Clinical trials: Xerostomia
Systemic Sclerosis, Gougerot Sjogren Syndrome
Echo Systemic Sclerosis
Systemic sclerosis is an autoimmune connective tissue disease with undefined etiology and characterized by progressive fibrosis of the skin and major organs.
- Conditions
- Systemic Sclerosis, Gougerot Sjogren Syndrome, Sicca-Asthenia-Polyalgia Syndrome
- Trial name
- NCT03143413
- Testing
- Ultrasonography
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Clermont-Ferrand
Xerostomia
Study of the Effectiveness of Cevimeline on Oral Health in Patients With Radiation Induced Xerostomia
The purpose of this study is to determine the effectiveness of cevimeline (versus placebo) on the oral health of patients who have dry mouth which was caused by radiation therapy that was given for treatment of head and/or neck…
- Trial name
- SMILE (NCT00466388)
- Testing
- Cevimeline
- Where
- 7 sites in United States
- Volunteers
- 54 people
- Sponsor
- American Academy of Otolaryngology-Head and Neck Surgery Foundation
Sjögren Syndrome
Study of Safety and Efficacy of Multiple Doses of CFZ533 in Two Distinct Populations of Patients With Sjogren's Syndrome
This study was to evaluate the safety, efficacy, pharmacokinetics (PK) and pharmacodynamics (PD) of multiple doses of CFZ533 (iscalimab) in patients with Sjögren's Syndrome (SjS).
- Trial name
- TWINSS (NCT03905525)
- Testing
- CFZ533
- Where
- 71 sites in United States, Argentina and 21 more
- Volunteers
- 273 people
- Sponsor
- Novartis Pharmaceuticals
Xerostomia
Effect of Korean Red Ginseng (KRG) on Dry Mouth
The purpose of this study is to determine the effect of KRG (Korean Red Ginseng) on Dry Mouth (Xerostomia).
- Trial name
- NCT00911768
- Testing
- Korean Red Ginseng Powder Capsule, Corn-starch powder with ginseng flavor
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- The Korean Society of Ginseng
Xerostomia, Sjogren's Syndrome
Study of NGX267 Oral Capsules in Patients With Xerostomia Associated With Sjorgren's Syndrome
The purpose of this study is to evaluate the effectiveness of NGX267 in the improvement of decreased salivary flow associated with primary or secondary Sjögren's syndrome.
- Trial name
- NCT00637793
- Testing
- NGX267
- Where
- 3 sites in United States
- Volunteers
- 24 people
- Sponsor
- TorreyPines Therapeutics
Head and Neck Neoplasms, Xerostomia
Evaluation of Treatment Related Toxicity After Radiotherapy for Head and Neck Cancer
Radiotherapy plays an important role in the curative treatment of head and neck cancer. This treatment however is associated with significant acute and late toxicity with xerostomia and dysphagia severely implicating the…
- Conditions
- Head and Neck Neoplasms, Xerostomia, Deglutition Disorders
- Trial name
- NCT01621048
- Where
- Belgium
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Xerostomia Due to Radiotherapy
Clinical Trial to Evaluate the Effect and Safety of MSV in Xerostomy
Phase II not controlled, open-label, prospective, single center clinical trial
- Trial name
- NCT03743155
- Testing
- mesenchymal cells
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Institut de Terapia Regenerativa Tissular
Cancer of Head Neck, Radiation-Induced Xerostomia
Efficacy of Oral Moisturizing Jelly on Oral Health and Nutrition in Post-radiotherapy Head and Neck Cancer Patients
This randomized control trial aims to investigate the efficacy of oral moisturizing jelly in head and neck cancer patients with xerostomia.
- Conditions
- Cancer of Head Neck, Radiation-Induced Xerostomia, Dry Mouth
- Trial name
- NCT03035825
- Testing
- Oral moisturizing jelly, Artificial saliva
- Where
- Thailand
- Volunteers
- 73 people
- Sponsor
- Dental Innovation Foundation Under Royal Patronage
Mucositis, Dry Mouth
Effect of Fluoride Varnish and CPP-ACP on Oral and Salivary Symptoms During Chemotherapy
The purpose of this study was to investigate the effect of Fluoride varnish and Casein Phospho-Peptide Amorphous Calcium Phosphate (CPP-ACP) containing paste on oral symptoms and salivary characteristics in patients under…
- Conditions
- Mucositis, Dry Mouth, Infection
- Trial name
- NCT01737307
- Testing
- Fluoride varnish, Oral Hygiene, CPP-ACP
- Where
- Iran
- Volunteers
- 30 people
- Sponsor
- Azad University of Medical Sciences
Head and Neck Cancer, Oral Complications
Pilocarpine in Preventing Mucositis and Dry Mouth in Patients Receiving Radiation Therapy for Head and Neck Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs such as pilocarpine may protect normal cells from the side effects of radiation therapy.
- Trial name
- NCT00003139
- Testing
- pilocarpine hydrochloride
- Where
- 232 sites in United States, Canada
- Volunteers
- 249 people
- Sponsor
- Radiation Therapy Oncology Group
Cancer, Head and Neck Cancer
Trial Comparing Oral Pilocarpine (Salagen) Versus Submandibular Salivary Gland Transfer Protocol, For the Prevention of Radiation (XRT) Induced Xerostomia in Head and Neck Cancer Patients
This is a study to see whether the drug Salagen or salivary gland transfer is better for the prevention of dryness of the mouth in patients with head and neck cancer receiving radiation treatment.
- Trial name
- NCT00168181
- Testing
- Submandibular gland Transfer, Salagen
- Where
- Canada
- Volunteers
- 220 people
- Sponsor
- Alberta Health services
Sjogren's Syndrome, Non-celiac Gluten Sensitivity
Wheat-free Diet in the Treatment of Sjogren's Syndrome
Recent data show that some foods can increase intestinal mucosa permeability and immune activation of subjects with gastrointestinal (GI) symptoms.
- Trial name
- NCT05644795
- Testing
- Wheat/milk free diet (W/MFD) group, Rice/turkey free diet (R/TFD) group
- Where
- 3 sites in Italy
- Volunteers
- 30 people
- Sponsor
- University of Palermo
Xerostomia Due to Radiotherapy, Hyposalivation
Allogeneic Mesenchymal Stem Cells for Radiation-induced Hyposalivation and Xerostomia/Dry Mouth
An investigator-initiated, non-randomized, open label study to investigate the safety, feasibility and tolerability of intraglandular injection of allogeneic mesenchymal stem/stromal cells (MSCs) into the submandibular and…
- Conditions
- Xerostomia Due to Radiotherapy, Hyposalivation, Xerostomia, Oropharynx Cancer
- Trial name
- MESRIX-SAFETY (NCT03874572)
- Testing
- Allogeneic adipose derived stem/stromal cells
- Where
- 2 sites in Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Mortality, Oral Health
De-adoption of Oral Chlorhexidine Prophylaxis and Implementation of an Oral Care Bundle (CHORAL)
The objective of the CHORAL study is to evaluate the de-adoption of oral chlorhexidine and the introduction of a bundle of oral care practices on selected outcomes in critically ill mechanically ventilated adults.
- Conditions
- Mortality, Oral Health, Dryness, Mouth, Pain, Orofacial
- Trial name
- CHORAL (NCT03382730)
- Testing
- Chlorhexidine Mouth Rinse, Chlorhexidine Mouth Rinse De-Adoption
- Where
- 5 sites in Canada
- Volunteers
- 3,260 people
- Sponsor
- University of Toronto
Head and Neck Cancer, Radiation Toxicity
Electroacupuncture in Treating Chronic Dry Mouth Caused By Radiation Therapy in Patients With Head and Neck Cancer
RATIONALE: Electroacupuncture may help relieve chronic dry mouth caused by radiation therapy. It is not yet known whether electroacupuncture is more effective than a placebo in treating chronic dry mouth caused by radiation…
- Conditions
- Head and Neck Cancer, Radiation Toxicity, Xerostomia
- Trial name
- NCT00623129
- Testing
- questionnaire administration, electroacupuncture therapy, management of therapy complications
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Sjogren's Syndrome, Autoimmune Diseases
A Study of CD19/BCMA Chimeric Antigen Receptor T Cells Therapy for Patients With Refractory Sjogren's Syndrome
A Study of CD19/BCMA Chimeric Antigen Receptor T Cells Therapy for Patients With Refractory Sjogren's Syndrome
- Trial name
- NCT05085431
- Testing
- Assigned Interventions CD19/BCMA CAR T-cells
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Zhejiang University
Sjogren's Syndrome
Interstitial Lung Diseases in Primary Sjogren's Syndrome
Patients with pSS seen in the Division of Rheumatology, the second affiliated hospital of Zhejiang University, School of Medicine (SAHZU) during January 2016 to July 2018, were retrospectively reviewed.
- Trial name
- NCT04978883
- Testing
- No intervention
- Volunteers
- 170 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Xerostomia
Hypnosis for Treating Xerostomia Following Radiotherapy in Head & Neck Cancer Patients
xerostomia develops in all patients with head and neck cancer following radiotherapy. it consists one of the main side effects which affects quality of life. currently, there is no standard of care for treating this condition.
- Trial name
- NCT00408759
- Testing
- hypnosis
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Bnai Zion Medical Center
Xerostomia, Dry Mouth
Efficacy of Natural Enzymes Mouthwash: a Randomised Controlled Trial
The goal of this clinical is to assess the efficacy of natural enzymes mouthwash in the treatment of xerostomia (dry mouth). The main questions it aims to answer are: (1) the efficacy of natural enzymes mouthwash in the…
- Trial name
- NCT05640362
- Testing
- Natural enzymes mouthwash, Benzydamine mouthwash
- Where
- Malaysia
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Sjogren's Syndrome
tDCS for Fatigue in Sjogren's Syndrome
Sjogren's Syndrome (SS) is an autoimune disease of unknown etiology characterized by lymphocytic infiltration of the exocrine glands and other organs.
- Trial name
- NCT04119128
- Testing
- Active Transcranial Direct Current Stimulation
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- Federal University of São Paulo