Clinical trials: Wrinkles
Facial Wrinkles at the Nasolabial Folds
A Study to Compare the Safety and Effectiveness of a Non-FDA Approved Device Dermal Gel Extra (DGE) and an FDA Approved Device for the Correction of Nasolabial Folds (NLFs)
The purpose of this research study is to evaluate the safety and effectiveness of injection with DGE Injectable Gel (hyaluronic acid with lidocaine manufactured by Genzyme Biosurgery) as compared to injection with Restylane (a…
- Trial name
- NCT00444626
- Testing
- Dermal Gel Extra (DGE), Restylane, EMLA Cream
- Where
- 6 sites in United States
- Volunteers
- 140 people
- Sponsor
- Genzyme, a Sanofi Company
Facial Rhytides, Crow's Feet Lines
Patient Satisfaction Study of Combined Facial Treatment With BOTOX® Cosmetic, JUVÉDERM® and LATISSE® (HARMONY Study)
A study to evaluate patient satisfaction, aesthetic and psychological impact of combined treatment with BOTOX® Cosmetic (onabotulinumtoxinA), JUVÉDERM® ULTRA XC, JUVÉDERM® ULTRA PLUS XC, JUVÉDERM® VOLUMA® XC, and LATISSE®…
- Conditions
- Facial Rhytides, Crow's Feet Lines, Glabellar Lines, Nasolabial Fold
- Trial name
- NCT02176356
- Testing
- onabotulinumtoxinA, bimatoprost ophthalmic solution 0.03%, JUVÉDERM® ULTRA XC
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- Allergan
Wrinkles in Decolletage
An Open-label Study of Poly-l-lactic Acid for Correction of Wrinkles in the décolletage Area
This is a prospective open-label study to evaluate safety and effectiveness of two different reconstitution volumes of poly-l-lactic acid (PLLA) for correction of wrinkles in the décolletage area.
- Trial name
- NCT05538728
- Testing
- poly-l-lactic acid (Sculptra)
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Skin Wrinkling
Emervel Classic Lidocaine Versus Juvederm® Ultra in Treatment of Moderate to Severe Facial Wrinkles and Folds
The purpose of this study is to compare the effectiveness and safety of Emervel Classic Lidocaine versus Juvederm® Ultra in the treatment of moderate to severe facial wrinkles and folds.
- Trial name
- NCT01205048
- Testing
- Emervel Classic Lidocaine, Juvederm® Ultra
- Where
- 12 sites in United States
- Volunteers
- 171 people
- Sponsor
- Galderma R&D
Facial Rhytides
An Observational Retrospective Study to Evaluate Treatment Patterns of Botulinum Toxin Type A
This is a retrospective chart review to evaluate treatment patterns of botulinum toxin Type A for the treatment of facial lines.
- Trial name
- NCT01608659
- Testing
- botulinum toxin Type A
- Where
- Argentina
- Volunteers
- 110 people
- Sponsor
- Allergan
Wrinkle, Nasolabial Fold
RHA® 4 NLF Cannula
This is a randomized, controlled, single-blinded, within-subject (split-face), multicenter, prospective study to investigate whether RHA®4 injected in NLFs with a cannula is non-inferior to RHA®4 injected in NLFs with a sharp…
- Conditions
- Wrinkle, Nasolabial Fold, Aging
- Trial name
- NCT04754646
- Testing
- Split-face injection of RHA® 4 with a cannula into a single NLF., Split-face injection of RHA® 4 with a needle (TSK 27G x ½") into the contralateral NLF.
- Where
- 4 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Teoxane SA
Jowls
Jowl Improvement With Injectable Fillers
This is a prospective clinical study to demonstrate a reduction in jowling and laxity of the jawline that can be achieved following facial volume enhancement using JUVÉDERM VOLUMA™ XC (0.3% w/w lidocaine).
- Trial name
- NCT04389866
- Testing
- JUVÉDERM VOLUMA™ XC
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Advanced Dermatology
Glabellar Rhytides
Treatment With Botulinum Toxin Type A (BOTOX®) in Chinese Patients With Moderate to Severe Frown Lines
A study to evaluate safety and efficacy of treatment with botulinum toxin Type A (BOTOX®) in Chinese patients with moderate to severe frown lines (Glabellar Rhytides) previously treated with facial laser resurfacing.
- Trial name
- NCT01814670
- Testing
- botulinum toxin Type A
- Where
- China
- Volunteers
- 185 people
- Sponsor
- Allergan
Décolleté Wrinkles
Evaluation of the Effectiveness and Safety of Diluted RADIESSE® in the Treatment of Décolleté Wrinkles
Trial to confirm the effectiveness and demonstrate the safety of treatment with diluted Radiesse for correction of Décolleté Wrinkles.
- Trial name
- NCT05163353
- Testing
- Treatment with diluted Radiesse
- Where
- 9 sites in United States
- Volunteers
- 152 people
- Sponsor
- Merz North America, Inc.
Nasolabial Folds
Safety & Tolerability Study That Compares Restylane to Restylane With Lidocaine While Correcting Wrinkles in the Nasolabial Folds
Safety \& tolerability study that compares Restylane to Restylane with Lidocaine (Restylane-L) while correcting wrinkles in the area around your nose.
- Trial name
- NCT00797459
- Testing
- Restylane and Restylane-L
- Where
- 3 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medicis Global Service Corporation
Skin Abnormalities
Change in Skin Elasticity With RF and PEMF
This study will measure the difference in skin elasticity in females only before and after treatment with radiofrequency and pulsed electromagnetic field therapy.
- Trial name
- NCT03002194
- Testing
- Cutometer, Photographs
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Venus Concept
Chest Wrinkles
Evaluation of the Ulthera System for the Treatment of the Decolletage
This is prospective, multi-center clinical trial. Enrolled subjects will receive one Ulthera® treatment on the decolletage. Follow-up visits will occur at 90 and 180 days following treatment.
- Trial name
- NCT01713686
- Testing
- Ulthera System Treatment
- Where
- 4 sites in United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Ulthera, Inc
Bilateral Nasolabial Fold Wrinkles
Safety and Efficacy Study of Isolagen Therapy in the Treatment of Nasolabial Fold Wrinkles
The purpose of this study is to evaluate the safety profile and the treatment effect of Isolagen TherapyTM compared with placebo when administered to bilateral nasolabial fold wrinkles.
- Trial name
- NCT00655356
- Testing
- Autologous Human Fibroblasts (azficel-T)
- Where
- 6 sites in United States
- Volunteers
- 218 people
- Sponsor
- Castle Creek Biosciences, LLC.
Wrinkles
Evaluation of the Safety and Efficacy of the Pico Laser With a Specialized Lens Array for the Treatment of Wrinkles
The purpose of this study is to evaluate the efficacy and safety of the treatment of wrinkles using the picosecond 755nm Alexandrite laser.
- Trial name
- NCT02091089
- Testing
- 755nm Alexandrite laser
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cynosure, Inc.
Glabellar Lines, Wrinkles
Comparison of Dysport Reconstitution at 1.5 mL and 2.5 mL for the Treatment of Moderate to Severe Glabellar Lines
This study is designed to evaluate the safety, efficacy, and subject and investigator satisfaction of 2 different injection volumes of Dysport in the glabellar lines. 1.
- Trial name
- NCT02718118
- Testing
- Dysport reconstituted at 1.5 mL (0.05 mL/injection), Dysport reconstituted at 2.5 mL (0.08 mL/injection)
- Where
- 3 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Pigmentation, Wrinkle
Post Market Clinical Follow Up Study to Collect Additional Data and Imaging
The intended use of the PicoSure device with focus lens array used in this study is to assess images to support additional marketing claims for the treatment of pigmentation and mild to moderate wrinkles.
- Trial name
- NCT04881058
- Testing
- RF Non-Invasive Treatment
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Cynosure, Inc.
Nasolabial Folds
Evaluate Efficacy, Safety & Subject Satisfaction of Pain Management With Pliaglis® Cream for Dermal Filler Injections
Pliaglis® Cream versus compounded topical anesthetic for pain management during Restylane® injections for the correction of nasolabial folds.
- Trial name
- NCT00716443
- Testing
- tetracaine 7% / lidocaine 7% cream (Pliaglis® Cream), benzocaine 20% / lidocaine 6% / tetracaine 4% ointment
- Where
- 4 sites in United States
- Volunteers
- 51 people
- Sponsor
- Galderma R&D
Cheek Wrinkles
Safety and Effectiveness of Sculptra Aesthetic for Correction of Cheek Wrinkles
The study has been designed to evaluate the safety and effectiveness of Sculptra Aesthetic as a single regimen for correction of cheek wrinkles after changes in reconstitution and injection procedures compared to the approved…
- Trial name
- NCT04124692
- Testing
- Sculptra Aesthetic new dilution
- Where
- 13 sites in United States
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Lateral Canthus Rhytides, Crow's Feet Lines
BOTOX® in the Treatment of Crow's Feet Lines in Japan
This study will evaluate the safety and efficacy of BOTOX® (botulinum toxin Type A) compared to placebo for the treatment of Crow's Feet Lines (Lateral Canthus Rhytides).
- Trial name
- NCT01797081
- Testing
- botulinum toxin Type A (24 U), botulinum toxin Type A (12 U), Normal Saline
- Where
- Japan
- Volunteers
- 300 people
- Sponsor
- Allergan
Wrinkles
Comparison of Two Botulinum Toxins Type A on Forehead Wrinkles
Single-centre, controlled, randomized, evaluator-blinded, bilateral (split-face) comparison study in subjects with moderate to severe forehead wrinkles.
- Trial name
- NCT01014871
- Testing
- Botulinum Toxin Type A - Azzalure, Botulinum Toxin Type A - Vistabel
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Galderma R&D