Clinical trials: Wrinkles
Forehead Rhytides
A Study Comparing the Safety, Efficacy, and Diffusion of Letibotulinum Toxin A Versus Other Botulinum Toxin Products in Adults With Moderate-to-Severe Forehead Wrinkles
The goal of this clinical trial is to learn if letibotulinum toxin A is effective and safe for treating moderate-to-severe horizontal forehead wrinkles in adults.
- Trial name
- NCT07072806
- Testing
- Letibotulinum toxin A, Prabotulinum toxin A, Onabotulinum toxin A
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Yonsei University
Facial Wrinkles
Cryo-Touch II for the Treatment of Wrinkles
This is a prospective, non-randomized study to evaluate the performance of the MyoScience Cryo-Touch II device for the treatment of wrinkles.
- Trial name
- NCT01167140
- Testing
- Cryo-Touch II
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Pacira Pharmaceuticals, Inc
Aging
Safety and Efficacy of the EndyMed Pro System Using RF Micro-needles Fractional Skin Remodeling
The need for cosmetic facial enhancement procedures with minimal down time and low risk has led to the development of methods for non-surgical skin rejuvenation.
- Trial name
- NCT02368626
- Testing
- EndyMed Pro™ RF Micro-Needles
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- EndyMed
Wrinkles, Ageing
Influence of of Cream With the Silver Fir Wood Extract (Belinal) on Skin
Objective of the study is to determine the influence of the cream with Silver fir wood (Abies alba) extract (Belinal) on the skin parameters and functions in comparison to the placebo cream.
- Conditions
- Wrinkles, Ageing, Photoprotection, Skin Care
- Trial name
- NCT02603029
- Testing
- Belinal cream
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- VIST - Faculty of Applied Sciences
Cheek, Wrinkle
Open Label Extension for 43USSA1812
To evaluate long-term safety and effectiveness data of Sculptra Aesthetic beyond the Month 12 duration of the pivotal study 43USSA1812 (NCT04124692) to help characterize the long-term safety and effectiveness profile of the more…
- Trial name
- NCT04595331
- Testing
- Sculptra Aethestic reconsituted with 8ml Sterile Water for Injection
- Where
- 13 sites in United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Upper Facial Lines (Glabellar Lines, Forehead Lines, & Lateral Canthal Lines)
Efficacy and Safety of DaxibotulinumtoxinA (DAXI) for Injection for Treatment of Upper Facial Lines
This is a Phase 2, multicenter, open-label, single-arm study to evaluate the efficacy and safety of DaxibotulinumtoxinA for injection (DAXI for injection) in the treatment of Glabellar Lines (GL), Dynamic Forehead Lines (FHL)…
- Trial name
- NCT04259086
- Testing
- DaxibotulinumtoxinA for injection
- Where
- 8 sites in United States, Canada
- Volunteers
- 48 people
- Sponsor
- Revance Therapeutics, Inc.
Photoaging, Wrinkle
A Clinical Study to Evaluate the Long-Term Efficacy and Tolerability of a Daily Anti-Aging Daily Serum
This double-blind, randomized, placebo-controlled, single-center clinical trial was conducted to assess the efficacy and tolerance of an anti-aging daily serum to improve moderate overall photodamage and skin fatigue after…
- Trial name
- NCT05514782
- Testing
- Cleansing Lotion, Facial Moisturizer, Sunscreen SPF 40+
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Revision Skincare
Wrinkles
Silk'n HST for Wrinkle Reduction - Clinical Study Protocol
The objective of the study is to evaluate the safety, efficacy and usage compliance of the home-use device Silk'n HST for self-treatment of periorbital wrinkles and skin laxity and improvement of skin appearance.
- Trial name
- NCT02913547
- Testing
- Silk'n HST
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Home Skinovations Ltd.
Photodamaged Skin, Rhytids
2910 nm Erbium-Doped Fluoride Fiber Glass Laser for the Treatment of Advanced Perioral Lines and Wrinkles
The primary objective is to assess the efficacy, safety and satisfaction associated with the resurfacing treatment of perioral lines and wrinkles with the 2,910 nm mid-infrared Fiber Laser (UltraClear, Acclaro Medical) using both…
- Conditions
- Photodamaged Skin, Rhytids, Lines Skin, Wrinkles and Rhytides
- Trial name
- NCT07222397
- Testing
- Laser Resurfacing
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- FA Corporation
Skin Laxity, Wrinkle
Clinical Study to Evaluate the Efficacy and Safety of Matrix Pro Treatment
This is a non-randomized, multi-center, open-label, prospective clinical trial evaluating clinical treatments with the Matrix Pro Applicator for the improvement of facial and/or submental and neck laxity.
- Conditions
- Skin Laxity, Wrinkle, Skin Condition
- Trial name
- NCT06726122
- Testing
- Profound Matrix
- Where
- 3 sites in Netherlands, United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Candela Corporation
Tear Trough Eyelid Deformity, Dark Eyelids
Periocular Rejuvenation by Topical Hyaluronic Acid Nano Particles
In this study, The investigators aims to evaluate the efficacy and safety of topical hyaluronic acid nanoparticles as a novel nanodermatological tool in periocular rejuvenation as a replacement approach of invasive dermal filler…
- Conditions
- Tear Trough Eyelid Deformity, Dark Eyelids, Wrinkle
- Trial name
- NCT05742399
- Testing
- Hyaluronic acid NanoGel
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Alexandria University
Intrinsic Aging of Skin
Comparative Study of Reconstituted JUVÉDERM® Ultra vs COSMODERM® 1 for Lip and Cheek Lines, Folds or Wrinkles
This study is being done to evaluate the differences in the performance of two well known injectable dermal fillers commonly used for the cosmetic treatment of age lines above the lips and on the cheeks when compared to each…
- Trial name
- JUVE_COSMO_1 (NCT01212809)
- Testing
- Juvéderm Ultra, Cosmoderm 1
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Steven Fagien
Skin Manifestations
Study to Evaluate the Safety and Effectiveness of GP0116
This is a prospective, randomized, evaluator-blinded, comparator-controlled, parallel group, multicenter study in the U.S. for correction of moderate to severe dynamic facial wrinkles and folds, such as nasolabial folds (NLFs).
- Trial name
- NLF (NCT05987163)
- Testing
- GP0116, Active Comparator: FDA approved dermal filler device (RHA 3)
- Where
- 19 sites in United States, Puerto Rico
- Volunteers
- 186 people
- Sponsor
- Galderma R&D
Wrinkle
Injection Site Pain Botulinum Toxin Reconstituted in NS With and Without Sodium Bicarbonate
This study was designed to investigate the effects of botulinum toxin type A injections diluted with the mixture of sodium bicarbonate (SB) and normal saline (NS) on pain reduction, onset of action and duration of action.
- Trial name
- NCT04579419
- Testing
- Sodium Bicarbonate, Normal Saline
- Where
- Saudi Arabia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz Medical City
Forehead Rhytides, Glabellar Rhytides
A Safety and Efficacy Study of OnabotulinumtoxinA in Forehead and Glabellar Facial Rhytides
This is a safety and efficacy study of onabotulinumtoxinA in subjects with forehead and glabellar facial rhytides (frown lines).
- Trial name
- NCT02261467
- Testing
- OnabotulinumtoxinA, Normal Saline
- Where
- 16 sites in United States, Canada and 1 more
- Volunteers
- 421 people
- Sponsor
- Allergan
Wrinkles
A Pilot Study Testing Onabotulinum Toxin A Versus Incobotulinum Toxin A Injections for Facial Wrinkles
The purpose of this study is to compare the effectiveness of Botox® (Onabotulinum Toxin A) versus Xeomin® (incobotulinum toxin A) for the treatment of forehead and glabellar (vertical lines between the eyebrows) wrinkles.
- Trial name
- NCT02019004
- Testing
- Onabotulinum Toxin A, Incobotulinum Toxin A
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Nasolabial Folds, Wrinkles
Non-comparative Evaluation of Facial Expressions Following Lower Face Correction Using Emervel Classic and Emervel Deep
Study is designed to characterize subject and treating investigator reported outcomes in the early post-treatment period, following bilateral correction of nasolabial folds using Emervel Classic and Emervel Deep. 1.
- Trial name
- NCT02672644
- Testing
- Emervel Classic, Emervel Deep
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Skin Wrinkles on Face and Neck Areas
Study to Determine Effectiveness of Activation Mist on Facial Skin Wrinkles
To determine the effect of Activation Mist (AM) on skin wrinkles and appearance.
- Trial name
- NCT01939964
- Testing
- Activation Mist
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- California Allergy and Asthma Medical Group, Inc.
Skin Aging, Wrinkles
Poly-L-lactic Acid (PLLA) Injection for Neck Skin Laxity: A Pilot Study
Skin aging of the neck commonly leads to wrinkles and skin laxity due to the gradual loss of collagen and structural support in the skin.
- Trial name
- NCT07689344
- Testing
- Poly-L-Lactic Acid (Sculptra) injection
- Where
- Thailand
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Institute of Dermatology, Thailand
Nasolabial Fold
Efficacy and Safety Evaluation Study of Neuramis® Deep Lidocaine in Correction of Nasolabial Fold
The purpose of this study is to compare the efficacy and safety of the study medical device, Neuramis® Deep Lidocaine and the control medical device, Restylane® PERLANE-L in correction of nasolabial folds
- Trial name
- NCT02751034
- Testing
- Neuramis® Deep Lidocaine, Restylane® PERLANE-L
- Where
- 2 sites in South Korea
- Volunteers
- 60 people
- Sponsor
- Medy-Tox