reconstruction procedure with either a patellar…
- Conditions
- Anterior Cruciate Ligament Rupture, Deficiency of Anterior Cruciate Ligament, Chronic Instability of Knee, Anterior Cruciate Ligament Injury
- Trial name
- NCT00529958
- Testing
- Patellar Tendon, Hamstring Tendon, Double-Bundle
- Where
- Canada
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Femoral Fracture
Analysis of the Relationship Between Early Postoperative Anemia and the Evolution of Autonomy at 6 Months in Patients 75 Years of Age and Older Operated on Following a Fracture of the Upper End of the Femur
Fracture of the upper extremity of the femur is a condition whose frequency increases with age. It is a serious disease, with multiple consequences such as a decrease in life expectancy, quality of life and patient autonomy.
- Trial name
- PAAF (NCT03810092)
- Where
- 5 sites in France
- Volunteers
- 255 people
- Sponsor
- Centre Hospitalier Departemental Vendee
COVID-19
Healthcare Worker Exposure Response and Outcomes of Hydroxychloroquine
This is a double blind, placebo controlled study in approximately 2,000 health care workers at risk for being exposed to COVID-19.
- Trial name
- HERO-HCQ (NCT04334148)
- Testing
- Hydroxychloroquine
- Where
- 34 sites in United States
- Volunteers
- 1,360 people, healthy volunteers welcome
- Sponsor
- Adrian Hernandez
Venous Thromboembolism, Thromboprophylaxis
Aspirin and Enoxaparin for VTE in Trauma
The purpose of this study is to determine if the addition of antiplatelet therapy (i.e. aspirin) to low-molecular-weight-heparin (i.e.
- Conditions
- Venous Thromboembolism, Thromboprophylaxis, Trauma
- Trial name
- NCT02396732
- Testing
- Aspirin, Enoxaparin
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Miami
Ecchymosis
Effects of Topical Vitamin K, Vitamin K and Retinol, and Arnica on Post-Laser Bruising
The objective of this study is to assess the comparative utility of topical formulations in hastening the resolution of skin bruising.
- Trial name
- NCT00363038
- Testing
- Petrolatum United States Pharmacopeia (USP), Vitamin K and retinol ointment, Arnica ointment
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Trauma, Hemorrhagic Shock
Control of Major Bleeding After Trauma Study
Bleeding is the most avoidable cause of death in trauma patients. Up to one-third of severely injured trauma patients are found to be coagulopathic and forty percent of the mortality following severe injury is due to…
- Trial name
- COMBAT (NCT01838863)
- Testing
- Type AB plasma, Crystalloid fluid (standard of care for resuscitation)
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Denver Health and Hospital Authority
Carpal Tunnel Syndrome (CTS)
Injection Versus Splinting in Carpal Tunnel Syndrome
Carpal Tunnel Syndrome (CTS) is a common condition in which a nerve (known as the median nerve) is squeezed where it passes through the wrist. It can cause pain or aching, tingling or numbness in the affected hand.
- Trial name
- INSTinCTS (NCT02038452)
- Testing
- Depo-Medrone, Wrist Splint
- Where
- United Kingdom
- Volunteers
- 234 people
- Sponsor
- Keele University
Spinal Cord Injury, Chronic Inflammation
Impact of Passive Heat on Metabolic, Inflammatory and Vascular Health in Persons With Spinal Cord Injury
SCI results in higher incidence of heart disease and diabetes and heart disease is the most common cause of death. Chronic inflammation, deleterious changes in vascular structure and impaired glucose metabolism are risk factors…
- Conditions
- Spinal Cord Injury, Chronic Inflammation, Glucose Metabolism, Endothelial Function
- Trial name
- SCIPHS (NCT04971408)
- Testing
- passive heat stress, Control
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- VA Office of Research and Development
TBI (Traumatic Brain Injury)
Improving Functions in MTBI Patients With Headache by rTMS
Due to recent wars in Afghanistan and Iraq, the number of Veteran suffering from Mild traumatic brain(MTBI) injury and PTSD increases rapidly.
- Trial name
- NCT01948947
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- VA Office of Research and Development
Surgical Wound
AMBULATE Continued Access Protocol to Evaluate the Cardiva Mid-Bore Venous Vascular Closure System (VVCS)
The objective of the trial is to demonstrate the safety and effectiveness of the Cardiva Mid-Bore Venous Vascular Closure System (VVCS) in sealing femoral venous access sites at the completion of catheter-based procedures…
- Trial name
- NCT03573206
- Testing
- Cardiva Mid-Bore Venous Vascular Closure Device (VVCS)
- Where
- 3 sites in United States
- Volunteers
- 168 people
- Sponsor
- Cardiva Medical, Inc.
Spinal Cord Injury
FES Rowing for Skeletal Health After SCI
Following a complete spinal cord injury (SCI), individuals experience progressive bone loss, especially in the legs, with up to 70% of persons with SCI sustaining a fracture at some point during their lifetime.
- Trial name
- FES-R (NCT02008149)
- Testing
- Rowing exercise
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- VA Office of Research and Development
Obesity, Weight Loss
Utilizing Protein During Weight Loss to Impact Physical Function and Bone
This study is an ancillary study to the Utilizing Protein During Weight Loss to Impact Physical Function (UPLIFT) trial (NCT03074643) to evaluate the effects of diet composition (i.e., amount of protein and carbohydrate) during a…
- Conditions
- Obesity, Weight Loss, Diet Modification, Aging
- Trial name
- UPLIFT-Bone (NCT03819478)
- Testing
- Weight loss intervention months 0-6, Exercise intervention months 0-6, NutraBio™ CarboMax Supplement
- Where
- United States
- Volunteers
- 187 people
- Sponsor
- Wake Forest University Health Sciences
Glenohumeral Internal Rotation Deficit (GIRD)
Effect of Joint Mobilization and Movement Control Exercises on Shoulder Pain and Function in Fast Bowlers (RCT)
The goal of this clinical trial is to determine combined effects of the Kinetic control for shoulder on pain, range, and function among fast bowlers.
- Trial name
- RCT (NCT07229274)
- Testing
- Kinetic control for shoulder internal rotation with mobilization with movement, stretches, strengthening and mobilization with movement
- Where
- 2 sites in Pakistan
- Volunteers
- 50 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Blood Clot, Trauma
PREVENTion of Clot in Orthopaedic Trauma
The purpose of this study is to compare aspirin versus low-molecular weight heparin (LMWH) (Enoxaparin) as a thromboprophylaxis in patients who sustain a fracture.
- Trial name
- PREVENT CLOT (NCT02984384)
- Testing
- Acetylsalicylic acid, Low Molecular Weight Heparin (LMWH)
- Where
- 21 sites in United States, Canada
- Volunteers
- 12,424 people
- Sponsor
- Major Extremity Trauma Research Consortium
Cervical Intraepithelial Neoplasia
Efficacy Study of Diathermy Cone Biopsy for the Treatment of Cervical Intraepithelial Lesion
The purpose of this trial is to determine whether SWETZ (Straight Wire Excision of Transformation Zone) is a superior alternative to LLETZ cone (Large Loop Excision of Transformation Zone cone biopsy) in the management of…
- Trial name
- NCT00995020
- Testing
- Straight Wire Excision of Transformation Zone, Large Loop Excision of Transformation Zone (cone biopsy)
- Where
- 2 sites in Brazil
- Volunteers
- 103 people
- Sponsor
- Oswaldo Cruz Foundation
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